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Critical role of Lin28‐TNFR2 signalling in cardiac stem cell activation and differentiation
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| Zeitschriftentitel: | Journal of Cellular and Molecular Medicine |
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| Personen und Körperschaften: | , , , , , , , |
| In: | Journal of Cellular and Molecular Medicine, 23, 2019, 4, S. 0-0 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Xiang, Qiuling Yang, Bicheng Li, Li Qiu, Bin Qiu, Caihong Gao, Xiao‐Bing Zhou, Huanjiao (Jenny) Min, Wang Xiang, Qiuling Yang, Bicheng Li, Li Qiu, Bin Qiu, Caihong Gao, Xiao‐Bing Zhou, Huanjiao (Jenny) Min, Wang |
|---|---|
| author |
Xiang, Qiuling Yang, Bicheng Li, Li Qiu, Bin Qiu, Caihong Gao, Xiao‐Bing Zhou, Huanjiao (Jenny) Min, Wang |
| spellingShingle |
Xiang, Qiuling Yang, Bicheng Li, Li Qiu, Bin Qiu, Caihong Gao, Xiao‐Bing Zhou, Huanjiao (Jenny) Min, Wang Journal of Cellular and Molecular Medicine Critical role of Lin28‐TNFR2 signalling in cardiac stem cell activation and differentiation Cell Biology Molecular Medicine |
| author_sort |
xiang, qiuling |
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Xiang, Qiuling Yang, Bicheng Li, Li Qiu, Bin Qiu, Caihong Gao, Xiao‐Bing Zhou, Huanjiao (Jenny) Min, Wang 1582-1838 1582-4934 Wiley Cell Biology Molecular Medicine http://dx.doi.org/10.1111/jcmm.14202 <jats:title>Abstract</jats:title><jats:p>Tumour necrotic factor receptor‐2 (TNFR2) has been to be cardiac‐protective and is expressed in cardiac progenitor cells. Our goal is to define the mechanism for TNFR2‐mediated cardiac stem cell activation and differentiation. By employing a protocol of in vitro cardiac stem cell (CSC) differentiation from human inducible pluripotent stem cell (hiPSC), we show that expression of TNFR2 precedes expression of CSC markers followed by expression of mature cardiomyocyte proteins. Activation of TNFR2 by a specific agonist promotes whereas inhibition of TNFR2 by neutralizing antibody diminishes hiPSC‐based CSC differentiation. Interestingly, pluripotent cell factor RNA‐binding protein Lin28 enhances TNFR2 protein expression in early CSC activation by directly binding to a conserved Lin28‐motif within the 3'UTR of Tnfr2 mRNA. Furthermore, inhibition of Lin28 blunts TNFR2 expression and TNFR2‐dependent CSC activation and differentiation. Our study demonstrates a critical role of Lin28‐TNFR2 axis in CSC activation and survival, providing a novel strategy to enhance stem cell‐based therapy for the ischaemic heart diseases.</jats:p> Critical role of Lin28‐TNFR2 signalling in cardiac stem cell activation and differentiation Journal of Cellular and Molecular Medicine |
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Critical role of Lin28‐TNFR2 signalling in cardiac stem cell activation and differentiation |
| title_unstemmed |
Critical role of Lin28‐TNFR2 signalling in cardiac stem cell activation and differentiation |
| title_full |
Critical role of Lin28‐TNFR2 signalling in cardiac stem cell activation and differentiation |
| title_fullStr |
Critical role of Lin28‐TNFR2 signalling in cardiac stem cell activation and differentiation |
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Critical role of Lin28‐TNFR2 signalling in cardiac stem cell activation and differentiation |
| title_short |
Critical role of Lin28‐TNFR2 signalling in cardiac stem cell activation and differentiation |
| title_sort |
critical role of lin28‐tnfr2 signalling in cardiac stem cell activation and differentiation |
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Cell Biology Molecular Medicine |
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http://dx.doi.org/10.1111/jcmm.14202 |
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2019 |
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<jats:title>Abstract</jats:title><jats:p>Tumour necrotic factor receptor‐2 (TNFR2) has been to be cardiac‐protective and is expressed in cardiac progenitor cells. Our goal is to define the mechanism for TNFR2‐mediated cardiac stem cell activation and differentiation. By employing a protocol of in vitro cardiac stem cell (CSC) differentiation from human inducible pluripotent stem cell (hiPSC), we show that expression of TNFR2 precedes expression of CSC markers followed by expression of mature cardiomyocyte proteins. Activation of TNFR2 by a specific agonist promotes whereas inhibition of TNFR2 by neutralizing antibody diminishes hiPSC‐based CSC differentiation. Interestingly, pluripotent cell factor RNA‐binding protein Lin28 enhances TNFR2 protein expression in early CSC activation by directly binding to a conserved Lin28‐motif within the 3'UTR of Tnfr2 mRNA. Furthermore, inhibition of Lin28 blunts TNFR2 expression and TNFR2‐dependent CSC activation and differentiation. Our study demonstrates a critical role of Lin28‐TNFR2 axis in CSC activation and survival, providing a novel strategy to enhance stem cell‐based therapy for the ischaemic heart diseases.</jats:p> |
