author_facet Samei, Ehsan
Samei, Ehsan
author Samei, Ehsan
spellingShingle Samei, Ehsan
Medical Physics
The performance of digital x‐ray imaging systems in detection of subtle lung nodules
General Medicine
author_sort samei, ehsan
spelling Samei, Ehsan 0094-2405 2473-4209 Wiley General Medicine http://dx.doi.org/10.1118/1.598364 <jats:p>Subtle lung nodules (SLNs) are lesions that are commonly missed in radiologic examinations of the chest. This thesis explores three factors that influence the detection of these lesions: contrast‐diameter characteristics of SLNs, physical performance of the imaging system, and structured noise in the chest radiographs. The contrast‐diameter characteristics of SLNs were determined from radiographs containing confirmed lesions. The nodules were found to have similar subject contrast profiles with diverse variability in peak contrast (0.02–0.13) and diameter (3–16 mm). The physical performance of a digital chest radiographic system was assessed by measuring its Modulation Transfer Function (MTF), Noise Power Spectrum (NPS), and Detective Quantum Efficiency (DQE) responses. The results showed that the system only minimally blurs the appearance of SLNs, and that for a typical chest exposure, the quantum mottle is low enough not to obscure the visibility of even the smallest SLNs. The relative influence of the structured and quantum noise was explored in a Receiver Operating Characteristic (ROC) study in which simulated tissue‐equivalent nodules were superimposed on images of either structured or quantum noise backgrounds. The detection threshold <jats:inline-graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="graphic/mp8364-math-0001.png" xlink:title="urn:x-wiley:00942405:media:mp8364:mp8364-math-0001" />=0.8) was achieved for nodules 4.5 mm in diameter against structured backgrounds, and for nodules 1.0 mm in diameter against quantum noise backgrounds. The results indicate that anatomical structured noise is the main factor limiting the detection of SLNs in chest radiographs.</jats:p> The performance of digital x‐ray imaging systems in detection of subtle lung nodules Medical Physics
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title The performance of digital x‐ray imaging systems in detection of subtle lung nodules
title_unstemmed The performance of digital x‐ray imaging systems in detection of subtle lung nodules
title_full The performance of digital x‐ray imaging systems in detection of subtle lung nodules
title_fullStr The performance of digital x‐ray imaging systems in detection of subtle lung nodules
title_full_unstemmed The performance of digital x‐ray imaging systems in detection of subtle lung nodules
title_short The performance of digital x‐ray imaging systems in detection of subtle lung nodules
title_sort the performance of digital x‐ray imaging systems in detection of subtle lung nodules
topic General Medicine
url http://dx.doi.org/10.1118/1.598364
publishDate 1998
physical 2077-2077
description <jats:p>Subtle lung nodules (SLNs) are lesions that are commonly missed in radiologic examinations of the chest. This thesis explores three factors that influence the detection of these lesions: contrast‐diameter characteristics of SLNs, physical performance of the imaging system, and structured noise in the chest radiographs. The contrast‐diameter characteristics of SLNs were determined from radiographs containing confirmed lesions. The nodules were found to have similar subject contrast profiles with diverse variability in peak contrast (0.02–0.13) and diameter (3–16 mm). The physical performance of a digital chest radiographic system was assessed by measuring its Modulation Transfer Function (MTF), Noise Power Spectrum (NPS), and Detective Quantum Efficiency (DQE) responses. The results showed that the system only minimally blurs the appearance of SLNs, and that for a typical chest exposure, the quantum mottle is low enough not to obscure the visibility of even the smallest SLNs. The relative influence of the structured and quantum noise was explored in a Receiver Operating Characteristic (ROC) study in which simulated tissue‐equivalent nodules were superimposed on images of either structured or quantum noise backgrounds. The detection threshold <jats:inline-graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="graphic/mp8364-math-0001.png" xlink:title="urn:x-wiley:00942405:media:mp8364:mp8364-math-0001" />=0.8) was achieved for nodules 4.5 mm in diameter against structured backgrounds, and for nodules 1.0 mm in diameter against quantum noise backgrounds. The results indicate that anatomical structured noise is the main factor limiting the detection of SLNs in chest radiographs.</jats:p>
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author Samei, Ehsan
author_facet Samei, Ehsan, Samei, Ehsan
author_sort samei, ehsan
container_issue 10
container_start_page 2077
