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Externally Suppressible Proline Quadruplet CCC U ⋅
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| Zeitschriftentitel: | Science |
|---|---|
| Personen und Körperschaften: | , |
| In: | Science, 175, 1972, 4022, S. 650-652 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Association for the Advancement of Science (AAAS)
|
| Schlagwörter: |
| author_facet |
Yourno, Joseph Kohno, Tadahiko Yourno, Joseph Kohno, Tadahiko |
|---|---|
| author |
Yourno, Joseph Kohno, Tadahiko |
| spellingShingle |
Yourno, Joseph Kohno, Tadahiko Science Externally Suppressible Proline Quadruplet CCC U ⋅ Multidisciplinary |
| author_sort |
yourno, joseph |
| spelling |
Yourno, Joseph Kohno, Tadahiko 0036-8075 1095-9203 American Association for the Advancement of Science (AAAS) Multidisciplinary http://dx.doi.org/10.1126/science.175.4022.650 <jats:p> Three (+1) frameshift mutations located at different genetic sites respond with high specificity to the same external suppressor. In each case, the suppressor restores small amounts of protein that is normal in electrophoretic mobility and heat stability. One of these proteins has been shown to have the wildtype amino acid sequence. The messenger RNA quadruplet CCC <jats:sup>U</jats:sup> <jats:sub>⋅</jats:sub> appears to be common to all three frameshift sites and to be translated by the suppressor as proline. A likely suppressor agent is a proline transfer RNA with a quadruplet anticodon or its functional equivalent. </jats:p> Externally Suppressible Proline Quadruplet CCC <sup>U</sup> <sub>⋅</sub> Science |
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10.1126/science.175.4022.650 |
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American Association for the Advancement of Science (AAAS), 1972 |
| imprint_str_mv |
American Association for the Advancement of Science (AAAS), 1972 |
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1095-9203 0036-8075 |
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1095-9203 0036-8075 |
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English |
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American Association for the Advancement of Science (AAAS) (CrossRef) |
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1972 |
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American Association for the Advancement of Science (AAAS) |
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ai |
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ai |
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Science |
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49 |
| title |
Externally Suppressible Proline Quadruplet CCC U ⋅ |
| title_unstemmed |
Externally Suppressible Proline Quadruplet CCC U ⋅ |
| title_full |
Externally Suppressible Proline Quadruplet CCC U ⋅ |
| title_fullStr |
Externally Suppressible Proline Quadruplet CCC U ⋅ |
| title_full_unstemmed |
Externally Suppressible Proline Quadruplet CCC U ⋅ |
| title_short |
Externally Suppressible Proline Quadruplet CCC U ⋅ |
| title_sort |
externally suppressible proline quadruplet ccc
<sup>u</sup>
<sub>⋅</sub> |
| topic |
Multidisciplinary |
| url |
http://dx.doi.org/10.1126/science.175.4022.650 |
| publishDate |
1972 |
| physical |
650-652 |
| description |
<jats:p>
Three (+1) frameshift mutations located at different genetic sites respond with high specificity to the same external suppressor. In each case, the suppressor restores small amounts of protein that is normal in electrophoretic mobility and heat stability. One of these proteins has been shown to have the wildtype amino acid sequence. The messenger RNA quadruplet CCC
<jats:sup>U</jats:sup>
<jats:sub>⋅</jats:sub>
appears to be common to all three frameshift sites and to be translated by the suppressor as proline. A likely suppressor agent is a proline transfer RNA with a quadruplet anticodon or its functional equivalent.
</jats:p> |
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| _version_ | 1792342712110809092 |
| author | Yourno, Joseph, Kohno, Tadahiko |
| author_facet | Yourno, Joseph, Kohno, Tadahiko, Yourno, Joseph, Kohno, Tadahiko |
| author_sort | yourno, joseph |
| container_issue | 4022 |
| container_start_page | 650 |
| container_title | Science |
| container_volume | 175 |
| description | <jats:p> Three (+1) frameshift mutations located at different genetic sites respond with high specificity to the same external suppressor. In each case, the suppressor restores small amounts of protein that is normal in electrophoretic mobility and heat stability. One of these proteins has been shown to have the wildtype amino acid sequence. The messenger RNA quadruplet CCC <jats:sup>U</jats:sup> <jats:sub>⋅</jats:sub> appears to be common to all three frameshift sites and to be translated by the suppressor as proline. A likely suppressor agent is a proline transfer RNA with a quadruplet anticodon or its functional equivalent. </jats:p> |
| doi_str_mv | 10.1126/science.175.4022.650 |
| facet_avail | Online |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
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| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
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| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEyNi9zY2llbmNlLjE3NS40MDIyLjY1MA |
| imprint | American Association for the Advancement of Science (AAAS), 1972 |
| imprint_str_mv | American Association for the Advancement of Science (AAAS), 1972 |
| institution | DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1 |
| issn | 1095-9203, 0036-8075 |
| issn_str_mv | 1095-9203, 0036-8075 |
| language | English |
| last_indexed | 2024-03-01T16:40:09.679Z |
| match_str | yourno1972externallysuppressibleprolinequadrupletcccu |
| mega_collection | American Association for the Advancement of Science (AAAS) (CrossRef) |
| physical | 650-652 |
| publishDate | 1972 |
| publishDateSort | 1972 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | ai |
| recordtype | ai |
| series | Science |
| source_id | 49 |
| spelling | Yourno, Joseph Kohno, Tadahiko 0036-8075 1095-9203 American Association for the Advancement of Science (AAAS) Multidisciplinary http://dx.doi.org/10.1126/science.175.4022.650 <jats:p> Three (+1) frameshift mutations located at different genetic sites respond with high specificity to the same external suppressor. In each case, the suppressor restores small amounts of protein that is normal in electrophoretic mobility and heat stability. One of these proteins has been shown to have the wildtype amino acid sequence. The messenger RNA quadruplet CCC <jats:sup>U</jats:sup> <jats:sub>⋅</jats:sub> appears to be common to all three frameshift sites and to be translated by the suppressor as proline. A likely suppressor agent is a proline transfer RNA with a quadruplet anticodon or its functional equivalent. </jats:p> Externally Suppressible Proline Quadruplet CCC <sup>U</sup> <sub>⋅</sub> Science |
| spellingShingle | Yourno, Joseph, Kohno, Tadahiko, Science, Externally Suppressible Proline Quadruplet CCC U ⋅, Multidisciplinary |
| title | Externally Suppressible Proline Quadruplet CCC U ⋅ |
| title_full | Externally Suppressible Proline Quadruplet CCC U ⋅ |
| title_fullStr | Externally Suppressible Proline Quadruplet CCC U ⋅ |
| title_full_unstemmed | Externally Suppressible Proline Quadruplet CCC U ⋅ |
| title_short | Externally Suppressible Proline Quadruplet CCC U ⋅ |
| title_sort | externally suppressible proline quadruplet ccc <sup>u</sup> <sub>⋅</sub> |
| title_unstemmed | Externally Suppressible Proline Quadruplet CCC U ⋅ |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1126/science.175.4022.650 |