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Synthesis and structure−activity relationships of teixobactin
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| Zeitschriftentitel: | Annals of the New York Academy of Sciences |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , |
| In: | Annals of the New York Academy of Sciences, 1459, 2020, 1, S. 86-105 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Karas, John A. Chen, Fan Schneider‐Futschik, Elena K. Kang, Zhisen Hussein, Maytham Swarbrick, James Hoyer, Daniel Giltrap, Andrew M. Payne, Richard J. Li, Jian Velkov, Tony Karas, John A. Chen, Fan Schneider‐Futschik, Elena K. Kang, Zhisen Hussein, Maytham Swarbrick, James Hoyer, Daniel Giltrap, Andrew M. Payne, Richard J. Li, Jian Velkov, Tony |
|---|---|
| author |
Karas, John A. Chen, Fan Schneider‐Futschik, Elena K. Kang, Zhisen Hussein, Maytham Swarbrick, James Hoyer, Daniel Giltrap, Andrew M. Payne, Richard J. Li, Jian Velkov, Tony |
| spellingShingle |
Karas, John A. Chen, Fan Schneider‐Futschik, Elena K. Kang, Zhisen Hussein, Maytham Swarbrick, James Hoyer, Daniel Giltrap, Andrew M. Payne, Richard J. Li, Jian Velkov, Tony Annals of the New York Academy of Sciences Synthesis and structure−activity relationships of teixobactin History and Philosophy of Science General Biochemistry, Genetics and Molecular Biology General Neuroscience |
| author_sort |
karas, john a. |
| spelling |
Karas, John A. Chen, Fan Schneider‐Futschik, Elena K. Kang, Zhisen Hussein, Maytham Swarbrick, James Hoyer, Daniel Giltrap, Andrew M. Payne, Richard J. Li, Jian Velkov, Tony 0077-8923 1749-6632 Wiley History and Philosophy of Science General Biochemistry, Genetics and Molecular Biology General Neuroscience http://dx.doi.org/10.1111/nyas.14282 <jats:title>Abstract</jats:title><jats:p>The discovery of antibiotics has led to the effective treatment of bacterial infections that were otherwise fatal and has had a transformative effect on modern medicine. Teixobactin is an unusual depsipeptide natural product that was recently discovered from a previously unculturable soil bacterium and found to possess potent antibacterial activity against several Gram positive pathogens, including methicillin‐resistant <jats:italic>Staphylococcus aureus</jats:italic> and vancomycin‐resistant <jats:italic>Enterococci</jats:italic>. One of the key features of teixobactin as an antibiotic lead is that resistance could not be generated in a laboratory setting. This is proposed to be a result of a mechanism of action that involves binding to essential cell wall synthesis building blocks, lipid II and lipid III. Since the initial isolation report in 2015, significant efforts have been made to understand its unique mechanism of action, develop efficient synthetic routes for its production, and thus enable the generation of analogues for structure−activity relationship studies and optimization of its pharmacological properties. Our review provides a comprehensive treatise on the progress in understanding teixobactin chemistry, structure−activity relationships, and mechanisms of antibacterial activity. Teixobactin represents an exciting starting point for the development of new antibiotics that can be used to combat multidrug‐resistant bacterial (“superbug”) infections.</jats:p> Synthesis and structure−activity relationships of teixobactin Annals of the New York Academy of Sciences |
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| title |
Synthesis and structure−activity relationships of teixobactin |
| title_unstemmed |
Synthesis and structure−activity relationships of teixobactin |
| title_full |
Synthesis and structure−activity relationships of teixobactin |
| title_fullStr |
Synthesis and structure−activity relationships of teixobactin |
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Synthesis and structure−activity relationships of teixobactin |
| title_short |
Synthesis and structure−activity relationships of teixobactin |
| title_sort |
synthesis and structure−activity relationships of teixobactin |
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History and Philosophy of Science General Biochemistry, Genetics and Molecular Biology General Neuroscience |
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http://dx.doi.org/10.1111/nyas.14282 |
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2020 |
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86-105 |
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<jats:title>Abstract</jats:title><jats:p>The discovery of antibiotics has led to the effective treatment of bacterial infections that were otherwise fatal and has had a transformative effect on modern medicine. Teixobactin is an unusual depsipeptide natural product that was recently discovered from a previously unculturable soil bacterium and found to possess potent antibacterial activity against several Gram positive pathogens, including methicillin‐resistant <jats:italic>Staphylococcus aureus</jats:italic> and vancomycin‐resistant <jats:italic>Enterococci</jats:italic>. One of the key features of teixobactin as an antibiotic lead is that resistance could not be generated in a laboratory setting. This is proposed to be a result of a mechanism of action that involves binding to essential cell wall synthesis building blocks, lipid II and lipid III. Since the initial isolation report in 2015, significant efforts have been made to understand its unique mechanism of action, develop efficient synthetic routes for its production, and thus enable the generation of analogues for structure−activity relationship studies and optimization of its pharmacological properties. Our review provides a comprehensive treatise on the progress in understanding teixobactin chemistry, structure−activity relationships, and mechanisms of antibacterial activity. Teixobactin represents an exciting starting point for the development of new antibiotics that can be used to combat multidrug‐resistant bacterial (“superbug”) infections.</jats:p> |
