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Caulobacter crescentus Adapts to Phosphate Starvation by Synthesizing Anionic Glycoglycerolipids and a Novel Glycosphingolipid
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| Zeitschriftentitel: | mBio |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | mBio, 10, 2019, 2 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
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| Schlagwörter: |
| author_facet |
Stankeviciute, Gabriele Guan, Ziqiang Goldfine, Howard Klein, Eric A. Stankeviciute, Gabriele Guan, Ziqiang Goldfine, Howard Klein, Eric A. |
|---|---|
| author |
Stankeviciute, Gabriele Guan, Ziqiang Goldfine, Howard Klein, Eric A. |
| spellingShingle |
Stankeviciute, Gabriele Guan, Ziqiang Goldfine, Howard Klein, Eric A. mBio Caulobacter crescentus Adapts to Phosphate Starvation by Synthesizing Anionic Glycoglycerolipids and a Novel Glycosphingolipid Virology Microbiology |
| author_sort |
stankeviciute, gabriele |
| spelling |
Stankeviciute, Gabriele Guan, Ziqiang Goldfine, Howard Klein, Eric A. 2161-2129 2150-7511 American Society for Microbiology Virology Microbiology http://dx.doi.org/10.1128/mbio.00107-19 <jats:p> Bacteria adapt to environmental changes in a variety of ways, including altering their cell shape. <jats:named-content content-type="genus-species">Caulobacter crescentus</jats:named-content> adapts to phosphate starvation by elongating its cell body and a polar stalk structure containing both inner and outer membranes. While we generally think of cellular membranes being composed largely of phospholipids, cellular elongation occurs when environmental phosphate, and therefore phospholipid synthesis, is limited. In order to adapt to these environmental constraints, <jats:named-content content-type="genus-species">C. crescentus</jats:named-content> synthesizes several glycolipid species, including a novel glycosphingolipid. This finding is significant because glycosphingolipids, while ubiquitous in eukaryotes, are extremely rare in bacteria. In this paper, we identify three proteins required for GSL-2 synthesis and demonstrate that they contribute to phage resistance. These findings suggest that bacteria may synthesize a wider variety of lipids in response to stresses than previously observed. </jats:p> Caulobacter crescentus Adapts to Phosphate Starvation by Synthesizing Anionic Glycoglycerolipids and a Novel Glycosphingolipid mBio |
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American Society for Microbiology, 2019 |
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American Society for Microbiology, 2019 |
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2161-2129 2150-7511 |
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| title |
Caulobacter crescentus Adapts to Phosphate Starvation by Synthesizing Anionic Glycoglycerolipids and a Novel Glycosphingolipid |
| title_unstemmed |
Caulobacter crescentus Adapts to Phosphate Starvation by Synthesizing Anionic Glycoglycerolipids and a Novel Glycosphingolipid |
| title_full |
Caulobacter crescentus Adapts to Phosphate Starvation by Synthesizing Anionic Glycoglycerolipids and a Novel Glycosphingolipid |
| title_fullStr |
Caulobacter crescentus Adapts to Phosphate Starvation by Synthesizing Anionic Glycoglycerolipids and a Novel Glycosphingolipid |
| title_full_unstemmed |
Caulobacter crescentus Adapts to Phosphate Starvation by Synthesizing Anionic Glycoglycerolipids and a Novel Glycosphingolipid |
| title_short |
Caulobacter crescentus Adapts to Phosphate Starvation by Synthesizing Anionic Glycoglycerolipids and a Novel Glycosphingolipid |
| title_sort |
caulobacter crescentus adapts to phosphate starvation by synthesizing anionic glycoglycerolipids and a novel glycosphingolipid |
| topic |
Virology Microbiology |
| url |
http://dx.doi.org/10.1128/mbio.00107-19 |
| publishDate |
2019 |
| physical |
|
| description |
<jats:p>
Bacteria adapt to environmental changes in a variety of ways, including altering their cell shape.
<jats:named-content content-type="genus-species">Caulobacter crescentus</jats:named-content>
adapts to phosphate starvation by elongating its cell body and a polar stalk structure containing both inner and outer membranes. While we generally think of cellular membranes being composed largely of phospholipids, cellular elongation occurs when environmental phosphate, and therefore phospholipid synthesis, is limited. In order to adapt to these environmental constraints,
<jats:named-content content-type="genus-species">C. crescentus</jats:named-content>
synthesizes several glycolipid species, including a novel glycosphingolipid. This finding is significant because glycosphingolipids, while ubiquitous in eukaryotes, are extremely rare in bacteria. In this paper, we identify three proteins required for GSL-2 synthesis and demonstrate that they contribute to phage resistance. These findings suggest that bacteria may synthesize a wider variety of lipids in response to stresses than previously observed.
