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Relationship between Total Homocysteine, Folic Acid, and Thyroid Hormones in Hypothyroid Dogs
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| Zeitschriftentitel: | Journal of Veterinary Internal Medicine |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | Journal of Veterinary Internal Medicine, 31, 2017, 5, S. 1403-1405 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Gołyński, M. Lutnicki, K. Krumrych, W. Szczepanik, M. Gołyńska, M. Wilkołek, P. Adamek, Ł. Sitkowski, Ł. Kurek, Ł. Gołyński, M. Lutnicki, K. Krumrych, W. Szczepanik, M. Gołyńska, M. Wilkołek, P. Adamek, Ł. Sitkowski, Ł. Kurek, Ł. |
|---|---|
| author |
Gołyński, M. Lutnicki, K. Krumrych, W. Szczepanik, M. Gołyńska, M. Wilkołek, P. Adamek, Ł. Sitkowski, Ł. Kurek, Ł. |
| spellingShingle |
Gołyński, M. Lutnicki, K. Krumrych, W. Szczepanik, M. Gołyńska, M. Wilkołek, P. Adamek, Ł. Sitkowski, Ł. Kurek, Ł. Journal of Veterinary Internal Medicine Relationship between Total Homocysteine, Folic Acid, and Thyroid Hormones in Hypothyroid Dogs General Veterinary |
| author_sort |
gołyński, m. |
| spelling |
Gołyński, M. Lutnicki, K. Krumrych, W. Szczepanik, M. Gołyńska, M. Wilkołek, P. Adamek, Ł. Sitkowski, Ł. Kurek, Ł. 0891-6640 1939-1676 Wiley General Veterinary http://dx.doi.org/10.1111/jvim.14804 <jats:sec><jats:title>Background</jats:title><jats:p>Both elevated homocysteine and decreased folic acid concentrations are observed in human patients with hypothyroidism and can influence the development of numerous secondary disorders.</jats:p></jats:sec><jats:sec><jats:title>Objectives</jats:title><jats:p>The aim of the study was to assess total homocysteine concentration in serum and to examine its relationship with the concentration of folic acid and thyroid hormones (<jats:styled-content style="fixed-case">tT</jats:styled-content>4 and <jats:styled-content style="fixed-case">fT</jats:styled-content>4).</jats:p></jats:sec><jats:sec><jats:title>Animals</jats:title><jats:p>Ten healthy and 19 hypothyroid client‐owned dogs.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Dogs with clinical signs of hypothyroidism had the diagnosis confirmed by additional tests. Total homocysteine, folic acid, total thyroxine, and free thyroxine concentrations in serum were evaluated.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Hypothyroid dogs were diagnosed with increased homocysteine (median 22.20 μmol/L; range, 16.50–37.75) and decreased folic acid (median 20.62 nmol/L; range, 10.54–26.35) concentrations, as compared to healthy dogs (11.52 μmol/L; range, 10.00–16.65 and 30.68 nmol/L; range, 22.84–38.52, respectively). In sick dogs, total homocysteine was inversely correlated with folic acid (ρ = −0.47, <jats:italic>P</jats:italic> < 0.001), total thyroxine (ρ = −0.69, <jats:italic>P</jats:italic> = 0.0092), and free thyroxine (ρ = −0.56, <jats:italic>P</jats:italic> = 0.0302).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Hypothyroidism in dogs causes hyperhomocysteinemia. Concomitant mild folic acid decrease in hypothyroid dogs might be as a result of hyperhomocysteinemia.</jats:p></jats:sec> Relationship between Total Homocysteine, Folic Acid, and Thyroid Hormones in Hypothyroid Dogs Journal of Veterinary Internal Medicine |
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10.1111/jvim.14804 |
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Online Free |
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Wiley, 2017 |
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Wiley, 2017 |
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0891-6640 1939-1676 |
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2017 |
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Wiley |
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Journal of Veterinary Internal Medicine |
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49 |
| title |
Relationship between Total Homocysteine, Folic Acid, and Thyroid Hormones in Hypothyroid Dogs |
| title_unstemmed |
Relationship between Total Homocysteine, Folic Acid, and Thyroid Hormones in Hypothyroid Dogs |
| title_full |
Relationship between Total Homocysteine, Folic Acid, and Thyroid Hormones in Hypothyroid Dogs |
