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Hepatitis A Virus 3C Protease Cleaves NEMO To Impair Induction of Beta Interferon
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| Zeitschriftentitel: | Journal of Virology |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Journal of Virology, 88, 2014, 17, S. 10252-10258 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
|
| Schlagwörter: |
| author_facet |
Wang, Dang Fang, Liurong Wei, Dahai Zhang, Huan Luo, Rui Chen, Huanchun Li, Kui Xiao, Shaobo Wang, Dang Fang, Liurong Wei, Dahai Zhang, Huan Luo, Rui Chen, Huanchun Li, Kui Xiao, Shaobo |
|---|---|
| author |
Wang, Dang Fang, Liurong Wei, Dahai Zhang, Huan Luo, Rui Chen, Huanchun Li, Kui Xiao, Shaobo |
| spellingShingle |
Wang, Dang Fang, Liurong Wei, Dahai Zhang, Huan Luo, Rui Chen, Huanchun Li, Kui Xiao, Shaobo Journal of Virology Hepatitis A Virus 3C Protease Cleaves NEMO To Impair Induction of Beta Interferon Virology Insect Science Immunology Microbiology |
| author_sort |
wang, dang |
| spelling |
Wang, Dang Fang, Liurong Wei, Dahai Zhang, Huan Luo, Rui Chen, Huanchun Li, Kui Xiao, Shaobo 0022-538X 1098-5514 American Society for Microbiology Virology Insect Science Immunology Microbiology http://dx.doi.org/10.1128/jvi.00869-14 <jats:title>ABSTRACT</jats:title> <jats:p> NEMO (NF-κB essential modulator) is a bridging adaptor indispensable for viral activation of interferon (IFN) antiviral response. Herein, we show that hepatitis A virus (HAV) 3C protease (3C <jats:sup>pro</jats:sup> ) cleaves NEMO at the Q304 residue, negating its signaling adaptor function and abrogating viral induction of IFN-β synthesis via the retinoic acid-inducible gene I/melanoma differentiation-associated protein 5 (RIG-I/MDA5) and Toll-like receptor 3 (TLR3) pathways. NEMO cleavage and IFN antagonism, however, were lost upon ablation of the catalytic activity of 3C <jats:sup>pro</jats:sup> . These data describe a novel immune evasion mechanism of HAV. </jats:p> Hepatitis A Virus 3C Protease Cleaves NEMO To Impair Induction of Beta Interferon Journal of Virology |
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American Society for Microbiology, 2014 |
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| title |
Hepatitis A Virus 3C Protease Cleaves NEMO To Impair Induction of Beta Interferon |
| title_unstemmed |
Hepatitis A Virus 3C Protease Cleaves NEMO To Impair Induction of Beta Interferon |
| title_full |
Hepatitis A Virus 3C Protease Cleaves NEMO To Impair Induction of Beta Interferon |
| title_fullStr |
Hepatitis A Virus 3C Protease Cleaves NEMO To Impair Induction of Beta Interferon |
| title_full_unstemmed |
Hepatitis A Virus 3C Protease Cleaves NEMO To Impair Induction of Beta Interferon |
| title_short |
Hepatitis A Virus 3C Protease Cleaves NEMO To Impair Induction of Beta Interferon |
| title_sort |
hepatitis a virus 3c protease cleaves nemo to impair induction of beta interferon |
| topic |
Virology Insect Science Immunology Microbiology |
| url |
http://dx.doi.org/10.1128/jvi.00869-14 |
| publishDate |
2014 |
| physical |
10252-10258 |
| description |
<jats:title>ABSTRACT</jats:title>
<jats:p>
NEMO (NF-κB essential modulator) is a bridging adaptor indispensable for viral activation of interferon (IFN) antiviral response. Herein, we show that hepatitis A virus (HAV) 3C protease (3C
<jats:sup>pro</jats:sup>
) cleaves NEMO at the Q304 residue, negating its signaling adaptor function and abrogating viral induction of IFN-β synthesis via the retinoic acid-inducible gene I/melanoma differentiation-associated protein 5 (RIG-I/MDA5) and Toll-like receptor 3 (TLR3) pathways. NEMO cleavage and IFN antagonism, however, were lost upon ablation of the catalytic activity of 3C
<jats:sup>pro</jats:sup>
. These data describe a novel immune evasion mechanism of HAV.
