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Nitric oxide synthase inhibition prevents activity‐induced calcineurin–NFATc1 signalling and fast‐to‐slow skeletal muscle fibre type conversions
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| Zeitschriftentitel: | The Journal of Physiology |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | The Journal of Physiology, 590, 2012, 6, S. 1427-1442 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Martins, Karen J. B. St‐Louis, Mathieu Murdoch, Gordon K. MacLean, Ian M. McDonald, Pamela Dixon, Walter T. Putman, Charles T. Michel, Robin N. Martins, Karen J. B. St‐Louis, Mathieu Murdoch, Gordon K. MacLean, Ian M. McDonald, Pamela Dixon, Walter T. Putman, Charles T. Michel, Robin N. |
|---|---|
| author |
Martins, Karen J. B. St‐Louis, Mathieu Murdoch, Gordon K. MacLean, Ian M. McDonald, Pamela Dixon, Walter T. Putman, Charles T. Michel, Robin N. |
| spellingShingle |
Martins, Karen J. B. St‐Louis, Mathieu Murdoch, Gordon K. MacLean, Ian M. McDonald, Pamela Dixon, Walter T. Putman, Charles T. Michel, Robin N. The Journal of Physiology Nitric oxide synthase inhibition prevents activity‐induced calcineurin–NFATc1 signalling and fast‐to‐slow skeletal muscle fibre type conversions Physiology |
| author_sort |
martins, karen j. b. |
| spelling |
Martins, Karen J. B. St‐Louis, Mathieu Murdoch, Gordon K. MacLean, Ian M. McDonald, Pamela Dixon, Walter T. Putman, Charles T. Michel, Robin N. 0022-3751 1469-7793 Wiley Physiology http://dx.doi.org/10.1113/jphysiol.2011.223370 <jats:title>Key points </jats:title><jats:p><jats:list list-type="explicit-label"> <jats:list-item><jats:p>Exercise is known to trigger skeletal muscle structural and functional adaptations.</jats:p></jats:list-item> <jats:list-item><jats:p>Control of these adaptive alterations is a complex process involving multiple signalling pathways and levels of regulation.</jats:p></jats:list-item> <jats:list-item><jats:p>The well‐characterized calcineurin–nuclear factor of activated T‐cells (NFATc1) signalling pathway is involved in the regulation of activity‐dependent alterations in skeletal muscle myosin heavy chain expression. Myosin heavy chain is a contractile protein that largely dictates a muscle's speed of contraction.</jats:p></jats:list-item> <jats:list-item><jats:p>We show that a signalling molecule called nitric oxide may be regulating alterations in myosin heavy chain expression via activity‐modulated calcineurin–NFATc1 signalling.</jats:p></jats:list-item> <jats:list-item><jats:p>These findings increase our understanding of how skeletal muscle adaptive alterations are regulated.</jats:p></jats:list-item> </jats:list></jats:p> Nitric oxide synthase inhibition prevents activity‐induced calcineurin–NFATc1 signalling and fast‐to‐slow skeletal muscle fibre type conversions The Journal of Physiology |
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Wiley, 2012 |
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| title |
Nitric oxide synthase inhibition prevents activity‐induced calcineurin–NFATc1 signalling and fast‐to‐slow skeletal muscle fibre type conversions |
| title_unstemmed |
Nitric oxide synthase inhibition prevents activity‐induced calcineurin–NFATc1 signalling and fast‐to‐slow skeletal muscle fibre type conversions |
| title_full |
Nitric oxide synthase inhibition prevents activity‐induced calcineurin–NFATc1 signalling and fast‐to‐slow skeletal muscle fibre type conversions |
| title_fullStr |
Nitric oxide synthase inhibition prevents activity‐induced calcineurin–NFATc1 signalling and fast‐to‐slow skeletal muscle fibre type conversions |
| title_full_unstemmed |
Nitric oxide synthase inhibition prevents activity‐induced calcineurin–NFATc1 signalling and fast‐to‐slow skeletal muscle fibre type conversions |
| title_short |
Nitric oxide synthase inhibition prevents activity‐induced calcineurin–NFATc1 signalling and fast‐to‐slow skeletal muscle fibre type conversions |
| title_sort |
nitric oxide synthase inhibition prevents activity‐induced calcineurin–nfatc1 signalling and fast‐to‐slow skeletal muscle fibre type conversions |
| topic |
Physiology |
| url |
http://dx.doi.org/10.1113/jphysiol.2011.223370 |
| publishDate |
2012 |
| physical |
1427-1442 |
| description |
<jats:title>Key points </jats:title><jats:p><jats:list list-type="explicit-label">
<jats:list-item><jats:p>Exercise is known to trigger skeletal muscle structural and functional adaptations.</jats:p></jats:list-item>
<jats:list-item><jats:p>Control of these adaptive alterations is a complex process involving multiple signalling pathways and levels of regulation.</jats:p></jats:list-item>
<jats:list-item><jats:p>The well‐characterized calcineurin–nuclear factor of activated T‐cells (NFATc1) signalling pathway is involved in the regulation of activity‐dependent alterations in skeletal muscle myosin heavy chain expression. Myosin heavy chain is a contractile protein that largely dictates a muscle's speed of contraction.</jats:p></jats:list-item>
<jats:list-item><jats:p>We show that a signalling molecule called nitric oxide may be regulating alterations in myosin heavy chain expression via activity‐modulated calcineurin–NFATc1 signalling.</jats:p></jats:list-item>
<jats:list-item><jats:p>These findings increase our understanding of how skeletal muscle adaptive alterations are regulated.</jats:p></jats:list-item>
