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Single nucleotide polymorphisms in long noncoding RNA, ANRIL, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular...
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| Zeitschriftentitel: | Journal of Periodontal Research |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Journal of Periodontal Research, 53, 2018, 5, S. 714-720 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Schulz, S. Seitter, L. Werdan, K. Hofmann, B. Schaller, H.‐G. Schlitt, A. Reichert, S. Schulz, S. Seitter, L. Werdan, K. Hofmann, B. Schaller, H.‐G. Schlitt, A. Reichert, S. |
|---|---|
| author |
Schulz, S. Seitter, L. Werdan, K. Hofmann, B. Schaller, H.‐G. Schlitt, A. Reichert, S. |
| spellingShingle |
Schulz, S. Seitter, L. Werdan, K. Hofmann, B. Schaller, H.‐G. Schlitt, A. Reichert, S. Journal of Periodontal Research Single nucleotide polymorphisms in long noncoding RNA, ANRIL, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease Periodontics |
| author_sort |
schulz, s. |
| spelling |
Schulz, S. Seitter, L. Werdan, K. Hofmann, B. Schaller, H.‐G. Schlitt, A. Reichert, S. 0022-3484 1600-0765 Wiley Periodontics http://dx.doi.org/10.1111/jre.12555 <jats:sec><jats:title>Background and Objective</jats:title><jats:p>Biological plausibility of an association between severe periodontitis and cardiovascular disease (CVD) has been proven. Genetic characteristics play an important role in both complex inflammatory diseases. Polymorphisms (single nucleotide polymorphisms [<jats:styled-content style="fixed-case">SNP</jats:styled-content>s]) in the long noncoding <jats:styled-content style="fixed-case">RNA,</jats:styled-content> antisense noncoding <jats:styled-content style="fixed-case">RNA</jats:styled-content> in the <jats:italic><jats:styled-content style="fixed-case">INK</jats:styled-content>4</jats:italic> locus (<jats:styled-content style="fixed-case">ANRIL),</jats:styled-content> were shown to play a leading role in both diseases. The primary objectives of the study were to assess, among cardiovascular (CV angiographically proven ≥50% stenosis of a main coronary artery) patients, the impact of <jats:styled-content style="fixed-case">ANRIL SNP</jats:styled-content>s rs133049 and rs3217992 on the severity of periodontitis and the previous history of coronary events, as well as on the occurrence of further adverse CV events.</jats:p></jats:sec><jats:sec><jats:title>Material and Methods</jats:title><jats:p>The prevalence of severe periodontitis was analyzed in 1002 <jats:styled-content style="fixed-case">CV</jats:styled-content> patients. <jats:styled-content style="fixed-case">ANRIL SNP</jats:styled-content>s rs133049 and rs3217992 were genotyped. The prognostic value of both <jats:styled-content style="fixed-case">ANRIL SNP</jats:styled-content>s for combined CV endpoint (stroke/transient ischemic attack [<jats:styled-content style="fixed-case">TIA]</jats:styled-content>, myocardial infarction, death from a CV‐related event, death from stroke) was evaluated after a 3‐year follow‐up period. Hazard ratios (<jats:styled-content style="fixed-case">HR</jats:styled-content>s) were adjusted for established CV risk factors applying Cox regression.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p><jats:styled-content style="fixed-case">ANRIL SNP</jats:styled-content>s rs133049 and rs3217992 were not associated with severe periodontitis or history of CVD in <jats:styled-content style="fixed-case">CV</jats:styled-content> patients. In the Kaplan‐Meier survival curve including the log rank‐test (<jats:italic>P</jats:italic> = .036) and Cox regression (hazard ratio = 1.684, <jats:italic>P</jats:italic> = .009) the <jats:styled-content style="fixed-case">AA</jats:styled-content> genotype of rs3217992 was shown to be an independent predictor for adverse CV events after 3 years of follow‐up.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p><jats:styled-content style="fixed-case">SNP</jats:styled-content>s in <jats:styled-content style="fixed-case">ANRIL</jats:styled-content> are not risk modulators for severe periodontitis and history of <jats:styled-content style="fixed-case">CVD</jats:styled-content> in <jats:styled-content style="fixed-case">CV</jats:styled-content> patients. The <jats:styled-content style="fixed-case">AA</jats:styled-content> genotype of <jats:styled-content style="fixed-case">ANRIL SNP</jats:styled-content>s rs3217992 possesses prognostic power for further CV events within 3 years of follow‐up.</jats:p></jats:sec> <scp>Single nucleotide polymorphisms</scp> in long noncoding <scp>RNA</scp>,<scp> ANRIL</scp>, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease Journal of Periodontal Research |
