Eintrag weiter verarbeiten
Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens
Gespeichert in:
| Zeitschriftentitel: | mSphere |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | mSphere, 3, 2018, 5 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
|
| Schlagwörter: |
| author_facet |
Mamouei, Zeinab Alqarihi, Abdullah Singh, Shakti Xu, Shuying Mansour, Michael K. Ibrahim, Ashraf S. Uppuluri, Priya Mamouei, Zeinab Alqarihi, Abdullah Singh, Shakti Xu, Shuying Mansour, Michael K. Ibrahim, Ashraf S. Uppuluri, Priya |
|---|---|
| author |
Mamouei, Zeinab Alqarihi, Abdullah Singh, Shakti Xu, Shuying Mansour, Michael K. Ibrahim, Ashraf S. Uppuluri, Priya |
| spellingShingle |
Mamouei, Zeinab Alqarihi, Abdullah Singh, Shakti Xu, Shuying Mansour, Michael K. Ibrahim, Ashraf S. Uppuluri, Priya mSphere Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens Molecular Biology Microbiology |
| author_sort |
mamouei, zeinab |
| spelling |
Mamouei, Zeinab Alqarihi, Abdullah Singh, Shakti Xu, Shuying Mansour, Michael K. Ibrahim, Ashraf S. Uppuluri, Priya 2379-5042 American Society for Microbiology Molecular Biology Microbiology http://dx.doi.org/10.1128/msphere.00539-18 <jats:p> The prevalence of fungal infections has seen a rise in the past decades due to advances in modern medicine leading to an expanding population of device-associated and immunocompromised patients. Furthermore, the spectrum of pathogenic fungi has changed, with the emergence of multidrug-resistant strains such as <jats:named-content content-type="genus-species">C. auris</jats:named-content> . High mortality related to fungal infections points to major limitations of current antifungal therapy and an unmet need for new antifungal drugs. We screened a library of repurposed FDA-approved inhibitors to identify compounds with activities against a diverse range of fungi in varied phases of growth. The assays identified alexidine dihydrochloride (AXD) to have pronounced antifungal activity, including against preformed biofilms, at concentrations lower than mammalian cell toxicity. AXD potentiated the activity of fluconazole and amphotericin B against <jats:italic>Candida</jats:italic> biofilms <jats:italic>in vitro</jats:italic> and prevented biofilm growth <jats:italic>in vivo</jats:italic> . Thus, AXD has the potential to be developed as a pan-antifungal, antibiofilm drug. </jats:p> Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens mSphere |
| doi_str_mv |
10.1128/msphere.00539-18 |
| facet_avail |
Online Free |
| finc_class_facet |
Biologie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEyOC9tc3BoZXJlLjAwNTM5LTE4 |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEyOC9tc3BoZXJlLjAwNTM5LTE4 |
| institution |
DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 |
| imprint |
American Society for Microbiology, 2018 |
| imprint_str_mv |
American Society for Microbiology, 2018 |
| issn |
2379-5042 |
| issn_str_mv |
2379-5042 |
| language |
English |
| mega_collection |
American Society for Microbiology (CrossRef) |
| match_str |
mamouei2018alexidinedihydrochloridehasbroadspectrumactivitiesagainstdiversefungalpathogens |
| publishDateSort |
2018 |
| publisher |
American Society for Microbiology |
| recordtype |
ai |
| record_format |
ai |
| series |
mSphere |
| source_id |
49 |
| title |
Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens |
| title_unstemmed |
Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens |
| title_full |
Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens |
| title_fullStr |
Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens |
| title_full_unstemmed |
Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens |
| title_short |
Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens |
| title_sort |
alexidine dihydrochloride has broad-spectrum activities against diverse fungal pathogens |
| topic |
Molecular Biology Microbiology |
| url |
http://dx.doi.org/10.1128/msphere.00539-18 |
| publishDate |
2018 |
| physical |
|
| description |
<jats:p>
The prevalence of fungal infections has seen a rise in the past decades due to advances in modern medicine leading to an expanding population of device-associated and immunocompromised patients. Furthermore, the spectrum of pathogenic fungi has changed, with the emergence of multidrug-resistant strains such as
<jats:named-content content-type="genus-species">C. auris</jats:named-content>
. High mortality related to fungal infections points to major limitations of current antifungal therapy and an unmet need for new antifungal drugs. We screened a library of repurposed FDA-approved inhibitors to identify compounds with activities against a diverse range of fungi in varied phases of growth. The assays identified alexidine dihydrochloride (AXD) to have pronounced antifungal activity, including against preformed biofilms, at concentrations lower than mammalian cell toxicity. AXD potentiated the activity of fluconazole and amphotericin B against
<jats:italic>Candida</jats:italic>
biofilms
<jats:italic>in vitro</jats:italic>
and prevented biofilm growth
<jats:italic>in vivo</jats:italic>
. Thus, AXD has the potential to be developed as a pan-antifungal, antibiofilm drug.