</jats:list></jats:p> |
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| author | Martins, Karen J. B., St‐Louis, Mathieu, Murdoch, Gordon K., MacLean, Ian M., McDonald, Pamela, Dixon, Walter T., Putman, Charles T., Michel, Robin N. |
| author_facet | Martins, Karen J. B., St‐Louis, Mathieu, Murdoch, Gordon K., MacLean, Ian M., McDonald, Pamela, Dixon, Walter T., Putman, Charles T., Michel, Robin N., Martins, Karen J. B., St‐Louis, Mathieu, Murdoch, Gordon K., MacLean, Ian M., McDonald, Pamela, Dixon, Walter T., Putman, Charles T., Michel, Robin N. |
| author_sort | martins, karen j. b. |
| container_issue | 6 |
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| container_title | The Journal of Physiology |
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| description | <jats:title>Key points </jats:title><jats:p><jats:list list-type="explicit-label"> <jats:list-item><jats:p>Exercise is known to trigger skeletal muscle structural and functional adaptations.</jats:p></jats:list-item> <jats:list-item><jats:p>Control of these adaptive alterations is a complex process involving multiple signalling pathways and levels of regulation.</jats:p></jats:list-item> <jats:list-item><jats:p>The well‐characterized calcineurin–nuclear factor of activated T‐cells (NFATc1) signalling pathway is involved in the regulation of activity‐dependent alterations in skeletal muscle myosin heavy chain expression. Myosin heavy chain is a contractile protein that largely dictates a muscle's speed of contraction.</jats:p></jats:list-item> <jats:list-item><jats:p>We show that a signalling molecule called nitric oxide may be regulating alterations in myosin heavy chain expression via activity‐modulated calcineurin–NFATc1 signalling.</jats:p></jats:list-item> <jats:list-item><jats:p>These findings increase our understanding of how skeletal muscle adaptive alterations are regulated.</jats:p></jats:list-item> </jats:list></jats:p> |
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| institution | DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1 |
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| spelling | Martins, Karen J. B. St‐Louis, Mathieu Murdoch, Gordon K. MacLean, Ian M. McDonald, Pamela Dixon, Walter T. Putman, Charles T. Michel, Robin N. 0022-3751 1469-7793 Wiley Physiology http://dx.doi.org/10.1113/jphysiol.2011.223370 <jats:title>Key points </jats:title><jats:p><jats:list list-type="explicit-label"> <jats:list-item><jats:p>Exercise is known to trigger skeletal muscle structural and functional adaptations.</jats:p></jats:list-item> <jats:list-item><jats:p>Control of these adaptive alterations is a complex process involving multiple signalling pathways and levels of regulation.</jats:p></jats:list-item> <jats:list-item><jats:p>The well‐characterized calcineurin–nuclear factor of activated T‐cells (NFATc1) signalling pathway is involved in the regulation of activity‐dependent alterations in skeletal muscle myosin heavy chain expression. Myosin heavy chain is a contractile protein that largely dictates a muscle's speed of contraction.</jats:p></jats:list-item> <jats:list-item><jats:p>We show that a signalling molecule called nitric oxide may be regulating alterations in myosin heavy chain expression via activity‐modulated calcineurin–NFATc1 signalling.</jats:p></jats:list-item> <jats:list-item><jats:p>These findings increase our understanding of how skeletal muscle adaptive alterations are regulated.</jats:p></jats:list-item> </jats:list></jats:p> Nitric oxide synthase inhibition prevents activity‐induced calcineurin–NFATc1 signalling and fast‐to‐slow skeletal muscle fibre type conversions The Journal of Physiology |
| spellingShingle | Martins, Karen J. B., St‐Louis, Mathieu, Murdoch, Gordon K., MacLean, Ian M., McDonald, Pamela, Dixon, Walter T., Putman, Charles T., Michel, Robin N., The Journal of Physiology, Nitric oxide synthase inhibition prevents activity‐induced calcineurin–NFATc1 signalling and fast‐to‐slow skeletal muscle fibre type conversions, Physiology |
| title | Nitric oxide synthase inhibition prevents activity‐induced calcineurin–NFATc1 signalling and fast‐to‐slow skeletal muscle fibre type conversions |
| title_full | Nitric oxide synthase inhibition prevents activity‐induced calcineurin–NFATc1 signalling and fast‐to‐slow skeletal muscle fibre type conversions |
| title_fullStr | Nitric oxide synthase inhibition prevents activity‐induced calcineurin–NFATc1 signalling and fast‐to‐slow skeletal muscle fibre type conversions |
| title_full_unstemmed | Nitric oxide synthase inhibition prevents activity‐induced calcineurin–NFATc1 signalling and fast‐to‐slow skeletal muscle fibre type conversions |
| title_short | Nitric oxide synthase inhibition prevents activity‐induced calcineurin–NFATc1 signalling and fast‐to‐slow skeletal muscle fibre type conversions |
| title_sort | nitric oxide synthase inhibition prevents activity‐induced calcineurin–nfatc1 signalling and fast‐to‐slow skeletal muscle fibre type conversions |
| title_unstemmed | Nitric oxide synthase inhibition prevents activity‐induced calcineurin–NFATc1 signalling and fast‐to‐slow skeletal muscle fibre type conversions |
| topic | Physiology |
| url | http://dx.doi.org/10.1113/jphysiol.2011.223370 |