Eintrag weiter verarbeiten
Early diffusion weighted imaging and expression of heat shock protein 70 in newborn pigs with hypoxic ischaemic encephalopathy
Gespeichert in:
| Zeitschriftentitel: | Postgraduate Medical Journal |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | Postgraduate Medical Journal, 81, 2005, 959, S. 589-593 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Oxford University Press (OUP)
|
| Schlagwörter: |
| author_facet |
Cheng, Y Liu, G R Guan, J T Guo, Y L Li, Y K Wu, R H Cheng, Y Liu, G R Guan, J T Guo, Y L Li, Y K Wu, R H |
|---|---|
| author |
Cheng, Y Liu, G R Guan, J T Guo, Y L Li, Y K Wu, R H |
| spellingShingle |
Cheng, Y Liu, G R Guan, J T Guo, Y L Li, Y K Wu, R H Postgraduate Medical Journal Early diffusion weighted imaging and expression of heat shock protein 70 in newborn pigs with hypoxic ischaemic encephalopathy General Medicine |
| author_sort |
cheng, y |
| spelling |
Cheng, Y Liu, G R Guan, J T Guo, Y L Li, Y K Wu, R H 0032-5473 1469-0756 Oxford University Press (OUP) General Medicine http://dx.doi.org/10.1136/pgmj.2004.030114 <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Objective</jats:title> <jats:p>To establish a cerebral hypoxia ischaemic model in piglets and to explore the early diffusion weighted imaging (DWI) as well as the expression of heat shock protein 70 (HSP70) with hypoxic ischaemic encephalopathy (HIE).</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>Twenty four 3 day old piglets were permanently ligated common carotid arteries bilaterally and ventilated with 3% oxygen for 30 minutes, and their brains were examined at three hours, six hours, and 24 hours after hypoxic ischaemia with T2 weighted images and diffusion weighted images. Apparent diffusion coefficient (ADC) values were measured and HSP70 expression was detected in the central and peripheral regions of lesions.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Abnormal signal intensity was detected on DWI and ADC maps in three hypoxic ischaemic groups. ADC values in the central lesions rapidly decreased, whereas ADC values in the peripheral regions reduced prominently at 24 hours after hypoxic ischaemia. There were significant differences (p&lt;0.01) between ADC values of the central regions and the peripheral regions of lesions. The number of HSP70 positive cells was low at three hours, raised at the highest peak at six hours, and then rapidly decreased. There was statistical difference between HSP70 positive cells in the central regions and those in peripheral regions (p&lt;0.01).</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>DWI may identify more early lesions, and improve conspicuity in the acute setting. ADC values can be used as an objective measure for hypoxic ischaemic injury. Tissue reversibility can be further reflected according to the information of ADC values and HSP70 immunohistochemical staining.</jats:p> </jats:sec> Early diffusion weighted imaging and expression of heat shock protein 70 in newborn pigs with hypoxic ischaemic encephalopathy Postgraduate Medical Journal |
| doi_str_mv |
10.1136/pgmj.2004.030114 |
| facet_avail |
Online Free |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEzNi9wZ21qLjIwMDQuMDMwMTE0 |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEzNi9wZ21qLjIwMDQuMDMwMTE0 |
| institution |
DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Rs1 DE-Pl11 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 |
| imprint |
Oxford University Press (OUP), 2005 |
| imprint_str_mv |
Oxford University Press (OUP), 2005 |
| issn |
0032-5473 1469-0756 |
| issn_str_mv |
0032-5473 1469-0756 |
| language |
English |
| mega_collection |
Oxford University Press (OUP) (CrossRef) |
| match_str |
cheng2005earlydiffusionweightedimagingandexpressionofheatshockprotein70innewbornpigswithhypoxicischaemicencephalopathy |
| publishDateSort |
2005 |
| publisher |
Oxford University Press (OUP) |
| recordtype |
ai |
| record_format |
ai |
| series |
Postgraduate Medical Journal |
| source_id |
49 |
| title |
Early diffusion weighted imaging and expression of heat shock protein 70 in newborn pigs with hypoxic ischaemic encephalopathy |
| title_unstemmed |
Early diffusion weighted imaging and expression of heat shock protein 70 in newborn pigs with hypoxic ischaemic encephalopathy |
| title_full |
Early diffusion weighted imaging and expression of heat shock protein 70 in newborn pigs with hypoxic ischaemic encephalopathy |
| title_fullStr |
Early diffusion weighted imaging and expression of heat shock protein 70 in newborn pigs with hypoxic ischaemic encephalopathy |
| title_full_unstemmed |
Early diffusion weighted imaging and expression of heat shock protein 70 in newborn pigs with hypoxic ischaemic encephalopathy |
| title_short |
Early diffusion weighted imaging and expression of heat shock protein 70 in newborn pigs with hypoxic ischaemic encephalopathy |
