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DNA Methylation Epigenetically Regulates Gene Expression in Burkholderia cenocepacia and Controls Biofilm Formation, Cell Aggregation, and Motility
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| Zeitschriftentitel: | mSphere |
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| Personen und Körperschaften: | , , , , , |
| In: | mSphere, 5, 2020, 4 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
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| Schlagwörter: |
| author_facet |
Vandenbussche, Ian Sass, Andrea Pinto-Carbó, Marta Mannweiler, Olga Eberl, Leo Coenye, Tom Vandenbussche, Ian Sass, Andrea Pinto-Carbó, Marta Mannweiler, Olga Eberl, Leo Coenye, Tom |
|---|---|
| author |
Vandenbussche, Ian Sass, Andrea Pinto-Carbó, Marta Mannweiler, Olga Eberl, Leo Coenye, Tom |
| spellingShingle |
Vandenbussche, Ian Sass, Andrea Pinto-Carbó, Marta Mannweiler, Olga Eberl, Leo Coenye, Tom mSphere DNA Methylation Epigenetically Regulates Gene Expression in Burkholderia cenocepacia and Controls Biofilm Formation, Cell Aggregation, and Motility Molecular Biology Microbiology |
| author_sort |
vandenbussche, ian |
| spelling |
Vandenbussche, Ian Sass, Andrea Pinto-Carbó, Marta Mannweiler, Olga Eberl, Leo Coenye, Tom 2379-5042 American Society for Microbiology Molecular Biology Microbiology http://dx.doi.org/10.1128/msphere.00455-20 <jats:p> CF patients diagnosed with <jats:named-content content-type="genus-species">Burkholderia cenocepacia</jats:named-content> infections often experience rapid deterioration of lung function, known as cepacia syndrome. <jats:named-content content-type="genus-species">B. cenocepacia</jats:named-content> has a large multireplicon genome, and much remains to be learned about regulation of gene expression in this organism. From studies in other (model) organisms, it is known that epigenetic changes through DNA methylation play an important role in this regulation. The identification of <jats:named-content content-type="genus-species">B. cenocepacia</jats:named-content> genes of which the expression is regulated by DNA methylation and identification of the regulatory systems involved in this methylation are likely to advance the biological understanding of <jats:named-content content-type="genus-species">B. cenocepacia</jats:named-content> cell adaptation via epigenetic regulation. In time, this might lead to novel approaches to tackle <jats:named-content content-type="genus-species">B. cenocepacia</jats:named-content> infections in CF patients. </jats:p> DNA Methylation Epigenetically Regulates Gene Expression in Burkholderia cenocepacia and Controls Biofilm Formation, Cell Aggregation, and Motility mSphere |
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American Society for Microbiology, 2020 |
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American Society for Microbiology, 2020 |
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| title |
DNA Methylation Epigenetically Regulates Gene Expression in Burkholderia cenocepacia and Controls Biofilm Formation, Cell Aggregation, and Motility |
| title_unstemmed |
DNA Methylation Epigenetically Regulates Gene Expression in Burkholderia cenocepacia and Controls Biofilm Formation, Cell Aggregation, and Motility |
| title_full |
DNA Methylation Epigenetically Regulates Gene Expression in Burkholderia cenocepacia and Controls Biofilm Formation, Cell Aggregation, and Motility |
| title_fullStr |
DNA Methylation Epigenetically Regulates Gene Expression in Burkholderia cenocepacia and Controls Biofilm Formation, Cell Aggregation, and Motility |
| title_full_unstemmed |
DNA Methylation Epigenetically Regulates Gene Expression in Burkholderia cenocepacia and Controls Biofilm Formation, Cell Aggregation, and Motility |
| title_short |
DNA Methylation Epigenetically Regulates Gene Expression in Burkholderia cenocepacia and Controls Biofilm Formation, Cell Aggregation, and Motility |
| title_sort |
dna methylation epigenetically regulates gene expression in burkholderia cenocepacia and controls biofilm formation, cell aggregation, and motility |
| topic |
Molecular Biology Microbiology |
| url |
http://dx.doi.org/10.1128/msphere.00455-20 |
| publishDate |
2020 |
| physical |
|
| description |
<jats:p>
CF patients diagnosed with
<jats:named-content content-type="genus-species">Burkholderia cenocepacia</jats:named-content>
infections often experience rapid deterioration of lung function, known as cepacia syndrome.
<jats:named-content content-type="genus-species">B. cenocepacia</jats:named-content>
has a large multireplicon genome, and much remains to be learned about regulation of gene expression in this organism. From studies in other (model) organisms, it is known that epigenetic changes through DNA methylation play an important role in this regulation. The identification of
<jats:named-content content-type="genus-species">B. cenocepacia</jats:named-content>
genes of which the expression is regulated by DNA methylation and identification of the regulatory systems involved in this methylation are likely to advance the biological understanding of
<jats:named-content content-type="genus-species">B. cenocepacia</jats:named-content>
cell adaptation via epigenetic regulation. In time, this might lead to novel approaches to tackle
<jats:named-content content-type="genus-species">B. cenocepacia</jats:named-content>
infections in CF patients.
