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Extracellular vesicles from human umbilical cord mesenchymal stem cells improve nerve regeneration after sciatic nerve transection in rats
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| Zeitschriftentitel: | Journal of Cellular and Molecular Medicine |
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| Personen und Körperschaften: | , , , , , , , , , , |
| In: | Journal of Cellular and Molecular Medicine, 23, 2019, 4, S. 2822-2835 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Ma, Yongbin Dong, Liyang Zhou, Dan Li, Li Zhang, Wenzhe Zhen, Yu Wang, Ting Su, Jianhua Chen, Deyu Mao, Chaoming Wang, Xuefeng Ma, Yongbin Dong, Liyang Zhou, Dan Li, Li Zhang, Wenzhe Zhen, Yu Wang, Ting Su, Jianhua Chen, Deyu Mao, Chaoming Wang, Xuefeng |
|---|---|
| author |
Ma, Yongbin Dong, Liyang Zhou, Dan Li, Li Zhang, Wenzhe Zhen, Yu Wang, Ting Su, Jianhua Chen, Deyu Mao, Chaoming Wang, Xuefeng |
| spellingShingle |
Ma, Yongbin Dong, Liyang Zhou, Dan Li, Li Zhang, Wenzhe Zhen, Yu Wang, Ting Su, Jianhua Chen, Deyu Mao, Chaoming Wang, Xuefeng Journal of Cellular and Molecular Medicine Extracellular vesicles from human umbilical cord mesenchymal stem cells improve nerve regeneration after sciatic nerve transection in rats Cell Biology Molecular Medicine |
| author_sort |
ma, yongbin |
| spelling |
Ma, Yongbin Dong, Liyang Zhou, Dan Li, Li Zhang, Wenzhe Zhen, Yu Wang, Ting Su, Jianhua Chen, Deyu Mao, Chaoming Wang, Xuefeng 1582-1838 1582-4934 Wiley Cell Biology Molecular Medicine http://dx.doi.org/10.1111/jcmm.14190 <jats:title>Abstract</jats:title><jats:p>Peripheral nerve injury results in limited nerve regeneration and severe functional impairment. Mesenchymal stem cells (MSCs) are a remarkable tool for peripheral nerve regeneration. The involvement of human umbilical cord MSC‐derived extracellular vesicles (hUCMSC‐EVs) in peripheral nerve regeneration, however, remains unknown. In this study, we evaluated functional recovery and nerve regeneration in rats that received hUCMSC‐EV treatment after nerve transection. We observed that hUCMSC‐EV treatment promoted the recovery of motor function and the regeneration of axons; increased the sciatic functional index; resulted in the generation of numerous axons and of several Schwann cells that surrounded individual axons; and attenuated the atrophy of the gastrocnemius muscle. hUCMSC‐EVs aggregated to rat nerve defects, down‐regulated interleukin (IL)‐6 and IL‐1β, up‐regulated IL‐10 and modulated inflammation in the injured nerve. These effects likely contributed to the promotion of nerve regeneration. Our findings indicate that hUCMSC‐EVs can improve functional recovery and nerve regeneration by providing a favourable microenvironment for nerve regeneration. Thus, hUCMSC‐EVs have considerable potential for application in the treatment of peripheral nerve injury.</jats:p> Extracellular vesicles from human umbilical cord mesenchymal stem cells improve nerve regeneration after sciatic nerve transection in rats Journal of Cellular and Molecular Medicine |
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| title |
Extracellular vesicles from human umbilical cord mesenchymal stem cells improve nerve regeneration after sciatic nerve transection in rats |
| title_unstemmed |
Extracellular vesicles from human umbilical cord mesenchymal stem cells improve nerve regeneration after sciatic nerve transection in rats |
| title_full |
Extracellular vesicles from human umbilical cord mesenchymal stem cells improve nerve regeneration after sciatic nerve transection in rats |
| title_fullStr |
Extracellular vesicles from human umbilical cord mesenchymal stem cells improve nerve regeneration after sciatic nerve transection in rats |
| title_full_unstemmed |
Extracellular vesicles from human umbilical cord mesenchymal stem cells improve nerve regeneration after sciatic nerve transection in rats |
| title_short |
Extracellular vesicles from human umbilical cord mesenchymal stem cells improve nerve regeneration after sciatic nerve transection in rats |
| title_sort |
extracellular vesicles from human umbilical cord mesenchymal stem cells improve nerve regeneration after sciatic nerve transection in rats |
| topic |
Cell Biology Molecular Medicine |
| url |
http://dx.doi.org/10.1111/jcmm.14190 |
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2019 |
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2822-2835 |
| description |
<jats:title>Abstract</jats:title><jats:p>Peripheral nerve injury results in limited nerve regeneration and severe functional impairment. Mesenchymal stem cells (MSCs) are a remarkable tool for peripheral nerve regeneration. The involvement of human umbilical cord MSC‐derived extracellular vesicles (hUCMSC‐EVs) in peripheral nerve regeneration, however, remains unknown. In this study, we evaluated functional recovery and nerve regeneration in rats that received hUCMSC‐EV treatment after nerve transection. We observed that hUCMSC‐EV treatment promoted the recovery of motor function and the regeneration of axons; increased the sciatic functional index; resulted in the generation of numerous axons and of several Schwann cells that surrounded individual axons; and attenuated the atrophy of the gastrocnemius muscle. hUCMSC‐EVs aggregated to rat nerve defects, down‐regulated interleukin (IL)‐6 and IL‐1β, up‐regulated IL‐10 and modulated inflammation in the injured nerve. These effects likely contributed to the promotion of nerve regeneration. Our findings indicate that hUCMSC‐EVs can improve functional recovery and nerve regeneration by providing a favourable microenvironment for nerve regeneration. Thus, hUCMSC‐EVs have considerable potential for application in the treatment of peripheral nerve injury.</jats:p> |
