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Cold Atmospheric Air Plasma Sterilization against Spores and Other Microorganisms of Clinical Interest
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| Zeitschriftentitel: | Applied and Environmental Microbiology |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | Applied and Environmental Microbiology, 78, 2012, 15, S. 5077-5082 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
|
| Schlagwörter: |
| author_facet |
Klämpfl, Tobias G. Isbary, Georg Shimizu, Tetsuji Li, Yang-Fang Zimmermann, Julia L. Stolz, Wilhelm Schlegel, Jürgen Morfill, Gregor E. Schmidt, Hans-Ulrich Klämpfl, Tobias G. Isbary, Georg Shimizu, Tetsuji Li, Yang-Fang Zimmermann, Julia L. Stolz, Wilhelm Schlegel, Jürgen Morfill, Gregor E. Schmidt, Hans-Ulrich |
|---|---|
| author |
Klämpfl, Tobias G. Isbary, Georg Shimizu, Tetsuji Li, Yang-Fang Zimmermann, Julia L. Stolz, Wilhelm Schlegel, Jürgen Morfill, Gregor E. Schmidt, Hans-Ulrich |
| spellingShingle |
Klämpfl, Tobias G. Isbary, Georg Shimizu, Tetsuji Li, Yang-Fang Zimmermann, Julia L. Stolz, Wilhelm Schlegel, Jürgen Morfill, Gregor E. Schmidt, Hans-Ulrich Applied and Environmental Microbiology Cold Atmospheric Air Plasma Sterilization against Spores and Other Microorganisms of Clinical Interest Ecology Applied Microbiology and Biotechnology Food Science Biotechnology |
| author_sort |
klämpfl, tobias g. |
| spelling |
Klämpfl, Tobias G. Isbary, Georg Shimizu, Tetsuji Li, Yang-Fang Zimmermann, Julia L. Stolz, Wilhelm Schlegel, Jürgen Morfill, Gregor E. Schmidt, Hans-Ulrich 0099-2240 1098-5336 American Society for Microbiology Ecology Applied Microbiology and Biotechnology Food Science Biotechnology http://dx.doi.org/10.1128/aem.00583-12 <jats:title>ABSTRACT</jats:title> <jats:p> Physical cold atmospheric surface microdischarge (SMD) plasma operating in ambient air has promising properties for the sterilization of sensitive medical devices where conventional methods are not applicable. Furthermore, SMD plasma could revolutionize the field of disinfection at health care facilities. The antimicrobial effects on Gram-negative and Gram-positive bacteria of clinical relevance, as well as the fungus <jats:named-content content-type="genus-species">Candida albicans</jats:named-content> , were tested. Thirty seconds of plasma treatment led to a 4 to 6 log <jats:sub>10</jats:sub> CFU reduction on agar plates. <jats:named-content content-type="genus-species">C. albicans</jats:named-content> was the hardest to inactivate. The sterilizing effect on standard bioindicators (bacterial endospores) was evaluated on dry test specimens that were wrapped in Tyvek coupons. The experimental <jats:italic>D</jats:italic> <jats:sub>23</jats:sub> <jats:sub>°</jats:sub> <jats:sub>C</jats:sub> values for <jats:named-content content-type="genus-species">Bacillus subtilis</jats:named-content> , <jats:named-content content-type="genus-species">Bacillus pumilus</jats:named-content> , <jats:named-content content-type="genus-species">Bacillus atrophaeus</jats:named-content> , and <jats:named-content content-type="genus-species">Geobacillus stearothermophilus</jats:named-content> were determined as 0.3 min, 0.5 min, 0.6 min, and 0.9 min, respectively. These decimal reduction times ( <jats:italic>D</jats:italic> values) are distinctly lower than <jats:italic>D</jats:italic> values obtained with other reference methods. Importantly, the high inactivation rate was independent of the material of the test specimen. Possible inactivation mechanisms for relevant microorganisms are briefly discussed, emphasizing the important role of neutral reactive plasma species and pointing to recent diagnostic methods that will contribute to a better understanding of the strong biocidal effect of SMD air plasma. </jats:p> Cold Atmospheric Air Plasma Sterilization against Spores and Other Microorganisms of Clinical Interest Applied and Environmental Microbiology |
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10.1128/aem.00583-12 |
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Online Free |
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American Society for Microbiology, 2012 |
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American Society for Microbiology, 2012 |
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0099-2240 1098-5336 |
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2012 |
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American Society for Microbiology |
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Applied and Environmental Microbiology |
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49 |
| title |
Cold Atmospheric Air Plasma Sterilization against Spores and Other Microorganisms of Clinical Interest |
| title_unstemmed |
Cold Atmospheric Air Plasma Sterilization against Spores and Other Microorganisms of Clinical Interest |
| title_full |
Cold Atmospheric Air Plasma Sterilization against Spores and Other Microorganisms of Clinical Interest |
| title_fullStr |
Cold Atmospheric Air Plasma Sterilization against Spores and Other Microorganisms of Clinical Interest |
| title_full_unstemmed |
Cold Atmospheric Air Plasma Sterilization against Spores and Other Microorganisms of Clinical Interest |
| title_short |
Cold Atmospheric Air Plasma Sterilization against Spores and Other Microorganisms of Clinical Interest |
| title_sort |
cold atmospheric air plasma sterilization against spores and other microorganisms of clinical interest |
| topic |
Ecology Applied Microbiology and Biotechnology Food Science Biotechnology |
| url |
http://dx.doi.org/10.1128/aem.00583-12 |
| publishDate |
2012 |
| physical |
5077-5082 |
| description |
<jats:title>ABSTRACT</jats:title>
<jats:p>
Physical cold atmospheric surface microdischarge (SMD) plasma operating in ambient air has promising properties for the sterilization of sensitive medical devices where conventional methods are not applicable. Furthermore, SMD plasma could revolutionize the field of disinfection at health care facilities. The antimicrobial effects on Gram-negative and Gram-positive bacteria of clinical relevance, as well as the fungus
<jats:named-content content-type="genus-species">Candida albicans</jats:named-content>
, were tested. Thirty seconds of plasma treatment led to a 4 to 6 log
<jats:sub>10</jats:sub>
CFU reduction on agar plates.
