Eintrag weiter verarbeiten
Retinoids Selective for Retinoid X Receptor Response Pathways
Gespeichert in:
| Zeitschriftentitel: | Science |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Science, 258, 1992, 5090, S. 1944-1946 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Association for the Advancement of Science (AAAS)
|
| Schlagwörter: |
| author_facet |
Lehmann, Jürgen M. Jong, Ling Fanjul, Andrea Cameron, James F. Lu, Xian Ping Haefner, Pamela Dawson, Marcia I. Pfahl, Magnus Lehmann, Jürgen M. Jong, Ling Fanjul, Andrea Cameron, James F. Lu, Xian Ping Haefner, Pamela Dawson, Marcia I. Pfahl, Magnus |
|---|---|
| author |
Lehmann, Jürgen M. Jong, Ling Fanjul, Andrea Cameron, James F. Lu, Xian Ping Haefner, Pamela Dawson, Marcia I. Pfahl, Magnus |
| spellingShingle |
Lehmann, Jürgen M. Jong, Ling Fanjul, Andrea Cameron, James F. Lu, Xian Ping Haefner, Pamela Dawson, Marcia I. Pfahl, Magnus Science Retinoids Selective for Retinoid X Receptor Response Pathways Multidisciplinary |
| author_sort |
lehmann, jürgen m. |
| spelling |
Lehmann, Jürgen M. Jong, Ling Fanjul, Andrea Cameron, James F. Lu, Xian Ping Haefner, Pamela Dawson, Marcia I. Pfahl, Magnus 0036-8075 1095-9203 American Association for the Advancement of Science (AAAS) Multidisciplinary http://dx.doi.org/10.1126/science.1335166 <jats:p> Retinoids have a broad spectrum of biological activities and are useful therapeutic agents. Their physiological activities are mediated by two types of receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs). RARs, as well as several related receptors, require heterodimerization with RXRs for effective DNA binding and function. However, in the presence of 9- <jats:italic>cis</jats:italic> -retinoic acid, a ligand for both RARs and RXRs, RXRs can also form homodimers. A series of retinoids is reported that selectively activates RXR homodimers but does not affect RAR-RXR heterodimers and thus demonstrates that both retinoid response pathways can be independently activated. </jats:p> Retinoids Selective for Retinoid X Receptor Response Pathways Science |
| doi_str_mv |
10.1126/science.1335166 |
| facet_avail |
Online |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEyNi9zY2llbmNlLjEzMzUxNjY |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEyNi9zY2llbmNlLjEzMzUxNjY |
| institution |
DE-Bn3 DE-Brt1 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 |
| imprint |
American Association for the Advancement of Science (AAAS), 1992 |
| imprint_str_mv |
American Association for the Advancement of Science (AAAS), 1992 |
| issn |
0036-8075 1095-9203 |
| issn_str_mv |
0036-8075 1095-9203 |
| language |
English |
| mega_collection |
American Association for the Advancement of Science (AAAS) (CrossRef) |
| match_str |
lehmann1992retinoidsselectiveforretinoidxreceptorresponsepathways |
| publishDateSort |
1992 |
| publisher |
American Association for the Advancement of Science (AAAS) |
| recordtype |
ai |
| record_format |
ai |
| series |
Science |
| source_id |
49 |
| title |
Retinoids Selective for Retinoid X Receptor Response Pathways |
| title_unstemmed |
Retinoids Selective for Retinoid X Receptor Response Pathways |
| title_full |
Retinoids Selective for Retinoid X Receptor Response Pathways |
| title_fullStr |
Retinoids Selective for Retinoid X Receptor Response Pathways |
| title_full_unstemmed |
Retinoids Selective for Retinoid X Receptor Response Pathways |
| title_short |
Retinoids Selective for Retinoid X Receptor Response Pathways |
| title_sort |
retinoids selective for retinoid x receptor response pathways |
| topic |
Multidisciplinary |
| url |
http://dx.doi.org/10.1126/science.1335166 |
| publishDate |
1992 |
| physical |
1944-1946 |
| description |
<jats:p>
Retinoids have a broad spectrum of biological activities and are useful therapeutic agents. Their physiological activities are mediated by two types of receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs). RARs, as well as several related receptors, require heterodimerization with RXRs for effective DNA binding and function. However, in the presence of 9-
<jats:italic>cis</jats:italic>
-retinoic acid, a ligand for both RARs and RXRs, RXRs can also form homodimers. A series of retinoids is reported that selectively activates RXR homodimers but does not affect RAR-RXR heterodimers and thus demonstrates that both retinoid response pathways can be independently activated.
