Eintrag weiter verarbeiten
Respiratory Heterogeneity Shapes Biofilm Formation and Host Colonization in Uropathogenic Escherichia coli
Gespeichert in:
Zeitschriftentitel: | mBio |
---|---|
Personen und Körperschaften: | , , , , , , , , , , |
In: | mBio, 10, 2019, 2 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
American Society for Microbiology
|
Schlagwörter: |
author_facet |
Beebout, Connor J. Eberly, Allison R. Werby, Sabrina H. Reasoner, Seth A. Brannon, John R. De, Shuvro Fitzgerald, Madison J. Huggins, Marissa M. Clayton, Douglass B. Cegelski, Lynette Hadjifrangiskou, Maria Beebout, Connor J. Eberly, Allison R. Werby, Sabrina H. Reasoner, Seth A. Brannon, John R. De, Shuvro Fitzgerald, Madison J. Huggins, Marissa M. Clayton, Douglass B. Cegelski, Lynette Hadjifrangiskou, Maria |
---|---|
author |
Beebout, Connor J. Eberly, Allison R. Werby, Sabrina H. Reasoner, Seth A. Brannon, John R. De, Shuvro Fitzgerald, Madison J. Huggins, Marissa M. Clayton, Douglass B. Cegelski, Lynette Hadjifrangiskou, Maria |
spellingShingle |
Beebout, Connor J. Eberly, Allison R. Werby, Sabrina H. Reasoner, Seth A. Brannon, John R. De, Shuvro Fitzgerald, Madison J. Huggins, Marissa M. Clayton, Douglass B. Cegelski, Lynette Hadjifrangiskou, Maria mBio Respiratory Heterogeneity Shapes Biofilm Formation and Host Colonization in Uropathogenic Escherichia coli Virology Microbiology |
author_sort |
beebout, connor j. |
spelling |
Beebout, Connor J. Eberly, Allison R. Werby, Sabrina H. Reasoner, Seth A. Brannon, John R. De, Shuvro Fitzgerald, Madison J. Huggins, Marissa M. Clayton, Douglass B. Cegelski, Lynette Hadjifrangiskou, Maria 2161-2129 2150-7511 American Society for Microbiology Virology Microbiology http://dx.doi.org/10.1128/mbio.02400-18 <jats:p> Biofilms are multicellular bacterial communities encased in a self-secreted extracellular matrix comprised of polysaccharides, proteinaceous fibers, and DNA. Organization of these components lends spatial organization in the biofilm community. Here we demonstrate that oxygen gradients in uropathogenic <jats:named-content content-type="genus-species">Escherichia coli</jats:named-content> (UPEC) biofilms lead to spatially distinct expression programs for quinol oxidases—components of the terminal electron transport chain. Our studies reveal that the cytochrome <jats:italic>bd</jats:italic> -expressing subpopulation is critical for biofilm development and matrix production. In addition, we show that quinol oxidases are heterogeneously expressed in planktonic populations and that this respiratory heterogeneity provides a fitness advantage during infection. These studies define the contributions of quinol oxidases to biofilm physiology and suggest the presence of respiratory bet-hedging behavior in UPEC. </jats:p> Respiratory Heterogeneity Shapes Biofilm Formation and Host Colonization in Uropathogenic Escherichia coli mBio |
doi_str_mv |
10.1128/mbio.02400-18 |
facet_avail |
Online Free |
finc_class_facet |
Medizin Biologie |
format |
ElectronicArticle |
fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEyOC9tYmlvLjAyNDAwLTE4 |
id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEyOC9tYmlvLjAyNDAwLTE4 |
institution |
DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 |
imprint |
American Society for Microbiology, 2019 |
imprint_str_mv |
American Society for Microbiology, 2019 |
issn |
2150-7511 2161-2129 |
issn_str_mv |
2150-7511 2161-2129 |
language |
English |
mega_collection |
American Society for Microbiology (CrossRef) |
match_str |
beebout2019respiratoryheterogeneityshapesbiofilmformationandhostcolonizationinuropathogenicescherichiacoli |
publishDateSort |
2019 |
publisher |
American Society for Microbiology |
recordtype |
ai |
record_format |
ai |
series |
mBio |
source_id |
49 |
title |
Respiratory Heterogeneity Shapes Biofilm Formation and Host Colonization in Uropathogenic Escherichia coli |
title_unstemmed |
Respiratory Heterogeneity Shapes Biofilm Formation and Host Colonization in Uropathogenic Escherichia coli |
title_full |
Respiratory Heterogeneity Shapes Biofilm Formation and Host Colonization in Uropathogenic Escherichia coli |
title_fullStr |
Respiratory Heterogeneity Shapes Biofilm Formation and Host Colonization in Uropathogenic Escherichia coli |
title_full_unstemmed |
Respiratory Heterogeneity Shapes Biofilm Formation and Host Colonization in Uropathogenic Escherichia coli |