| title_fullStr |
Relationship between Total Homocysteine, Folic Acid, and Thyroid Hormones in Hypothyroid Dogs |
| title_full_unstemmed |
Relationship between Total Homocysteine, Folic Acid, and Thyroid Hormones in Hypothyroid Dogs |
| title_short |
Relationship between Total Homocysteine, Folic Acid, and Thyroid Hormones in Hypothyroid Dogs |
| title_sort |
relationship between total homocysteine, folic acid, and thyroid hormones in hypothyroid dogs |
| topic |
General Veterinary |
| url |
http://dx.doi.org/10.1111/jvim.14804 |
| publishDate |
2017 |
| physical |
1403-1405 |
| description |
<jats:sec><jats:title>Background</jats:title><jats:p>Both elevated homocysteine and decreased folic acid concentrations are observed in human patients with hypothyroidism and can influence the development of numerous secondary disorders.</jats:p></jats:sec><jats:sec><jats:title>Objectives</jats:title><jats:p>The aim of the study was to assess total homocysteine concentration in serum and to examine its relationship with the concentration of folic acid and thyroid hormones (<jats:styled-content style="fixed-case">tT</jats:styled-content>4 and <jats:styled-content style="fixed-case">fT</jats:styled-content>4).</jats:p></jats:sec><jats:sec><jats:title>Animals</jats:title><jats:p>Ten healthy and 19 hypothyroid client‐owned dogs.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Dogs with clinical signs of hypothyroidism had the diagnosis confirmed by additional tests. Total homocysteine, folic acid, total thyroxine, and free thyroxine concentrations in serum were evaluated.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Hypothyroid dogs were diagnosed with increased homocysteine (median 22.20 μmol/L; range, 16.50–37.75) and decreased folic acid (median 20.62 nmol/L; range, 10.54–26.35) concentrations, as compared to healthy dogs (11.52 μmol/L; range, 10.00–16.65 and 30.68 nmol/L; range, 22.84–38.52, respectively). In sick dogs, total homocysteine was inversely correlated with folic acid (ρ = −0.47, <jats:italic>P</jats:italic> < 0.001), total thyroxine (ρ = −0.69, <jats:italic>P</jats:italic> = 0.0092), and free thyroxine (ρ = −0.56, <jats:italic>P</jats:italic> = 0.0302).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Hypothyroidism in dogs causes hyperhomocysteinemia. Concomitant mild folic acid decrease in hypothyroid dogs might be as a result of hyperhomocysteinemia.</jats:p></jats:sec> |
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| author | Gołyński, M., Lutnicki, K., Krumrych, W., Szczepanik, M., Gołyńska, M., Wilkołek, P., Adamek, Ł., Sitkowski, Ł., Kurek, Ł. |
| author_facet | Gołyński, M., Lutnicki, K., Krumrych, W., Szczepanik, M., Gołyńska, M., Wilkołek, P., Adamek, Ł., Sitkowski, Ł., Kurek, Ł., Gołyński, M., Lutnicki, K., Krumrych, W., Szczepanik, M., Gołyńska, M., Wilkołek, P., Adamek, Ł., Sitkowski, Ł., Kurek, Ł. |
| author_sort | gołyński, m. |
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| description | <jats:sec><jats:title>Background</jats:title><jats:p>Both elevated homocysteine and decreased folic acid concentrations are observed in human patients with hypothyroidism and can influence the development of numerous secondary disorders.</jats:p></jats:sec><jats:sec><jats:title>Objectives</jats:title><jats:p>The aim of the study was to assess total homocysteine concentration in serum and to examine its relationship with the concentration of folic acid and thyroid hormones (<jats:styled-content style="fixed-case">tT</jats:styled-content>4 and <jats:styled-content style="fixed-case">fT</jats:styled-content>4).</jats:p></jats:sec><jats:sec><jats:title>Animals</jats:title><jats:p>Ten healthy and 19 hypothyroid client‐owned dogs.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Dogs with clinical signs of hypothyroidism had the diagnosis confirmed by additional tests. Total homocysteine, folic acid, total thyroxine, and free thyroxine concentrations in serum were evaluated.