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Imaging Mass Spectrometry and Proteome Analysis of Marek’s Disease Virus-Induced Tumors
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| Zeitschriftentitel: | mSphere |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | mSphere, 4, 2019, 1 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
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| Schlagwörter: |
| author_facet |
Pauker, V. I. Bertzbach, L. D. Hohmann, A. Kheimar, A. Teifke, J. P. Mettenleiter, T. C. Karger, A. Kaufer, B. B. Pauker, V. I. Bertzbach, L. D. Hohmann, A. Kheimar, A. Teifke, J. P. Mettenleiter, T. C. Karger, A. Kaufer, B. B. |
|---|---|
| author |
Pauker, V. I. Bertzbach, L. D. Hohmann, A. Kheimar, A. Teifke, J. P. Mettenleiter, T. C. Karger, A. Kaufer, B. B. |
| spellingShingle |
Pauker, V. I. Bertzbach, L. D. Hohmann, A. Kheimar, A. Teifke, J. P. Mettenleiter, T. C. Karger, A. Kaufer, B. B. mSphere Imaging Mass Spectrometry and Proteome Analysis of Marek’s Disease Virus-Induced Tumors Molecular Biology Microbiology |
| author_sort |
pauker, v. i. |
| spelling |
Pauker, V. I. Bertzbach, L. D. Hohmann, A. Kheimar, A. Teifke, J. P. Mettenleiter, T. C. Karger, A. Kaufer, B. B. 2379-5042 American Society for Microbiology Molecular Biology Microbiology http://dx.doi.org/10.1128/msphere.00569-18 <jats:p>Marek’s disease virus (MDV) is an oncogenic alphaherpesvirus that infects chickens and causes the most frequent clinically diagnosed cancer in the animal kingdom. Not only is MDV an important pathogen that threatens the poultry industry but it is also used as a natural virus-host model for herpesvirus-induced tumor formation. In order to visualize MDV-induced lymphoma and to identify potential biomarkers in an unbiased approach, we performed imaging mass spectrometry (IMS) and noncontact laser capture microdissection. This study provides a first description of the visualization of MDV-induced tumors by IMS that could be applied also for diagnostic purposes. In addition, we identified and validated potential biomarkers for MDV-induced tumors that could provide the basis for future research on pathogenesis and tumorigenesis of this malignancy.</jats:p> Imaging Mass Spectrometry and Proteome Analysis of Marek’s Disease Virus-Induced Tumors mSphere |
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American Society for Microbiology, 2019 |
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| title |
Imaging Mass Spectrometry and Proteome Analysis of Marek’s Disease Virus-Induced Tumors |
| title_unstemmed |
Imaging Mass Spectrometry and Proteome Analysis of Marek’s Disease Virus-Induced Tumors |
| title_full |
Imaging Mass Spectrometry and Proteome Analysis of Marek’s Disease Virus-Induced Tumors |
| title_fullStr |
Imaging Mass Spectrometry and Proteome Analysis of Marek’s Disease Virus-Induced Tumors |
| title_full_unstemmed |
Imaging Mass Spectrometry and Proteome Analysis of Marek’s Disease Virus-Induced Tumors |
| title_short |
Imaging Mass Spectrometry and Proteome Analysis of Marek’s Disease Virus-Induced Tumors |
| title_sort |
imaging mass spectrometry and proteome analysis of marek’s disease virus-induced tumors |
| topic |
Molecular Biology Microbiology |
| url |
http://dx.doi.org/10.1128/msphere.00569-18 |
| publishDate |
2019 |
| physical |
|
| description |
<jats:p>Marek’s disease virus (MDV) is an oncogenic alphaherpesvirus that infects chickens and causes the most frequent clinically diagnosed cancer in the animal kingdom. Not only is MDV an important pathogen that threatens the poultry industry but it is also used as a natural virus-host model for herpesvirus-induced tumor formation. In order to visualize MDV-induced lymphoma and to identify potential biomarkers in an unbiased approach, we performed imaging mass spectrometry (IMS) and noncontact laser capture microdissection. This study provides a first description of the visualization of MDV-induced tumors by IMS that could be applied also for diagnostic purposes. In addition, we identified and validated potential biomarkers for MDV-induced tumors that could provide the basis for future research on pathogenesis and tumorigenesis of this malignancy.</jats:p> |
