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Biosynthesis of β-(1→5)-Galactofuranosyl Chains of Fungal-Type and O -Mannose-Type Galactomannans within the Invasive Pathogen Aspergillus fumigatus
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| Zeitschriftentitel: | mSphere |
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| Personen und Körperschaften: | , , , , , , , , , |
| In: | mSphere, 5, 2020, 1 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
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| Schlagwörter: |
| author_facet |
Chihara, Yuria Tanaka, Yutaka Izumi, Minoru Hagiwara, Daisuke Watanabe, Akira Takegawa, Kaoru Kamei, Katsuhiko Shibata, Nobuyuki Ohta, Kazuyoshi Oka, Takuji Chihara, Yuria Tanaka, Yutaka Izumi, Minoru Hagiwara, Daisuke Watanabe, Akira Takegawa, Kaoru Kamei, Katsuhiko Shibata, Nobuyuki Ohta, Kazuyoshi Oka, Takuji |
|---|---|
| author |
Chihara, Yuria Tanaka, Yutaka Izumi, Minoru Hagiwara, Daisuke Watanabe, Akira Takegawa, Kaoru Kamei, Katsuhiko Shibata, Nobuyuki Ohta, Kazuyoshi Oka, Takuji |
| spellingShingle |
Chihara, Yuria Tanaka, Yutaka Izumi, Minoru Hagiwara, Daisuke Watanabe, Akira Takegawa, Kaoru Kamei, Katsuhiko Shibata, Nobuyuki Ohta, Kazuyoshi Oka, Takuji mSphere Biosynthesis of β-(1→5)-Galactofuranosyl Chains of Fungal-Type and O -Mannose-Type Galactomannans within the Invasive Pathogen Aspergillus fumigatus Molecular Biology Microbiology |
| author_sort |
chihara, yuria |
| spelling |
Chihara, Yuria Tanaka, Yutaka Izumi, Minoru Hagiwara, Daisuke Watanabe, Akira Takegawa, Kaoru Kamei, Katsuhiko Shibata, Nobuyuki Ohta, Kazuyoshi Oka, Takuji 2379-5042 American Society for Microbiology Molecular Biology Microbiology http://dx.doi.org/10.1128/msphere.00770-19 <jats:p> β-(1→5)-Galactofuranosyl residues are widely distributed in the subphylum Pezizomycotina of the phylum Ascomycota. Pezizomycotina includes many plant and animal pathogens. Although the structure of β-(1→5)-galactofuranosyl residues of galactomannans in filamentous fungi was discovered long ago, it remains unclear which enzyme is responsible for biosynthesis of this glycan. Fungal cell wall formation processes are complicated, and information concerning glycosyltransferases is essential for understanding them. In this study, we showed that GfsA and GfsC are responsible for the biosynthesis of all β-(1→5)-galactofuranosyl residues of fungal-type and <jats:italic>O</jats:italic> -mannose-type galactomannans. The data presented here indicate that β-(1→5)-galactofuranosyl residues are involved in cell growth, conidiation, polarity, and cell surface hydrophobicity. Our new understanding of β-(1→5)-galactofuranosyl residue biosynthesis provides important novel insights into the formation of the complex cell wall structure and the virulence of the members of the subphylum Pezizomycotina. </jats:p> Biosynthesis of β-(1→5)-Galactofuranosyl Chains of Fungal-Type and <i>O</i> -Mannose-Type Galactomannans within the Invasive Pathogen Aspergillus fumigatus mSphere |
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10.1128/msphere.00770-19 |
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American Society for Microbiology, 2020 |
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| title |
Biosynthesis of β-(1→5)-Galactofuranosyl Chains of Fungal-Type and O -Mannose-Type Galactomannans within the Invasive Pathogen Aspergillus fumigatus |
| title_unstemmed |
Biosynthesis of β-(1→5)-Galactofuranosyl Chains of Fungal-Type and O -Mannose-Type Galactomannans within the Invasive Pathogen Aspergillus fumigatus |
| title_full |
Biosynthesis of β-(1→5)-Galactofuranosyl Chains of Fungal-Type and O -Mannose-Type Galactomannans within the Invasive Pathogen Aspergillus fumigatus |
| title_fullStr |
Biosynthesis of β-(1→5)-Galactofuranosyl Chains of Fungal-Type and O -Mannose-Type Galactomannans within the Invasive Pathogen Aspergillus fumigatus |
| title_full_unstemmed |
Biosynthesis of β-(1→5)-Galactofuranosyl Chains of Fungal-Type and O -Mannose-Type Galactomannans within the Invasive Pathogen Aspergillus fumigatus |
| title_short |
Biosynthesis of β-(1→5)-Galactofuranosyl Chains of Fungal-Type and O -Mannose-Type Galactomannans within the Invasive Pathogen Aspergillus fumigatus |
| title_sort |
biosynthesis of β-(1→5)-galactofuranosyl chains of fungal-type and
<i>o</i>
-mannose-type galactomannans within the invasive pathogen aspergillus fumigatus |
| topic |
Molecular Biology Microbiology |
| url |
http://dx.doi.org/10.1128/msphere.00770-19 |
| publishDate |
2020 |
| physical |
|
| description |
<jats:p>
β-(1→5)-Galactofuranosyl residues are widely distributed in the subphylum Pezizomycotina of the phylum Ascomycota. Pezizomycotina includes many plant and animal pathogens. Although the structure of β-(1→5)-galactofuranosyl residues of galactomannans in filamentous fungi was discovered long ago, it remains unclear which enzyme is responsible for biosynthesis of this glycan. Fungal cell wall formation processes are complicated, and information concerning glycosyltransferases is essential for understanding them. In this study, we showed that GfsA and GfsC are responsible for the biosynthesis of all β-(1→5)-galactofuranosyl residues of fungal-type and
<jats:italic>O</jats:italic>
-mannose-type galactomannans. The data presented here indicate that β-(1→5)-galactofuranosyl residues are involved in cell growth, conidiation, polarity, and cell surface hydrophobicity. Our new understanding of β-(1→5)-galactofuranosyl residue biosynthesis provides important novel insights into the formation of the complex cell wall structure and the virulence of the members of the subphylum Pezizomycotina.