</jats:p> |
| container_issue |
5 |
| container_start_page |
0 |
| container_title |
mSphere |
| container_volume |
3 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792348913767809036 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T18:18:44.93Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Alexidine+Dihydrochloride+Has+Broad-Spectrum+Activities+against+Diverse+Fungal+Pathogens&rft.date=2018-10-31&genre=article&issn=2379-5042&volume=3&issue=5&jtitle=mSphere&atitle=Alexidine+Dihydrochloride+Has+Broad-Spectrum+Activities+against+Diverse+Fungal+Pathogens&aulast=Uppuluri&aufirst=Priya&rft_id=info%3Adoi%2F10.1128%2Fmsphere.00539-18&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792348913767809036 |
| author | Mamouei, Zeinab, Alqarihi, Abdullah, Singh, Shakti, Xu, Shuying, Mansour, Michael K., Ibrahim, Ashraf S., Uppuluri, Priya |
| author_facet | Mamouei, Zeinab, Alqarihi, Abdullah, Singh, Shakti, Xu, Shuying, Mansour, Michael K., Ibrahim, Ashraf S., Uppuluri, Priya, Mamouei, Zeinab, Alqarihi, Abdullah, Singh, Shakti, Xu, Shuying, Mansour, Michael K., Ibrahim, Ashraf S., Uppuluri, Priya |
| author_sort | mamouei, zeinab |
| container_issue | 5 |
| container_start_page | 0 |
| container_title | mSphere |
| container_volume | 3 |
| description | <jats:p> The prevalence of fungal infections has seen a rise in the past decades due to advances in modern medicine leading to an expanding population of device-associated and immunocompromised patients. Furthermore, the spectrum of pathogenic fungi has changed, with the emergence of multidrug-resistant strains such as <jats:named-content content-type="genus-species">C. auris</jats:named-content> . High mortality related to fungal infections points to major limitations of current antifungal therapy and an unmet need for new antifungal drugs. We screened a library of repurposed FDA-approved inhibitors to identify compounds with activities against a diverse range of fungi in varied phases of growth. The assays identified alexidine dihydrochloride (AXD) to have pronounced antifungal activity, including against preformed biofilms, at concentrations lower than mammalian cell toxicity. AXD potentiated the activity of fluconazole and amphotericin B against <jats:italic>Candida</jats:italic> biofilms <jats:italic>in vitro</jats:italic> and prevented biofilm growth <jats:italic>in vivo</jats:italic> . Thus, AXD has the potential to be developed as a pan-antifungal, antibiofilm drug. </jats:p> |
| doi_str_mv | 10.1128/msphere.00539-18 |
| facet_avail | Online, Free |
| finc_class_facet | Biologie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEyOC9tc3BoZXJlLjAwNTM5LTE4 |
| imprint | American Society for Microbiology, 2018 |
| imprint_str_mv | American Society for Microbiology, 2018 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
| issn | 2379-5042 |
| issn_str_mv | 2379-5042 |
| language | English |
| last_indexed | 2024-03-01T18:18:44.93Z |
| match_str | mamouei2018alexidinedihydrochloridehasbroadspectrumactivitiesagainstdiversefungalpathogens |
| mega_collection | American Society for Microbiology (CrossRef) |
| physical | |
| publishDate | 2018 |
| publishDateSort | 2018 |
| publisher | American Society for Microbiology |
| record_format | ai |
| recordtype | ai |
| series | mSphere |
| source_id | 49 |
| spelling | Mamouei, Zeinab Alqarihi, Abdullah Singh, Shakti Xu, Shuying Mansour, Michael K. Ibrahim, Ashraf S. Uppuluri, Priya 2379-5042 American Society for Microbiology Molecular Biology Microbiology http://dx.doi.org/10.1128/msphere.00539-18 <jats:p> The prevalence of fungal infections has seen a rise in the past decades due to advances in modern medicine leading to an expanding population of device-associated and immunocompromised patients. Furthermore, the spectrum of pathogenic fungi has changed, with the emergence of multidrug-resistant strains such as <jats:named-content content-type="genus-species">C. auris</jats:named-content> . High mortality related to fungal infections points to major limitations of current antifungal therapy and an unmet need for new antifungal drugs. We screened a library of repurposed FDA-approved inhibitors to identify compounds with activities against a diverse range of fungi in varied phases of growth. The assays identified alexidine dihydrochloride (AXD) to have pronounced antifungal activity, including against preformed biofilms, at concentrations lower than mammalian cell toxicity. AXD potentiated the activity of fluconazole and amphotericin B against <jats:italic>Candida</jats:italic> biofilms <jats:italic>in vitro</jats:italic> and prevented biofilm growth <jats:italic>in vivo</jats:italic> . Thus, AXD has the potential to be developed as a pan-antifungal, antibiofilm drug. </jats:p> Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens mSphere |
| spellingShingle | Mamouei, Zeinab, Alqarihi, Abdullah, Singh, Shakti, Xu, Shuying, Mansour, Michael K., Ibrahim, Ashraf S., Uppuluri, Priya, mSphere, Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens, Molecular Biology, Microbiology |
| title | Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens |
| title_full | Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens |
| title_fullStr | Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens |
| title_full_unstemmed | Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens |
| title_short | Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens |
| title_sort | alexidine dihydrochloride has broad-spectrum activities against diverse fungal pathogens |
| title_unstemmed | Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens |
| topic | Molecular Biology, Microbiology |
| url | http://dx.doi.org/10.1128/msphere.00539-18 |