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| author | Pauker, V. I., Bertzbach, L. D., Hohmann, A., Kheimar, A., Teifke, J. P., Mettenleiter, T. C., Karger, A., Kaufer, B. B. |
| author_facet | Pauker, V. I., Bertzbach, L. D., Hohmann, A., Kheimar, A., Teifke, J. P., Mettenleiter, T. C., Karger, A., Kaufer, B. B., Pauker, V. I., Bertzbach, L. D., Hohmann, A., Kheimar, A., Teifke, J. P., Mettenleiter, T. C., Karger, A., Kaufer, B. B. |
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| description | <jats:p>Marek’s disease virus (MDV) is an oncogenic alphaherpesvirus that infects chickens and causes the most frequent clinically diagnosed cancer in the animal kingdom. Not only is MDV an important pathogen that threatens the poultry industry but it is also used as a natural virus-host model for herpesvirus-induced tumor formation. In order to visualize MDV-induced lymphoma and to identify potential biomarkers in an unbiased approach, we performed imaging mass spectrometry (IMS) and noncontact laser capture microdissection. This study provides a first description of the visualization of MDV-induced tumors by IMS that could be applied also for diagnostic purposes. In addition, we identified and validated potential biomarkers for MDV-induced tumors that could provide the basis for future research on pathogenesis and tumorigenesis of this malignancy.</jats:p> |
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| spelling | Pauker, V. I. Bertzbach, L. D. Hohmann, A. Kheimar, A. Teifke, J. P. Mettenleiter, T. C. Karger, A. Kaufer, B. B. 2379-5042 American Society for Microbiology Molecular Biology Microbiology http://dx.doi.org/10.1128/msphere.00569-18 <jats:p>Marek’s disease virus (MDV) is an oncogenic alphaherpesvirus that infects chickens and causes the most frequent clinically diagnosed cancer in the animal kingdom. Not only is MDV an important pathogen that threatens the poultry industry but it is also used as a natural virus-host model for herpesvirus-induced tumor formation. In order to visualize MDV-induced lymphoma and to identify potential biomarkers in an unbiased approach, we performed imaging mass spectrometry (IMS) and noncontact laser capture microdissection. This study provides a first description of the visualization of MDV-induced tumors by IMS that could be applied also for diagnostic purposes. In addition, we identified and validated potential biomarkers for MDV-induced tumors that could provide the basis for future research on pathogenesis and tumorigenesis of this malignancy.</jats:p> Imaging Mass Spectrometry and Proteome Analysis of Marek’s Disease Virus-Induced Tumors mSphere |
| spellingShingle | Pauker, V. I., Bertzbach, L. D., Hohmann, A., Kheimar, A., Teifke, J. P., Mettenleiter, T. C., Karger, A., Kaufer, B. B., mSphere, Imaging Mass Spectrometry and Proteome Analysis of Marek’s Disease Virus-Induced Tumors, Molecular Biology, Microbiology |
| title | Imaging Mass Spectrometry and Proteome Analysis of Marek’s Disease Virus-Induced Tumors |
| title_full | Imaging Mass Spectrometry and Proteome Analysis of Marek’s Disease Virus-Induced Tumors |
| title_fullStr | Imaging Mass Spectrometry and Proteome Analysis of Marek’s Disease Virus-Induced Tumors |
| title_full_unstemmed | Imaging Mass Spectrometry and Proteome Analysis of Marek’s Disease Virus-Induced Tumors |
| title_short | Imaging Mass Spectrometry and Proteome Analysis of Marek’s Disease Virus-Induced Tumors |
| title_sort | imaging mass spectrometry and proteome analysis of marek’s disease virus-induced tumors |
| title_unstemmed | Imaging Mass Spectrometry and Proteome Analysis of Marek’s Disease Virus-Induced Tumors |
| topic | Molecular Biology, Microbiology |
| url | http://dx.doi.org/10.1128/msphere.00569-18 |