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Novel peptide dermaseptin‐PS1 exhibits anticancer activity via induction of intrinsic apoptosis signalling
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| Zeitschriftentitel: | Journal of Cellular and Molecular Medicine |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | Journal of Cellular and Molecular Medicine, 23, 2019, 2, S. 1300-1312 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Long, Qilin Li, Lei Wang, Hao Li, Miaoran Wang, Lei Zhou, Mei Su, Qiaozhu Chen, Tianbao Wu, Yuxin Long, Qilin Li, Lei Wang, Hao Li, Miaoran Wang, Lei Zhou, Mei Su, Qiaozhu Chen, Tianbao Wu, Yuxin |
|---|---|
| author |
Long, Qilin Li, Lei Wang, Hao Li, Miaoran Wang, Lei Zhou, Mei Su, Qiaozhu Chen, Tianbao Wu, Yuxin |
| spellingShingle |
Long, Qilin Li, Lei Wang, Hao Li, Miaoran Wang, Lei Zhou, Mei Su, Qiaozhu Chen, Tianbao Wu, Yuxin Journal of Cellular and Molecular Medicine Novel peptide dermaseptin‐PS1 exhibits anticancer activity via induction of intrinsic apoptosis signalling Cell Biology Molecular Medicine |
| author_sort |
long, qilin |
| spelling |
Long, Qilin Li, Lei Wang, Hao Li, Miaoran Wang, Lei Zhou, Mei Su, Qiaozhu Chen, Tianbao Wu, Yuxin 1582-1838 1582-4934 Wiley Cell Biology Molecular Medicine http://dx.doi.org/10.1111/jcmm.14032 <jats:title>Abstract</jats:title><jats:p>Antimicrobial peptides (<jats:styled-content style="fixed-case">AMP</jats:styled-content>) secreted by the granular glands of frog skin have been widely reported to exhibit strong bacteriostatic and bactericidal activities. Many of them have been documented with potent antiproliferative effects on multiple cancer cells, many studies also suggested that <jats:styled-content style="fixed-case">AMP</jats:styled-content>s exert their functions via disrupting cell membranes. However, whether and how other cell death induction mechanism is involved in mammalian cancer cells has rarely been investigated. In this study, a novel <jats:styled-content style="fixed-case">AMP</jats:styled-content> named Dermaseptin‐<jats:styled-content style="fixed-case">PS</jats:styled-content>1 was isolated and identified from <jats:italic>Phyllomedusa sauvagei</jats:italic>, it showed strong antimicrobial activities against three types of microorganisms. In vitro antiproliferative studies on human glioblastoma U‐251 <jats:styled-content style="fixed-case">MG</jats:styled-content> cells indicated that Dermaseptin‐<jats:styled-content style="fixed-case">PS</jats:styled-content>1 disrupted cell membranes at the concentrations of 10<jats:sup>−5</jats:sup> M and above, while the cell membrane integrity was not affected when concentrations were decreased to 10<jats:sup>−6</jats:sup> M or lower. Further examinations revealed that, at the relatively low concentration (10<jats:sup>−6</jats:sup> M), Dermaseptin‐<jats:styled-content style="fixed-case">PS</jats:styled-content>1 induced apoptosis through mitochondrial‐related signal pathway in U‐251 <jats:styled-content style="fixed-case">MG</jats:styled-content> cells. Thus, for the first time, we report a novel frog skin derived <jats:styled-content style="fixed-case">AMP</jats:styled-content> with anticancer property by distinct mechanisms, which largely depends on its concentration. Together, our study provides new insights into the mechanism‐illustrated drug design and the optimisation of dose control for cancer treatment in clinic.</jats:p> Novel peptide dermaseptin‐<scp>PS</scp>1 exhibits anticancer activity via induction of intrinsic apoptosis signalling Journal of Cellular and Molecular Medicine |
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| title |
Novel peptide dermaseptin‐PS1 exhibits anticancer activity via induction of intrinsic apoptosis signalling |
| title_unstemmed |
Novel peptide dermaseptin‐PS1 exhibits anticancer activity via induction of intrinsic apoptosis signalling |
| title_full |
Novel peptide dermaseptin‐PS1 exhibits anticancer activity via induction of intrinsic apoptosis signalling |
| title_fullStr |
Novel peptide dermaseptin‐PS1 exhibits anticancer activity via induction of intrinsic apoptosis signalling |