title_short |
Respiratory Heterogeneity Shapes Biofilm Formation and Host Colonization in Uropathogenic Escherichia coli |
title_sort |
respiratory heterogeneity shapes biofilm formation and host colonization in uropathogenic escherichia coli |
topic |
Virology Microbiology |
url |
http://dx.doi.org/10.1128/mbio.02400-18 |
publishDate |
2019 |
physical |
|
description |
<jats:p>
Biofilms are multicellular bacterial communities encased in a self-secreted extracellular matrix comprised of polysaccharides, proteinaceous fibers, and DNA. Organization of these components lends spatial organization in the biofilm community. Here we demonstrate that oxygen gradients in uropathogenic
<jats:named-content content-type="genus-species">Escherichia coli</jats:named-content>
(UPEC) biofilms lead to spatially distinct expression programs for quinol oxidases—components of the terminal electron transport chain. Our studies reveal that the cytochrome
<jats:italic>bd</jats:italic>
-expressing subpopulation is critical for biofilm development and matrix production. In addition, we show that quinol oxidases are heterogeneously expressed in planktonic populations and that this respiratory heterogeneity provides a fitness advantage during infection. These studies define the contributions of quinol oxidases to biofilm physiology and suggest the presence of respiratory bet-hedging behavior in UPEC.
</jats:p> |
container_issue |
2 |
container_start_page |
0 |
container_title |
mBio |
container_volume |
10 |
format_de105 |
Article, E-Article |
format_de14 |
Article, E-Article |
format_de15 |
Article, E-Article |
format_de520 |
Article, E-Article |
format_de540 |
Article, E-Article |
format_dech1 |
Article, E-Article |
format_ded117 |
Article, E-Article |
format_degla1 |
E-Article |
format_del152 |
Buch |
format_del189 |
Article, E-Article |
format_dezi4 |
Article |
format_dezwi2 |
Article, E-Article |
format_finc |
Article, E-Article |
format_nrw |
Article, E-Article |
_version_ |
1792347802471235592 |
geogr_code |
not assigned |
last_indexed |
2024-03-01T18:01:04.312Z |
geogr_code_person |
not assigned |
openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Respiratory+Heterogeneity+Shapes+Biofilm+Formation+and+Host+Colonization+in+Uropathogenic+Escherichia+coli&rft.date=2019-04-30&genre=article&issn=2150-7511&volume=10&issue=2&jtitle=mBio&atitle=Respiratory+Heterogeneity+Shapes+Biofilm+Formation+and+Host+Colonization+in+Uropathogenic+Escherichia+coli&aulast=Hadjifrangiskou&aufirst=Maria&rft_id=info%3Adoi%2F10.1128%2Fmbio.02400-18&rft.language%5B0%5D=eng |
SOLR | |
_version_ | 1792347802471235592 |
author | Beebout, Connor J., Eberly, Allison R., Werby, Sabrina H., Reasoner, Seth A., Brannon, John R., De, Shuvro, Fitzgerald, Madison J., Huggins, Marissa M., Clayton, Douglass B., Cegelski, Lynette, Hadjifrangiskou, Maria |
author_facet | Beebout, Connor J., Eberly, Allison R., Werby, Sabrina H., Reasoner, Seth A., Brannon, John R., De, Shuvro, Fitzgerald, Madison J., Huggins, Marissa M., Clayton, Douglass B., Cegelski, Lynette, Hadjifrangiskou, Maria, Beebout, Connor J., Eberly, Allison R., Werby, Sabrina H., Reasoner, Seth A., Brannon, John R., De, Shuvro, Fitzgerald, Madison J., Huggins, Marissa M., Clayton, Douglass B., Cegelski, Lynette, Hadjifrangiskou, Maria |
author_sort | beebout, connor j. |
container_issue | 2 |
container_start_page | 0 |
container_title | mBio |
container_volume | 10 |
description | <jats:p> Biofilms are multicellular bacterial communities encased in a self-secreted extracellular matrix comprised of polysaccharides, proteinaceous fibers, and DNA. Organization of these components lends spatial organization in the biofilm community. Here we demonstrate that oxygen gradients in uropathogenic <jats:named-content content-type="genus-species">Escherichia coli</jats:named-content> (UPEC) biofilms lead to spatially distinct expression programs for quinol oxidases—components of the terminal electron transport chain. Our studies reveal that the cytochrome <jats:italic>bd</jats:italic> -expressing subpopulation is critical for biofilm development and matrix production. In addition, we show that quinol oxidases are heterogeneously expressed in planktonic populations and that this respiratory heterogeneity provides a fitness advantage during infection. These studies define the contributions of quinol oxidases to biofilm physiology and suggest the presence of respiratory bet-hedging behavior in UPEC. </jats:p> |
