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ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli
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| Zeitschriftentitel: | mSphere |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , , , |
| In: | mSphere, 5, 2020, 4 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
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| Schlagwörter: |
| author_facet |
Wallenstein, Alexander Rehm, Nadine Brinkmann, Marina Selle, Martina Bossuet-Greif, Nadège Sauer, Daniel Bunk, Boyke Spröer, Cathrin Wami, Haleluya Tesfaye Homburg, Stefan von Bünau, Rudolf König, Simone Nougayrède, Jean-Philippe Overmann, Jörg Oswald, Eric Müller, Rolf Dobrindt, Ulrich Wallenstein, Alexander Rehm, Nadine Brinkmann, Marina Selle, Martina Bossuet-Greif, Nadège Sauer, Daniel Bunk, Boyke Spröer, Cathrin Wami, Haleluya Tesfaye Homburg, Stefan von Bünau, Rudolf König, Simone Nougayrède, Jean-Philippe Overmann, Jörg Oswald, Eric Müller, Rolf Dobrindt, Ulrich |
|---|---|
| author |
Wallenstein, Alexander Rehm, Nadine Brinkmann, Marina Selle, Martina Bossuet-Greif, Nadège Sauer, Daniel Bunk, Boyke Spröer, Cathrin Wami, Haleluya Tesfaye Homburg, Stefan von Bünau, Rudolf König, Simone Nougayrède, Jean-Philippe Overmann, Jörg Oswald, Eric Müller, Rolf Dobrindt, Ulrich |
| spellingShingle |
Wallenstein, Alexander Rehm, Nadine Brinkmann, Marina Selle, Martina Bossuet-Greif, Nadège Sauer, Daniel Bunk, Boyke Spröer, Cathrin Wami, Haleluya Tesfaye Homburg, Stefan von Bünau, Rudolf König, Simone Nougayrède, Jean-Philippe Overmann, Jörg Oswald, Eric Müller, Rolf Dobrindt, Ulrich mSphere ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli Molecular Biology Microbiology |
| author_sort |
wallenstein, alexander |
| spelling |
Wallenstein, Alexander Rehm, Nadine Brinkmann, Marina Selle, Martina Bossuet-Greif, Nadège Sauer, Daniel Bunk, Boyke Spröer, Cathrin Wami, Haleluya Tesfaye Homburg, Stefan von Bünau, Rudolf König, Simone Nougayrède, Jean-Philippe Overmann, Jörg Oswald, Eric Müller, Rolf Dobrindt, Ulrich 2379-5042 American Society for Microbiology Molecular Biology Microbiology http://dx.doi.org/10.1128/msphere.00591-20 <jats:p>The nonribosomal peptide/polyketide hybrid colibactin can be considered a bacterial virulence factor involved in extraintestinal infection and also a procarcinogen. Nevertheless, and despite its genotoxic effect, colibactin expression can also inhibit bacterial or tumor growth and correlates with probiotic anti-inflammatory and analgesic properties. Although the biological function of this natural compound has been studied extensively, our understanding of the regulation of colibactin expression is still far from complete. We investigated in detail the role of regulatory elements involved in colibactin expression and in the growth conditions that promote colibactin expression. In this way, our data shed light on the regulatory mechanisms involved in colibactin expression and may support the expression and purification of this interesting nonribosomal peptide/polyketide hybrid for further molecular characterization.</jats:p> ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli mSphere |
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| title |
ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli |
| title_unstemmed |
ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli |
| title_full |
ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli |
| title_fullStr |
ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli |
| title_full_unstemmed |
ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli |
| title_short |
ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli |
| title_sort |
clbr is the key transcriptional activator of colibactin gene expression in escherichia coli |
| topic |
Molecular Biology Microbiology |
| url |
http://dx.doi.org/10.1128/msphere.00591-20 |
| publishDate |
2020 |
| physical |
|
| description |
<jats:p>The nonribosomal peptide/polyketide hybrid colibactin can be considered a bacterial virulence factor involved in extraintestinal infection and also a procarcinogen. Nevertheless, and despite its genotoxic effect, colibactin expression can also inhibit bacterial or tumor growth and correlates with probiotic anti-inflammatory and analgesic properties. Although the biological function of this natural compound has been studied extensively, our understanding of the regulation of colibactin expression is still far from complete. We investigated in detail the role of regulatory elements involved in colibactin expression and in the growth conditions that promote colibactin expression. In this way, our data shed light on the regulatory mechanisms involved in colibactin expression and may support the expression and purification of this interesting nonribosomal peptide/polyketide hybrid for further molecular characterization.</jats:p> |
