Eintrag weiter verarbeiten
Systemic redistribution of the intramyocardially injected mesenchymal stem cells by repeated remote ischaemic post‐conditioning
Gespeichert in:
| Zeitschriftentitel: | Journal of Cellular and Molecular Medicine |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | Journal of Cellular and Molecular Medicine, 22, 2018, 1, S. 417-428 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Jiang, Qin Yu, Tao Huang, Keli Zhang, Hao Zheng, Zhe Hu, Shengshou Jiang, Qin Yu, Tao Huang, Keli Zhang, Hao Zheng, Zhe Hu, Shengshou |
|---|---|
| author |
Jiang, Qin Yu, Tao Huang, Keli Zhang, Hao Zheng, Zhe Hu, Shengshou |
| spellingShingle |
Jiang, Qin Yu, Tao Huang, Keli Zhang, Hao Zheng, Zhe Hu, Shengshou Journal of Cellular and Molecular Medicine Systemic redistribution of the intramyocardially injected mesenchymal stem cells by repeated remote ischaemic post‐conditioning Cell Biology Molecular Medicine |
| author_sort |
jiang, qin |
| spelling |
Jiang, Qin Yu, Tao Huang, Keli Zhang, Hao Zheng, Zhe Hu, Shengshou 1582-1838 1582-4934 Wiley Cell Biology Molecular Medicine http://dx.doi.org/10.1111/jcmm.13331 <jats:title>Abstract</jats:title><jats:p>We investigated the effect of repeated remote ischaemic post‐conditioning (RIPoC) on the organ distribution of the intramyocardially injected MSCs in rat myocardial ischemia model. Myocardial ischemia of adult female Sprague‐Dawley rats was induced by 30‐min. obstruction of the left anterior descending coronary artery. Repeated RIPoC was induced after ischemia with three cycles of 5‐min. occlusion and reperfusion of the limb with the frequency of half a day, 1 or 2 days, respectively. Compared with that by single RIPoC, repeated RIPoC transiently reduced oxidative stress, lipid peroxidation and inflammation in ischaemic myocardium; the gene expression of stromal cell‐derived factor‐1 alpha (SDF‐1α) was consistently induced by repeated RIPoC procedures. A total of 4 × 10<jats:sup>6</jats:sup> male bone marrow‐derived MSCs were intramyocardially injected into ischaemic myocardium at 1 week after reperfusion. Three weeks later, immunohistological examination and quantitative reverse transcriptase polymerase chain reaction demonstrated that repeated RIPoC significantly increased MSCs retention in myocardium and decreased MSCs distribution over the lungs, spleen and liver; echocardiography assessment revealed that further cardiac function enhancement imposed by repeated RIPoC procedure. Furthermore, blockade with the anti‐CXCR4 antibody before cell transplantation markedly attenuated the benefits of therapeutic efficacy and cardiac function. Repeated RIPoC enhanced MSCs engraftment in ischaemic myocardium and reduced the distribution of MSCs over peripheral organs in a frequency‐effect way, but it reached a ceiling of maximal effect when applied with every 1 day. The SDF1α‐CXCR4 interaction played a major role in MSCs systemic redistribution induced by repeated RIPoC.</jats:p> Systemic redistribution of the intramyocardially injected mesenchymal stem cells by repeated remote ischaemic post‐conditioning Journal of Cellular and Molecular Medicine |
| doi_str_mv |
10.1111/jcmm.13331 |
| facet_avail |
Online Free |
| finc_class_facet |
Biologie Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9qY21tLjEzMzMx |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9qY21tLjEzMzMx |
| institution |
DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 |
| imprint |
Wiley, 2018 |
| imprint_str_mv |
Wiley, 2018 |
| issn |
1582-1838 1582-4934 |
| issn_str_mv |
1582-1838 1582-4934 |
| language |
English |
| mega_collection |
Wiley (CrossRef) |
| match_str |
jiang2018systemicredistributionoftheintramyocardiallyinjectedmesenchymalstemcellsbyrepeatedremoteischaemicpostconditioning |
| publishDateSort |
2018 |
| publisher |
Wiley |
| recordtype |
ai |
| record_format |
ai |
| series |
Journal of Cellular and Molecular Medicine |
| source_id |
49 |
| title |
Systemic redistribution of the intramyocardially injected mesenchymal stem cells by repeated remote ischaemic post‐conditioning |
| title_unstemmed |
Systemic redistribution of the intramyocardially injected mesenchymal stem cells by repeated remote ischaemic post‐conditioning |
| title_full |
Systemic redistribution of the intramyocardially injected mesenchymal stem cells by repeated remote ischaemic post‐conditioning |
| title_fullStr |
Systemic redistribution of the intramyocardially injected mesenchymal stem cells by repeated remote ischaemic post‐conditioning |
| title_full_unstemmed |
Systemic redistribution of the intramyocardially injected mesenchymal stem cells by repeated remote ischaemic post‐conditioning |
| title_short |
Systemic redistribution of the intramyocardially injected mesenchymal stem cells by repeated remote ischaemic post‐conditioning |
| title_sort |