</jats:p> |
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| author | Wang, Dang, Fang, Liurong, Wei, Dahai, Zhang, Huan, Luo, Rui, Chen, Huanchun, Li, Kui, Xiao, Shaobo |
| author_facet | Wang, Dang, Fang, Liurong, Wei, Dahai, Zhang, Huan, Luo, Rui, Chen, Huanchun, Li, Kui, Xiao, Shaobo, Wang, Dang, Fang, Liurong, Wei, Dahai, Zhang, Huan, Luo, Rui, Chen, Huanchun, Li, Kui, Xiao, Shaobo |
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| description | <jats:title>ABSTRACT</jats:title> <jats:p> NEMO (NF-κB essential modulator) is a bridging adaptor indispensable for viral activation of interferon (IFN) antiviral response. Herein, we show that hepatitis A virus (HAV) 3C protease (3C <jats:sup>pro</jats:sup> ) cleaves NEMO at the Q304 residue, negating its signaling adaptor function and abrogating viral induction of IFN-β synthesis via the retinoic acid-inducible gene I/melanoma differentiation-associated protein 5 (RIG-I/MDA5) and Toll-like receptor 3 (TLR3) pathways. NEMO cleavage and IFN antagonism, however, were lost upon ablation of the catalytic activity of 3C <jats:sup>pro</jats:sup> . These data describe a novel immune evasion mechanism of HAV. </jats:p> |
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| spelling | Wang, Dang Fang, Liurong Wei, Dahai Zhang, Huan Luo, Rui Chen, Huanchun Li, Kui Xiao, Shaobo 0022-538X 1098-5514 American Society for Microbiology Virology Insect Science Immunology Microbiology http://dx.doi.org/10.1128/jvi.00869-14 <jats:title>ABSTRACT</jats:title> <jats:p> NEMO (NF-κB essential modulator) is a bridging adaptor indispensable for viral activation of interferon (IFN) antiviral response. Herein, we show that hepatitis A virus (HAV) 3C protease (3C <jats:sup>pro</jats:sup> ) cleaves NEMO at the Q304 residue, negating its signaling adaptor function and abrogating viral induction of IFN-β synthesis via the retinoic acid-inducible gene I/melanoma differentiation-associated protein 5 (RIG-I/MDA5) and Toll-like receptor 3 (TLR3) pathways. NEMO cleavage and IFN antagonism, however, were lost upon ablation of the catalytic activity of 3C <jats:sup>pro</jats:sup> . These data describe a novel immune evasion mechanism of HAV. </jats:p> Hepatitis A Virus 3C Protease Cleaves NEMO To Impair Induction of Beta Interferon Journal of Virology |
| spellingShingle | Wang, Dang, Fang, Liurong, Wei, Dahai, Zhang, Huan, Luo, Rui, Chen, Huanchun, Li, Kui, Xiao, Shaobo, Journal of Virology, Hepatitis A Virus 3C Protease Cleaves NEMO To Impair Induction of Beta Interferon, Virology, Insect Science, Immunology, Microbiology |
| title | Hepatitis A Virus 3C Protease Cleaves NEMO To Impair Induction of Beta Interferon |
| title_full | Hepatitis A Virus 3C Protease Cleaves NEMO To Impair Induction of Beta Interferon |
| title_fullStr | Hepatitis A Virus 3C Protease Cleaves NEMO To Impair Induction of Beta Interferon |
| title_full_unstemmed | Hepatitis A Virus 3C Protease Cleaves NEMO To Impair Induction of Beta Interferon |
| title_short | Hepatitis A Virus 3C Protease Cleaves NEMO To Impair Induction of Beta Interferon |
| title_sort | hepatitis a virus 3c protease cleaves nemo to impair induction of beta interferon |
| title_unstemmed | Hepatitis A Virus 3C Protease Cleaves NEMO To Impair Induction of Beta Interferon |
| topic | Virology, Insect Science, Immunology, Microbiology |
| url | http://dx.doi.org/10.1128/jvi.00869-14 |