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Evaluation of dermal myelinated nerve fibers in diabetes mellitus
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| Zeitschriftentitel: | Journal of the Peripheral Nervous System |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | Journal of the Peripheral Nervous System, 18, 2013, 2, S. 162-167 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Peltier, Amanda C. Myers, M. Iliza Artibee, Kay J. Hamilton, Audra D. Yan, Qing Guo, Jiasong Shi, Yaping Wang, Lily Li, Jun Peltier, Amanda C. Myers, M. Iliza Artibee, Kay J. Hamilton, Audra D. Yan, Qing Guo, Jiasong Shi, Yaping Wang, Lily Li, Jun |
|---|---|
| author |
Peltier, Amanda C. Myers, M. Iliza Artibee, Kay J. Hamilton, Audra D. Yan, Qing Guo, Jiasong Shi, Yaping Wang, Lily Li, Jun |
| spellingShingle |
Peltier, Amanda C. Myers, M. Iliza Artibee, Kay J. Hamilton, Audra D. Yan, Qing Guo, Jiasong Shi, Yaping Wang, Lily Li, Jun Journal of the Peripheral Nervous System Evaluation of dermal myelinated nerve fibers in diabetes mellitus Neurology (clinical) General Neuroscience |
| author_sort |
peltier, amanda c. |
| spelling |
Peltier, Amanda C. Myers, M. Iliza Artibee, Kay J. Hamilton, Audra D. Yan, Qing Guo, Jiasong Shi, Yaping Wang, Lily Li, Jun 1085-9489 1529-8027 Wiley Neurology (clinical) General Neuroscience http://dx.doi.org/10.1111/jns5.12027 <jats:title>Abstract</jats:title><jats:p>Skin biopsies have primarily been used to study the non‐myelinated nerve fibers of the epidermis in a variety of neuropathies. In this study, we have expanded the skin biopsy technique to glabrous, non‐hairy skin to evaluate myelinated nerve fibers in the most highly prevalent peripheral nerve disease, diabetic polyneuropathy (<jats:styled-content style="fixed-case">DPN</jats:styled-content>). Twenty patients with <jats:styled-content style="fixed-case">DPN</jats:styled-content> (Type I, n = 9; Type <jats:styled-content style="fixed-case">II</jats:styled-content>, n = 11) and 16 age‐matched healthy controls (age 29–73) underwent skin biopsy of the index finger, nerve conduction studies (NCS), and composite neuropathy scoring. In patients with <jats:styled-content style="fixed-case">DPN</jats:styled-content>, we found a statistically significant reduction of both mechanoreceptive Meissner corpuscles (<jats:styled-content style="fixed-case">MCs</jats:styled-content>) and their afferent myelinated nerve fibers (p = 0.01). This myelinated nerve fiber loss was correlated with the decreased amplitudes of sensory/motor responses in NCS. This study supports the utilization of skin biopsy to quantitatively evaluate axonal loss of myelinated nerve fibers in patients with <jats:styled-content style="fixed-case">DPN</jats:styled-content>.</jats:p> Evaluation of dermal myelinated nerve fibers in diabetes mellitus Journal of the Peripheral Nervous System |
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| title |
Evaluation of dermal myelinated nerve fibers in diabetes mellitus |
| title_unstemmed |
Evaluation of dermal myelinated nerve fibers in diabetes mellitus |
| title_full |
Evaluation of dermal myelinated nerve fibers in diabetes mellitus |
| title_fullStr |
Evaluation of dermal myelinated nerve fibers in diabetes mellitus |
| title_full_unstemmed |
Evaluation of dermal myelinated nerve fibers in diabetes mellitus |
| title_short |
Evaluation of dermal myelinated nerve fibers in diabetes mellitus |
| title_sort |
evaluation of dermal myelinated nerve fibers in diabetes mellitus |
| topic |
Neurology (clinical) General Neuroscience |
| url |
http://dx.doi.org/10.1111/jns5.12027 |
| publishDate |
2013 |
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162-167 |
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<jats:title>Abstract</jats:title><jats:p>Skin biopsies have primarily been used to study the non‐myelinated nerve fibers of the epidermis in a variety of neuropathies. In this study, we have expanded the skin biopsy technique to glabrous, non‐hairy skin to evaluate myelinated nerve fibers in the most highly prevalent peripheral nerve disease, diabetic polyneuropathy (<jats:styled-content style="fixed-case">DPN</jats:styled-content>). Twenty patients with <jats:styled-content style="fixed-case">DPN</jats:styled-content> (Type I, n = 9; Type <jats:styled-content style="fixed-case">II</jats:styled-content>, n = 11) and 16 age‐matched healthy controls (age 29–73) underwent skin biopsy of the index finger, nerve conduction studies (NCS), and composite neuropathy scoring. In patients with <jats:styled-content style="fixed-case">DPN</jats:styled-content>, we found a statistically significant reduction of both mechanoreceptive Meissner corpuscles (<jats:styled-content style="fixed-case">MCs</jats:styled-content>) and their afferent myelinated nerve fibers (p = 0.01). This myelinated nerve fiber loss was correlated with the decreased amplitudes of sensory/motor responses in NCS. This study supports the utilization of skin biopsy to quantitatively evaluate axonal loss of myelinated nerve fibers in patients with <jats:styled-content style="fixed-case">DPN</jats:styled-content>.</jats:p> |
