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Immunogenic cross-reactivity between human tissues and the enterobacterial common antigen
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| Zeitschriftentitel: | Infection and Immunity |
|---|---|
| Personen und Körperschaften: | , |
| In: | Infection and Immunity, 17, 1977, 1, S. 36-42 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
|
| Schlagwörter: |
| author_facet |
Morgenstern, M A Gorzynski, E A Morgenstern, M A Gorzynski, E A |
|---|---|
| author |
Morgenstern, M A Gorzynski, E A |
| spellingShingle |
Morgenstern, M A Gorzynski, E A Infection and Immunity Immunogenic cross-reactivity between human tissues and the enterobacterial common antigen Infectious Diseases Immunology Microbiology Parasitology |
| author_sort |
morgenstern, m a |
| spelling |
Morgenstern, M A Gorzynski, E A 0019-9567 1098-5522 American Society for Microbiology Infectious Diseases Immunology Microbiology Parasitology http://dx.doi.org/10.1128/iai.17.1.36-42.1977 <jats:p>Sterile tissues of human subjects free from infection and malignancy were assessed for an antigen that cross-reacts with the enterobacterial common antigen (ECA). Extracts of heated homogenates (HE) and ethanol-soluble (ES) fractions of liver, kidney, muscle, and heart tissues were examined for their capacities to react with ECA antibodies, as measured by hemagglutination procedures, and to elicit ECA humoral antibodies in rabbits. Both HE and ES extracts of human liver and kidney tissues specifically inhibited ECA hemagglutination. However, ES fractions of HE preparations demonstrated significantly greater inhibiton than their HE sources. In addition, both liver and kidney ES fractions primed rabbits for a rapid and specific secondary ECA humoral response to a single administration of ECA. The cross-reactivity noted between human tissue and ECA cannot be attributed to indigenous microorganisms present in the tissues, as subcultures of tissue homogenates were always sterile. Moreover, preliminary experiments with human fetal subjects, devoid of microbial flora, yielded similar results.</jats:p> Immunogenic cross-reactivity between human tissues and the enterobacterial common antigen Infection and Immunity |
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American Society for Microbiology, 1977 |
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American Society for Microbiology, 1977 |
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0019-9567 1098-5522 |
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Immunogenic cross-reactivity between human tissues and the enterobacterial common antigen |
| title_unstemmed |
Immunogenic cross-reactivity between human tissues and the enterobacterial common antigen |
| title_full |
Immunogenic cross-reactivity between human tissues and the enterobacterial common antigen |
| title_fullStr |
Immunogenic cross-reactivity between human tissues and the enterobacterial common antigen |
| title_full_unstemmed |
Immunogenic cross-reactivity between human tissues and the enterobacterial common antigen |
| title_short |
Immunogenic cross-reactivity between human tissues and the enterobacterial common antigen |
| title_sort |
immunogenic cross-reactivity between human tissues and the enterobacterial common antigen |
| topic |
Infectious Diseases Immunology Microbiology Parasitology |
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http://dx.doi.org/10.1128/iai.17.1.36-42.1977 |
| publishDate |
1977 |
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36-42 |
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<jats:p>Sterile tissues of human subjects free from infection and malignancy were assessed for an antigen that cross-reacts with the enterobacterial common antigen (ECA). Extracts of heated homogenates (HE) and ethanol-soluble (ES) fractions of liver, kidney, muscle, and heart tissues were examined for their capacities to react with ECA antibodies, as measured by hemagglutination procedures, and to elicit ECA humoral antibodies in rabbits. Both HE and ES extracts of human liver and kidney tissues specifically inhibited ECA hemagglutination. However, ES fractions of HE preparations demonstrated significantly greater inhibiton than their HE sources. In addition, both liver and kidney ES fractions primed rabbits for a rapid and specific secondary ECA humoral response to a single administration of ECA. The cross-reactivity noted between human tissue and ECA cannot be attributed to indigenous microorganisms present in the tissues, as subcultures of tissue homogenates were always sterile. Moreover, preliminary experiments with human fetal subjects, devoid of microbial flora, yielded similar results.</jats:p> |