</jats:p> |
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| author | Chihara, Yuria, Tanaka, Yutaka, Izumi, Minoru, Hagiwara, Daisuke, Watanabe, Akira, Takegawa, Kaoru, Kamei, Katsuhiko, Shibata, Nobuyuki, Ohta, Kazuyoshi, Oka, Takuji |
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| description | <jats:p> β-(1→5)-Galactofuranosyl residues are widely distributed in the subphylum Pezizomycotina of the phylum Ascomycota. Pezizomycotina includes many plant and animal pathogens. Although the structure of β-(1→5)-galactofuranosyl residues of galactomannans in filamentous fungi was discovered long ago, it remains unclear which enzyme is responsible for biosynthesis of this glycan. Fungal cell wall formation processes are complicated, and information concerning glycosyltransferases is essential for understanding them. In this study, we showed that GfsA and GfsC are responsible for the biosynthesis of all β-(1→5)-galactofuranosyl residues of fungal-type and <jats:italic>O</jats:italic> -mannose-type galactomannans. The data presented here indicate that β-(1→5)-galactofuranosyl residues are involved in cell growth, conidiation, polarity, and cell surface hydrophobicity. Our new understanding of β-(1→5)-galactofuranosyl residue biosynthesis provides important novel insights into the formation of the complex cell wall structure and the virulence of the members of the subphylum Pezizomycotina. </jats:p> |
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| spelling | Chihara, Yuria Tanaka, Yutaka Izumi, Minoru Hagiwara, Daisuke Watanabe, Akira Takegawa, Kaoru Kamei, Katsuhiko Shibata, Nobuyuki Ohta, Kazuyoshi Oka, Takuji 2379-5042 American Society for Microbiology Molecular Biology Microbiology http://dx.doi.org/10.1128/msphere.00770-19 <jats:p> β-(1→5)-Galactofuranosyl residues are widely distributed in the subphylum Pezizomycotina of the phylum Ascomycota. Pezizomycotina includes many plant and animal pathogens. Although the structure of β-(1→5)-galactofuranosyl residues of galactomannans in filamentous fungi was discovered long ago, it remains unclear which enzyme is responsible for biosynthesis of this glycan. Fungal cell wall formation processes are complicated, and information concerning glycosyltransferases is essential for understanding them. In this study, we showed that GfsA and GfsC are responsible for the biosynthesis of all β-(1→5)-galactofuranosyl residues of fungal-type and <jats:italic>O</jats:italic> -mannose-type galactomannans. The data presented here indicate that β-(1→5)-galactofuranosyl residues are involved in cell growth, conidiation, polarity, and cell surface hydrophobicity. Our new understanding of β-(1→5)-galactofuranosyl residue biosynthesis provides important novel insights into the formation of the complex cell wall structure and the virulence of the members of the subphylum Pezizomycotina. </jats:p> Biosynthesis of β-(1→5)-Galactofuranosyl Chains of Fungal-Type and <i>O</i> -Mannose-Type Galactomannans within the Invasive Pathogen Aspergillus fumigatus mSphere |
| spellingShingle | Chihara, Yuria, Tanaka, Yutaka, Izumi, Minoru, Hagiwara, Daisuke, Watanabe, Akira, Takegawa, Kaoru, Kamei, Katsuhiko, Shibata, Nobuyuki, Ohta, Kazuyoshi, Oka, Takuji, mSphere, Biosynthesis of β-(1→5)-Galactofuranosyl Chains of Fungal-Type and O -Mannose-Type Galactomannans within the Invasive Pathogen Aspergillus fumigatus, Molecular Biology, Microbiology |
| title | Biosynthesis of β-(1→5)-Galactofuranosyl Chains of Fungal-Type and O -Mannose-Type Galactomannans within the Invasive Pathogen Aspergillus fumigatus |
| title_full | Biosynthesis of β-(1→5)-Galactofuranosyl Chains of Fungal-Type and O -Mannose-Type Galactomannans within the Invasive Pathogen Aspergillus fumigatus |
| title_fullStr | Biosynthesis of β-(1→5)-Galactofuranosyl Chains of Fungal-Type and O -Mannose-Type Galactomannans within the Invasive Pathogen Aspergillus fumigatus |
| title_full_unstemmed | Biosynthesis of β-(1→5)-Galactofuranosyl Chains of Fungal-Type and O -Mannose-Type Galactomannans within the Invasive Pathogen Aspergillus fumigatus |
| title_short | Biosynthesis of β-(1→5)-Galactofuranosyl Chains of Fungal-Type and O -Mannose-Type Galactomannans within the Invasive Pathogen Aspergillus fumigatus |
| title_sort | biosynthesis of β-(1→5)-galactofuranosyl chains of fungal-type and <i>o</i> -mannose-type galactomannans within the invasive pathogen aspergillus fumigatus |
| title_unstemmed | Biosynthesis of β-(1→5)-Galactofuranosyl Chains of Fungal-Type and O -Mannose-Type Galactomannans within the Invasive Pathogen Aspergillus fumigatus |
| topic | Molecular Biology, Microbiology |
| url | http://dx.doi.org/10.1128/msphere.00770-19 |