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Planktonic and Sessile Artificial Colonic Microbiota Harbor Distinct Composition and Reestablish Differently upon Frozen and Freeze-Dried Long-Term Storage
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| Zeitschriftentitel: | mSystems |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | mSystems, 5, 2020, 1 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
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| Schlagwörter: |
| author_facet |
Bircher, Lea Schwab, Clarissa Geirnaert, Annelies Greppi, Anna Lacroix, Christophe Bircher, Lea Schwab, Clarissa Geirnaert, Annelies Greppi, Anna Lacroix, Christophe |
|---|---|
| author |
Bircher, Lea Schwab, Clarissa Geirnaert, Annelies Greppi, Anna Lacroix, Christophe |
| spellingShingle |
Bircher, Lea Schwab, Clarissa Geirnaert, Annelies Greppi, Anna Lacroix, Christophe mSystems Planktonic and Sessile Artificial Colonic Microbiota Harbor Distinct Composition and Reestablish Differently upon Frozen and Freeze-Dried Long-Term Storage Computer Science Applications Genetics Molecular Biology Modeling and Simulation Ecology, Evolution, Behavior and Systematics Biochemistry Physiology Microbiology |
| author_sort |
bircher, lea |
| spelling |
Bircher, Lea Schwab, Clarissa Geirnaert, Annelies Greppi, Anna Lacroix, Christophe 2379-5077 American Society for Microbiology Computer Science Applications Genetics Molecular Biology Modeling and Simulation Ecology, Evolution, Behavior and Systematics Biochemistry Physiology Microbiology http://dx.doi.org/10.1128/msystems.00521-19 <jats:p> Fecal microbiota transplantation has been successfully applied in the treatment of recurrent <jats:named-content content-type="genus-species">Clostridium difficile</jats:named-content> infection and has been suggested as an alternative therapy for other intestinal disorders such as inflammatory bowel disease or metabolic syndrome. “Artificial” colonic microbiota delivered by PolyFermS continuous fermentation models can provide a controllable and reproducible alternative to fecal transplantation, but effective preservation strategies must be developed. In this study, we systematically investigated the response of sessile and planktonic artificial colonic microbiota to cryopreservation and lyophilization. We suggest that functional redundancy is an important factor in providing functional stability with respect to exposure to stress during processing and storage. Functional redundancy in compositionally reduced microbial systems may be considered when designing microbial products for therapy. </jats:p> Planktonic and Sessile Artificial Colonic Microbiota Harbor Distinct Composition and Reestablish Differently upon Frozen and Freeze-Dried Long-Term Storage mSystems |
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10.1128/msystems.00521-19 |
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American Society for Microbiology, 2020 |
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| title |
Planktonic and Sessile Artificial Colonic Microbiota Harbor Distinct Composition and Reestablish Differently upon Frozen and Freeze-Dried Long-Term Storage |
| title_unstemmed |
Planktonic and Sessile Artificial Colonic Microbiota Harbor Distinct Composition and Reestablish Differently upon Frozen and Freeze-Dried Long-Term Storage |
| title_full |
Planktonic and Sessile Artificial Colonic Microbiota Harbor Distinct Composition and Reestablish Differently upon Frozen and Freeze-Dried Long-Term Storage |
| title_fullStr |
Planktonic and Sessile Artificial Colonic Microbiota Harbor Distinct Composition and Reestablish Differently upon Frozen and Freeze-Dried Long-Term Storage |
| title_full_unstemmed |
Planktonic and Sessile Artificial Colonic Microbiota Harbor Distinct Composition and Reestablish Differently upon Frozen and Freeze-Dried Long-Term Storage |
| title_short |
Planktonic and Sessile Artificial Colonic Microbiota Harbor Distinct Composition and Reestablish Differently upon Frozen and Freeze-Dried Long-Term Storage |
| title_sort |
planktonic and sessile artificial colonic microbiota harbor distinct composition and reestablish differently upon frozen and freeze-dried long-term storage |
| topic |
Computer Science Applications Genetics Molecular Biology Modeling and Simulation Ecology, Evolution, Behavior and Systematics Biochemistry Physiology Microbiology |
| url |
http://dx.doi.org/10.1128/msystems.00521-19 |
| publishDate |
2020 |
| physical |
|
| description |
<jats:p>
Fecal microbiota transplantation has been successfully applied in the treatment of recurrent
<jats:named-content content-type="genus-species">Clostridium difficile</jats:named-content>
infection and has been suggested as an alternative therapy for other intestinal disorders such as inflammatory bowel disease or metabolic syndrome. “Artificial” colonic microbiota delivered by PolyFermS continuous fermentation models can provide a controllable and reproducible alternative to fecal transplantation, but effective preservation strategies must be developed. In this study, we systematically investigated the response of sessile and planktonic artificial colonic microbiota to cryopreservation and lyophilization. We suggest that functional redundancy is an important factor in providing functional stability with respect to exposure to stress during processing and storage. Functional redundancy in compositionally reduced microbial systems may be considered when designing microbial products for therapy.
