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Clinical findings and survival time in dogs with advanced heart failure
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| Zeitschriftentitel: | Journal of Veterinary Internal Medicine |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | Journal of Veterinary Internal Medicine, 32, 2018, 3, S. 944-950 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Beaumier, Amelie Rush, John E. Yang, Vicky K. Freeman, Lisa M. Beaumier, Amelie Rush, John E. Yang, Vicky K. Freeman, Lisa M. |
|---|---|
| author |
Beaumier, Amelie Rush, John E. Yang, Vicky K. Freeman, Lisa M. |
| spellingShingle |
Beaumier, Amelie Rush, John E. Yang, Vicky K. Freeman, Lisa M. Journal of Veterinary Internal Medicine Clinical findings and survival time in dogs with advanced heart failure General Veterinary |
| author_sort |
beaumier, amelie |
| spelling |
Beaumier, Amelie Rush, John E. Yang, Vicky K. Freeman, Lisa M. 0891-6640 1939-1676 Wiley General Veterinary http://dx.doi.org/10.1111/jvim.15126 <jats:sec><jats:title>Background</jats:title><jats:p>Dogs with advanced heart failure are a clinical challenge for veterinarians but there are no studies reporting clinical features and outcome of this population.</jats:p></jats:sec><jats:sec><jats:title>Hypothesis/Objectives</jats:title><jats:p>To describe clinical findings and outcome of dogs with advanced heart failure caused by degenerative mitral valve disease (DMVD).</jats:p></jats:sec><jats:sec><jats:title>Animals</jats:title><jats:p>Fifty‐four dogs with advanced heart failure because of DMVD.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>For study purposes, advanced heart failure was defined as recurrence of congestive heart failure signs despite receiving the initially prescribed dose of pimobendan, angiotensin‐converting‐enzyme inhibitor (ACEI), and furosemide >4 mg/kg/day. Data were collected for the time of diagnosis of Stage C heart failure and time of diagnosis of advanced heart failure. Date of death was recorded.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>At the diagnosis of advanced heart failure, doses of pimobendan (n = 30), furosemide (n = 28), ACEI (n = 13), and spironolactone (n = 4) were increased, with ≥1 new medications added in most dogs. After initial diagnosis of advanced heart failure, 38 (70%) dogs had additional medications adjustments (median = 2 [range, 0‐27]), with the final total medication number ranging from 2‐10 (median = 5). Median survival time after diagnosis of advanced heart failure was 281 days (range, 3‐885 days). Dogs receiving a furosemide dose >6.70 mg/kg/day had significantly longer median survival times (402 days [range, 3‐885 days] versus 129 days [range 9‐853 days]; <jats:italic>P</jats:italic> = .017).</jats:p></jats:sec><jats:sec><jats:title>Conclusions and Clinical Importance</jats:title><jats:p>Dogs with advanced heart failure can have relatively long survival times. Higher furosemide dose and non‐hospitalization were associated with longer survival.</jats:p></jats:sec> Clinical findings and survival time in dogs with advanced heart failure Journal of Veterinary Internal Medicine |
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10.1111/jvim.15126 |
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Online Free |
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Wiley, 2018 |
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Wiley, 2018 |
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0891-6640 1939-1676 |
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0891-6640 1939-1676 |
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2018 |
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Wiley |
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Journal of Veterinary Internal Medicine |
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| title |
Clinical findings and survival time in dogs with advanced heart failure |
| title_unstemmed |
Clinical findings and survival time in dogs with advanced heart failure |
| title_full |
Clinical findings and survival time in dogs with advanced heart failure |
| title_fullStr |
Clinical findings and survival time in dogs with advanced heart failure |
| title_full_unstemmed |
Clinical findings and survival time in dogs with advanced heart failure |
| title_short |
Clinical findings and survival time in dogs with advanced heart failure |
| title_sort |
clinical findings and survival time in dogs with advanced heart failure |
| topic |
General Veterinary |
| url |
http://dx.doi.org/10.1111/jvim.15126 |
| publishDate |
2018 |
| physical |
944-950 |
| description |
<jats:sec><jats:title>Background</jats:title><jats:p>Dogs with advanced heart failure are a clinical challenge for veterinarians but there are no studies reporting clinical features and outcome of this population.</jats:p></jats:sec><jats:sec><jats:title>Hypothesis/Objectives</jats:title><jats:p>To describe clinical findings and outcome of dogs with advanced heart failure caused by degenerative mitral valve disease (DMVD).</jats:p></jats:sec><jats:sec><jats:title>Animals</jats:title><jats:p>Fifty‐four dogs with advanced heart failure because of DMVD.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>For study purposes, advanced heart failure was defined as recurrence of congestive heart failure signs despite receiving the initially prescribed dose of pimobendan, angiotensin‐converting‐enzyme inhibitor (ACEI), and furosemide >4 mg/kg/day. Data were collected for the time of diagnosis of Stage C heart failure and time of diagnosis of advanced heart failure. Date of death was recorded.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>At the diagnosis of advanced heart failure, doses of pimobendan (n = 30), furosemide (n = 28), ACEI (n = 13), and spironolactone (n = 4) were increased, with ≥1 new medications added in most dogs. After initial diagnosis of advanced heart failure, 38 (70%) dogs had additional medications adjustments (median = 2 [range, 0‐27]), with the final total medication number ranging from 2‐10 (median = 5). Median survival time after diagnosis of advanced heart failure was 281 days (range, 3‐885 days). Dogs receiving a furosemide dose >6.70 mg/kg/day had significantly longer median survival times (402 days [range, 3‐885 days] versus 129 days [range 9‐853 days]; <jats:italic>P</jats:italic> = .017).</jats:p></jats:sec><jats:sec><jats:title>Conclusions and Clinical Importance</jats:title><jats:p>Dogs with advanced heart failure can have relatively long survival times. Higher furosemide dose and non‐hospitalization were associated with longer survival.</jats:p></jats:sec> |