<jats:named-content content-type="genus-species">C. albicans</jats:named-content>
was the hardest to inactivate. The sterilizing effect on standard bioindicators (bacterial endospores) was evaluated on dry test specimens that were wrapped in Tyvek coupons. The experimental
<jats:italic>D</jats:italic>
<jats:sub>23</jats:sub>
<jats:sub>°</jats:sub>
<jats:sub>C</jats:sub>
values for
<jats:named-content content-type="genus-species">Bacillus subtilis</jats:named-content>
,
<jats:named-content content-type="genus-species">Bacillus pumilus</jats:named-content>
,
<jats:named-content content-type="genus-species">Bacillus atrophaeus</jats:named-content>
, and
<jats:named-content content-type="genus-species">Geobacillus stearothermophilus</jats:named-content>
were determined as 0.3 min, 0.5 min, 0.6 min, and 0.9 min, respectively. These decimal reduction times (
<jats:italic>D</jats:italic>
values) are distinctly lower than
<jats:italic>D</jats:italic>
values obtained with other reference methods. Importantly, the high inactivation rate was independent of the material of the test specimen. Possible inactivation mechanisms for relevant microorganisms are briefly discussed, emphasizing the important role of neutral reactive plasma species and pointing to recent diagnostic methods that will contribute to a better understanding of the strong biocidal effect of SMD air plasma.
</jats:p> |
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| author | Klämpfl, Tobias G., Isbary, Georg, Shimizu, Tetsuji, Li, Yang-Fang, Zimmermann, Julia L., Stolz, Wilhelm, Schlegel, Jürgen, Morfill, Gregor E., Schmidt, Hans-Ulrich |
| author_facet | Klämpfl, Tobias G., Isbary, Georg, Shimizu, Tetsuji, Li, Yang-Fang, Zimmermann, Julia L., Stolz, Wilhelm, Schlegel, Jürgen, Morfill, Gregor E., Schmidt, Hans-Ulrich, Klämpfl, Tobias G., Isbary, Georg, Shimizu, Tetsuji, Li, Yang-Fang, Zimmermann, Julia L., Stolz, Wilhelm, Schlegel, Jürgen, Morfill, Gregor E., Schmidt, Hans-Ulrich |
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| description | <jats:title>ABSTRACT</jats:title> <jats:p> Physical cold atmospheric surface microdischarge (SMD) plasma operating in ambient air has promising properties for the sterilization of sensitive medical devices where conventional methods are not applicable. Furthermore, SMD plasma could revolutionize the field of disinfection at health care facilities. The antimicrobial effects on Gram-negative and Gram-positive bacteria of clinical relevance, as well as the fungus <jats:named-content content-type="genus-species">Candida albicans</jats:named-content> , were tested. Thirty seconds of plasma treatment led to a 4 to 6 log <jats:sub>10</jats:sub> CFU reduction on agar plates. <jats:named-content content-type="genus-species">C. albicans</jats:named-content> was the hardest to inactivate. The sterilizing effect on standard bioindicators (bacterial endospores) was evaluated on dry test specimens that were wrapped in Tyvek coupons. The experimental <jats:italic>D</jats:italic> <jats:sub>23</jats:sub> <jats:sub>°</jats:sub> <jats:sub>C</jats:sub> values for <jats:named-content content-type="genus-species">Bacillus subtilis</jats:named-content> , <jats:named-content content-type="genus-species">Bacillus pumilus</jats:named-content> , <jats:named-content content-type="genus-species">Bacillus atrophaeus</jats:named-content> , and <jats:named-content content-type="genus-species">Geobacillus stearothermophilus</jats:named-content> were determined as 0.3 min, 0.5 min, 0.6 min, and 0.9 min, respectively. These decimal reduction times ( <jats:italic>D</jats:italic> values) are distinctly lower than <jats:italic>D</jats:italic> values obtained with other reference methods. Importantly, the high inactivation rate was independent of the material of the test specimen. Possible inactivation mechanisms for relevant microorganisms are briefly discussed, emphasizing the important role of neutral reactive plasma species and pointing to recent diagnostic methods that will contribute to a better understanding of the strong biocidal effect of SMD air plasma. </jats:p> |