</jats:p> |
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| author | Bircher, Lea, Schwab, Clarissa, Geirnaert, Annelies, Greppi, Anna, Lacroix, Christophe |
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| description | <jats:p> Fecal microbiota transplantation has been successfully applied in the treatment of recurrent <jats:named-content content-type="genus-species">Clostridium difficile</jats:named-content> infection and has been suggested as an alternative therapy for other intestinal disorders such as inflammatory bowel disease or metabolic syndrome. “Artificial” colonic microbiota delivered by PolyFermS continuous fermentation models can provide a controllable and reproducible alternative to fecal transplantation, but effective preservation strategies must be developed. In this study, we systematically investigated the response of sessile and planktonic artificial colonic microbiota to cryopreservation and lyophilization. We suggest that functional redundancy is an important factor in providing functional stability with respect to exposure to stress during processing and storage. Functional redundancy in compositionally reduced microbial systems may be considered when designing microbial products for therapy. </jats:p> |
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| spelling | Bircher, Lea Schwab, Clarissa Geirnaert, Annelies Greppi, Anna Lacroix, Christophe 2379-5077 American Society for Microbiology Computer Science Applications Genetics Molecular Biology Modeling and Simulation Ecology, Evolution, Behavior and Systematics Biochemistry Physiology Microbiology http://dx.doi.org/10.1128/msystems.00521-19 <jats:p> Fecal microbiota transplantation has been successfully applied in the treatment of recurrent <jats:named-content content-type="genus-species">Clostridium difficile</jats:named-content> infection and has been suggested as an alternative therapy for other intestinal disorders such as inflammatory bowel disease or metabolic syndrome. “Artificial” colonic microbiota delivered by PolyFermS continuous fermentation models can provide a controllable and reproducible alternative to fecal transplantation, but effective preservation strategies must be developed. In this study, we systematically investigated the response of sessile and planktonic artificial colonic microbiota to cryopreservation and lyophilization. We suggest that functional redundancy is an important factor in providing functional stability with respect to exposure to stress during processing and storage. Functional redundancy in compositionally reduced microbial systems may be considered when designing microbial products for therapy. </jats:p> Planktonic and Sessile Artificial Colonic Microbiota Harbor Distinct Composition and Reestablish Differently upon Frozen and Freeze-Dried Long-Term Storage mSystems |
| spellingShingle | Bircher, Lea, Schwab, Clarissa, Geirnaert, Annelies, Greppi, Anna, Lacroix, Christophe, mSystems, Planktonic and Sessile Artificial Colonic Microbiota Harbor Distinct Composition and Reestablish Differently upon Frozen and Freeze-Dried Long-Term Storage, Computer Science Applications, Genetics, Molecular Biology, Modeling and Simulation, Ecology, Evolution, Behavior and Systematics, Biochemistry, Physiology, Microbiology |
| title | Planktonic and Sessile Artificial Colonic Microbiota Harbor Distinct Composition and Reestablish Differently upon Frozen and Freeze-Dried Long-Term Storage |
| title_full | Planktonic and Sessile Artificial Colonic Microbiota Harbor Distinct Composition and Reestablish Differently upon Frozen and Freeze-Dried Long-Term Storage |
| title_fullStr | Planktonic and Sessile Artificial Colonic Microbiota Harbor Distinct Composition and Reestablish Differently upon Frozen and Freeze-Dried Long-Term Storage |
| title_full_unstemmed | Planktonic and Sessile Artificial Colonic Microbiota Harbor Distinct Composition and Reestablish Differently upon Frozen and Freeze-Dried Long-Term Storage |
| title_short | Planktonic and Sessile Artificial Colonic Microbiota Harbor Distinct Composition and Reestablish Differently upon Frozen and Freeze-Dried Long-Term Storage |
| title_sort | planktonic and sessile artificial colonic microbiota harbor distinct composition and reestablish differently upon frozen and freeze-dried long-term storage |
| title_unstemmed | Planktonic and Sessile Artificial Colonic Microbiota Harbor Distinct Composition and Reestablish Differently upon Frozen and Freeze-Dried Long-Term Storage |
| topic | Computer Science Applications, Genetics, Molecular Biology, Modeling and Simulation, Ecology, Evolution, Behavior and Systematics, Biochemistry, Physiology, Microbiology |
| url | http://dx.doi.org/10.1128/msystems.00521-19 |