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| author | Karas, John A., Chen, Fan, Schneider‐Futschik, Elena K., Kang, Zhisen, Hussein, Maytham, Swarbrick, James, Hoyer, Daniel, Giltrap, Andrew M., Payne, Richard J., Li, Jian, Velkov, Tony |
| author_facet | Karas, John A., Chen, Fan, Schneider‐Futschik, Elena K., Kang, Zhisen, Hussein, Maytham, Swarbrick, James, Hoyer, Daniel, Giltrap, Andrew M., Payne, Richard J., Li, Jian, Velkov, Tony, Karas, John A., Chen, Fan, Schneider‐Futschik, Elena K., Kang, Zhisen, Hussein, Maytham, Swarbrick, James, Hoyer, Daniel, Giltrap, Andrew M., Payne, Richard J., Li, Jian, Velkov, Tony |
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| description | <jats:title>Abstract</jats:title><jats:p>The discovery of antibiotics has led to the effective treatment of bacterial infections that were otherwise fatal and has had a transformative effect on modern medicine. Teixobactin is an unusual depsipeptide natural product that was recently discovered from a previously unculturable soil bacterium and found to possess potent antibacterial activity against several Gram positive pathogens, including methicillin‐resistant <jats:italic>Staphylococcus aureus</jats:italic> and vancomycin‐resistant <jats:italic>Enterococci</jats:italic>. One of the key features of teixobactin as an antibiotic lead is that resistance could not be generated in a laboratory setting. This is proposed to be a result of a mechanism of action that involves binding to essential cell wall synthesis building blocks, lipid II and lipid III. Since the initial isolation report in 2015, significant efforts have been made to understand its unique mechanism of action, develop efficient synthetic routes for its production, and thus enable the generation of analogues for structure−activity relationship studies and optimization of its pharmacological properties. Our review provides a comprehensive treatise on the progress in understanding teixobactin chemistry, structure−activity relationships, and mechanisms of antibacterial activity. Teixobactin represents an exciting starting point for the development of new antibiotics that can be used to combat multidrug‐resistant bacterial (“superbug”) infections.</jats:p> |
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| spelling | Karas, John A. Chen, Fan Schneider‐Futschik, Elena K. Kang, Zhisen Hussein, Maytham Swarbrick, James Hoyer, Daniel Giltrap, Andrew M. Payne, Richard J. Li, Jian Velkov, Tony 0077-8923 1749-6632 Wiley History and Philosophy of Science General Biochemistry, Genetics and Molecular Biology General Neuroscience http://dx.doi.org/10.1111/nyas.14282 <jats:title>Abstract</jats:title><jats:p>The discovery of antibiotics has led to the effective treatment of bacterial infections that were otherwise fatal and has had a transformative effect on modern medicine. Teixobactin is an unusual depsipeptide natural product that was recently discovered from a previously unculturable soil bacterium and found to possess potent antibacterial activity against several Gram positive pathogens, including methicillin‐resistant <jats:italic>Staphylococcus aureus</jats:italic> and vancomycin‐resistant <jats:italic>Enterococci</jats:italic>. One of the key features of teixobactin as an antibiotic lead is that resistance could not be generated in a laboratory setting. This is proposed to be a result of a mechanism of action that involves binding to essential cell wall synthesis building blocks, lipid II and lipid III. Since the initial isolation report in 2015, significant efforts have been made to understand its unique mechanism of action, develop efficient synthetic routes for its production, and thus enable the generation of analogues for structure−activity relationship studies and optimization of its pharmacological properties. Our review provides a comprehensive treatise on the progress in understanding teixobactin chemistry, structure−activity relationships, and mechanisms of antibacterial activity. Teixobactin represents an exciting starting point for the development of new antibiotics that can be used to combat multidrug‐resistant bacterial (“superbug”) infections.</jats:p> Synthesis and structure−activity relationships of teixobactin Annals of the New York Academy of Sciences |
| spellingShingle | Karas, John A., Chen, Fan, Schneider‐Futschik, Elena K., Kang, Zhisen, Hussein, Maytham, Swarbrick, James, Hoyer, Daniel, Giltrap, Andrew M., Payne, Richard J., Li, Jian, Velkov, Tony, Annals of the New York Academy of Sciences, Synthesis and structure−activity relationships of teixobactin, History and Philosophy of Science, General Biochemistry, Genetics and Molecular Biology, General Neuroscience |
| title | Synthesis and structure−activity relationships of teixobactin |
| title_full | Synthesis and structure−activity relationships of teixobactin |
| title_fullStr | Synthesis and structure−activity relationships of teixobactin |
| title_full_unstemmed | Synthesis and structure−activity relationships of teixobactin |
| title_short | Synthesis and structure−activity relationships of teixobactin |
| title_sort | synthesis and structure−activity relationships of teixobactin |
| title_unstemmed | Synthesis and structure−activity relationships of teixobactin |
| topic | History and Philosophy of Science, General Biochemistry, Genetics and Molecular Biology, General Neuroscience |
| url | http://dx.doi.org/10.1111/nyas.14282 |