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Polyethylene Glycol-Based Hydrogels for Controlled Release of the Antimicrobial Subtilosin for Prophylaxis of Bacterial Vaginosis
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| Zeitschriftentitel: | Antimicrobial Agents and Chemotherapy |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | Antimicrobial Agents and Chemotherapy, 58, 2014, 5, S. 2747-2753 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
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| Schlagwörter: |
| author_facet |
Sundara Rajan, Sujata Cavera, Veronica L. Zhang, Xiaoping Singh, Yashveer Chikindas, Michael L. Sinko, Patrick J. Sundara Rajan, Sujata Cavera, Veronica L. Zhang, Xiaoping Singh, Yashveer Chikindas, Michael L. Sinko, Patrick J. |
|---|---|
| author |
Sundara Rajan, Sujata Cavera, Veronica L. Zhang, Xiaoping Singh, Yashveer Chikindas, Michael L. Sinko, Patrick J. |
| spellingShingle |
Sundara Rajan, Sujata Cavera, Veronica L. Zhang, Xiaoping Singh, Yashveer Chikindas, Michael L. Sinko, Patrick J. Antimicrobial Agents and Chemotherapy Polyethylene Glycol-Based Hydrogels for Controlled Release of the Antimicrobial Subtilosin for Prophylaxis of Bacterial Vaginosis Infectious Diseases Pharmacology (medical) Pharmacology |
| author_sort |
sundara rajan, sujata |
| spelling |
Sundara Rajan, Sujata Cavera, Veronica L. Zhang, Xiaoping Singh, Yashveer Chikindas, Michael L. Sinko, Patrick J. 0066-4804 1098-6596 American Society for Microbiology Infectious Diseases Pharmacology (medical) Pharmacology http://dx.doi.org/10.1128/aac.02446-14 <jats:title>ABSTRACT</jats:title> <jats:p> Current treatment options for bacterial vaginosis (BV) have been shown to be inadequate at preventing recurrence and do not provide protection against associated infections, such as that with HIV. This study examines the feasibility of incorporating the antimicrobial peptide subtilosin within covalently cross-linked polyethylene glycol (PEG)-based hydrogels for vaginal administration. The PEG-based hydrogels (4% and 6% [wt/vol]) provided a two-phase release of subtilosin, with an initial rapid release rate of 4.0 μg/h (0 to 12 h) followed by a slow, sustained release rate of 0.26 μg/h (12 to 120 h). The subtilosin-containing hydrogels inhibited the growth of the major BV-associated pathogen <jats:named-content xmlns:xlink="http://www.w3.org/1999/xlink" content-type="genus-species" xlink:type="simple">Gardnerella vaginalis</jats:named-content> with a reduction of 8 log <jats:sub>10</jats:sub> CFU/ml with hydrogels containing ≥15 μg entrapped subtilosin. In addition, the growth of four common species of vaginal lactobacilli was not significantly inhibited in the presence of the subtilosin-containing hydrogels. The above findings demonstrate the potential application of vaginal subtilosin-containing hydrogels for prophylaxis of BV. </jats:p> Polyethylene Glycol-Based Hydrogels for Controlled Release of the Antimicrobial Subtilosin for Prophylaxis of Bacterial Vaginosis Antimicrobial Agents and Chemotherapy |
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American Society for Microbiology, 2014 |
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American Society for Microbiology, 2014 |
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0066-4804 1098-6596 |
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Antimicrobial Agents and Chemotherapy |
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49 |
| title |
Polyethylene Glycol-Based Hydrogels for Controlled Release of the Antimicrobial Subtilosin for Prophylaxis of Bacterial Vaginosis |
| title_unstemmed |
Polyethylene Glycol-Based Hydrogels for Controlled Release of the Antimicrobial Subtilosin for Prophylaxis of Bacterial Vaginosis |
