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Ectodysplasin A regulates epithelial barrier function through sonic hedgehog signalling pathway
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| Zeitschriftentitel: | Journal of Cellular and Molecular Medicine |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , |
| In: | Journal of Cellular and Molecular Medicine, 22, 2018, 1, S. 230-240 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Li, Sanming Zhou, Jing Zhang, Liying Li, Juan Yu, Jingwen Ning, Ke Qu, Yangluowa He, Hui Chen, Yongxiong Reinach, Peter S. Liu, Chia‐Yang Liu, Zuguo Li, Wei Li, Sanming Zhou, Jing Zhang, Liying Li, Juan Yu, Jingwen Ning, Ke Qu, Yangluowa He, Hui Chen, Yongxiong Reinach, Peter S. Liu, Chia‐Yang Liu, Zuguo Li, Wei |
|---|---|
| author |
Li, Sanming Zhou, Jing Zhang, Liying Li, Juan Yu, Jingwen Ning, Ke Qu, Yangluowa He, Hui Chen, Yongxiong Reinach, Peter S. Liu, Chia‐Yang Liu, Zuguo Li, Wei |
| spellingShingle |
Li, Sanming Zhou, Jing Zhang, Liying Li, Juan Yu, Jingwen Ning, Ke Qu, Yangluowa He, Hui Chen, Yongxiong Reinach, Peter S. Liu, Chia‐Yang Liu, Zuguo Li, Wei Journal of Cellular and Molecular Medicine Ectodysplasin A regulates epithelial barrier function through sonic hedgehog signalling pathway Cell Biology Molecular Medicine |
| author_sort |
li, sanming |
| spelling |
Li, Sanming Zhou, Jing Zhang, Liying Li, Juan Yu, Jingwen Ning, Ke Qu, Yangluowa He, Hui Chen, Yongxiong Reinach, Peter S. Liu, Chia‐Yang Liu, Zuguo Li, Wei 1582-1838 1582-4934 Wiley Cell Biology Molecular Medicine http://dx.doi.org/10.1111/jcmm.13311 <jats:title>Abstract</jats:title><jats:p>Ectodysplasin A (Eda), a member of the tumour necrosis factor superfamily, plays an important role in ectodermal organ development. An <jats:italic><jats:styled-content style="fixed-case">EDA</jats:styled-content></jats:italic> mutation underlies the most common of ectodermal dysplasias, that is X‐linked hypohidrotic ectodermal dysplasia (<jats:styled-content style="fixed-case">XLHED</jats:styled-content>) in humans. Even though it lacks a developmental function, the role of Eda during the postnatal stage remains elusive. In this study, we found tight junctional proteins <jats:styled-content style="fixed-case">ZO</jats:styled-content>‐1 and claudin‐1 expression is largely reduced in epidermal, corneal and lung epithelia in <jats:italic>Eda</jats:italic> mutant <jats:italic>Tabby</jats:italic> mice at different postnatal ages. These declines are associated with tail ulceration, corneal pannus formation and lung infection. Furthermore, topical application of recombinant Eda protein markedly mitigated corneal barrier dysfunction. Using cultures of a human corneal epithelial cell line and <jats:italic>Tabby</jats:italic> mouse skin tissue explants, Eda up‐regulated expression of <jats:styled-content style="fixed-case">ZO</jats:styled-content>‐1 and claudin‐1 through activation of the sonic hedgehog signalling pathway. We conclude that <jats:italic><jats:styled-content style="fixed-case">EDA</jats:styled-content></jats:italic> gene expression contributes to the maintenance of epithelial barrier function. Such insight may help efforts to identify novel strategies for improving management of <jats:styled-content style="fixed-case">XLHED</jats:styled-content> disease manifestations in a clinical setting.</jats:p> Ectodysplasin A regulates epithelial barrier function through sonic hedgehog signalling pathway Journal of Cellular and Molecular Medicine |
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10.1111/jcmm.13311 |
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| title |
Ectodysplasin A regulates epithelial barrier function through sonic hedgehog signalling pathway |
| title_unstemmed |
Ectodysplasin A regulates epithelial barrier function through sonic hedgehog signalling pathway |
| title_full |
Ectodysplasin A regulates epithelial barrier function through sonic hedgehog signalling pathway |
| title_fullStr |
Ectodysplasin A regulates epithelial barrier function through sonic hedgehog signalling pathway |