| title_full_unstemmed |
Novel peptide dermaseptin‐PS1 exhibits anticancer activity via induction of intrinsic apoptosis signalling |
| title_short |
Novel peptide dermaseptin‐PS1 exhibits anticancer activity via induction of intrinsic apoptosis signalling |
| title_sort |
novel peptide dermaseptin‐<scp>ps</scp>1 exhibits anticancer activity via induction of intrinsic apoptosis signalling |
| topic |
Cell Biology Molecular Medicine |
| url |
http://dx.doi.org/10.1111/jcmm.14032 |
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2019 |
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1300-1312 |
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<jats:title>Abstract</jats:title><jats:p>Antimicrobial peptides (<jats:styled-content style="fixed-case">AMP</jats:styled-content>) secreted by the granular glands of frog skin have been widely reported to exhibit strong bacteriostatic and bactericidal activities. Many of them have been documented with potent antiproliferative effects on multiple cancer cells, many studies also suggested that <jats:styled-content style="fixed-case">AMP</jats:styled-content>s exert their functions via disrupting cell membranes. However, whether and how other cell death induction mechanism is involved in mammalian cancer cells has rarely been investigated. In this study, a novel <jats:styled-content style="fixed-case">AMP</jats:styled-content> named Dermaseptin‐<jats:styled-content style="fixed-case">PS</jats:styled-content>1 was isolated and identified from <jats:italic>Phyllomedusa sauvagei</jats:italic>, it showed strong antimicrobial activities against three types of microorganisms. In vitro antiproliferative studies on human glioblastoma U‐251 <jats:styled-content style="fixed-case">MG</jats:styled-content> cells indicated that Dermaseptin‐<jats:styled-content style="fixed-case">PS</jats:styled-content>1 disrupted cell membranes at the concentrations of 10<jats:sup>−5</jats:sup> M and above, while the cell membrane integrity was not affected when concentrations were decreased to 10<jats:sup>−6</jats:sup> M or lower. Further examinations revealed that, at the relatively low concentration (10<jats:sup>−6</jats:sup> M), Dermaseptin‐<jats:styled-content style="fixed-case">PS</jats:styled-content>1 induced apoptosis through mitochondrial‐related signal pathway in U‐251 <jats:styled-content style="fixed-case">MG</jats:styled-content> cells. Thus, for the first time, we report a novel frog skin derived <jats:styled-content style="fixed-case">AMP</jats:styled-content> with anticancer property by distinct mechanisms, which largely depends on its concentration. Together, our study provides new insights into the mechanism‐illustrated drug design and the optimisation of dose control for cancer treatment in clinic.</jats:p> |
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| author | Long, Qilin, Li, Lei, Wang, Hao, Li, Miaoran, Wang, Lei, Zhou, Mei, Su, Qiaozhu, Chen, Tianbao, Wu, Yuxin |
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| description | <jats:title>Abstract</jats:title><jats:p>Antimicrobial peptides (<jats:styled-content style="fixed-case">AMP</jats:styled-content>) secreted by the granular glands of frog skin have been widely reported to exhibit strong bacteriostatic and bactericidal activities. Many of them have been documented with potent antiproliferative effects on multiple cancer cells, many studies also suggested that <jats:styled-content style="fixed-case">AMP</jats:styled-content>s exert their functions via disrupting cell membranes. However, whether and how other cell death induction mechanism is involved in mammalian cancer cells has rarely been investigated. In this study, a novel <jats:styled-content style="fixed-case">AMP</jats:styled-content> named Dermaseptin‐<jats:styled-content style="fixed-case">PS</jats:styled-content>1 was isolated and identified from <jats:italic>Phyllomedusa sauvagei</jats:italic>, it showed strong antimicrobial activities against three types of microorganisms. In vitro antiproliferative studies on human glioblastoma U‐251 <jats:styled-content