| title_full |
Polyethylene Glycol-Based Hydrogels for Controlled Release of the Antimicrobial Subtilosin for Prophylaxis of Bacterial Vaginosis |
| title_fullStr |
Polyethylene Glycol-Based Hydrogels for Controlled Release of the Antimicrobial Subtilosin for Prophylaxis of Bacterial Vaginosis |
| title_full_unstemmed |
Polyethylene Glycol-Based Hydrogels for Controlled Release of the Antimicrobial Subtilosin for Prophylaxis of Bacterial Vaginosis |
| title_short |
Polyethylene Glycol-Based Hydrogels for Controlled Release of the Antimicrobial Subtilosin for Prophylaxis of Bacterial Vaginosis |
| title_sort |
polyethylene glycol-based hydrogels for controlled release of the antimicrobial subtilosin for prophylaxis of bacterial vaginosis |
| topic |
Infectious Diseases Pharmacology (medical) Pharmacology |
| url |
http://dx.doi.org/10.1128/aac.02446-14 |
| publishDate |
2014 |
| physical |
2747-2753 |
| description |
<jats:title>ABSTRACT</jats:title>
<jats:p>
Current treatment options for bacterial vaginosis (BV) have been shown to be inadequate at preventing recurrence and do not provide protection against associated infections, such as that with HIV. This study examines the feasibility of incorporating the antimicrobial peptide subtilosin within covalently cross-linked polyethylene glycol (PEG)-based hydrogels for vaginal administration. The PEG-based hydrogels (4% and 6% [wt/vol]) provided a two-phase release of subtilosin, with an initial rapid release rate of 4.0 μg/h (0 to 12 h) followed by a slow, sustained release rate of 0.26 μg/h (12 to 120 h). The subtilosin-containing hydrogels inhibited the growth of the major BV-associated pathogen
<jats:named-content xmlns:xlink="http://www.w3.org/1999/xlink" content-type="genus-species" xlink:type="simple">Gardnerella vaginalis</jats:named-content>
with a reduction of 8 log
<jats:sub>10</jats:sub>
CFU/ml with hydrogels containing ≥15 μg entrapped subtilosin. In addition, the growth of four common species of vaginal lactobacilli was not significantly inhibited in the presence of the subtilosin-containing hydrogels. The above findings demonstrate the potential application of vaginal subtilosin-containing hydrogels for prophylaxis of BV.
</jats:p> |
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| author | Sundara Rajan, Sujata, Cavera, Veronica L., Zhang, Xiaoping, Singh, Yashveer, Chikindas, Michael L., Sinko, Patrick J. |
| author_facet | Sundara Rajan, Sujata, Cavera, Veronica L., Zhang, Xiaoping, Singh, Yashveer, Chikindas, Michael L., Sinko, Patrick J., Sundara Rajan, Sujata, Cavera, Veronica L., Zhang, Xiaoping, Singh, Yashveer, Chikindas, Michael L., Sinko, Patrick J. |
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| description | <jats:title>ABSTRACT</jats:title> <jats:p> Current treatment options for bacterial vaginosis (BV) have been shown to be inadequate at preventing recurrence and do not provide protection against associated infections, such as that with HIV. This study examines the feasibility of incorporating the antimicrobial peptide subtilosin within covalently cross-linked polyethylene glycol (PEG)-based hydrogels for vaginal administration. The PEG-based hydrogels (4% and 6% [wt/vol]) provided a two-phase release of subtilosin, with an initial rapid release rate of 4.0 μg/h (0 to 12 h) followed by a slow, sustained release rate of 0.26 μg/h (12 to 120 h). The subtilosin-containing hydrogels inhibited the growth of the major BV-associated pathogen <jats:named-content xmlns:xlink="http://www.w3.org/1999/xlink" content-type="genus-species" xlink:type="simple">Gardnerella vaginalis</jats:named-content> with a reduction of 8 log <jats:sub>10</jats:sub> CFU/ml with hydrogels containing ≥15 μg entrapped subtilosin. In addition, the growth of four common species of vaginal lactobacilli was not significantly inhibited in the presence of the subtilosin-containing hydrogels. The above findings demonstrate the potential application of vaginal subtilosin-containing hydrogels for prophylaxis of BV. </jats:p> |