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| author | Morgenstern, M A, Gorzynski, E A |
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| description | <jats:p>Sterile tissues of human subjects free from infection and malignancy were assessed for an antigen that cross-reacts with the enterobacterial common antigen (ECA). Extracts of heated homogenates (HE) and ethanol-soluble (ES) fractions of liver, kidney, muscle, and heart tissues were examined for their capacities to react with ECA antibodies, as measured by hemagglutination procedures, and to elicit ECA humoral antibodies in rabbits. Both HE and ES extracts of human liver and kidney tissues specifically inhibited ECA hemagglutination. However, ES fractions of HE preparations demonstrated significantly greater inhibiton than their HE sources. In addition, both liver and kidney ES fractions primed rabbits for a rapid and specific secondary ECA humoral response to a single administration of ECA. The cross-reactivity noted between human tissue and ECA cannot be attributed to indigenous microorganisms present in the tissues, as subcultures of tissue homogenates were always sterile. Moreover, preliminary experiments with human fetal subjects, devoid of microbial flora, yielded similar results.</jats:p> |
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| imprint | American Society for Microbiology, 1977 |
| imprint_str_mv | American Society for Microbiology, 1977 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, FID-BBI-DE-23, DE-105, DE-14, DE-Ch1, DE-L229 |
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| physical | 36-42 |
| publishDate | 1977 |
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| spelling | Morgenstern, M A Gorzynski, E A 0019-9567 1098-5522 American Society for Microbiology Infectious Diseases Immunology Microbiology Parasitology http://dx.doi.org/10.1128/iai.17.1.36-42.1977 <jats:p>Sterile tissues of human subjects free from infection and malignancy were assessed for an antigen that cross-reacts with the enterobacterial common antigen (ECA). Extracts of heated homogenates (HE) and ethanol-soluble (ES) fractions of liver, kidney, muscle, and heart tissues were examined for their capacities to react with ECA antibodies, as measured by hemagglutination procedures, and to elicit ECA humoral antibodies in rabbits. Both HE and ES extracts of human liver and kidney tissues specifically inhibited ECA hemagglutination. However, ES fractions of HE preparations demonstrated significantly greater inhibiton than their HE sources. In addition, both liver and kidney ES fractions primed rabbits for a rapid and specific secondary ECA humoral response to a single administration of ECA. The cross-reactivity noted between human tissue and ECA cannot be attributed to indigenous microorganisms present in the tissues, as subcultures of tissue homogenates were always sterile. Moreover, preliminary experiments with human fetal subjects, devoid of microbial flora, yielded similar results.</jats:p> Immunogenic cross-reactivity between human tissues and the enterobacterial common antigen Infection and Immunity |
| spellingShingle | Morgenstern, M A, Gorzynski, E A, Infection and Immunity, Immunogenic cross-reactivity between human tissues and the enterobacterial common antigen, Infectious Diseases, Immunology, Microbiology, Parasitology |
| title | Immunogenic cross-reactivity between human tissues and the enterobacterial common antigen |
| title_full | Immunogenic cross-reactivity between human tissues and the enterobacterial common antigen |
| title_fullStr | Immunogenic cross-reactivity between human tissues and the enterobacterial common antigen |
| title_full_unstemmed | Immunogenic cross-reactivity between human tissues and the enterobacterial common antigen |
| title_short | Immunogenic cross-reactivity between human tissues and the enterobacterial common antigen |
| title_sort | immunogenic cross-reactivity between human tissues and the enterobacterial common antigen |
| title_unstemmed | Immunogenic cross-reactivity between human tissues and the enterobacterial common antigen |
| topic | Infectious Diseases, Immunology, Microbiology, Parasitology |
| url | http://dx.doi.org/10.1128/iai.17.1.36-42.1977 |