| title_full_unstemmed |
Ectodysplasin A regulates epithelial barrier function through sonic hedgehog signalling pathway |
| title_short |
Ectodysplasin A regulates epithelial barrier function through sonic hedgehog signalling pathway |
| title_sort |
ectodysplasin a regulates epithelial barrier function through sonic hedgehog signalling pathway |
| topic |
Cell Biology Molecular Medicine |
| url |
http://dx.doi.org/10.1111/jcmm.13311 |
| publishDate |
2018 |
| physical |
230-240 |
| description |
<jats:title>Abstract</jats:title><jats:p>Ectodysplasin A (Eda), a member of the tumour necrosis factor superfamily, plays an important role in ectodermal organ development. An <jats:italic><jats:styled-content style="fixed-case">EDA</jats:styled-content></jats:italic> mutation underlies the most common of ectodermal dysplasias, that is X‐linked hypohidrotic ectodermal dysplasia (<jats:styled-content style="fixed-case">XLHED</jats:styled-content>) in humans. Even though it lacks a developmental function, the role of Eda during the postnatal stage remains elusive. In this study, we found tight junctional proteins <jats:styled-content style="fixed-case">ZO</jats:styled-content>‐1 and claudin‐1 expression is largely reduced in epidermal, corneal and lung epithelia in <jats:italic>Eda</jats:italic> mutant <jats:italic>Tabby</jats:italic> mice at different postnatal ages. These declines are associated with tail ulceration, corneal pannus formation and lung infection. Furthermore, topical application of recombinant Eda protein markedly mitigated corneal barrier dysfunction. Using cultures of a human corneal epithelial cell line and <jats:italic>Tabby</jats:italic> mouse skin tissue explants, Eda up‐regulated expression of <jats:styled-content style="fixed-case">ZO</jats:styled-content>‐1 and claudin‐1 through activation of the sonic hedgehog signalling pathway. We conclude that <jats:italic><jats:styled-content style="fixed-case">EDA</jats:styled-content></jats:italic> gene expression contributes to the maintenance of epithelial barrier function. Such insight may help efforts to identify novel strategies for improving management of <jats:styled-content style="fixed-case">XLHED</jats:styled-content> disease manifestations in a clinical setting.</jats:p> |
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| author | Li, Sanming, Zhou, Jing, Zhang, Liying, Li, Juan, Yu, Jingwen, Ning, Ke, Qu, Yangluowa, He, Hui, Chen, Yongxiong, Reinach, Peter S., Liu, Chia‐Yang, Liu, Zuguo, Li, Wei |
| author_facet | Li, Sanming, Zhou, Jing, Zhang, Liying, Li, Juan, Yu, Jingwen, Ning, Ke, Qu, Yangluowa, He, Hui, Chen, Yongxiong, Reinach, Peter S., Liu, Chia‐Yang, Liu, Zuguo, Li, Wei, Li, Sanming, Zhou, Jing, Zhang, Liying, Li, Juan, Yu, Jingwen, Ning, Ke, Qu, Yangluowa, He, Hui, Chen, Yongxiong, Reinach, Peter S., Liu, Chia‐Yang, Liu, Zuguo, Li, Wei |
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| description | <jats:title>Abstract</jats:title><jats:p>Ectodysplasin A (Eda), a member of the tumour necrosis factor superfamily, plays an important role in ectodermal organ development. An <jats:italic><jats:styled-content style="fixed-case">EDA</jats:styled-content></jats:italic> mutation underlies the most common of ectodermal dysplasias, that is X‐linked hypohidrotic ectodermal dysplasia (<jats:styled-content style="fixed-case">XLHED</jats:styled-content>) in humans. Even though it lacks a developmental function, the role of Eda during the postnatal stage remains elusive. In this study, we found tight junctional proteins <jats:styled-content style="fixed-case">ZO</jats:styled-content>‐1 and claudin‐1 expression is largely reduced in epidermal, corneal and lung epithelia in <jats:italic>Eda</jats:italic> mutant <jats:italic>Tabby</jats:italic> mice at different postnatal ages. These declines are associated with tail ulceration, corneal pannus formation and lung infection. Furthermore, topical application of recombinant Eda protein markedly mitigated corneal barrier dysfunction. Using cultures of a human corneal epithelial cell line and <jats:italic>Tabby</jats:italic> mouse skin tissue explants, Eda up‐regulated expression of <jats:styled-content style="fixed-case">ZO</jats:styled-content>‐1 and claudin‐1 through activation of the sonic hedgehog signalling pathway. We conclude that <jats:italic><jats:styled-content style="fixed-case">EDA</jats:styled-content></jats:italic> gene expression contributes to the maintenance of epithelial barrier function. Such insight may help efforts to identify novel strategies for improving management of <jats:styled-content style="fixed-case">XLHED</jats:styled-content> disease manifestations in a clinical setting.</jats:p> |
