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Magnesium Links Starvation-Mediated Antibiotic Persistence to ATP
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| Zeitschriftentitel: | mSphere |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | mSphere, 5, 2020, 1 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
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| Schlagwörter: |
| author_facet |
Xu, Tao Wang, Xuyang Meng, Lu Zhu, Mengqi Wu, Jing Xu, Yuanyuan Zhang, Ying Zhang, Wenhong Xu, Tao Wang, Xuyang Meng, Lu Zhu, Mengqi Wu, Jing Xu, Yuanyuan Zhang, Ying Zhang, Wenhong |
|---|---|
| author |
Xu, Tao Wang, Xuyang Meng, Lu Zhu, Mengqi Wu, Jing Xu, Yuanyuan Zhang, Ying Zhang, Wenhong |
| spellingShingle |
Xu, Tao Wang, Xuyang Meng, Lu Zhu, Mengqi Wu, Jing Xu, Yuanyuan Zhang, Ying Zhang, Wenhong mSphere Magnesium Links Starvation-Mediated Antibiotic Persistence to ATP Molecular Biology Microbiology |
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xu, tao |
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Xu, Tao Wang, Xuyang Meng, Lu Zhu, Mengqi Wu, Jing Xu, Yuanyuan Zhang, Ying Zhang, Wenhong 2379-5042 American Society for Microbiology Molecular Biology Microbiology http://dx.doi.org/10.1128/msphere.00862-19 <jats:p> Various genes have been identified to be involved in bacterial persister formation regardless of the presence or absence of persister genes. Despite recent discoveries of the roles of ATP and membrane potential in persister formation, the key element that triggers change of ATP or membrane potential remains elusive. Our work demonstrates that Mg <jats:sup>2+</jats:sup> instead of other ions or nutrient components is the key element for persistence by inducing a decrease of cytoplasmic ATP, which subsequently induces persister formation. In addition, we observed tight regulation of genes for Mg <jats:sup>2+</jats:sup> transport in different growth phases in <jats:named-content content-type="genus-species">S. aureus</jats:named-content> . These findings indicate that despite being a key nutrient, Mg <jats:sup>2+</jats:sup> also served as a key signal in persister formation during growth. </jats:p> Magnesium Links Starvation-Mediated Antibiotic Persistence to ATP mSphere |
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American Society for Microbiology, 2020 |
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American Society for Microbiology, 2020 |
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| title |
Magnesium Links Starvation-Mediated Antibiotic Persistence to ATP |
| title_unstemmed |
Magnesium Links Starvation-Mediated Antibiotic Persistence to ATP |
| title_full |
Magnesium Links Starvation-Mediated Antibiotic Persistence to ATP |
| title_fullStr |
Magnesium Links Starvation-Mediated Antibiotic Persistence to ATP |
| title_full_unstemmed |
Magnesium Links Starvation-Mediated Antibiotic Persistence to ATP |
| title_short |
Magnesium Links Starvation-Mediated Antibiotic Persistence to ATP |
| title_sort |
magnesium links starvation-mediated antibiotic persistence to atp |
| topic |
Molecular Biology Microbiology |
| url |
http://dx.doi.org/10.1128/msphere.00862-19 |
| publishDate |
2020 |
| physical |
|
| description |
<jats:p>
Various genes have been identified to be involved in bacterial persister formation regardless of the presence or absence of persister genes. Despite recent discoveries of the roles of ATP and membrane potential in persister formation, the key element that triggers change of ATP or membrane potential remains elusive. Our work demonstrates that Mg
<jats:sup>2+</jats:sup>
instead of other ions or nutrient components is the key element for persistence by inducing a decrease of cytoplasmic ATP, which subsequently induces persister formation. In addition, we observed tight regulation of genes for Mg
<jats:sup>2+</jats:sup>
transport in different growth phases in
<jats:named-content content-type="genus-species">S. aureus</jats:named-content>
. These findings indicate that despite being a key nutrient, Mg
<jats:sup>2+</jats:sup>
also served as a key signal in persister formation during growth.