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| author | Beaumier, Amelie, Rush, John E., Yang, Vicky K., Freeman, Lisa M. |
| author_facet | Beaumier, Amelie, Rush, John E., Yang, Vicky K., Freeman, Lisa M., Beaumier, Amelie, Rush, John E., Yang, Vicky K., Freeman, Lisa M. |
| author_sort | beaumier, amelie |
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| container_title | Journal of Veterinary Internal Medicine |
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| description | <jats:sec><jats:title>Background</jats:title><jats:p>Dogs with advanced heart failure are a clinical challenge for veterinarians but there are no studies reporting clinical features and outcome of this population.</jats:p></jats:sec><jats:sec><jats:title>Hypothesis/Objectives</jats:title><jats:p>To describe clinical findings and outcome of dogs with advanced heart failure caused by degenerative mitral valve disease (DMVD).</jats:p></jats:sec><jats:sec><jats:title>Animals</jats:title><jats:p>Fifty‐four dogs with advanced heart failure because of DMVD.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>For study purposes, advanced heart failure was defined as recurrence of congestive heart failure signs despite receiving the initially prescribed dose of pimobendan, angiotensin‐converting‐enzyme inhibitor (ACEI), and furosemide >4 mg/kg/day. Data were collected for the time of diagnosis of Stage C heart failure and time of diagnosis of advanced heart failure. Date of death was recorded.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>At the diagnosis of advanced heart failure, doses of pimobendan (n = 30), furosemide (n = 28), ACEI (n = 13), and spironolactone (n = 4) were increased, with ≥1 new medications added in most dogs. After initial diagnosis of advanced heart failure, 38 (70%) dogs had additional medications adjustments (median = 2 [range, 0‐27]), with the final total medication number ranging from 2‐10 (median = 5). Median survival time after diagnosis of advanced heart failure was 281 days (range, 3‐885 days). Dogs receiving a furosemide dose >6.70 mg/kg/day had significantly longer median survival times (402 days [range, 3‐885 days] versus 129 days [range 9‐853 days]; <jats:italic>P</jats:italic> = .017).</jats:p></jats:sec><jats:sec><jats:title>Conclusions and Clinical Importance</jats:title><jats:p>Dogs with advanced heart failure can have relatively long survival times. Higher furosemide dose and non‐hospitalization were associated with longer survival.</jats:p></jats:sec> |
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| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1, DE-L229 |
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| spelling | Beaumier, Amelie Rush, John E. Yang, Vicky K. Freeman, Lisa M. 0891-6640 1939-1676 Wiley General Veterinary http://dx.doi.org/10.1111/jvim.15126 <jats:sec><jats:title>Background</jats:title><jats:p>Dogs with advanced heart failure are a clinical challenge for veterinarians but there are no studies reporting clinical features and outcome of this population.</jats:p></jats:sec><jats:sec><jats:title>Hypothesis/Objectives</jats:title><jats:p>To describe clinical findings and outcome of dogs with advanced heart failure caused by degenerative mitral valve disease (DMVD).</jats:p></jats:sec><jats:sec><jats:title>Animals</jats:title><jats:p>Fifty‐four dogs with advanced heart failure because of DMVD.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>For study purposes, advanced heart failure was defined as recurrence of congestive heart failure signs despite receiving the initially prescribed dose of pimobendan, angiotensin‐converting‐enzyme inhibitor (ACEI), and furosemide >4 mg/kg/day. Data were collected for the time of diagnosis of Stage C heart failure and time of diagnosis of advanced heart failure. Date of death was recorded.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>At the diagnosis of advanced heart failure, doses of pimobendan (n = 30), furosemide (n = 28), ACEI (n = 13), and spironolactone (n = 4) were increased, with ≥1 new medications added in most dogs. After initial diagnosis of advanced heart failure, 38 (70%) dogs had additional medications adjustments (median = 2 [range, 0‐27]), with the final total medication number ranging from 2‐10 (median = 5). Median survival time after diagnosis of advanced heart failure was 281 days (range, 3‐885 days). Dogs receiving a furosemide dose >6.70 mg/kg/day had significantly longer median survival times (402 days [range, 3‐885 days] versus 129 days [range 9‐853 days]; <jats:italic>P</jats:italic> = .017).</jats:p></jats:sec><jats:sec><jats:title>Conclusions and Clinical Importance</jats:title><jats:p>Dogs with advanced heart failure can have relatively long survival times. Higher furosemide dose and non‐hospitalization were associated with longer survival.</jats:p></jats:sec> Clinical findings and survival time in dogs with advanced heart failure Journal of Veterinary Internal Medicine |
| spellingShingle | Beaumier, Amelie, Rush, John E., Yang, Vicky K., Freeman, Lisa M., Journal of Veterinary Internal Medicine, Clinical findings and survival time in dogs with advanced heart failure, General Veterinary |
| title | Clinical findings and survival time in dogs with advanced heart failure |
| title_full | Clinical findings and survival time in dogs with advanced heart failure |
| title_fullStr | Clinical findings and survival time in dogs with advanced heart failure |
| title_full_unstemmed | Clinical findings and survival time in dogs with advanced heart failure |
| title_short | Clinical findings and survival time in dogs with advanced heart failure |
| title_sort | clinical findings and survival time in dogs with advanced heart failure |
| title_unstemmed | Clinical findings and survival time in dogs with advanced heart failure |
| topic | General Veterinary |
| url | http://dx.doi.org/10.1111/jvim.15126 |