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A VAMP-Binding Protein from Aplysia Required for Neurotransmitter Release
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| Zeitschriftentitel: | Science |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | Science, 269, 1995, 5230, S. 1580-1583 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Association for the Advancement of Science (AAAS)
|
| Schlagwörter: |
| author_facet |
Skehel, Paul A. Martin, Kelsey C. Kandel, Eric R. Bartsch, Dusan Skehel, Paul A. Martin, Kelsey C. Kandel, Eric R. Bartsch, Dusan |
|---|---|
| author |
Skehel, Paul A. Martin, Kelsey C. Kandel, Eric R. Bartsch, Dusan |
| spellingShingle |
Skehel, Paul A. Martin, Kelsey C. Kandel, Eric R. Bartsch, Dusan Science A VAMP-Binding Protein from Aplysia Required for Neurotransmitter Release Multidisciplinary |
| author_sort |
skehel, paul a. |
| spelling |
Skehel, Paul A. Martin, Kelsey C. Kandel, Eric R. Bartsch, Dusan 0036-8075 1095-9203 American Association for the Advancement of Science (AAAS) Multidisciplinary http://dx.doi.org/10.1126/science.7667638 <jats:p> Before the fusion of synaptic vesicles with the plasma membrane, a protein complex is thought to form between VAMP—an integral membrane protein of the vesicle—and two proteins associated with the plasma membrane, SNAP-25 and syntaxin. The yeast two-hybrid interaction cloning system has now been used to identify additional proteins from <jats:italic>Aplysia</jats:italic> that interact directly with VAMP. A 33-kilodalton membrane protein, termed VAP-33 (VAMP-associated protein of 33 kilodaltons), was identified whose corresponding messenger RNA was detected only in the central nervous system and the gill of <jats:italic>Aplysia</jats:italic> . Presynaptic injection of antibodies specific for VAP-33 inhibited synaptic transmission, which suggests that VAP-33 is required for the exocytosis of neurotransmitter. </jats:p> A VAMP-Binding Protein from <i>Aplysia</i> Required for Neurotransmitter Release Science |
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American Association for the Advancement of Science (AAAS), 1995 |
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American Association for the Advancement of Science (AAAS), 1995 |
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Science |
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| title |
A VAMP-Binding Protein from Aplysia Required for Neurotransmitter Release |
| title_unstemmed |
A VAMP-Binding Protein from Aplysia Required for Neurotransmitter Release |
| title_full |
A VAMP-Binding Protein from Aplysia Required for Neurotransmitter Release |
| title_fullStr |
A VAMP-Binding Protein from Aplysia Required for Neurotransmitter Release |
| title_full_unstemmed |
A VAMP-Binding Protein from Aplysia Required for Neurotransmitter Release |
| title_short |
A VAMP-Binding Protein from Aplysia Required for Neurotransmitter Release |
| title_sort |
a vamp-binding protein from
<i>aplysia</i>
required for neurotransmitter release |
| topic |
Multidisciplinary |
| url |
http://dx.doi.org/10.1126/science.7667638 |
| publishDate |
1995 |
| physical |
1580-1583 |
| description |
<jats:p>
Before the fusion of synaptic vesicles with the plasma membrane, a protein complex is thought to form between VAMP—an integral membrane protein of the vesicle—and two proteins associated with the plasma membrane, SNAP-25 and syntaxin. The yeast two-hybrid interaction cloning system has now been used to identify additional proteins from
<jats:italic>Aplysia</jats:italic>
that interact directly with VAMP. A 33-kilodalton membrane protein, termed VAP-33 (VAMP-associated protein of 33 kilodaltons), was identified whose corresponding messenger RNA was detected only in the central nervous system and the gill of
<jats:italic>Aplysia</jats:italic>
. Presynaptic injection of antibodies specific for VAP-33 inhibited synaptic transmission, which suggests that VAP-33 is required for the exocytosis of neurotransmitter.
</jats:p> |
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| author | Skehel, Paul A., Martin, Kelsey C., Kandel, Eric R., Bartsch, Dusan |
| author_facet | Skehel, Paul A., Martin, Kelsey C., Kandel, Eric R., Bartsch, Dusan, Skehel, Paul A., Martin, Kelsey C., Kandel, Eric R., Bartsch, Dusan |
| author_sort | skehel, paul a. |
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| description | <jats:p> Before the fusion of synaptic vesicles with the plasma membrane, a protein complex is thought to form between VAMP—an integral membrane protein of the vesicle—and two proteins associated with the plasma membrane, SNAP-25 and syntaxin. The yeast two-hybrid interaction cloning system has now been used to identify additional proteins from <jats:italic>Aplysia</jats:italic> that interact directly with VAMP. A 33-kilodalton membrane protein, termed VAP-33 (VAMP-associated protein of 33 kilodaltons), was identified whose corresponding messenger RNA was detected only in the central nervous system and the gill of <jats:italic>Aplysia</jats:italic> . Presynaptic injection of antibodies specific for VAP-33 inhibited synaptic transmission, which suggests that VAP-33 is required for the exocytosis of neurotransmitter. </jats:p> |
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| imprint | American Association for the Advancement of Science (AAAS), 1995 |
| imprint_str_mv | American Association for the Advancement of Science (AAAS), 1995 |
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| physical | 1580-1583 |
| publishDate | 1995 |
| publishDateSort | 1995 |
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| series | Science |
| source_id | 49 |
| spelling | Skehel, Paul A. Martin, Kelsey C. Kandel, Eric R. Bartsch, Dusan 0036-8075 1095-9203 American Association for the Advancement of Science (AAAS) Multidisciplinary http://dx.doi.org/10.1126/science.7667638 <jats:p> Before the fusion of synaptic vesicles with the plasma membrane, a protein complex is thought to form between VAMP—an integral membrane protein of the vesicle—and two proteins associated with the plasma membrane, SNAP-25 and syntaxin. The yeast two-hybrid interaction cloning system has now been used to identify additional proteins from <jats:italic>Aplysia</jats:italic> that interact directly with VAMP. A 33-kilodalton membrane protein, termed VAP-33 (VAMP-associated protein of 33 kilodaltons), was identified whose corresponding messenger RNA was detected only in the central nervous system and the gill of <jats:italic>Aplysia</jats:italic> . Presynaptic injection of antibodies specific for VAP-33 inhibited synaptic transmission, which suggests that VAP-33 is required for the exocytosis of neurotransmitter. </jats:p> A VAMP-Binding Protein from <i>Aplysia</i> Required for Neurotransmitter Release Science |
| spellingShingle | Skehel, Paul A., Martin, Kelsey C., Kandel, Eric R., Bartsch, Dusan, Science, A VAMP-Binding Protein from Aplysia Required for Neurotransmitter Release, Multidisciplinary |
| title | A VAMP-Binding Protein from Aplysia Required for Neurotransmitter Release |
| title_full | A VAMP-Binding Protein from Aplysia Required for Neurotransmitter Release |
| title_fullStr | A VAMP-Binding Protein from Aplysia Required for Neurotransmitter Release |
| title_full_unstemmed | A VAMP-Binding Protein from Aplysia Required for Neurotransmitter Release |
| title_short | A VAMP-Binding Protein from Aplysia Required for Neurotransmitter Release |
| title_sort | a vamp-binding protein from <i>aplysia</i> required for neurotransmitter release |
| title_unstemmed | A VAMP-Binding Protein from Aplysia Required for Neurotransmitter Release |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1126/science.7667638 |