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Induction of Interferon in Mice by Mycoplasmas
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Zeitschriftentitel: | Infection and Immunity |
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Personen und Körperschaften: | , , , |
In: | Infection and Immunity, 10, 1974, 6, S. 1296-1301 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
American Society for Microbiology
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Schlagwörter: |
author_facet |
Rinaldo, Charles R. Cole, Barry C. Overall, James C. Glasgow, Lowell A. Rinaldo, Charles R. Cole, Barry C. Overall, James C. Glasgow, Lowell A. |
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author |
Rinaldo, Charles R. Cole, Barry C. Overall, James C. Glasgow, Lowell A. |
spellingShingle |
Rinaldo, Charles R. Cole, Barry C. Overall, James C. Glasgow, Lowell A. Infection and Immunity Induction of Interferon in Mice by Mycoplasmas Infectious Diseases Immunology Microbiology Parasitology |
author_sort |
rinaldo, charles r. |
spelling |
Rinaldo, Charles R. Cole, Barry C. Overall, James C. Glasgow, Lowell A. 0019-9567 1098-5522 American Society for Microbiology Infectious Diseases Immunology Microbiology Parasitology http://dx.doi.org/10.1128/iai.10.6.1296-1301.1974 <jats:p> Interferon was induced in mice after intraperitoneal inoculation with four different mycoplasmas. Peak levels of between 100 and 300 U of interferon per ml were attained by 6 h postinfection with each of the mycoplasmas except <jats:italic>Mycoplasma arthritidis</jats:italic> , which induced higher titers (400 to 11,800 U/ml) by this time. A fifth mycoplasma, <jats:italic>M. pulmonis</jats:italic> , induced interferon inconsistently and at a later (72 to 96 h) time. <jats:italic>Mycoplasmatales</jats:italic> virus MVL51 and sterile mycoplasmal broth did not stimulate interferon production in vivo. All of the mycoplasmas and MVL51 failed to induce interferon in murine spleen cell, peritoneal exudate cell, or peripheral blood leukocyte cultures. Preinfecting the mycoplasmas with MVL51 or treating the organisms with trypsin or dilutions of specific antisera did not enhance their ability to induce interferon in vitro. </jats:p> Induction of Interferon in Mice by Mycoplasmas Infection and Immunity |
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10.1128/iai.10.6.1296-1301.1974 |
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American Society for Microbiology, 1974 |
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American Society for Microbiology, 1974 |
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1974 |
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American Society for Microbiology |
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Infection and Immunity |
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title |
Induction of Interferon in Mice by Mycoplasmas |
title_unstemmed |
Induction of Interferon in Mice by Mycoplasmas |
title_full |
Induction of Interferon in Mice by Mycoplasmas |
title_fullStr |
Induction of Interferon in Mice by Mycoplasmas |
title_full_unstemmed |
Induction of Interferon in Mice by Mycoplasmas |
title_short |
Induction of Interferon in Mice by Mycoplasmas |
title_sort |
induction of interferon in mice by mycoplasmas |
topic |
Infectious Diseases Immunology Microbiology Parasitology |
url |
http://dx.doi.org/10.1128/iai.10.6.1296-1301.1974 |
publishDate |
1974 |
physical |
1296-1301 |
description |
<jats:p>
Interferon was induced in mice after intraperitoneal inoculation with four different mycoplasmas. Peak levels of between 100 and 300 U of interferon per ml were attained by 6 h postinfection with each of the mycoplasmas except
<jats:italic>Mycoplasma arthritidis</jats:italic>
, which induced higher titers (400 to 11,800 U/ml) by this time. A fifth mycoplasma,
<jats:italic>M. pulmonis</jats:italic>
, induced interferon inconsistently and at a later (72 to 96 h) time.
<jats:italic>Mycoplasmatales</jats:italic>
virus MVL51 and sterile mycoplasmal broth did not stimulate interferon production in vivo. All of the mycoplasmas and MVL51 failed to induce interferon in murine spleen cell, peritoneal exudate cell, or peripheral blood leukocyte cultures. Preinfecting the mycoplasmas with MVL51 or treating the organisms with trypsin or dilutions of specific antisera did not enhance their ability to induce interferon in vitro.
