Eintrag weiter verarbeiten
Molecular and biological properties of BK virus-IR, a BK virus variant isolated from a human tumor
Gespeichert in:
| Zeitschriftentitel: | Journal of Virology |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | Journal of Virology, 59, 1986, 2, S. 500-505 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
|
| Schlagwörter: |
| author_facet |
Pagnani, M Negrini, M Reschiglian, P Corallini, A Balboni, P G Scherneck, S Macino, G Milanesi, G Barbanti-Brodano, G Pagnani, M Negrini, M Reschiglian, P Corallini, A Balboni, P G Scherneck, S Macino, G Milanesi, G Barbanti-Brodano, G |
|---|---|
| author |
Pagnani, M Negrini, M Reschiglian, P Corallini, A Balboni, P G Scherneck, S Macino, G Milanesi, G Barbanti-Brodano, G |
| spellingShingle |
Pagnani, M Negrini, M Reschiglian, P Corallini, A Balboni, P G Scherneck, S Macino, G Milanesi, G Barbanti-Brodano, G Journal of Virology Molecular and biological properties of BK virus-IR, a BK virus variant isolated from a human tumor Virology Insect Science Immunology Microbiology |
| author_sort |
pagnani, m |
| spelling |
Pagnani, M Negrini, M Reschiglian, P Corallini, A Balboni, P G Scherneck, S Macino, G Milanesi, G Barbanti-Brodano, G 0022-538X 1098-5514 American Society for Microbiology Virology Insect Science Immunology Microbiology http://dx.doi.org/10.1128/jvi.59.2.500-505.1986 <jats:p>We describe the molecular and biological properties of BK virus (BKV)-IR, a new BKV variant isolated from a human tumor of pancreatic islets. BKV-IR bears a 253-base-pair (bp) deletion and an 80-bp insertion in the early region of the genome. The deletion abolishes the expression of small-t antigen. The inserted sequences, grouped in four clusters, produce rearrangements in the first and second enhancer elements. They are bound by 12-bp direct repeats and could form a 217-base stem-loop structure suggestive of an insertion sequence. As compared with wild-type BKV, BKV-IR transformed hamster cells with a reduced efficiency and induced ependymomas in hamsters at a lower frequency and with a longer latency period. Tumors induced by BKV-IR, however, showed features of higher malignancy. The possible role of the insertion sequence-like element in transformation by BKV-IR is discussed.</jats:p> Molecular and biological properties of BK virus-IR, a BK virus variant isolated from a human tumor Journal of Virology |
| doi_str_mv |
10.1128/jvi.59.2.500-505.1986 |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin Biologie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEyOC9qdmkuNTkuMi41MDAtNTA1LjE5ODY |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEyOC9qdmkuNTkuMi41MDAtNTA1LjE5ODY |
| institution |
DE-Gla1 DE-Zi4 DE-15 DE-Rs1 DE-Pl11 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 |
| imprint |
American Society for Microbiology, 1986 |
| imprint_str_mv |
American Society for Microbiology, 1986 |
| issn |
0022-538X 1098-5514 |
| issn_str_mv |
0022-538X 1098-5514 |
| language |
English |
| mega_collection |
American Society for Microbiology (CrossRef) |
| match_str |
pagnani1986molecularandbiologicalpropertiesofbkvirusirabkvirusvariantisolatedfromahumantumor |
| publishDateSort |
1986 |
| publisher |
American Society for Microbiology |
| recordtype |
ai |
| record_format |
ai |
| series |
Journal of Virology |
| source_id |
49 |
| title |
Molecular and biological properties of BK virus-IR, a BK virus variant isolated from a human tumor |
| title_unstemmed |
Molecular and biological properties of BK virus-IR, a BK virus variant isolated from a human tumor |
| title_full |
Molecular and biological properties of BK virus-IR, a BK virus variant isolated from a human tumor |
| title_fullStr |
Molecular and biological properties of BK virus-IR, a BK virus variant isolated from a human tumor |
| title_full_unstemmed |
Molecular and biological properties of BK virus-IR, a BK virus variant isolated from a human tumor |
| title_short |
Molecular and biological properties of BK virus-IR, a BK virus variant isolated from a human tumor |
| title_sort |
molecular and biological properties of bk virus-ir, a bk virus variant isolated from a human tumor |
| topic |
Virology Insect Science Immunology Microbiology |
| url |
http://dx.doi.org/10.1128/jvi.59.2.500-505.1986 |
| publishDate |
1986 |
| physical |
500-505 |
| description |
<jats:p>We describe the molecular and biological properties of BK virus (BKV)-IR, a new BKV variant isolated from a human tumor of pancreatic islets. BKV-IR bears a 253-base-pair (bp) deletion and an 80-bp insertion in the early region of the genome. The deletion abolishes the expression of small-t antigen. The inserted sequences, grouped in four clusters, produce rearrangements in the first and second enhancer elements. They are bound by 12-bp direct repeats and could form a 217-base stem-loop structure suggestive of an insertion sequence. As compared with wild-type BKV, BKV-IR transformed hamster cells with a reduced efficiency and induced ependymomas in hamsters at a lower frequency and with a longer latency period. Tumors induced by BKV-IR, however, showed features of higher malignancy. The possible role of the insertion sequence-like element in transformation by BKV-IR is discussed.</jats:p> |
| container_issue |
2 |
| container_start_page |
500 |
| container_title |
Journal of Virology |
| container_volume |
