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PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer
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| Zeitschriftentitel: | Journal of Cellular and Molecular Medicine |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Journal of Cellular and Molecular Medicine, 23, 2019, 5, S. 3603-3615 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Zhang, Lei Wang, Xue Lai, Chong Zhang, Honghe Lai, Maode Zhang, Lei Wang, Xue Lai, Chong Zhang, Honghe Lai, Maode |
|---|---|
| author |
Zhang, Lei Wang, Xue Lai, Chong Zhang, Honghe Lai, Maode |
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Zhang, Lei Wang, Xue Lai, Chong Zhang, Honghe Lai, Maode Journal of Cellular and Molecular Medicine PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer Cell Biology Molecular Medicine |
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zhang, lei |
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Zhang, Lei Wang, Xue Lai, Chong Zhang, Honghe Lai, Maode 1582-1838 1582-4934 Wiley Cell Biology Molecular Medicine http://dx.doi.org/10.1111/jcmm.14261 <jats:title>Abstract</jats:title><jats:p>Prostate transmembrane protein androgen induced 1 (PMEPA1) has been reported to promote cancer progression. Metastasis is the main factor leading to cancer progression and poor prognosis, and at the beginning of metastasis, epithelial‐to‐mesenchymal transition (EMT) is a crucial activation. However, the relationship between PMEPA1 and EMT in colorectal cancer metastasis is still poorly understood. In this study, we first testified that PMEPA1 expresses higher in tumour than normal tissue in Gene Expression Omnibus database, in the Cancer Genome Atlas (TCGA) as well as in the clinical data we collected. Moreover, the higher expression was associated with poor prognosis. We furthermore demonstrated PMEPA1 promotes colorectal cancer metastasis and EMT in vivo and in vitro. We found that PMEPA1 activates the bone morphogenetic proteins (BMP) signalling of TGF‐β signalling resulting in promoting EMT and accelerating the proliferation and metastasis of colorectal cancer.</jats:p> PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer Journal of Cellular and Molecular Medicine |
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| title |
PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer |
| title_unstemmed |
PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer |
| title_full |
PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer |
| title_fullStr |
PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer |
| title_full_unstemmed |
PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer |
| title_short |
PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer |
| title_sort |
pmepa1 induces emt via a non‐canonical tgf‐β signalling in colorectal cancer |
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Cell Biology Molecular Medicine |
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http://dx.doi.org/10.1111/jcmm.14261 |
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2019 |
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<jats:title>Abstract</jats:title><jats:p>Prostate transmembrane protein androgen induced 1 (PMEPA1) has been reported to promote cancer progression. Metastasis is the main factor leading to cancer progression and poor prognosis, and at the beginning of metastasis, epithelial‐to‐mesenchymal transition (EMT) is a crucial activation. However, the relationship between PMEPA1 and EMT in colorectal cancer metastasis is still poorly understood. In this study, we first testified that PMEPA1 expresses higher in tumour than normal tissue in Gene Expression Omnibus database, in the Cancer Genome Atlas (TCGA) as well as in the clinical data we collected. Moreover, the higher expression was associated with poor prognosis. We furthermore demonstrated PMEPA1 promotes colorectal cancer metastasis and EMT in vivo and in vitro. We found that PMEPA1 activates the bone morphogenetic proteins (BMP) signalling of TGF‐β signalling resulting in promoting EMT and accelerating the proliferation and metastasis of colorectal cancer.</jats:p> |
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| author | Zhang, Lei, Wang, Xue, Lai, Chong, Zhang, Honghe, Lai, Maode |
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| description | <jats:title>Abstract</jats:title><jats:p>Prostate transmembrane protein androgen induced 1 (PMEPA1) has been reported to promote cancer progression. Metastasis is the main factor leading to cancer progression and poor prognosis, and at the beginning of metastasis, epithelial‐to‐mesenchymal transition (EMT) is a crucial activation. However, the relationship between PMEPA1 and EMT in colorectal cancer metastasis is still poorly understood. In this study, we first testified that PMEPA1 expresses higher in tumour than normal tissue in Gene Expression Omnibus database, in the Cancer Genome Atlas (TCGA) as well as in the clinical data we collected. Moreover, the higher expression was associated with poor prognosis. We furthermore demonstrated PMEPA1 promotes colorectal cancer metastasis and EMT in vivo and in vitro. We found that PMEPA1 activates the bone morphogenetic proteins (BMP) signalling of TGF‐β signalling resulting in promoting EMT and accelerating the proliferation and metastasis of colorectal cancer.</jats:p> |
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| spelling | Zhang, Lei Wang, Xue Lai, Chong Zhang, Honghe Lai, Maode 1582-1838 1582-4934 Wiley Cell Biology Molecular Medicine http://dx.doi.org/10.1111/jcmm.14261 <jats:title>Abstract</jats:title><jats:p>Prostate transmembrane protein androgen induced 1 (PMEPA1) has been reported to promote cancer progression. Metastasis is the main factor leading to cancer progression and poor prognosis, and at the beginning of metastasis, epithelial‐to‐mesenchymal transition (EMT) is a crucial activation. However, the relationship between PMEPA1 and EMT in colorectal cancer metastasis is still poorly understood. In this study, we first testified that PMEPA1 expresses higher in tumour than normal tissue in Gene Expression Omnibus database, in the Cancer Genome Atlas (TCGA) as well as in the clinical data we collected. Moreover, the higher expression was associated with poor prognosis. We furthermore demonstrated PMEPA1 promotes colorectal cancer metastasis and EMT in vivo and in vitro. We found that PMEPA1 activates the bone morphogenetic proteins (BMP) signalling of TGF‐β signalling resulting in promoting EMT and accelerating the proliferation and metastasis of colorectal cancer.</jats:p> PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer Journal of Cellular and Molecular Medicine |
| spellingShingle | Zhang, Lei, Wang, Xue, Lai, Chong, Zhang, Honghe, Lai, Maode, Journal of Cellular and Molecular Medicine, PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer, Cell Biology, Molecular Medicine |
| title | PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer |
| title_full | PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer |
| title_fullStr | PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer |
| title_full_unstemmed | PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer |
| title_short | PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer |
| title_sort | pmepa1 induces emt via a non‐canonical tgf‐β signalling in colorectal cancer |
| title_unstemmed | PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer |
| topic | Cell Biology, Molecular Medicine |
| url | http://dx.doi.org/10.1111/jcmm.14261 |