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| spelling | Li, Sanming Zhou, Jing Zhang, Liying Li, Juan Yu, Jingwen Ning, Ke Qu, Yangluowa He, Hui Chen, Yongxiong Reinach, Peter S. Liu, Chia‐Yang Liu, Zuguo Li, Wei 1582-1838 1582-4934 Wiley Cell Biology Molecular Medicine http://dx.doi.org/10.1111/jcmm.13311 <jats:title>Abstract</jats:title><jats:p>Ectodysplasin A (Eda), a member of the tumour necrosis factor superfamily, plays an important role in ectodermal organ development. An <jats:italic><jats:styled-content style="fixed-case">EDA</jats:styled-content></jats:italic> mutation underlies the most common of ectodermal dysplasias, that is X‐linked hypohidrotic ectodermal dysplasia (<jats:styled-content style="fixed-case">XLHED</jats:styled-content>) in humans. Even though it lacks a developmental function, the role of Eda during the postnatal stage remains elusive. In this study, we found tight junctional proteins <jats:styled-content style="fixed-case">ZO</jats:styled-content>‐1 and claudin‐1 expression is largely reduced in epidermal, corneal and lung epithelia in <jats:italic>Eda</jats:italic> mutant <jats:italic>Tabby</jats:italic> mice at different postnatal ages. These declines are associated with tail ulceration, corneal pannus formation and lung infection. Furthermore, topical application of recombinant Eda protein markedly mitigated corneal barrier dysfunction. Using cultures of a human corneal epithelial cell line and <jats:italic>Tabby</jats:italic> mouse skin tissue explants, Eda up‐regulated expression of <jats:styled-content style="fixed-case">ZO</jats:styled-content>‐1 and claudin‐1 through activation of the sonic hedgehog signalling pathway. We conclude that <jats:italic><jats:styled-content style="fixed-case">EDA</jats:styled-content></jats:italic> gene expression contributes to the maintenance of epithelial barrier function. Such insight may help efforts to identify novel strategies for improving management of <jats:styled-content style="fixed-case">XLHED</jats:styled-content> disease manifestations in a clinical setting.</jats:p> Ectodysplasin A regulates epithelial barrier function through sonic hedgehog signalling pathway Journal of Cellular and Molecular Medicine |
| spellingShingle | Li, Sanming, Zhou, Jing, Zhang, Liying, Li, Juan, Yu, Jingwen, Ning, Ke, Qu, Yangluowa, He, Hui, Chen, Yongxiong, Reinach, Peter S., Liu, Chia‐Yang, Liu, Zuguo, Li, Wei, Journal of Cellular and Molecular Medicine, Ectodysplasin A regulates epithelial barrier function through sonic hedgehog signalling pathway, Cell Biology, Molecular Medicine |
| title | Ectodysplasin A regulates epithelial barrier function through sonic hedgehog signalling pathway |
| title_full | Ectodysplasin A regulates epithelial barrier function through sonic hedgehog signalling pathway |
| title_fullStr | Ectodysplasin A regulates epithelial barrier function through sonic hedgehog signalling pathway |
| title_full_unstemmed | Ectodysplasin A regulates epithelial barrier function through sonic hedgehog signalling pathway |
| title_short | Ectodysplasin A regulates epithelial barrier function through sonic hedgehog signalling pathway |
| title_sort | ectodysplasin a regulates epithelial barrier function through sonic hedgehog signalling pathway |
| title_unstemmed | Ectodysplasin A regulates epithelial barrier function through sonic hedgehog signalling pathway |
| topic | Cell Biology, Molecular Medicine |
| url | http://dx.doi.org/10.1111/jcmm.13311 |