</jats:p> |
| container_issue |
5090 |
| container_start_page |
1944 |
| container_title |
Science |
| container_volume |
258 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792342933290090502 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T16:43:04.189Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Retinoids+Selective+for+Retinoid+X+Receptor+Response+Pathways&rft.date=1992-12-18&genre=article&issn=1095-9203&volume=258&issue=5090&spage=1944&epage=1946&pages=1944-1946&jtitle=Science&atitle=Retinoids+Selective+for+Retinoid+X+Receptor+Response+Pathways&aulast=Pfahl&aufirst=Magnus&rft_id=info%3Adoi%2F10.1126%2Fscience.1335166&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792342933290090502 |
| author | Lehmann, Jürgen M., Jong, Ling, Fanjul, Andrea, Cameron, James F., Lu, Xian Ping, Haefner, Pamela, Dawson, Marcia I., Pfahl, Magnus |
| author_facet | Lehmann, Jürgen M., Jong, Ling, Fanjul, Andrea, Cameron, James F., Lu, Xian Ping, Haefner, Pamela, Dawson, Marcia I., Pfahl, Magnus, Lehmann, Jürgen M., Jong, Ling, Fanjul, Andrea, Cameron, James F., Lu, Xian Ping, Haefner, Pamela, Dawson, Marcia I., Pfahl, Magnus |
| author_sort | lehmann, jürgen m. |
| container_issue | 5090 |
| container_start_page | 1944 |
| container_title | Science |
| container_volume | 258 |
| description | <jats:p> Retinoids have a broad spectrum of biological activities and are useful therapeutic agents. Their physiological activities are mediated by two types of receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs). RARs, as well as several related receptors, require heterodimerization with RXRs for effective DNA binding and function. However, in the presence of 9- <jats:italic>cis</jats:italic> -retinoic acid, a ligand for both RARs and RXRs, RXRs can also form homodimers. A series of retinoids is reported that selectively activates RXR homodimers but does not affect RAR-RXR heterodimers and thus demonstrates that both retinoid response pathways can be independently activated. </jats:p> |
| doi_str_mv | 10.1126/science.1335166 |
| facet_avail | Online |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEyNi9zY2llbmNlLjEzMzUxNjY |
| imprint | American Association for the Advancement of Science (AAAS), 1992 |
| imprint_str_mv | American Association for the Advancement of Science (AAAS), 1992 |
| institution | DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275 |
| issn | 0036-8075, 1095-9203 |
| issn_str_mv | 0036-8075, 1095-9203 |
| language | English |
| last_indexed | 2024-03-01T16:43:04.189Z |
| match_str | lehmann1992retinoidsselectiveforretinoidxreceptorresponsepathways |
| mega_collection | American Association for the Advancement of Science (AAAS) (CrossRef) |
| physical | 1944-1946 |
| publishDate | 1992 |
| publishDateSort | 1992 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | ai |
| recordtype | ai |
| series | Science |
| source_id | 49 |
| spelling | Lehmann, Jürgen M. Jong, Ling Fanjul, Andrea Cameron, James F. Lu, Xian Ping Haefner, Pamela Dawson, Marcia I. Pfahl, Magnus 0036-8075 1095-9203 American Association for the Advancement of Science (AAAS) Multidisciplinary http://dx.doi.org/10.1126/science.1335166 <jats:p> Retinoids have a broad spectrum of biological activities and are useful therapeutic agents. Their physiological activities are mediated by two types of receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs). RARs, as well as several related receptors, require heterodimerization with RXRs for effective DNA binding and function. However, in the presence of 9- <jats:italic>cis</jats:italic> -retinoic acid, a ligand for both RARs and RXRs, RXRs can also form homodimers. A series of retinoids is reported that selectively activates RXR homodimers but does not affect RAR-RXR heterodimers and thus demonstrates that both retinoid response pathways can be independently activated. </jats:p> Retinoids Selective for Retinoid X Receptor Response Pathways Science |
| spellingShingle | Lehmann, Jürgen M., Jong, Ling, Fanjul, Andrea, Cameron, James F., Lu, Xian Ping, Haefner, Pamela, Dawson, Marcia I., Pfahl, Magnus, Science, Retinoids Selective for Retinoid X Receptor Response Pathways, Multidisciplinary |
| title | Retinoids Selective for Retinoid X Receptor Response Pathways |
| title_full | Retinoids Selective for Retinoid X Receptor Response Pathways |
| title_fullStr | Retinoids Selective for Retinoid X Receptor Response Pathways |
| title_full_unstemmed | Retinoids Selective for Retinoid X Receptor Response Pathways |
| title_short | Retinoids Selective for Retinoid X Receptor Response Pathways |
| title_sort | retinoids selective for retinoid x receptor response pathways |
| title_unstemmed | Retinoids Selective for Retinoid X Receptor Response Pathways |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1126/science.1335166 |