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Wiley, 2018 |
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Journal of Periodontal Research |
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49 |
| title |
Single nucleotide polymorphisms in long noncoding RNA, ANRIL, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease |
| title_unstemmed |
Single nucleotide polymorphisms in long noncoding RNA, ANRIL, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease |
| title_full |
Single nucleotide polymorphisms in long noncoding RNA, ANRIL, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease |
| title_fullStr |
Single nucleotide polymorphisms in long noncoding RNA, ANRIL, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease |
| title_full_unstemmed |
Single nucleotide polymorphisms in long noncoding RNA, ANRIL, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease |
| title_short |
Single nucleotide polymorphisms in long noncoding RNA, ANRIL, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease |
| title_sort |
<scp>single nucleotide polymorphisms</scp> in long noncoding <scp>rna</scp>,<scp> anril</scp>, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease |
| topic |
Periodontics |
| url |
http://dx.doi.org/10.1111/jre.12555 |
| publishDate |
2018 |
| physical |
714-720 |
| description |
<jats:sec><jats:title>Background and Objective</jats:title><jats:p>Biological plausibility of an association between severe periodontitis and cardiovascular disease (CVD) has been proven. Genetic characteristics play an important role in both complex inflammatory diseases. Polymorphisms (single nucleotide polymorphisms [<jats:styled-content style="fixed-case">SNP</jats:styled-content>s]) in the long noncoding <jats:styled-content style="fixed-case">RNA,</jats:styled-content> antisense noncoding <jats:styled-content style="fixed-case">RNA</jats:styled-content> in the <jats:italic><jats:styled-content style="fixed-case">INK</jats:styled-content>4</jats:italic> locus (<jats:styled-content style="fixed-case">ANRIL),</jats:styled-content> were shown to play a leading role in both diseases. The primary objectives of the study were to assess, among cardiovascular (CV angiographically proven ≥50% stenosis of a main coronary artery) patients, the impact of <jats:styled-content style="fixed-case">ANRIL SNP</jats:styled-content>s rs133049 and rs3217992 on the severity of periodontitis and the previous history of coronary events, as well as on the occurrence of further adverse CV events.</jats:p></jats:sec><jats:sec><jats:title>Material and Methods</jats:title><jats:p>The prevalence of severe periodontitis was analyzed in 1002 <jats:styled-content style="fixed-case">CV</jats:styled-content> patients. <jats:styled-content style="fixed-case">ANRIL SNP</jats:styled-content>s rs133049 and rs3217992 were genotyped. The prognostic value of both <jats:styled-content style="fixed-case">ANRIL SNP</jats:styled-content>s for combined CV endpoint (stroke/transient ischemic attack [<jats:styled-content style="fixed-case">TIA]</jats:styled-content>, myocardial infarction, death from a CV‐related event, death from stroke) was evaluated after a 3‐year follow‐up period. Hazard ratios (<jats:styled-content style="fixed-case">HR</jats:styled-content>s) were adjusted for established CV risk factors applying Cox regression.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p><jats:styled-content style="fixed-case">ANRIL SNP</jats:styled-content>s rs133049 and rs3217992 were not associated with severe periodontitis or history of CVD in <jats:styled-content style="fixed-case">CV</jats:styled-content> patients. In the Kaplan‐Meier survival curve including the log rank‐test (<jats:italic>P</jats:italic> = .036) and Cox regression (hazard ratio = 1.684, <jats:italic>P</jats:italic> = .009) the <jats:styled-content style="fixed-case">AA</jats:styled-content> genotype of rs3217992 was shown to be an independent predictor for adverse CV events after 3 years of follow‐up.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p><jats:styled-content style="fixed-case">SNP</jats:styled-content>s in <jats:styled-content style="fixed-case">ANRIL</jats:styled-content> are not risk modulators for severe periodontitis and history of <jats:styled-content style="fixed-case">CVD</jats:styled-content> in <jats:styled-content style="fixed-case">CV</jats:styled-content> patients. The <jats:styled-content style="fixed-case">AA</jats:styled-content> genotype of <jats:styled-content style="fixed-case">ANRIL SNP</jats:styled-content>s rs3217992 possesses prognostic power for further CV events within 3 years of follow‐up.</jats:p></jats:sec> |