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| imprint | American Society for Microbiology, 2012 |
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| spelling | Klämpfl, Tobias G. Isbary, Georg Shimizu, Tetsuji Li, Yang-Fang Zimmermann, Julia L. Stolz, Wilhelm Schlegel, Jürgen Morfill, Gregor E. Schmidt, Hans-Ulrich 0099-2240 1098-5336 American Society for Microbiology Ecology Applied Microbiology and Biotechnology Food Science Biotechnology http://dx.doi.org/10.1128/aem.00583-12 <jats:title>ABSTRACT</jats:title> <jats:p> Physical cold atmospheric surface microdischarge (SMD) plasma operating in ambient air has promising properties for the sterilization of sensitive medical devices where conventional methods are not applicable. Furthermore, SMD plasma could revolutionize the field of disinfection at health care facilities. The antimicrobial effects on Gram-negative and Gram-positive bacteria of clinical relevance, as well as the fungus <jats:named-content content-type="genus-species">Candida albicans</jats:named-content> , were tested. Thirty seconds of plasma treatment led to a 4 to 6 log <jats:sub>10</jats:sub> CFU reduction on agar plates. <jats:named-content content-type="genus-species">C. albicans</jats:named-content> was the hardest to inactivate. The sterilizing effect on standard bioindicators (bacterial endospores) was evaluated on dry test specimens that were wrapped in Tyvek coupons. The experimental <jats:italic>D</jats:italic> <jats:sub>23</jats:sub> <jats:sub>°</jats:sub> <jats:sub>C</jats:sub> values for <jats:named-content content-type="genus-species">Bacillus subtilis</jats:named-content> , <jats:named-content content-type="genus-species">Bacillus pumilus</jats:named-content> , <jats:named-content content-type="genus-species">Bacillus atrophaeus</jats:named-content> , and <jats:named-content content-type="genus-species">Geobacillus stearothermophilus</jats:named-content> were determined as 0.3 min, 0.5 min, 0.6 min, and 0.9 min, respectively. These decimal reduction times ( <jats:italic>D</jats:italic> values) are distinctly lower than <jats:italic>D</jats:italic> values obtained with other reference methods. Importantly, the high inactivation rate was independent of the material of the test specimen. Possible inactivation mechanisms for relevant microorganisms are briefly discussed, emphasizing the important role of neutral reactive plasma species and pointing to recent diagnostic methods that will contribute to a better understanding of the strong biocidal effect of SMD air plasma. </jats:p> Cold Atmospheric Air Plasma Sterilization against Spores and Other Microorganisms of Clinical Interest Applied and Environmental Microbiology |
| spellingShingle | Klämpfl, Tobias G., Isbary, Georg, Shimizu, Tetsuji, Li, Yang-Fang, Zimmermann, Julia L., Stolz, Wilhelm, Schlegel, Jürgen, Morfill, Gregor E., Schmidt, Hans-Ulrich, Applied and Environmental Microbiology, Cold Atmospheric Air Plasma Sterilization against Spores and Other Microorganisms of Clinical Interest, Ecology, Applied Microbiology and Biotechnology, Food Science, Biotechnology |
| title | Cold Atmospheric Air Plasma Sterilization against Spores and Other Microorganisms of Clinical Interest |
| title_full | Cold Atmospheric Air Plasma Sterilization against Spores and Other Microorganisms of Clinical Interest |
| title_fullStr | Cold Atmospheric Air Plasma Sterilization against Spores and Other Microorganisms of Clinical Interest |
| title_full_unstemmed | Cold Atmospheric Air Plasma Sterilization against Spores and Other Microorganisms of Clinical Interest |
| title_short | Cold Atmospheric Air Plasma Sterilization against Spores and Other Microorganisms of Clinical Interest |
| title_sort | cold atmospheric air plasma sterilization against spores and other microorganisms of clinical interest |
| title_unstemmed | Cold Atmospheric Air Plasma Sterilization against Spores and Other Microorganisms of Clinical Interest |
| topic | Ecology, Applied Microbiology and Biotechnology, Food Science, Biotechnology |
| url | http://dx.doi.org/10.1128/aem.00583-12 |