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A Race against Time: Reduced Azithromycin Susceptibility in Salmonella enterica Serovar Typhi in Pakistan
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| Zeitschriftentitel: | mSphere |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , |
| In: | mSphere, 5, 2020, 4 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
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| Schlagwörter: |
| author_facet |
Iqbal, Junaid Dehraj, Irum F. Carey, Megan E. Dyson, Zoe A. Garrett, Denise Seidman, Jessica C. Kabir, Furqan Saha, Senjuti Baker, Stephen Qamar, Farah N. Iqbal, Junaid Dehraj, Irum F. Carey, Megan E. Dyson, Zoe A. Garrett, Denise Seidman, Jessica C. Kabir, Furqan Saha, Senjuti Baker, Stephen Qamar, Farah N. |
|---|---|
| author |
Iqbal, Junaid Dehraj, Irum F. Carey, Megan E. Dyson, Zoe A. Garrett, Denise Seidman, Jessica C. Kabir, Furqan Saha, Senjuti Baker, Stephen Qamar, Farah N. |
| spellingShingle |
Iqbal, Junaid Dehraj, Irum F. Carey, Megan E. Dyson, Zoe A. Garrett, Denise Seidman, Jessica C. Kabir, Furqan Saha, Senjuti Baker, Stephen Qamar, Farah N. mSphere A Race against Time: Reduced Azithromycin Susceptibility in Salmonella enterica Serovar Typhi in Pakistan Molecular Biology Microbiology |
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iqbal, junaid |
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Iqbal, Junaid Dehraj, Irum F. Carey, Megan E. Dyson, Zoe A. Garrett, Denise Seidman, Jessica C. Kabir, Furqan Saha, Senjuti Baker, Stephen Qamar, Farah N. 2379-5042 American Society for Microbiology Molecular Biology Microbiology http://dx.doi.org/10.1128/msphere.00215-20 <jats:p> The emergence of XDR <jats:italic>Salmonella</jats:italic> Typhi in Pakistan has left azithromycin as the only viable oral treatment option. Here, we report the detection of an azithromycin resistance-associated mutation in one <jats:italic>S.</jats:italic> Typhi isolate. This finding is important because any possible spread of azithromycin resistance in <jats:italic>S.</jats:italic> Typhi isolates would make it nearly impossible to treat in outpatient settings due to the need of injectable antibiotics. Our findings also signify the importance of introduction of typhoid conjugate vaccine in regions of endemicity such as Pakistan. </jats:p> A Race against Time: Reduced Azithromycin Susceptibility in <i>Salmonella enterica</i> Serovar Typhi in Pakistan mSphere |
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| title |
A Race against Time: Reduced Azithromycin Susceptibility in Salmonella enterica Serovar Typhi in Pakistan |
| title_unstemmed |
A Race against Time: Reduced Azithromycin Susceptibility in Salmonella enterica Serovar Typhi in Pakistan |
| title_full |
A Race against Time: Reduced Azithromycin Susceptibility in Salmonella enterica Serovar Typhi in Pakistan |
| title_fullStr |
A Race against Time: Reduced Azithromycin Susceptibility in Salmonella enterica Serovar Typhi in Pakistan |
| title_full_unstemmed |
A Race against Time: Reduced Azithromycin Susceptibility in Salmonella enterica Serovar Typhi in Pakistan |
| title_short |
A Race against Time: Reduced Azithromycin Susceptibility in Salmonella enterica Serovar Typhi in Pakistan |
| title_sort |
a race against time: reduced azithromycin susceptibility in
<i>salmonella enterica</i>
serovar typhi in pakistan |
| topic |
Molecular Biology Microbiology |
| url |
http://dx.doi.org/10.1128/msphere.00215-20 |
| publishDate |
2020 |
| physical |
|
| description |
<jats:p>
The emergence of XDR
<jats:italic>Salmonella</jats:italic>
Typhi in Pakistan has left azithromycin as the only viable oral treatment option. Here, we report the detection of an azithromycin resistance-associated mutation in one
<jats:italic>S.</jats:italic>
Typhi isolate. This finding is important because any possible spread of azithromycin resistance in
<jats:italic>S.</jats:italic>
Typhi isolates would make it nearly impossible to treat in outpatient settings due to the need of injectable antibiotics. Our findings also signify the importance of introduction of typhoid conjugate vaccine in regions of endemicity such as Pakistan.
