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Renal Fructose-Metabolizing Enzymes: Significance in Hereditary Fructose Intolerance
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| Zeitschriftentitel: | Science |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Science, 165, 1969, 3891, S. 402-403 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Association for the Advancement of Science (AAAS)
|
| Schlagwörter: |
| author_facet |
Kranhold, Joseph F. Loh, Dana Morris, R. Curtis Kranhold, Joseph F. Loh, Dana Morris, R. Curtis |
|---|---|
| author |
Kranhold, Joseph F. Loh, Dana Morris, R. Curtis |
| spellingShingle |
Kranhold, Joseph F. Loh, Dana Morris, R. Curtis Science Renal Fructose-Metabolizing Enzymes: Significance in Hereditary Fructose Intolerance Multidisciplinary |
| author_sort |
kranhold, joseph f. |
| spelling |
Kranhold, Joseph F. Loh, Dana Morris, R. Curtis 0036-8075 1095-9203 American Association for the Advancement of Science (AAAS) Multidisciplinary http://dx.doi.org/10.1126/science.165.3891.402 <jats:p>In patients with hereditary fructose intolerance, which is characterized by deficient aldolase activity toward fructose-1-phosphate, fructose induces a renal tubular dysfunction that implicates only the proximal convoluted tubule. Because normal metabolism of fructose by way of fructose-1-phosphate requires fructokinase, aldolase "B," and triokinase, the exclusively cortical location of these enzymes indicates that the medulla is not involved in the metabolic abnormality presumably causal of the renal dysfunction.</jats:p> Renal Fructose-Metabolizing Enzymes: Significance in Hereditary Fructose Intolerance Science |
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American Association for the Advancement of Science (AAAS), 1969 |
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1969 |
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American Association for the Advancement of Science (AAAS) |
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Science |
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49 |
| title |
Renal Fructose-Metabolizing Enzymes: Significance in Hereditary Fructose Intolerance |
| title_unstemmed |
Renal Fructose-Metabolizing Enzymes: Significance in Hereditary Fructose Intolerance |
| title_full |
Renal Fructose-Metabolizing Enzymes: Significance in Hereditary Fructose Intolerance |
| title_fullStr |
Renal Fructose-Metabolizing Enzymes: Significance in Hereditary Fructose Intolerance |
| title_full_unstemmed |
Renal Fructose-Metabolizing Enzymes: Significance in Hereditary Fructose Intolerance |
| title_short |
Renal Fructose-Metabolizing Enzymes: Significance in Hereditary Fructose Intolerance |
| title_sort |
renal fructose-metabolizing enzymes: significance in hereditary fructose intolerance |
| topic |
Multidisciplinary |
| url |
http://dx.doi.org/10.1126/science.165.3891.402 |
| publishDate |
1969 |
| physical |
402-403 |
| description |
<jats:p>In patients with hereditary fructose intolerance, which is characterized by deficient aldolase activity toward fructose-1-phosphate, fructose induces a renal tubular dysfunction that implicates only the proximal convoluted tubule. Because normal metabolism of fructose by way of fructose-1-phosphate requires fructokinase, aldolase "B," and triokinase, the exclusively cortical location of these enzymes indicates that the medulla is not involved in the metabolic abnormality presumably causal of the renal dysfunction.</jats:p> |
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| author | Kranhold, Joseph F., Loh, Dana, Morris, R. Curtis |
| author_facet | Kranhold, Joseph F., Loh, Dana, Morris, R. Curtis, Kranhold, Joseph F., Loh, Dana, Morris, R. Curtis |
| author_sort | kranhold, joseph f. |
| container_issue | 3891 |
| container_start_page | 402 |
| container_title | Science |
| container_volume | 165 |
| description | <jats:p>In patients with hereditary fructose intolerance, which is characterized by deficient aldolase activity toward fructose-1-phosphate, fructose induces a renal tubular dysfunction that implicates only the proximal convoluted tubule. Because normal metabolism of fructose by way of fructose-1-phosphate requires fructokinase, aldolase "B," and triokinase, the exclusively cortical location of these enzymes indicates that the medulla is not involved in the metabolic abnormality presumably causal of the renal dysfunction.</jats:p> |
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| imprint | American Association for the Advancement of Science (AAAS), 1969 |
| imprint_str_mv | American Association for the Advancement of Science (AAAS), 1969 |
| institution | DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4 |
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| physical | 402-403 |
| publishDate | 1969 |
| publishDateSort | 1969 |
| publisher | American Association for the Advancement of Science (AAAS) |
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| recordtype | ai |
| series | Science |
| source_id | 49 |
| spelling | Kranhold, Joseph F. Loh, Dana Morris, R. Curtis 0036-8075 1095-9203 American Association for the Advancement of Science (AAAS) Multidisciplinary http://dx.doi.org/10.1126/science.165.3891.402 <jats:p>In patients with hereditary fructose intolerance, which is characterized by deficient aldolase activity toward fructose-1-phosphate, fructose induces a renal tubular dysfunction that implicates only the proximal convoluted tubule. Because normal metabolism of fructose by way of fructose-1-phosphate requires fructokinase, aldolase "B," and triokinase, the exclusively cortical location of these enzymes indicates that the medulla is not involved in the metabolic abnormality presumably causal of the renal dysfunction.</jats:p> Renal Fructose-Metabolizing Enzymes: Significance in Hereditary Fructose Intolerance Science |
| spellingShingle | Kranhold, Joseph F., Loh, Dana, Morris, R. Curtis, Science, Renal Fructose-Metabolizing Enzymes: Significance in Hereditary Fructose Intolerance, Multidisciplinary |
| title | Renal Fructose-Metabolizing Enzymes: Significance in Hereditary Fructose Intolerance |
| title_full | Renal Fructose-Metabolizing Enzymes: Significance in Hereditary Fructose Intolerance |
| title_fullStr | Renal Fructose-Metabolizing Enzymes: Significance in Hereditary Fructose Intolerance |
| title_full_unstemmed | Renal Fructose-Metabolizing Enzymes: Significance in Hereditary Fructose Intolerance |
| title_short | Renal Fructose-Metabolizing Enzymes: Significance in Hereditary Fructose Intolerance |
| title_sort | renal fructose-metabolizing enzymes: significance in hereditary fructose intolerance |
| title_unstemmed | Renal Fructose-Metabolizing Enzymes: Significance in Hereditary Fructose Intolerance |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1126/science.165.3891.402 |