systemic redistribution of the intramyocardially injected mesenchymal stem cells by repeated remote ischaemic post‐conditioning |
| topic |
Cell Biology Molecular Medicine |
| url |
http://dx.doi.org/10.1111/jcmm.13331 |
| publishDate |
2018 |
| physical |
417-428 |
| description |
<jats:title>Abstract</jats:title><jats:p>We investigated the effect of repeated remote ischaemic post‐conditioning (RIPoC) on the organ distribution of the intramyocardially injected MSCs in rat myocardial ischemia model. Myocardial ischemia of adult female Sprague‐Dawley rats was induced by 30‐min. obstruction of the left anterior descending coronary artery. Repeated RIPoC was induced after ischemia with three cycles of 5‐min. occlusion and reperfusion of the limb with the frequency of half a day, 1 or 2 days, respectively. Compared with that by single RIPoC, repeated RIPoC transiently reduced oxidative stress, lipid peroxidation and inflammation in ischaemic myocardium; the gene expression of stromal cell‐derived factor‐1 alpha (SDF‐1α) was consistently induced by repeated RIPoC procedures. A total of 4 × 10<jats:sup>6</jats:sup> male bone marrow‐derived MSCs were intramyocardially injected into ischaemic myocardium at 1 week after reperfusion. Three weeks later, immunohistological examination and quantitative reverse transcriptase polymerase chain reaction demonstrated that repeated RIPoC significantly increased MSCs retention in myocardium and decreased MSCs distribution over the lungs, spleen and liver; echocardiography assessment revealed that further cardiac function enhancement imposed by repeated RIPoC procedure. Furthermore, blockade with the anti‐CXCR4 antibody before cell transplantation markedly attenuated the benefits of therapeutic efficacy and cardiac function. Repeated RIPoC enhanced MSCs engraftment in ischaemic myocardium and reduced the distribution of MSCs over peripheral organs in a frequency‐effect way, but it reached a ceiling of maximal effect when applied with every 1 day. The SDF1α‐CXCR4 interaction played a major role in MSCs systemic redistribution induced by repeated RIPoC.</jats:p> |
| container_issue |
1 |
| container_start_page |
417 |
| container_title |
Journal of Cellular and Molecular Medicine |
| container_volume |
22 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792337723661484039 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T15:20:27.321Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Systemic+redistribution+of+the+intramyocardially+injected+mesenchymal+stem+cells+by+repeated+remote+ischaemic+post%E2%80%90conditioning&rft.date=2018-01-01&genre=article&issn=1582-4934&volume=22&issue=1&spage=417&epage=428&pages=417-428&jtitle=Journal+of+Cellular+and+Molecular+Medicine&atitle=Systemic+redistribution+of+the+intramyocardially+injected+mesenchymal+stem+cells+by+repeated+remote+ischaemic+post%E2%80%90conditioning&aulast=Hu&aufirst=Shengshou&rft_id=info%3Adoi%2F10.1111%2Fjcmm.13331&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792337723661484039 |
| author | Jiang, Qin, Yu, Tao, Huang, Keli, Zhang, Hao, Zheng, Zhe, Hu, Shengshou |
| author_facet | Jiang, Qin, Yu, Tao, Huang, Keli, Zhang, Hao, Zheng, Zhe, Hu, Shengshou, Jiang, Qin, Yu, Tao, Huang, Keli, Zhang, Hao, Zheng, Zhe, Hu, Shengshou |
| author_sort | jiang, qin |
| container_issue | 1 |
| container_start_page | 417 |
| container_title | Journal of Cellular and Molecular Medicine |
| container_volume | 22 |
| description | <jats:title>Abstract</jats:title><jats:p>We investigated the effect of repeated remote ischaemic post‐conditioning (RIPoC) on the organ distribution of the intramyocardially injected MSCs in rat myocardial ischemia model. Myocardial ischemia of adult female Sprague‐Dawley rats was induced by 30‐min. obstruction of the left anterior descending coronary artery. Repeated RIPoC was induced after ischemia with three cycles of 5‐min. occlusion and reperfusion of the limb with the frequency of half a day, 1 or 2 days, respectively. Compared with that by single RIPoC, repeated RIPoC transiently reduced oxidative stress, lipid peroxidation and inflammation in ischaemic myocardium; the gene expression of stromal cell‐derived factor‐1 alpha (SDF‐1α) was consistently induced by repeated RIPoC procedures. A total of 4 × 10<jats:sup>6</jats:sup> male bone marrow‐derived MSCs were intramyocardially injected into ischaemic myocardium at 1 week after reperfusion. Three weeks later, immunohistological examination and quantitative reverse transcriptase polymerase chain reaction demonstrated that repeated RIPoC significantly increased MSCs retention in myocardium and decreased MSCs distribution over the lungs, spleen and liver; echocardiography assessment revealed that further cardiac function enhancement imposed by repeated RIPoC procedure. Furthermore, blockade with the anti‐CXCR4 antibody before cell transplantation markedly attenuated the benefits of therapeutic efficacy and cardiac function. Repeated RIPoC enhanced MSCs engraftment in ischaemic myocardium and reduced the distribution of MSCs over peripheral organs in a frequency‐effect way, but it reached a ceiling of maximal effect when applied with every 1 day. The SDF1α‐CXCR4 interaction played a major role in MSCs systemic redistribution induced by repeated RIPoC.</jats:p> |