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| author | Wallenstein, Alexander, Rehm, Nadine, Brinkmann, Marina, Selle, Martina, Bossuet-Greif, Nadège, Sauer, Daniel, Bunk, Boyke, Spröer, Cathrin, Wami, Haleluya Tesfaye, Homburg, Stefan, von Bünau, Rudolf, König, Simone, Nougayrède, Jean-Philippe, Overmann, Jörg, Oswald, Eric, Müller, Rolf, Dobrindt, Ulrich |
| author_facet | Wallenstein, Alexander, Rehm, Nadine, Brinkmann, Marina, Selle, Martina, Bossuet-Greif, Nadège, Sauer, Daniel, Bunk, Boyke, Spröer, Cathrin, Wami, Haleluya Tesfaye, Homburg, Stefan, von Bünau, Rudolf, König, Simone, Nougayrède, Jean-Philippe, Overmann, Jörg, Oswald, Eric, Müller, Rolf, Dobrindt, Ulrich, Wallenstein, Alexander, Rehm, Nadine, Brinkmann, Marina, Selle, Martina, Bossuet-Greif, Nadège, Sauer, Daniel, Bunk, Boyke, Spröer, Cathrin, Wami, Haleluya Tesfaye, Homburg, Stefan, von Bünau, Rudolf, König, Simone, Nougayrède, Jean-Philippe, Overmann, Jörg, Oswald, Eric, Müller, Rolf, Dobrindt, Ulrich |
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| description | <jats:p>The nonribosomal peptide/polyketide hybrid colibactin can be considered a bacterial virulence factor involved in extraintestinal infection and also a procarcinogen. Nevertheless, and despite its genotoxic effect, colibactin expression can also inhibit bacterial or tumor growth and correlates with probiotic anti-inflammatory and analgesic properties. Although the biological function of this natural compound has been studied extensively, our understanding of the regulation of colibactin expression is still far from complete. We investigated in detail the role of regulatory elements involved in colibactin expression and in the growth conditions that promote colibactin expression. In this way, our data shed light on the regulatory mechanisms involved in colibactin expression and may support the expression and purification of this interesting nonribosomal peptide/polyketide hybrid for further molecular characterization.</jats:p> |
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| spelling | Wallenstein, Alexander Rehm, Nadine Brinkmann, Marina Selle, Martina Bossuet-Greif, Nadège Sauer, Daniel Bunk, Boyke Spröer, Cathrin Wami, Haleluya Tesfaye Homburg, Stefan von Bünau, Rudolf König, Simone Nougayrède, Jean-Philippe Overmann, Jörg Oswald, Eric Müller, Rolf Dobrindt, Ulrich 2379-5042 American Society for Microbiology Molecular Biology Microbiology http://dx.doi.org/10.1128/msphere.00591-20 <jats:p>The nonribosomal peptide/polyketide hybrid colibactin can be considered a bacterial virulence factor involved in extraintestinal infection and also a procarcinogen. Nevertheless, and despite its genotoxic effect, colibactin expression can also inhibit bacterial or tumor growth and correlates with probiotic anti-inflammatory and analgesic properties. Although the biological function of this natural compound has been studied extensively, our understanding of the regulation of colibactin expression is still far from complete. We investigated in detail the role of regulatory elements involved in colibactin expression and in the growth conditions that promote colibactin expression. In this way, our data shed light on the regulatory mechanisms involved in colibactin expression and may support the expression and purification of this interesting nonribosomal peptide/polyketide hybrid for further molecular characterization.</jats:p> ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli mSphere |
| spellingShingle | Wallenstein, Alexander, Rehm, Nadine, Brinkmann, Marina, Selle, Martina, Bossuet-Greif, Nadège, Sauer, Daniel, Bunk, Boyke, Spröer, Cathrin, Wami, Haleluya Tesfaye, Homburg, Stefan, von Bünau, Rudolf, König, Simone, Nougayrède, Jean-Philippe, Overmann, Jörg, Oswald, Eric, Müller, Rolf, Dobrindt, Ulrich, mSphere, ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli, Molecular Biology, Microbiology |
| title | ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli |
| title_full | ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli |
| title_fullStr | ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli |
| title_full_unstemmed | ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli |
| title_short | ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli |
| title_sort | clbr is the key transcriptional activator of colibactin gene expression in escherichia coli |
| title_unstemmed | ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli |
| topic | Molecular Biology, Microbiology |
| url | http://dx.doi.org/10.1128/msphere.00591-20 |