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| author | Peltier, Amanda C., Myers, M. Iliza, Artibee, Kay J., Hamilton, Audra D., Yan, Qing, Guo, Jiasong, Shi, Yaping, Wang, Lily, Li, Jun |
| author_facet | Peltier, Amanda C., Myers, M. Iliza, Artibee, Kay J., Hamilton, Audra D., Yan, Qing, Guo, Jiasong, Shi, Yaping, Wang, Lily, Li, Jun, Peltier, Amanda C., Myers, M. Iliza, Artibee, Kay J., Hamilton, Audra D., Yan, Qing, Guo, Jiasong, Shi, Yaping, Wang, Lily, Li, Jun |
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| description | <jats:title>Abstract</jats:title><jats:p>Skin biopsies have primarily been used to study the non‐myelinated nerve fibers of the epidermis in a variety of neuropathies. In this study, we have expanded the skin biopsy technique to glabrous, non‐hairy skin to evaluate myelinated nerve fibers in the most highly prevalent peripheral nerve disease, diabetic polyneuropathy (<jats:styled-content style="fixed-case">DPN</jats:styled-content>). Twenty patients with <jats:styled-content style="fixed-case">DPN</jats:styled-content> (Type I, n = 9; Type <jats:styled-content style="fixed-case">II</jats:styled-content>, n = 11) and 16 age‐matched healthy controls (age 29–73) underwent skin biopsy of the index finger, nerve conduction studies (NCS), and composite neuropathy scoring. In patients with <jats:styled-content style="fixed-case">DPN</jats:styled-content>, we found a statistically significant reduction of both mechanoreceptive Meissner corpuscles (<jats:styled-content style="fixed-case">MCs</jats:styled-content>) and their afferent myelinated nerve fibers (p = 0.01). This myelinated nerve fiber loss was correlated with the decreased amplitudes of sensory/motor responses in NCS. This study supports the utilization of skin biopsy to quantitatively evaluate axonal loss of myelinated nerve fibers in patients with <jats:styled-content style="fixed-case">DPN</jats:styled-content>.</jats:p> |
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| spelling | Peltier, Amanda C. Myers, M. Iliza Artibee, Kay J. Hamilton, Audra D. Yan, Qing Guo, Jiasong Shi, Yaping Wang, Lily Li, Jun 1085-9489 1529-8027 Wiley Neurology (clinical) General Neuroscience http://dx.doi.org/10.1111/jns5.12027 <jats:title>Abstract</jats:title><jats:p>Skin biopsies have primarily been used to study the non‐myelinated nerve fibers of the epidermis in a variety of neuropathies. In this study, we have expanded the skin biopsy technique to glabrous, non‐hairy skin to evaluate myelinated nerve fibers in the most highly prevalent peripheral nerve disease, diabetic polyneuropathy (<jats:styled-content style="fixed-case">DPN</jats:styled-content>). Twenty patients with <jats:styled-content style="fixed-case">DPN</jats:styled-content> (Type I, n = 9; Type <jats:styled-content style="fixed-case">II</jats:styled-content>, n = 11) and 16 age‐matched healthy controls (age 29–73) underwent skin biopsy of the index finger, nerve conduction studies (NCS), and composite neuropathy scoring. In patients with <jats:styled-content style="fixed-case">DPN</jats:styled-content>, we found a statistically significant reduction of both mechanoreceptive Meissner corpuscles (<jats:styled-content style="fixed-case">MCs</jats:styled-content>) and their afferent myelinated nerve fibers (p = 0.01). This myelinated nerve fiber loss was correlated with the decreased amplitudes of sensory/motor responses in NCS. This study supports the utilization of skin biopsy to quantitatively evaluate axonal loss of myelinated nerve fibers in patients with <jats:styled-content style="fixed-case">DPN</jats:styled-content>.</jats:p> Evaluation of dermal myelinated nerve fibers in diabetes mellitus Journal of the Peripheral Nervous System |
| spellingShingle | Peltier, Amanda C., Myers, M. Iliza, Artibee, Kay J., Hamilton, Audra D., Yan, Qing, Guo, Jiasong, Shi, Yaping, Wang, Lily, Li, Jun, Journal of the Peripheral Nervous System, Evaluation of dermal myelinated nerve fibers in diabetes mellitus, Neurology (clinical), General Neuroscience |
| title | Evaluation of dermal myelinated nerve fibers in diabetes mellitus |
| title_full | Evaluation of dermal myelinated nerve fibers in diabetes mellitus |
| title_fullStr | Evaluation of dermal myelinated nerve fibers in diabetes mellitus |
| title_full_unstemmed | Evaluation of dermal myelinated nerve fibers in diabetes mellitus |
| title_short | Evaluation of dermal myelinated nerve fibers in diabetes mellitus |
| title_sort | evaluation of dermal myelinated nerve fibers in diabetes mellitus |
| title_unstemmed | Evaluation of dermal myelinated nerve fibers in diabetes mellitus |
| topic | Neurology (clinical), General Neuroscience |
| url | http://dx.doi.org/10.1111/jns5.12027 |