| title_sort |
early diffusion weighted imaging and expression of heat shock protein 70 in newborn pigs with hypoxic ischaemic encephalopathy |
| topic |
General Medicine |
| url |
http://dx.doi.org/10.1136/pgmj.2004.030114 |
| publishDate |
2005 |
| physical |
589-593 |
| description |
<jats:title>Abstract</jats:title>
<jats:sec>
<jats:title>Objective</jats:title>
<jats:p>To establish a cerebral hypoxia ischaemic model in piglets and to explore the early diffusion weighted imaging (DWI) as well as the expression of heat shock protein 70 (HSP70) with hypoxic ischaemic encephalopathy (HIE).</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Methods</jats:title>
<jats:p>Twenty four 3 day old piglets were permanently ligated common carotid arteries bilaterally and ventilated with 3% oxygen for 30 minutes, and their brains were examined at three hours, six hours, and 24 hours after hypoxic ischaemia with T2 weighted images and diffusion weighted images. Apparent diffusion coefficient (ADC) values were measured and HSP70 expression was detected in the central and peripheral regions of lesions.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Results</jats:title>
<jats:p>Abnormal signal intensity was detected on DWI and ADC maps in three hypoxic ischaemic groups. ADC values in the central lesions rapidly decreased, whereas ADC values in the peripheral regions reduced prominently at 24 hours after hypoxic ischaemia. There were significant differences (p&lt;0.01) between ADC values of the central regions and the peripheral regions of lesions. The number of HSP70 positive cells was low at three hours, raised at the highest peak at six hours, and then rapidly decreased. There was statistical difference between HSP70 positive cells in the central regions and those in peripheral regions (p&lt;0.01).</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusion</jats:title>
<jats:p>DWI may identify more early lesions, and improve conspicuity in the acute setting. ADC values can be used as an objective measure for hypoxic ischaemic injury. Tissue reversibility can be further reflected according to the information of ADC values and HSP70 immunohistochemical staining.</jats:p>
</jats:sec> |
| container_issue |
959 |
| container_start_page |
589 |
| container_title |
Postgraduate Medical Journal |
| container_volume |
81 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792330939560361985 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T13:32:47.549Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Early+diffusion+weighted+imaging+and+expression+of+heat+shock+protein+70+in+newborn+pigs+with+hypoxic+ischaemic+encephalopathy&rft.date=2005-09-01&genre=article&issn=1469-0756&volume=81&issue=959&spage=589&epage=593&pages=589-593&jtitle=Postgraduate+Medical+Journal&atitle=Early+diffusion+weighted+imaging+and+expression+of+heat+shock+protein+70+in+newborn+pigs+with+hypoxic+ischaemic+encephalopathy&aulast=Wu&aufirst=R+H&rft_id=info%3Adoi%2F10.1136%2Fpgmj.2004.030114&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792330939560361985 |
| author | Cheng, Y, Liu, G R, Guan, J T, Guo, Y L, Li, Y K, Wu, R H |
| author_facet | Cheng, Y, Liu, G R, Guan, J T, Guo, Y L, Li, Y K, Wu, R H, Cheng, Y, Liu, G R, Guan, J T, Guo, Y L, Li, Y K, Wu, R H |
| author_sort | cheng, y |
| container_issue | 959 |
| container_start_page | 589 |
| container_title | Postgraduate Medical Journal |
| container_volume | 81 |
| description | <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Objective</jats:title> <jats:p>To establish a cerebral hypoxia ischaemic model in piglets and to explore the early diffusion weighted imaging (DWI) as well as the expression of heat shock protein 70 (HSP70) with hypoxic ischaemic encephalopathy (HIE).</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>Twenty four 3 day old piglets were permanently ligated common carotid arteries bilaterally and ventilated with 3% oxygen for 30 minutes, and their brains were examined at three hours, six hours, and 24 hours after hypoxic ischaemia with T2 weighted images and diffusion weighted images. Apparent diffusion coefficient (ADC) values were measured and HSP70 expression was detected in the central and peripheral regions of lesions.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Abnormal signal intensity was detected on DWI and ADC maps in three hypoxic ischaemic groups. ADC values in the central lesions rapidly decreased, whereas ADC values in the peripheral regions reduced prominently at 24 hours after hypoxic ischaemia. There were significant differences (p&lt;0.01) between ADC values of the central regions and the peripheral regions of lesions. The number of HSP70 positive cells was low at three hours, raised at the highest peak at six hours, and then rapidly decreased. There was statistical difference between HSP70 positive cells in the central regions and those in peripheral regions (p&lt;0.01).</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>DWI may identify more early lesions, and improve conspicuity in the acute setting. ADC values can be used as an objective measure for hypoxic ischaemic injury. Tissue reversibility can be further reflected according to the information of ADC values and HSP70 immunohistochemical staining.</jats:p> </jats:sec> |