doi_str_mv | 10.1128/mbio.02400-18 |
facet_avail | Online, Free |
finc_class_facet | Medizin, Biologie |
format | ElectronicArticle |
format_de105 | Article, E-Article |
format_de14 | Article, E-Article |
format_de15 | Article, E-Article |
format_de520 | Article, E-Article |
format_de540 | Article, E-Article |
format_dech1 | Article, E-Article |
format_ded117 | Article, E-Article |
format_degla1 | E-Article |
format_del152 | Buch |
format_del189 | Article, E-Article |
format_dezi4 | Article |
format_dezwi2 | Article, E-Article |
format_finc | Article, E-Article |
format_nrw | Article, E-Article |
geogr_code | not assigned |
geogr_code_person | not assigned |
id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEyOC9tYmlvLjAyNDAwLTE4 |
imprint | American Society for Microbiology, 2019 |
imprint_str_mv | American Society for Microbiology, 2019 |
institution | DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14 |
issn | 2150-7511, 2161-2129 |
issn_str_mv | 2150-7511, 2161-2129 |
language | English |
last_indexed | 2024-03-01T18:01:04.312Z |
match_str | beebout2019respiratoryheterogeneityshapesbiofilmformationandhostcolonizationinuropathogenicescherichiacoli |
mega_collection | American Society for Microbiology (CrossRef) |
physical | |
publishDate | 2019 |
publishDateSort | 2019 |
publisher | American Society for Microbiology |
record_format | ai |
recordtype | ai |
series | mBio |
source_id | 49 |
spelling | Beebout, Connor J. Eberly, Allison R. Werby, Sabrina H. Reasoner, Seth A. Brannon, John R. De, Shuvro Fitzgerald, Madison J. Huggins, Marissa M. Clayton, Douglass B. Cegelski, Lynette Hadjifrangiskou, Maria 2161-2129 2150-7511 American Society for Microbiology Virology Microbiology http://dx.doi.org/10.1128/mbio.02400-18 <jats:p> Biofilms are multicellular bacterial communities encased in a self-secreted extracellular matrix comprised of polysaccharides, proteinaceous fibers, and DNA. Organization of these components lends spatial organization in the biofilm community. Here we demonstrate that oxygen gradients in uropathogenic <jats:named-content content-type="genus-species">Escherichia coli</jats:named-content> (UPEC) biofilms lead to spatially distinct expression programs for quinol oxidases—components of the terminal electron transport chain. Our studies reveal that the cytochrome <jats:italic>bd</jats:italic> -expressing subpopulation is critical for biofilm development and matrix production. In addition, we show that quinol oxidases are heterogeneously expressed in planktonic populations and that this respiratory heterogeneity provides a fitness advantage during infection. These studies define the contributions of quinol oxidases to biofilm physiology and suggest the presence of respiratory bet-hedging behavior in UPEC. </jats:p> Respiratory Heterogeneity Shapes Biofilm Formation and Host Colonization in Uropathogenic Escherichia coli mBio |
spellingShingle | Beebout, Connor J., Eberly, Allison R., Werby, Sabrina H., Reasoner, Seth A., Brannon, John R., De, Shuvro, Fitzgerald, Madison J., Huggins, Marissa M., Clayton, Douglass B., Cegelski, Lynette, Hadjifrangiskou, Maria, mBio, Respiratory Heterogeneity Shapes Biofilm Formation and Host Colonization in Uropathogenic Escherichia coli, Virology, Microbiology |
title | Respiratory Heterogeneity Shapes Biofilm Formation and Host Colonization in Uropathogenic Escherichia coli |
title_full | Respiratory Heterogeneity Shapes Biofilm Formation and Host Colonization in Uropathogenic Escherichia coli |
title_fullStr | Respiratory Heterogeneity Shapes Biofilm Formation and Host Colonization in Uropathogenic Escherichia coli |
title_full_unstemmed | Respiratory Heterogeneity Shapes Biofilm Formation and Host Colonization in Uropathogenic Escherichia coli |
title_short | Respiratory Heterogeneity Shapes Biofilm Formation and Host Colonization in Uropathogenic Escherichia coli |
title_sort | respiratory heterogeneity shapes biofilm formation and host colonization in uropathogenic escherichia coli |
title_unstemmed | Respiratory Heterogeneity Shapes Biofilm Formation and Host Colonization in Uropathogenic Escherichia coli |
topic | Virology, Microbiology |
url | http://dx.doi.org/10.1128/mbio.02400-18 |