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| author | Ma, Yongbin, Dong, Liyang, Zhou, Dan, Li, Li, Zhang, Wenzhe, Zhen, Yu, Wang, Ting, Su, Jianhua, Chen, Deyu, Mao, Chaoming, Wang, Xuefeng |
| author_facet | Ma, Yongbin, Dong, Liyang, Zhou, Dan, Li, Li, Zhang, Wenzhe, Zhen, Yu, Wang, Ting, Su, Jianhua, Chen, Deyu, Mao, Chaoming, Wang, Xuefeng, Ma, Yongbin, Dong, Liyang, Zhou, Dan, Li, Li, Zhang, Wenzhe, Zhen, Yu, Wang, Ting, Su, Jianhua, Chen, Deyu, Mao, Chaoming, Wang, Xuefeng |
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| description | <jats:title>Abstract</jats:title><jats:p>Peripheral nerve injury results in limited nerve regeneration and severe functional impairment. Mesenchymal stem cells (MSCs) are a remarkable tool for peripheral nerve regeneration. The involvement of human umbilical cord MSC‐derived extracellular vesicles (hUCMSC‐EVs) in peripheral nerve regeneration, however, remains unknown. In this study, we evaluated functional recovery and nerve regeneration in rats that received hUCMSC‐EV treatment after nerve transection. We observed that hUCMSC‐EV treatment promoted the recovery of motor function and the regeneration of axons; increased the sciatic functional index; resulted in the generation of numerous axons and of several Schwann cells that surrounded individual axons; and attenuated the atrophy of the gastrocnemius muscle. hUCMSC‐EVs aggregated to rat nerve defects, down‐regulated interleukin (IL)‐6 and IL‐1β, up‐regulated IL‐10 and modulated inflammation in the injured nerve. These effects likely contributed to the promotion of nerve regeneration. Our findings indicate that hUCMSC‐EVs can improve functional recovery and nerve regeneration by providing a favourable microenvironment for nerve regeneration. Thus, hUCMSC‐EVs have considerable potential for application in the treatment of peripheral nerve injury.</jats:p> |
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| spelling | Ma, Yongbin Dong, Liyang Zhou, Dan Li, Li Zhang, Wenzhe Zhen, Yu Wang, Ting Su, Jianhua Chen, Deyu Mao, Chaoming Wang, Xuefeng 1582-1838 1582-4934 Wiley Cell Biology Molecular Medicine http://dx.doi.org/10.1111/jcmm.14190 <jats:title>Abstract</jats:title><jats:p>Peripheral nerve injury results in limited nerve regeneration and severe functional impairment. Mesenchymal stem cells (MSCs) are a remarkable tool for peripheral nerve regeneration. The involvement of human umbilical cord MSC‐derived extracellular vesicles (hUCMSC‐EVs) in peripheral nerve regeneration, however, remains unknown. In this study, we evaluated functional recovery and nerve regeneration in rats that received hUCMSC‐EV treatment after nerve transection. We observed that hUCMSC‐EV treatment promoted the recovery of motor function and the regeneration of axons; increased the sciatic functional index; resulted in the generation of numerous axons and of several Schwann cells that surrounded individual axons; and attenuated the atrophy of the gastrocnemius muscle. hUCMSC‐EVs aggregated to rat nerve defects, down‐regulated interleukin (IL)‐6 and IL‐1β, up‐regulated IL‐10 and modulated inflammation in the injured nerve. These effects likely contributed to the promotion of nerve regeneration. Our findings indicate that hUCMSC‐EVs can improve functional recovery and nerve regeneration by providing a favourable microenvironment for nerve regeneration. Thus, hUCMSC‐EVs have considerable potential for application in the treatment of peripheral nerve injury.</jats:p> Extracellular vesicles from human umbilical cord mesenchymal stem cells improve nerve regeneration after sciatic nerve transection in rats Journal of Cellular and Molecular Medicine |
| spellingShingle | Ma, Yongbin, Dong, Liyang, Zhou, Dan, Li, Li, Zhang, Wenzhe, Zhen, Yu, Wang, Ting, Su, Jianhua, Chen, Deyu, Mao, Chaoming, Wang, Xuefeng, Journal of Cellular and Molecular Medicine, Extracellular vesicles from human umbilical cord mesenchymal stem cells improve nerve regeneration after sciatic nerve transection in rats, Cell Biology, Molecular Medicine |
| title | Extracellular vesicles from human umbilical cord mesenchymal stem cells improve nerve regeneration after sciatic nerve transection in rats |
| title_full | Extracellular vesicles from human umbilical cord mesenchymal stem cells improve nerve regeneration after sciatic nerve transection in rats |
| title_fullStr | Extracellular vesicles from human umbilical cord mesenchymal stem cells improve nerve regeneration after sciatic nerve transection in rats |
| title_full_unstemmed | Extracellular vesicles from human umbilical cord mesenchymal stem cells improve nerve regeneration after sciatic nerve transection in rats |
| title_short | Extracellular vesicles from human umbilical cord mesenchymal stem cells improve nerve regeneration after sciatic nerve transection in rats |
| title_sort | extracellular vesicles from human umbilical cord mesenchymal stem cells improve nerve regeneration after sciatic nerve transection in rats |
| title_unstemmed | Extracellular vesicles from human umbilical cord mesenchymal stem cells improve nerve regeneration after sciatic nerve transection in rats |
| topic | Cell Biology, Molecular Medicine |
| url | http://dx.doi.org/10.1111/jcmm.14190 |