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| author | Schulz, S., Seitter, L., Werdan, K., Hofmann, B., Schaller, H.‐G., Schlitt, A., Reichert, S. |
| author_facet | Schulz, S., Seitter, L., Werdan, K., Hofmann, B., Schaller, H.‐G., Schlitt, A., Reichert, S., Schulz, S., Seitter, L., Werdan, K., Hofmann, B., Schaller, H.‐G., Schlitt, A., Reichert, S. |
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| description | <jats:sec><jats:title>Background and Objective</jats:title><jats:p>Biological plausibility of an association between severe periodontitis and cardiovascular disease (CVD) has been proven. Genetic characteristics play an important role in both complex inflammatory diseases. Polymorphisms (single nucleotide polymorphisms [<jats:styled-content style="fixed-case">SNP</jats:styled-content>s]) in the long noncoding <jats:styled-content style="fixed-case">RNA,</jats:styled-content> antisense noncoding <jats:styled-content style="fixed-case">RNA</jats:styled-content> in the <jats:italic><jats:styled-content style="fixed-case">INK</jats:styled-content>4</jats:italic> locus (<jats:styled-content style="fixed-case">ANRIL),</jats:styled-content> were shown to play a leading role in both diseases. The primary objectives of the study were to assess, among cardiovascular (CV angiographically proven ≥50% stenosis of a main coronary artery) patients, the impact of <jats:styled-content style="fixed-case">ANRIL SNP</jats:styled-content>s rs133049 and rs3217992 on the severity of periodontitis and the previous history of coronary events, as well as on the occurrence of further adverse CV events.</jats:p></jats:sec><jats:sec><jats:title>Material and Methods</jats:title><jats:p>The prevalence of severe periodontitis was analyzed in 1002 <jats:styled-content style="fixed-case">CV</jats:styled-content> patients. <jats:styled-content style="fixed-case">ANRIL SNP</jats:styled-content>s rs133049 and rs3217992 were genotyped. The prognostic value of both <jats:styled-content style="fixed-case">ANRIL SNP</jats:styled-content>s for combined CV endpoint (stroke/transient ischemic attack [<jats:styled-content style="fixed-case">TIA]</jats:styled-content>, myocardial infarction, death from a CV‐related event, death from stroke) was evaluated after a 3‐year follow‐up period. Hazard ratios (<jats:styled-content style="fixed-case">HR</jats:styled-content>s) were adjusted for established CV risk factors applying Cox regression.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p><jats:styled-content style="fixed-case">ANRIL SNP</jats:styled-content>s rs133049 and rs3217992 were not associated with severe periodontitis or history of CVD in <jats:styled-content style="fixed-case">CV</jats:styled-content> patients. In the Kaplan‐Meier survival curve including the log rank‐test (<jats:italic>P</jats:italic> = .036) and Cox regression (hazard ratio = 1.684, <jats:italic>P</jats:italic> = .009) the <jats:styled-content style="fixed-case">AA</jats:styled-content> genotype of rs3217992 was shown to be an independent predictor for adverse CV events after 3 years of follow‐up.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p><jats:styled-content style="fixed-case">SNP</jats:styled-content>s in <jats:styled-content style="fixed-case">ANRIL</jats:styled-content> are not risk modulators for severe periodontitis and history of <jats:styled-content style="fixed-case">CVD</jats:styled-content> in <jats:styled-content style="fixed-case">CV</jats:styled-content> patients. The <jats:styled-content style="fixed-case">AA</jats:styled-content> genotype of <jats:styled-content style="fixed-case">ANRIL SNP</jats:styled-content>s rs3217992 possesses prognostic power for further CV events within 3 years of follow‐up.</jats:p></jats:sec> |
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| imprint | Wiley, 2018 |
| imprint_str_mv | Wiley, 2018 |
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| physical | 714-720 |