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Hypothyroid dogs were diagnosed with increased homocysteine (median 22.20 μmol/L; range, 16.50–37.75) and decreased folic acid (median 20.62 nmol/L; range, 10.54–26.35) concentrations, as compared to healthy dogs (11.52 μmol/L; range, 10.00–16.65 and 30.68 nmol/L; range, 22.84–38.52, respectively). In sick dogs, total homocysteine was inversely correlated with folic acid (ρ = −0.47, <jats:italic>P</jats:italic> < 0.001), total thyroxine (ρ = −0.69, <jats:italic>P</jats:italic> = 0.0092), and free thyroxine (ρ = −0.56, <jats:italic>P</jats:italic> = 0.0302).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Hypothyroidism in dogs causes hyperhomocysteinemia. Concomitant mild folic acid decrease in hypothyroid dogs might be as a result of hyperhomocysteinemia.</jats:p></jats:sec> |
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| imprint | Wiley, 2017 |
| imprint_str_mv | Wiley, 2017 |
| institution | DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1 |
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| spelling | Gołyński, M. Lutnicki, K. Krumrych, W. Szczepanik, M. Gołyńska, M. Wilkołek, P. Adamek, Ł. Sitkowski, Ł. Kurek, Ł. 0891-6640 1939-1676 Wiley General Veterinary http://dx.doi.org/10.1111/jvim.14804 <jats:sec><jats:title>Background</jats:title><jats:p>Both elevated homocysteine and decreased folic acid concentrations are observed in human patients with hypothyroidism and can influence the development of numerous secondary disorders.</jats:p></jats:sec><jats:sec><jats:title>Objectives</jats:title><jats:p>The aim of the study was to assess total homocysteine concentration in serum and to examine its relationship with the concentration of folic acid and thyroid hormones (<jats:styled-content style="fixed-case">tT</jats:styled-content>4 and <jats:styled-content style="fixed-case">fT</jats:styled-content>4).</jats:p></jats:sec><jats:sec><jats:title>Animals</jats:title><jats:p>Ten healthy and 19 hypothyroid client‐owned dogs.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Dogs with clinical signs of hypothyroidism had the diagnosis confirmed by additional tests. Total homocysteine, folic acid, total thyroxine, and free thyroxine concentrations in serum were evaluated.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Hypothyroid dogs were diagnosed with increased homocysteine (median 22.20 μmol/L; range, 16.50–37.75) and decreased folic acid (median 20.62 nmol/L; range, 10.54–26.35) concentrations, as compared to healthy dogs (11.52 μmol/L; range, 10.00–16.65 and 30.68 nmol/L; range, 22.84–38.52, respectively). In sick dogs, total homocysteine was inversely correlated with folic acid (ρ = −0.47, <jats:italic>P</jats:italic> < 0.001), total thyroxine (ρ = −0.69, <jats:italic>P</jats:italic> = 0.0092), and free thyroxine (ρ = −0.56, <jats:italic>P</jats:italic> = 0.0302).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Hypothyroidism in dogs causes hyperhomocysteinemia. Concomitant mild folic acid decrease in hypothyroid dogs might be as a result of hyperhomocysteinemia.</jats:p></jats:sec> Relationship between Total Homocysteine, Folic Acid, and Thyroid Hormones in Hypothyroid Dogs Journal of Veterinary Internal Medicine |
| spellingShingle | Gołyński, M., Lutnicki, K., Krumrych, W., Szczepanik, M., Gołyńska, M., Wilkołek, P., Adamek, Ł., Sitkowski, Ł., Kurek, Ł., Journal of Veterinary Internal Medicine, Relationship between Total Homocysteine, Folic Acid, and Thyroid Hormones in Hypothyroid Dogs, General Veterinary |
| title | Relationship between Total Homocysteine, Folic Acid, and Thyroid Hormones in Hypothyroid Dogs |
| title_full | Relationship between Total Homocysteine, Folic Acid, and Thyroid Hormones in Hypothyroid Dogs |
| title_fullStr | Relationship between Total Homocysteine, Folic Acid, and Thyroid Hormones in Hypothyroid Dogs |
| title_full_unstemmed | Relationship between Total Homocysteine, Folic Acid, and Thyroid Hormones in Hypothyroid Dogs |
| title_short | Relationship between Total Homocysteine, Folic Acid, and Thyroid Hormones in Hypothyroid Dogs |
| title_sort | relationship between total homocysteine, folic acid, and thyroid hormones in hypothyroid dogs |
| title_unstemmed | Relationship between Total Homocysteine, Folic Acid, and Thyroid Hormones in Hypothyroid Dogs |
| topic | General Veterinary |
| url | http://dx.doi.org/10.1111/jvim.14804 |