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| author | Xiang, Qiuling, Yang, Bicheng, Li, Li, Qiu, Bin, Qiu, Caihong, Gao, Xiao‐Bing, Zhou, Huanjiao (Jenny), Min, Wang |
| author_facet | Xiang, Qiuling, Yang, Bicheng, Li, Li, Qiu, Bin, Qiu, Caihong, Gao, Xiao‐Bing, Zhou, Huanjiao (Jenny), Min, Wang, Xiang, Qiuling, Yang, Bicheng, Li, Li, Qiu, Bin, Qiu, Caihong, Gao, Xiao‐Bing, Zhou, Huanjiao (Jenny), Min, Wang |
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| description | <jats:title>Abstract</jats:title><jats:p>Tumour necrotic factor receptor‐2 (TNFR2) has been to be cardiac‐protective and is expressed in cardiac progenitor cells. Our goal is to define the mechanism for TNFR2‐mediated cardiac stem cell activation and differentiation. By employing a protocol of in vitro cardiac stem cell (CSC) differentiation from human inducible pluripotent stem cell (hiPSC), we show that expression of TNFR2 precedes expression of CSC markers followed by expression of mature cardiomyocyte proteins. Activation of TNFR2 by a specific agonist promotes whereas inhibition of TNFR2 by neutralizing antibody diminishes hiPSC‐based CSC differentiation. Interestingly, pluripotent cell factor RNA‐binding protein Lin28 enhances TNFR2 protein expression in early CSC activation by directly binding to a conserved Lin28‐motif within the 3'UTR of Tnfr2 mRNA. Furthermore, inhibition of Lin28 blunts TNFR2 expression and TNFR2‐dependent CSC activation and differentiation. Our study demonstrates a critical role of Lin28‐TNFR2 axis in CSC activation and survival, providing a novel strategy to enhance stem cell‐based therapy for the ischaemic heart diseases.</jats:p> |
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| spelling | Xiang, Qiuling Yang, Bicheng Li, Li Qiu, Bin Qiu, Caihong Gao, Xiao‐Bing Zhou, Huanjiao (Jenny) Min, Wang 1582-1838 1582-4934 Wiley Cell Biology Molecular Medicine http://dx.doi.org/10.1111/jcmm.14202 <jats:title>Abstract</jats:title><jats:p>Tumour necrotic factor receptor‐2 (TNFR2) has been to be cardiac‐protective and is expressed in cardiac progenitor cells. Our goal is to define the mechanism for TNFR2‐mediated cardiac stem cell activation and differentiation. By employing a protocol of in vitro cardiac stem cell (CSC) differentiation from human inducible pluripotent stem cell (hiPSC), we show that expression of TNFR2 precedes expression of CSC markers followed by expression of mature cardiomyocyte proteins. Activation of TNFR2 by a specific agonist promotes whereas inhibition of TNFR2 by neutralizing antibody diminishes hiPSC‐based CSC differentiation. Interestingly, pluripotent cell factor RNA‐binding protein Lin28 enhances TNFR2 protein expression in early CSC activation by directly binding to a conserved Lin28‐motif within the 3'UTR of Tnfr2 mRNA. Furthermore, inhibition of Lin28 blunts TNFR2 expression and TNFR2‐dependent CSC activation and differentiation. Our study demonstrates a critical role of Lin28‐TNFR2 axis in CSC activation and survival, providing a novel strategy to enhance stem cell‐based therapy for the ischaemic heart diseases.</jats:p> Critical role of Lin28‐TNFR2 signalling in cardiac stem cell activation and differentiation Journal of Cellular and Molecular Medicine |
| spellingShingle | Xiang, Qiuling, Yang, Bicheng, Li, Li, Qiu, Bin, Qiu, Caihong, Gao, Xiao‐Bing, Zhou, Huanjiao (Jenny), Min, Wang, Journal of Cellular and Molecular Medicine, Critical role of Lin28‐TNFR2 signalling in cardiac stem cell activation and differentiation, Cell Biology, Molecular Medicine |
| title | Critical role of Lin28‐TNFR2 signalling in cardiac stem cell activation and differentiation |
| title_full | Critical role of Lin28‐TNFR2 signalling in cardiac stem cell activation and differentiation |
| title_fullStr | Critical role of Lin28‐TNFR2 signalling in cardiac stem cell activation and differentiation |
| title_full_unstemmed | Critical role of Lin28‐TNFR2 signalling in cardiac stem cell activation and differentiation |
| title_short | Critical role of Lin28‐TNFR2 signalling in cardiac stem cell activation and differentiation |
| title_sort | critical role of lin28‐tnfr2 signalling in cardiac stem cell activation and differentiation |
| title_unstemmed | Critical role of Lin28‐TNFR2 signalling in cardiac stem cell activation and differentiation |
| topic | Cell Biology, Molecular Medicine |
| url | http://dx.doi.org/10.1111/jcmm.14202 |