</jats:p> |
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author | Rinaldo, Charles R., Cole, Barry C., Overall, James C., Glasgow, Lowell A. |
author_facet | Rinaldo, Charles R., Cole, Barry C., Overall, James C., Glasgow, Lowell A., Rinaldo, Charles R., Cole, Barry C., Overall, James C., Glasgow, Lowell A. |
author_sort | rinaldo, charles r. |
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description | <jats:p> Interferon was induced in mice after intraperitoneal inoculation with four different mycoplasmas. Peak levels of between 100 and 300 U of interferon per ml were attained by 6 h postinfection with each of the mycoplasmas except <jats:italic>Mycoplasma arthritidis</jats:italic> , which induced higher titers (400 to 11,800 U/ml) by this time. A fifth mycoplasma, <jats:italic>M. pulmonis</jats:italic> , induced interferon inconsistently and at a later (72 to 96 h) time. <jats:italic>Mycoplasmatales</jats:italic> virus MVL51 and sterile mycoplasmal broth did not stimulate interferon production in vivo. All of the mycoplasmas and MVL51 failed to induce interferon in murine spleen cell, peritoneal exudate cell, or peripheral blood leukocyte cultures. Preinfecting the mycoplasmas with MVL51 or treating the organisms with trypsin or dilutions of specific antisera did not enhance their ability to induce interferon in vitro. </jats:p> |
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imprint | American Society for Microbiology, 1974 |
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institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, FID-BBI-DE-23, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2 |
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series | Infection and Immunity |
source_id | 49 |
spelling | Rinaldo, Charles R. Cole, Barry C. Overall, James C. Glasgow, Lowell A. 0019-9567 1098-5522 American Society for Microbiology Infectious Diseases Immunology Microbiology Parasitology http://dx.doi.org/10.1128/iai.10.6.1296-1301.1974 <jats:p> Interferon was induced in mice after intraperitoneal inoculation with four different mycoplasmas. Peak levels of between 100 and 300 U of interferon per ml were attained by 6 h postinfection with each of the mycoplasmas except <jats:italic>Mycoplasma arthritidis</jats:italic> , which induced higher titers (400 to 11,800 U/ml) by this time. A fifth mycoplasma, <jats:italic>M. pulmonis</jats:italic> , induced interferon inconsistently and at a later (72 to 96 h) time. <jats:italic>Mycoplasmatales</jats:italic> virus MVL51 and sterile mycoplasmal broth did not stimulate interferon production in vivo. All of the mycoplasmas and MVL51 failed to induce interferon in murine spleen cell, peritoneal exudate cell, or peripheral blood leukocyte cultures. Preinfecting the mycoplasmas with MVL51 or treating the organisms with trypsin or dilutions of specific antisera did not enhance their ability to induce interferon in vitro. </jats:p> Induction of Interferon in Mice by Mycoplasmas Infection and Immunity |
spellingShingle | Rinaldo, Charles R., Cole, Barry C., Overall, James C., Glasgow, Lowell A., Infection and Immunity, Induction of Interferon in Mice by Mycoplasmas, Infectious Diseases, Immunology, Microbiology, Parasitology |
title | Induction of Interferon in Mice by Mycoplasmas |
title_full | Induction of Interferon in Mice by Mycoplasmas |
title_fullStr | Induction of Interferon in Mice by Mycoplasmas |
title_full_unstemmed | Induction of Interferon in Mice by Mycoplasmas |
title_short | Induction of Interferon in Mice by Mycoplasmas |
title_sort | induction of interferon in mice by mycoplasmas |
title_unstemmed | Induction of Interferon in Mice by Mycoplasmas |
topic | Infectious Diseases, Immunology, Microbiology, Parasitology |
url | http://dx.doi.org/10.1128/iai.10.6.1296-1301.1974 |