container_title Medical Physics
container_volume 25
description <jats:p>Subtle lung nodules (SLNs) are lesions that are commonly missed in radiologic examinations of the chest. This thesis explores three factors that influence the detection of these lesions: contrast‐diameter characteristics of SLNs, physical performance of the imaging system, and structured noise in the chest radiographs. The contrast‐diameter characteristics of SLNs were determined from radiographs containing confirmed lesions. The nodules were found to have similar subject contrast profiles with diverse variability in peak contrast (0.02–0.13) and diameter (3–16 mm). The physical performance of a digital chest radiographic system was assessed by measuring its Modulation Transfer Function (MTF), Noise Power Spectrum (NPS), and Detective Quantum Efficiency (DQE) responses. The results showed that the system only minimally blurs the appearance of SLNs, and that for a typical chest exposure, the quantum mottle is low enough not to obscure the visibility of even the smallest SLNs. The relative influence of the structured and quantum noise was explored in a Receiver Operating Characteristic (ROC) study in which simulated tissue‐equivalent nodules were superimposed on images of either structured or quantum noise backgrounds. The detection threshold <jats:inline-graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="graphic/mp8364-math-0001.png" xlink:title="urn:x-wiley:00942405:media:mp8364:mp8364-math-0001" />=0.8) was achieved for nodules 4.5 mm in diameter against structured backgrounds, and for nodules 1.0 mm in diameter against quantum noise backgrounds. The results indicate that anatomical structured noise is the main factor limiting the detection of SLNs in chest radiographs.</jats:p>
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id ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExOC8xLjU5ODM2NA
imprint Wiley, 1998
imprint_str_mv Wiley, 1998
institution DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14
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spelling Samei, Ehsan 0094-2405 2473-4209 Wiley General Medicine http://dx.doi.org/10.1118/1.598364 <jats:p>Subtle lung nodules (SLNs) are lesions that are commonly missed in radiologic examinations of the chest. This thesis explores three factors that influence the detection of these lesions: contrast‐diameter characteristics of SLNs, physical performance of the imaging system, and structured noise in the chest radiographs. The contrast‐diameter characteristics of SLNs were determined from radiographs containing confirmed lesions. The nodules were found to have similar subject contrast profiles with diverse variability in peak contrast (0.02–0.13) and diameter (3–16 mm). The physical performance of a digital chest radiographic system was assessed by measuring its Modulation Transfer Function (MTF), Noise Power Spectrum (NPS), and Detective Quantum Efficiency (DQE) responses. The results showed that the system only minimally blurs the appearance of SLNs, and that for a typical chest exposure, the quantum mottle is low enough not to obscure the visibility of even the smallest SLNs. The relative influence of the structured and quantum noise was explored in a Receiver Operating Characteristic (ROC) study in which simulated tissue‐equivalent nodules were superimposed on images of either structured or quantum noise backgrounds. The detection threshold <jats:inline-graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="graphic/mp8364-math-0001.png" xlink:title="urn:x-wiley:00942405:media:mp8364:mp8364-math-0001" />=0.8) was achieved for nodules 4.5 mm in diameter against structured backgrounds, and for nodules 1.0 mm in diameter against quantum noise backgrounds. The results indicate that anatomical structured noise is the main factor limiting the detection of SLNs in chest radiographs.</jats:p> The performance of digital x‐ray imaging systems in detection of subtle lung nodules Medical Physics
spellingShingle Samei, Ehsan, Medical Physics, The performance of digital x‐ray imaging systems in detection of subtle lung nodules, General Medicine
title The performance of digital x‐ray imaging systems in detection of subtle lung nodules
title_full The performance of digital x‐ray imaging systems in detection of subtle lung nodules
title_fullStr The performance of digital x‐ray imaging systems in detection of subtle lung nodules
title_full_unstemmed The performance of digital x‐ray imaging systems in detection of subtle lung nodules
title_short The performance of digital x‐ray imaging systems in detection of subtle lung nodules
title_sort the performance of digital x‐ray imaging systems in detection of subtle lung nodules
title_unstemmed The performance of digital x‐ray imaging systems in detection of subtle lung nodules
topic General Medicine
url http://dx.doi.org/10.1118/1.598364