| doi_str_mv | 10.1111/jcmm.13331 |
| facet_avail | Online, Free |
| finc_class_facet | Biologie, Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9qY21tLjEzMzMx |
| imprint | Wiley, 2018 |
| imprint_str_mv | Wiley, 2018 |
| institution | DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1 |
| issn | 1582-1838, 1582-4934 |
| issn_str_mv | 1582-1838, 1582-4934 |
| language | English |
| last_indexed | 2024-03-01T15:20:27.321Z |
| match_str | jiang2018systemicredistributionoftheintramyocardiallyinjectedmesenchymalstemcellsbyrepeatedremoteischaemicpostconditioning |
| mega_collection | Wiley (CrossRef) |
| physical | 417-428 |
| publishDate | 2018 |
| publishDateSort | 2018 |
| publisher | Wiley |
| record_format | ai |
| recordtype | ai |
| series | Journal of Cellular and Molecular Medicine |
| source_id | 49 |
| spelling | Jiang, Qin Yu, Tao Huang, Keli Zhang, Hao Zheng, Zhe Hu, Shengshou 1582-1838 1582-4934 Wiley Cell Biology Molecular Medicine http://dx.doi.org/10.1111/jcmm.13331 <jats:title>Abstract</jats:title><jats:p>We investigated the effect of repeated remote ischaemic post‐conditioning (RIPoC) on the organ distribution of the intramyocardially injected MSCs in rat myocardial ischemia model. Myocardial ischemia of adult female Sprague‐Dawley rats was induced by 30‐min. obstruction of the left anterior descending coronary artery. Repeated RIPoC was induced after ischemia with three cycles of 5‐min. occlusion and reperfusion of the limb with the frequency of half a day, 1 or 2 days, respectively. Compared with that by single RIPoC, repeated RIPoC transiently reduced oxidative stress, lipid peroxidation and inflammation in ischaemic myocardium; the gene expression of stromal cell‐derived factor‐1 alpha (SDF‐1α) was consistently induced by repeated RIPoC procedures. A total of 4 × 10<jats:sup>6</jats:sup> male bone marrow‐derived MSCs were intramyocardially injected into ischaemic myocardium at 1 week after reperfusion. Three weeks later, immunohistological examination and quantitative reverse transcriptase polymerase chain reaction demonstrated that repeated RIPoC significantly increased MSCs retention in myocardium and decreased MSCs distribution over the lungs, spleen and liver; echocardiography assessment revealed that further cardiac function enhancement imposed by repeated RIPoC procedure. Furthermore, blockade with the anti‐CXCR4 antibody before cell transplantation markedly attenuated the benefits of therapeutic efficacy and cardiac function. Repeated RIPoC enhanced MSCs engraftment in ischaemic myocardium and reduced the distribution of MSCs over peripheral organs in a frequency‐effect way, but it reached a ceiling of maximal effect when applied with every 1 day. The SDF1α‐CXCR4 interaction played a major role in MSCs systemic redistribution induced by repeated RIPoC.</jats:p> Systemic redistribution of the intramyocardially injected mesenchymal stem cells by repeated remote ischaemic post‐conditioning Journal of Cellular and Molecular Medicine |
| spellingShingle | Jiang, Qin, Yu, Tao, Huang, Keli, Zhang, Hao, Zheng, Zhe, Hu, Shengshou, Journal of Cellular and Molecular Medicine, Systemic redistribution of the intramyocardially injected mesenchymal stem cells by repeated remote ischaemic post‐conditioning, Cell Biology, Molecular Medicine |
| title | Systemic redistribution of the intramyocardially injected mesenchymal stem cells by repeated remote ischaemic post‐conditioning |
| title_full | Systemic redistribution of the intramyocardially injected mesenchymal stem cells by repeated remote ischaemic post‐conditioning |
| title_fullStr | Systemic redistribution of the intramyocardially injected mesenchymal stem cells by repeated remote ischaemic post‐conditioning |
| title_full_unstemmed | Systemic redistribution of the intramyocardially injected mesenchymal stem cells by repeated remote ischaemic post‐conditioning |
| title_short | Systemic redistribution of the intramyocardially injected mesenchymal stem cells by repeated remote ischaemic post‐conditioning |
| title_sort | systemic redistribution of the intramyocardially injected mesenchymal stem cells by repeated remote ischaemic post‐conditioning |
| title_unstemmed | Systemic redistribution of the intramyocardially injected mesenchymal stem cells by repeated remote ischaemic post‐conditioning |
| topic | Cell Biology, Molecular Medicine |
| url | http://dx.doi.org/10.1111/jcmm.13331 |