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| spelling | Schulz, S. Seitter, L. Werdan, K. Hofmann, B. Schaller, H.‐G. Schlitt, A. Reichert, S. 0022-3484 1600-0765 Wiley Periodontics http://dx.doi.org/10.1111/jre.12555 <jats:sec><jats:title>Background and Objective</jats:title><jats:p>Biological plausibility of an association between severe periodontitis and cardiovascular disease (CVD) has been proven. Genetic characteristics play an important role in both complex inflammatory diseases. Polymorphisms (single nucleotide polymorphisms [<jats:styled-content style="fixed-case">SNP</jats:styled-content>s]) in the long noncoding <jats:styled-content style="fixed-case">RNA,</jats:styled-content> antisense noncoding <jats:styled-content style="fixed-case">RNA</jats:styled-content> in the <jats:italic><jats:styled-content style="fixed-case">INK</jats:styled-content>4</jats:italic> locus (<jats:styled-content style="fixed-case">ANRIL),</jats:styled-content> were shown to play a leading role in both diseases. The primary objectives of the study were to assess, among cardiovascular (CV angiographically proven ≥50% stenosis of a main coronary artery) patients, the impact of <jats:styled-content style="fixed-case">ANRIL SNP</jats:styled-content>s rs133049 and rs3217992 on the severity of periodontitis and the previous history of coronary events, as well as on the occurrence of further adverse CV events.</jats:p></jats:sec><jats:sec><jats:title>Material and Methods</jats:title><jats:p>The prevalence of severe periodontitis was analyzed in 1002 <jats:styled-content style="fixed-case">CV</jats:styled-content> patients. <jats:styled-content style="fixed-case">ANRIL SNP</jats:styled-content>s rs133049 and rs3217992 were genotyped. The prognostic value of both <jats:styled-content style="fixed-case">ANRIL SNP</jats:styled-content>s for combined CV endpoint (stroke/transient ischemic attack [<jats:styled-content style="fixed-case">TIA]</jats:styled-content>, myocardial infarction, death from a CV‐related event, death from stroke) was evaluated after a 3‐year follow‐up period. Hazard ratios (<jats:styled-content style="fixed-case">HR</jats:styled-content>s) were adjusted for established CV risk factors applying Cox regression.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p><jats:styled-content style="fixed-case">ANRIL SNP</jats:styled-content>s rs133049 and rs3217992 were not associated with severe periodontitis or history of CVD in <jats:styled-content style="fixed-case">CV</jats:styled-content> patients. In the Kaplan‐Meier survival curve including the log rank‐test (<jats:italic>P</jats:italic> = .036) and Cox regression (hazard ratio = 1.684, <jats:italic>P</jats:italic> = .009) the <jats:styled-content style="fixed-case">AA</jats:styled-content> genotype of rs3217992 was shown to be an independent predictor for adverse CV events after 3 years of follow‐up.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p><jats:styled-content style="fixed-case">SNP</jats:styled-content>s in <jats:styled-content style="fixed-case">ANRIL</jats:styled-content> are not risk modulators for severe periodontitis and history of <jats:styled-content style="fixed-case">CVD</jats:styled-content> in <jats:styled-content style="fixed-case">CV</jats:styled-content> patients. The <jats:styled-content style="fixed-case">AA</jats:styled-content> genotype of <jats:styled-content style="fixed-case">ANRIL SNP</jats:styled-content>s rs3217992 possesses prognostic power for further CV events within 3 years of follow‐up.</jats:p></jats:sec> <scp>Single nucleotide polymorphisms</scp> in long noncoding <scp>RNA</scp>,<scp> ANRIL</scp>, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease Journal of Periodontal Research |
| spellingShingle | Schulz, S., Seitter, L., Werdan, K., Hofmann, B., Schaller, H.‐G., Schlitt, A., Reichert, S., Journal of Periodontal Research, Single nucleotide polymorphisms in long noncoding RNA, ANRIL, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease, Periodontics |
| title | Single nucleotide polymorphisms in long noncoding RNA, ANRIL, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease |
| title_full | Single nucleotide polymorphisms in long noncoding RNA, ANRIL, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease |
| title_fullStr | Single nucleotide polymorphisms in long noncoding RNA, ANRIL, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease |
| title_full_unstemmed | Single nucleotide polymorphisms in long noncoding RNA, ANRIL, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease |
| title_short | Single nucleotide polymorphisms in long noncoding RNA, ANRIL, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease |
| title_sort | <scp>single nucleotide polymorphisms</scp> in long noncoding <scp>rna</scp>,<scp> anril</scp>, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease |
| title_unstemmed | Single nucleotide polymorphisms in long noncoding RNA, ANRIL, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease |
| topic | Periodontics |
| url | http://dx.doi.org/10.1111/jre.12555 |