</jats:p> |
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| author | Iqbal, Junaid, Dehraj, Irum F., Carey, Megan E., Dyson, Zoe A., Garrett, Denise, Seidman, Jessica C., Kabir, Furqan, Saha, Senjuti, Baker, Stephen, Qamar, Farah N. |
| author_facet | Iqbal, Junaid, Dehraj, Irum F., Carey, Megan E., Dyson, Zoe A., Garrett, Denise, Seidman, Jessica C., Kabir, Furqan, Saha, Senjuti, Baker, Stephen, Qamar, Farah N., Iqbal, Junaid, Dehraj, Irum F., Carey, Megan E., Dyson, Zoe A., Garrett, Denise, Seidman, Jessica C., Kabir, Furqan, Saha, Senjuti, Baker, Stephen, Qamar, Farah N. |
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| description | <jats:p> The emergence of XDR <jats:italic>Salmonella</jats:italic> Typhi in Pakistan has left azithromycin as the only viable oral treatment option. Here, we report the detection of an azithromycin resistance-associated mutation in one <jats:italic>S.</jats:italic> Typhi isolate. This finding is important because any possible spread of azithromycin resistance in <jats:italic>S.</jats:italic> Typhi isolates would make it nearly impossible to treat in outpatient settings due to the need of injectable antibiotics. Our findings also signify the importance of introduction of typhoid conjugate vaccine in regions of endemicity such as Pakistan. </jats:p> |
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| spelling | Iqbal, Junaid Dehraj, Irum F. Carey, Megan E. Dyson, Zoe A. Garrett, Denise Seidman, Jessica C. Kabir, Furqan Saha, Senjuti Baker, Stephen Qamar, Farah N. 2379-5042 American Society for Microbiology Molecular Biology Microbiology http://dx.doi.org/10.1128/msphere.00215-20 <jats:p> The emergence of XDR <jats:italic>Salmonella</jats:italic> Typhi in Pakistan has left azithromycin as the only viable oral treatment option. Here, we report the detection of an azithromycin resistance-associated mutation in one <jats:italic>S.</jats:italic> Typhi isolate. This finding is important because any possible spread of azithromycin resistance in <jats:italic>S.</jats:italic> Typhi isolates would make it nearly impossible to treat in outpatient settings due to the need of injectable antibiotics. Our findings also signify the importance of introduction of typhoid conjugate vaccine in regions of endemicity such as Pakistan. </jats:p> A Race against Time: Reduced Azithromycin Susceptibility in <i>Salmonella enterica</i> Serovar Typhi in Pakistan mSphere |
| spellingShingle | Iqbal, Junaid, Dehraj, Irum F., Carey, Megan E., Dyson, Zoe A., Garrett, Denise, Seidman, Jessica C., Kabir, Furqan, Saha, Senjuti, Baker, Stephen, Qamar, Farah N., mSphere, A Race against Time: Reduced Azithromycin Susceptibility in Salmonella enterica Serovar Typhi in Pakistan, Molecular Biology, Microbiology |
| title | A Race against Time: Reduced Azithromycin Susceptibility in Salmonella enterica Serovar Typhi in Pakistan |
| title_full | A Race against Time: Reduced Azithromycin Susceptibility in Salmonella enterica Serovar Typhi in Pakistan |
| title_fullStr | A Race against Time: Reduced Azithromycin Susceptibility in Salmonella enterica Serovar Typhi in Pakistan |
| title_full_unstemmed | A Race against Time: Reduced Azithromycin Susceptibility in Salmonella enterica Serovar Typhi in Pakistan |
| title_short | A Race against Time: Reduced Azithromycin Susceptibility in Salmonella enterica Serovar Typhi in Pakistan |
| title_sort | a race against time: reduced azithromycin susceptibility in <i>salmonella enterica</i> serovar typhi in pakistan |
| title_unstemmed | A Race against Time: Reduced Azithromycin Susceptibility in Salmonella enterica Serovar Typhi in Pakistan |
| topic | Molecular Biology, Microbiology |
| url | http://dx.doi.org/10.1128/msphere.00215-20 |