59 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792342529397489664 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T16:35:58.882Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Molecular+and+biological+properties+of+BK+virus-IR%2C+a+BK+virus+variant+isolated+from+a+human+tumor&rft.date=1986-08-01&genre=article&issn=1098-5514&volume=59&issue=2&spage=500&epage=505&pages=500-505&jtitle=Journal+of+Virology&atitle=Molecular+and+biological+properties+of+BK+virus-IR%2C+a+BK+virus+variant+isolated+from+a+human+tumor&aulast=Barbanti-Brodano&aufirst=G&rft_id=info%3Adoi%2F10.1128%2Fjvi.59.2.500-505.1986&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792342529397489664 |
| author | Pagnani, M, Negrini, M, Reschiglian, P, Corallini, A, Balboni, P G, Scherneck, S, Macino, G, Milanesi, G, Barbanti-Brodano, G |
| author_facet | Pagnani, M, Negrini, M, Reschiglian, P, Corallini, A, Balboni, P G, Scherneck, S, Macino, G, Milanesi, G, Barbanti-Brodano, G, Pagnani, M, Negrini, M, Reschiglian, P, Corallini, A, Balboni, P G, Scherneck, S, Macino, G, Milanesi, G, Barbanti-Brodano, G |
| author_sort | pagnani, m |
| container_issue | 2 |
| container_start_page | 500 |
| container_title | Journal of Virology |
| container_volume | 59 |
| description | <jats:p>We describe the molecular and biological properties of BK virus (BKV)-IR, a new BKV variant isolated from a human tumor of pancreatic islets. BKV-IR bears a 253-base-pair (bp) deletion and an 80-bp insertion in the early region of the genome. The deletion abolishes the expression of small-t antigen. The inserted sequences, grouped in four clusters, produce rearrangements in the first and second enhancer elements. They are bound by 12-bp direct repeats and could form a 217-base stem-loop structure suggestive of an insertion sequence. As compared with wild-type BKV, BKV-IR transformed hamster cells with a reduced efficiency and induced ependymomas in hamsters at a lower frequency and with a longer latency period. Tumors induced by BKV-IR, however, showed features of higher malignancy. The possible role of the insertion sequence-like element in transformation by BKV-IR is discussed.</jats:p> |
| doi_str_mv | 10.1128/jvi.59.2.500-505.1986 |
| facet_avail | Online, Free |
| finc_class_facet | Medizin, Biologie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEyOC9qdmkuNTkuMi41MDAtNTA1LjE5ODY |
| imprint | American Society for Microbiology, 1986 |
| imprint_str_mv | American Society for Microbiology, 1986 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
| issn | 0022-538X, 1098-5514 |
| issn_str_mv | 0022-538X, 1098-5514 |
| language | English |
| last_indexed | 2024-03-01T16:35:58.882Z |
| match_str | pagnani1986molecularandbiologicalpropertiesofbkvirusirabkvirusvariantisolatedfromahumantumor |
| mega_collection | American Society for Microbiology (CrossRef) |
| physical | 500-505 |
| publishDate | 1986 |
| publishDateSort | 1986 |
| publisher | American Society for Microbiology |
| record_format | ai |
| recordtype | ai |
| series | Journal of Virology |
| source_id | 49 |
| spelling | Pagnani, M Negrini, M Reschiglian, P Corallini, A Balboni, P G Scherneck, S Macino, G Milanesi, G Barbanti-Brodano, G 0022-538X 1098-5514 American Society for Microbiology Virology Insect Science Immunology Microbiology http://dx.doi.org/10.1128/jvi.59.2.500-505.1986 <jats:p>We describe the molecular and biological properties of BK virus (BKV)-IR, a new BKV variant isolated from a human tumor of pancreatic islets. BKV-IR bears a 253-base-pair (bp) deletion and an 80-bp insertion in the early region of the genome. The deletion abolishes the expression of small-t antigen. The inserted sequences, grouped in four clusters, produce rearrangements in the first and second enhancer elements. They are bound by 12-bp direct repeats and could form a 217-base stem-loop structure suggestive of an insertion sequence. As compared with wild-type BKV, BKV-IR transformed hamster cells with a reduced efficiency and induced ependymomas in hamsters at a lower frequency and with a longer latency period. Tumors induced by BKV-IR, however, showed features of higher malignancy. The possible role of the insertion sequence-like element in transformation by BKV-IR is discussed.</jats:p> Molecular and biological properties of BK virus-IR, a BK virus variant isolated from a human tumor Journal of Virology |
| spellingShingle | Pagnani, M, Negrini, M, Reschiglian, P, Corallini, A, Balboni, P G, Scherneck, S, Macino, G, Milanesi, G, Barbanti-Brodano, G, Journal of Virology, Molecular and biological properties of BK virus-IR, a BK virus variant isolated from a human tumor, Virology, Insect Science, Immunology, Microbiology |
| title | Molecular and biological properties of BK virus-IR, a BK virus variant isolated from a human tumor |
| title_full | Molecular and biological properties of BK virus-IR, a BK virus variant isolated from a human tumor |
| title_fullStr | Molecular and biological properties of BK virus-IR, a BK virus variant isolated from a human tumor |
| title_full_unstemmed | Molecular and biological properties of BK virus-IR, a BK virus variant isolated from a human tumor |
| title_short | Molecular and biological properties of BK virus-IR, a BK virus variant isolated from a human tumor |
| title_sort | molecular and biological properties of bk virus-ir, a bk virus variant isolated from a human tumor |
| title_unstemmed | Molecular and biological properties of BK virus-IR, a BK virus variant isolated from a human tumor |
| topic | Virology, Insect Science, Immunology, Microbiology |
| url | http://dx.doi.org/10.1128/jvi.59.2.500-505.1986 |