</jats:p> |
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| author | Vandenbussche, Ian, Sass, Andrea, Pinto-Carbó, Marta, Mannweiler, Olga, Eberl, Leo, Coenye, Tom |
| author_facet | Vandenbussche, Ian, Sass, Andrea, Pinto-Carbó, Marta, Mannweiler, Olga, Eberl, Leo, Coenye, Tom, Vandenbussche, Ian, Sass, Andrea, Pinto-Carbó, Marta, Mannweiler, Olga, Eberl, Leo, Coenye, Tom |
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| description | <jats:p> CF patients diagnosed with <jats:named-content content-type="genus-species">Burkholderia cenocepacia</jats:named-content> infections often experience rapid deterioration of lung function, known as cepacia syndrome. <jats:named-content content-type="genus-species">B. cenocepacia</jats:named-content> has a large multireplicon genome, and much remains to be learned about regulation of gene expression in this organism. From studies in other (model) organisms, it is known that epigenetic changes through DNA methylation play an important role in this regulation. The identification of <jats:named-content content-type="genus-species">B. cenocepacia</jats:named-content> genes of which the expression is regulated by DNA methylation and identification of the regulatory systems involved in this methylation are likely to advance the biological understanding of <jats:named-content content-type="genus-species">B. cenocepacia</jats:named-content> cell adaptation via epigenetic regulation. In time, this might lead to novel approaches to tackle <jats:named-content content-type="genus-species">B. cenocepacia</jats:named-content> infections in CF patients. </jats:p> |
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| spelling | Vandenbussche, Ian Sass, Andrea Pinto-Carbó, Marta Mannweiler, Olga Eberl, Leo Coenye, Tom 2379-5042 American Society for Microbiology Molecular Biology Microbiology http://dx.doi.org/10.1128/msphere.00455-20 <jats:p> CF patients diagnosed with <jats:named-content content-type="genus-species">Burkholderia cenocepacia</jats:named-content> infections often experience rapid deterioration of lung function, known as cepacia syndrome. <jats:named-content content-type="genus-species">B. cenocepacia</jats:named-content> has a large multireplicon genome, and much remains to be learned about regulation of gene expression in this organism. From studies in other (model) organisms, it is known that epigenetic changes through DNA methylation play an important role in this regulation. The identification of <jats:named-content content-type="genus-species">B. cenocepacia</jats:named-content> genes of which the expression is regulated by DNA methylation and identification of the regulatory systems involved in this methylation are likely to advance the biological understanding of <jats:named-content content-type="genus-species">B. cenocepacia</jats:named-content> cell adaptation via epigenetic regulation. In time, this might lead to novel approaches to tackle <jats:named-content content-type="genus-species">B. cenocepacia</jats:named-content> infections in CF patients. </jats:p> DNA Methylation Epigenetically Regulates Gene Expression in Burkholderia cenocepacia and Controls Biofilm Formation, Cell Aggregation, and Motility mSphere |
| spellingShingle | Vandenbussche, Ian, Sass, Andrea, Pinto-Carbó, Marta, Mannweiler, Olga, Eberl, Leo, Coenye, Tom, mSphere, DNA Methylation Epigenetically Regulates Gene Expression in Burkholderia cenocepacia and Controls Biofilm Formation, Cell Aggregation, and Motility, Molecular Biology, Microbiology |
| title | DNA Methylation Epigenetically Regulates Gene Expression in Burkholderia cenocepacia and Controls Biofilm Formation, Cell Aggregation, and Motility |
| title_full | DNA Methylation Epigenetically Regulates Gene Expression in Burkholderia cenocepacia and Controls Biofilm Formation, Cell Aggregation, and Motility |
| title_fullStr | DNA Methylation Epigenetically Regulates Gene Expression in Burkholderia cenocepacia and Controls Biofilm Formation, Cell Aggregation, and Motility |
| title_full_unstemmed | DNA Methylation Epigenetically Regulates Gene Expression in Burkholderia cenocepacia and Controls Biofilm Formation, Cell Aggregation, and Motility |
| title_short | DNA Methylation Epigenetically Regulates Gene Expression in Burkholderia cenocepacia and Controls Biofilm Formation, Cell Aggregation, and Motility |
| title_sort | dna methylation epigenetically regulates gene expression in burkholderia cenocepacia and controls biofilm formation, cell aggregation, and motility |
| title_unstemmed | DNA Methylation Epigenetically Regulates Gene Expression in Burkholderia cenocepacia and Controls Biofilm Formation, Cell Aggregation, and Motility |
| topic | Molecular Biology, Microbiology |
| url | http://dx.doi.org/10.1128/msphere.00455-20 |