</jats:p> |
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| author | Stankeviciute, Gabriele, Guan, Ziqiang, Goldfine, Howard, Klein, Eric A. |
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| description | <jats:p> Bacteria adapt to environmental changes in a variety of ways, including altering their cell shape. <jats:named-content content-type="genus-species">Caulobacter crescentus</jats:named-content> adapts to phosphate starvation by elongating its cell body and a polar stalk structure containing both inner and outer membranes. While we generally think of cellular membranes being composed largely of phospholipids, cellular elongation occurs when environmental phosphate, and therefore phospholipid synthesis, is limited. In order to adapt to these environmental constraints, <jats:named-content content-type="genus-species">C. crescentus</jats:named-content> synthesizes several glycolipid species, including a novel glycosphingolipid. This finding is significant because glycosphingolipids, while ubiquitous in eukaryotes, are extremely rare in bacteria. In this paper, we identify three proteins required for GSL-2 synthesis and demonstrate that they contribute to phage resistance. These findings suggest that bacteria may synthesize a wider variety of lipids in response to stresses than previously observed. </jats:p> |
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| spelling | Stankeviciute, Gabriele Guan, Ziqiang Goldfine, Howard Klein, Eric A. 2161-2129 2150-7511 American Society for Microbiology Virology Microbiology http://dx.doi.org/10.1128/mbio.00107-19 <jats:p> Bacteria adapt to environmental changes in a variety of ways, including altering their cell shape. <jats:named-content content-type="genus-species">Caulobacter crescentus</jats:named-content> adapts to phosphate starvation by elongating its cell body and a polar stalk structure containing both inner and outer membranes. While we generally think of cellular membranes being composed largely of phospholipids, cellular elongation occurs when environmental phosphate, and therefore phospholipid synthesis, is limited. In order to adapt to these environmental constraints, <jats:named-content content-type="genus-species">C. crescentus</jats:named-content> synthesizes several glycolipid species, including a novel glycosphingolipid. This finding is significant because glycosphingolipids, while ubiquitous in eukaryotes, are extremely rare in bacteria. In this paper, we identify three proteins required for GSL-2 synthesis and demonstrate that they contribute to phage resistance. These findings suggest that bacteria may synthesize a wider variety of lipids in response to stresses than previously observed. </jats:p> Caulobacter crescentus Adapts to Phosphate Starvation by Synthesizing Anionic Glycoglycerolipids and a Novel Glycosphingolipid mBio |
| spellingShingle | Stankeviciute, Gabriele, Guan, Ziqiang, Goldfine, Howard, Klein, Eric A., mBio, Caulobacter crescentus Adapts to Phosphate Starvation by Synthesizing Anionic Glycoglycerolipids and a Novel Glycosphingolipid, Virology, Microbiology |
| title | Caulobacter crescentus Adapts to Phosphate Starvation by Synthesizing Anionic Glycoglycerolipids and a Novel Glycosphingolipid |
| title_full | Caulobacter crescentus Adapts to Phosphate Starvation by Synthesizing Anionic Glycoglycerolipids and a Novel Glycosphingolipid |
| title_fullStr | Caulobacter crescentus Adapts to Phosphate Starvation by Synthesizing Anionic Glycoglycerolipids and a Novel Glycosphingolipid |
| title_full_unstemmed | Caulobacter crescentus Adapts to Phosphate Starvation by Synthesizing Anionic Glycoglycerolipids and a Novel Glycosphingolipid |
| title_short | Caulobacter crescentus Adapts to Phosphate Starvation by Synthesizing Anionic Glycoglycerolipids and a Novel Glycosphingolipid |
| title_sort | caulobacter crescentus adapts to phosphate starvation by synthesizing anionic glycoglycerolipids and a novel glycosphingolipid |
| title_unstemmed | Caulobacter crescentus Adapts to Phosphate Starvation by Synthesizing Anionic Glycoglycerolipids and a Novel Glycosphingolipid |
| topic | Virology, Microbiology |
| url | http://dx.doi.org/10.1128/mbio.00107-19 |