</jats:p> |
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| author | Xu, Tao, Wang, Xuyang, Meng, Lu, Zhu, Mengqi, Wu, Jing, Xu, Yuanyuan, Zhang, Ying, Zhang, Wenhong |
| author_facet | Xu, Tao, Wang, Xuyang, Meng, Lu, Zhu, Mengqi, Wu, Jing, Xu, Yuanyuan, Zhang, Ying, Zhang, Wenhong, Xu, Tao, Wang, Xuyang, Meng, Lu, Zhu, Mengqi, Wu, Jing, Xu, Yuanyuan, Zhang, Ying, Zhang, Wenhong |
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| description | <jats:p> Various genes have been identified to be involved in bacterial persister formation regardless of the presence or absence of persister genes. Despite recent discoveries of the roles of ATP and membrane potential in persister formation, the key element that triggers change of ATP or membrane potential remains elusive. Our work demonstrates that Mg <jats:sup>2+</jats:sup> instead of other ions or nutrient components is the key element for persistence by inducing a decrease of cytoplasmic ATP, which subsequently induces persister formation. In addition, we observed tight regulation of genes for Mg <jats:sup>2+</jats:sup> transport in different growth phases in <jats:named-content content-type="genus-species">S. aureus</jats:named-content> . These findings indicate that despite being a key nutrient, Mg <jats:sup>2+</jats:sup> also served as a key signal in persister formation during growth. </jats:p> |
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| spelling | Xu, Tao Wang, Xuyang Meng, Lu Zhu, Mengqi Wu, Jing Xu, Yuanyuan Zhang, Ying Zhang, Wenhong 2379-5042 American Society for Microbiology Molecular Biology Microbiology http://dx.doi.org/10.1128/msphere.00862-19 <jats:p> Various genes have been identified to be involved in bacterial persister formation regardless of the presence or absence of persister genes. Despite recent discoveries of the roles of ATP and membrane potential in persister formation, the key element that triggers change of ATP or membrane potential remains elusive. Our work demonstrates that Mg <jats:sup>2+</jats:sup> instead of other ions or nutrient components is the key element for persistence by inducing a decrease of cytoplasmic ATP, which subsequently induces persister formation. In addition, we observed tight regulation of genes for Mg <jats:sup>2+</jats:sup> transport in different growth phases in <jats:named-content content-type="genus-species">S. aureus</jats:named-content> . These findings indicate that despite being a key nutrient, Mg <jats:sup>2+</jats:sup> also served as a key signal in persister formation during growth. </jats:p> Magnesium Links Starvation-Mediated Antibiotic Persistence to ATP mSphere |
| spellingShingle | Xu, Tao, Wang, Xuyang, Meng, Lu, Zhu, Mengqi, Wu, Jing, Xu, Yuanyuan, Zhang, Ying, Zhang, Wenhong, mSphere, Magnesium Links Starvation-Mediated Antibiotic Persistence to ATP, Molecular Biology, Microbiology |
| title | Magnesium Links Starvation-Mediated Antibiotic Persistence to ATP |
| title_full | Magnesium Links Starvation-Mediated Antibiotic Persistence to ATP |
| title_fullStr | Magnesium Links Starvation-Mediated Antibiotic Persistence to ATP |
| title_full_unstemmed | Magnesium Links Starvation-Mediated Antibiotic Persistence to ATP |
| title_short | Magnesium Links Starvation-Mediated Antibiotic Persistence to ATP |
| title_sort | magnesium links starvation-mediated antibiotic persistence to atp |
| title_unstemmed | Magnesium Links Starvation-Mediated Antibiotic Persistence to ATP |
| topic | Molecular Biology, Microbiology |
| url | http://dx.doi.org/10.1128/msphere.00862-19 |