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| spelling | Sundara Rajan, Sujata Cavera, Veronica L. Zhang, Xiaoping Singh, Yashveer Chikindas, Michael L. Sinko, Patrick J. 0066-4804 1098-6596 American Society for Microbiology Infectious Diseases Pharmacology (medical) Pharmacology http://dx.doi.org/10.1128/aac.02446-14 <jats:title>ABSTRACT</jats:title> <jats:p> Current treatment options for bacterial vaginosis (BV) have been shown to be inadequate at preventing recurrence and do not provide protection against associated infections, such as that with HIV. This study examines the feasibility of incorporating the antimicrobial peptide subtilosin within covalently cross-linked polyethylene glycol (PEG)-based hydrogels for vaginal administration. The PEG-based hydrogels (4% and 6% [wt/vol]) provided a two-phase release of subtilosin, with an initial rapid release rate of 4.0 μg/h (0 to 12 h) followed by a slow, sustained release rate of 0.26 μg/h (12 to 120 h). The subtilosin-containing hydrogels inhibited the growth of the major BV-associated pathogen <jats:named-content xmlns:xlink="http://www.w3.org/1999/xlink" content-type="genus-species" xlink:type="simple">Gardnerella vaginalis</jats:named-content> with a reduction of 8 log <jats:sub>10</jats:sub> CFU/ml with hydrogels containing ≥15 μg entrapped subtilosin. In addition, the growth of four common species of vaginal lactobacilli was not significantly inhibited in the presence of the subtilosin-containing hydrogels. The above findings demonstrate the potential application of vaginal subtilosin-containing hydrogels for prophylaxis of BV. </jats:p> Polyethylene Glycol-Based Hydrogels for Controlled Release of the Antimicrobial Subtilosin for Prophylaxis of Bacterial Vaginosis Antimicrobial Agents and Chemotherapy |
| spellingShingle | Sundara Rajan, Sujata, Cavera, Veronica L., Zhang, Xiaoping, Singh, Yashveer, Chikindas, Michael L., Sinko, Patrick J., Antimicrobial Agents and Chemotherapy, Polyethylene Glycol-Based Hydrogels for Controlled Release of the Antimicrobial Subtilosin for Prophylaxis of Bacterial Vaginosis, Infectious Diseases, Pharmacology (medical), Pharmacology |
| title | Polyethylene Glycol-Based Hydrogels for Controlled Release of the Antimicrobial Subtilosin for Prophylaxis of Bacterial Vaginosis |
| title_full | Polyethylene Glycol-Based Hydrogels for Controlled Release of the Antimicrobial Subtilosin for Prophylaxis of Bacterial Vaginosis |
| title_fullStr | Polyethylene Glycol-Based Hydrogels for Controlled Release of the Antimicrobial Subtilosin for Prophylaxis of Bacterial Vaginosis |
| title_full_unstemmed | Polyethylene Glycol-Based Hydrogels for Controlled Release of the Antimicrobial Subtilosin for Prophylaxis of Bacterial Vaginosis |
| title_short | Polyethylene Glycol-Based Hydrogels for Controlled Release of the Antimicrobial Subtilosin for Prophylaxis of Bacterial Vaginosis |
| title_sort | polyethylene glycol-based hydrogels for controlled release of the antimicrobial subtilosin for prophylaxis of bacterial vaginosis |
| title_unstemmed | Polyethylene Glycol-Based Hydrogels for Controlled Release of the Antimicrobial Subtilosin for Prophylaxis of Bacterial Vaginosis |
| topic | Infectious Diseases, Pharmacology (medical), Pharmacology |
| url | http://dx.doi.org/10.1128/aac.02446-14 |