| doi_str_mv | 10.1136/pgmj.2004.030114 |
| facet_avail | Online, Free |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEzNi9wZ21qLjIwMDQuMDMwMTE0 |
| imprint | Oxford University Press (OUP), 2005 |
| imprint_str_mv | Oxford University Press (OUP), 2005 |
| institution | DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3 |
| issn | 0032-5473, 1469-0756 |
| issn_str_mv | 0032-5473, 1469-0756 |
| language | English |
| last_indexed | 2024-03-01T13:32:47.549Z |
| match_str | cheng2005earlydiffusionweightedimagingandexpressionofheatshockprotein70innewbornpigswithhypoxicischaemicencephalopathy |
| mega_collection | Oxford University Press (OUP) (CrossRef) |
| physical | 589-593 |
| publishDate | 2005 |
| publishDateSort | 2005 |
| publisher | Oxford University Press (OUP) |
| record_format | ai |
| recordtype | ai |
| series | Postgraduate Medical Journal |
| source_id | 49 |
| spelling | Cheng, Y Liu, G R Guan, J T Guo, Y L Li, Y K Wu, R H 0032-5473 1469-0756 Oxford University Press (OUP) General Medicine http://dx.doi.org/10.1136/pgmj.2004.030114 <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Objective</jats:title> <jats:p>To establish a cerebral hypoxia ischaemic model in piglets and to explore the early diffusion weighted imaging (DWI) as well as the expression of heat shock protein 70 (HSP70) with hypoxic ischaemic encephalopathy (HIE).</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>Twenty four 3 day old piglets were permanently ligated common carotid arteries bilaterally and ventilated with 3% oxygen for 30 minutes, and their brains were examined at three hours, six hours, and 24 hours after hypoxic ischaemia with T2 weighted images and diffusion weighted images. Apparent diffusion coefficient (ADC) values were measured and HSP70 expression was detected in the central and peripheral regions of lesions.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Abnormal signal intensity was detected on DWI and ADC maps in three hypoxic ischaemic groups. ADC values in the central lesions rapidly decreased, whereas ADC values in the peripheral regions reduced prominently at 24 hours after hypoxic ischaemia. There were significant differences (p&lt;0.01) between ADC values of the central regions and the peripheral regions of lesions. The number of HSP70 positive cells was low at three hours, raised at the highest peak at six hours, and then rapidly decreased. There was statistical difference between HSP70 positive cells in the central regions and those in peripheral regions (p&lt;0.01).</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>DWI may identify more early lesions, and improve conspicuity in the acute setting. ADC values can be used as an objective measure for hypoxic ischaemic injury. Tissue reversibility can be further reflected according to the information of ADC values and HSP70 immunohistochemical staining.</jats:p> </jats:sec> Early diffusion weighted imaging and expression of heat shock protein 70 in newborn pigs with hypoxic ischaemic encephalopathy Postgraduate Medical Journal |
| spellingShingle | Cheng, Y, Liu, G R, Guan, J T, Guo, Y L, Li, Y K, Wu, R H, Postgraduate Medical Journal, Early diffusion weighted imaging and expression of heat shock protein 70 in newborn pigs with hypoxic ischaemic encephalopathy, General Medicine |
| title | Early diffusion weighted imaging and expression of heat shock protein 70 in newborn pigs with hypoxic ischaemic encephalopathy |
| title_full | Early diffusion weighted imaging and expression of heat shock protein 70 in newborn pigs with hypoxic ischaemic encephalopathy |
| title_fullStr | Early diffusion weighted imaging and expression of heat shock protein 70 in newborn pigs with hypoxic ischaemic encephalopathy |
| title_full_unstemmed | Early diffusion weighted imaging and expression of heat shock protein 70 in newborn pigs with hypoxic ischaemic encephalopathy |
| title_short | Early diffusion weighted imaging and expression of heat shock protein 70 in newborn pigs with hypoxic ischaemic encephalopathy |
| title_sort | early diffusion weighted imaging and expression of heat shock protein 70 in newborn pigs with hypoxic ischaemic encephalopathy |
| title_unstemmed | Early diffusion weighted imaging and expression of heat shock protein 70 in newborn pigs with hypoxic ischaemic encephalopathy |
| topic | General Medicine |
| url | http://dx.doi.org/10.1136/pgmj.2004.030114 |