style="fixed-case">MG</jats:styled-content> cells indicated that Dermaseptin‐<jats:styled-content style="fixed-case">PS</jats:styled-content>1 disrupted cell membranes at the concentrations of 10<jats:sup>−5</jats:sup> M and above, while the cell membrane integrity was not affected when concentrations were decreased to 10<jats:sup>−6</jats:sup> M or lower. Further examinations revealed that, at the relatively low concentration (10<jats:sup>−6</jats:sup> M), Dermaseptin‐<jats:styled-content style="fixed-case">PS</jats:styled-content>1 induced apoptosis through mitochondrial‐related signal pathway in U‐251 <jats:styled-content style="fixed-case">MG</jats:styled-content> cells. Thus, for the first time, we report a novel frog skin derived <jats:styled-content style="fixed-case">AMP</jats:styled-content> with anticancer property by distinct mechanisms, which largely depends on its concentration. Together, our study provides new insights into the mechanism‐illustrated drug design and the optimisation of dose control for cancer treatment in clinic.</jats:p> |
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| spelling | Long, Qilin Li, Lei Wang, Hao Li, Miaoran Wang, Lei Zhou, Mei Su, Qiaozhu Chen, Tianbao Wu, Yuxin 1582-1838 1582-4934 Wiley Cell Biology Molecular Medicine http://dx.doi.org/10.1111/jcmm.14032 <jats:title>Abstract</jats:title><jats:p>Antimicrobial peptides (<jats:styled-content style="fixed-case">AMP</jats:styled-content>) secreted by the granular glands of frog skin have been widely reported to exhibit strong bacteriostatic and bactericidal activities. Many of them have been documented with potent antiproliferative effects on multiple cancer cells, many studies also suggested that <jats:styled-content style="fixed-case">AMP</jats:styled-content>s exert their functions via disrupting cell membranes. However, whether and how other cell death induction mechanism is involved in mammalian cancer cells has rarely been investigated. In this study, a novel <jats:styled-content style="fixed-case">AMP</jats:styled-content> named Dermaseptin‐<jats:styled-content style="fixed-case">PS</jats:styled-content>1 was isolated and identified from <jats:italic>Phyllomedusa sauvagei</jats:italic>, it showed strong antimicrobial activities against three types of microorganisms. In vitro antiproliferative studies on human glioblastoma U‐251 <jats:styled-content style="fixed-case">MG</jats:styled-content> cells indicated that Dermaseptin‐<jats:styled-content style="fixed-case">PS</jats:styled-content>1 disrupted cell membranes at the concentrations of 10<jats:sup>−5</jats:sup> M and above, while the cell membrane integrity was not affected when concentrations were decreased to 10<jats:sup>−6</jats:sup> M or lower. Further examinations revealed that, at the relatively low concentration (10<jats:sup>−6</jats:sup> M), Dermaseptin‐<jats:styled-content style="fixed-case">PS</jats:styled-content>1 induced apoptosis through mitochondrial‐related signal pathway in U‐251 <jats:styled-content style="fixed-case">MG</jats:styled-content> cells. Thus, for the first time, we report a novel frog skin derived <jats:styled-content style="fixed-case">AMP</jats:styled-content> with anticancer property by distinct mechanisms, which largely depends on its concentration. Together, our study provides new insights into the mechanism‐illustrated drug design and the optimisation of dose control for cancer treatment in clinic.</jats:p> Novel peptide dermaseptin‐<scp>PS</scp>1 exhibits anticancer activity via induction of intrinsic apoptosis signalling Journal of Cellular and Molecular Medicine |
| spellingShingle | Long, Qilin, Li, Lei, Wang, Hao, Li, Miaoran, Wang, Lei, Zhou, Mei, Su, Qiaozhu, Chen, Tianbao, Wu, Yuxin, Journal of Cellular and Molecular Medicine, Novel peptide dermaseptin‐PS1 exhibits anticancer activity via induction of intrinsic apoptosis signalling, Cell Biology, Molecular Medicine |
| title | Novel peptide dermaseptin‐PS1 exhibits anticancer activity via induction of intrinsic apoptosis signalling |
| title_full | Novel peptide dermaseptin‐PS1 exhibits anticancer activity via induction of intrinsic apoptosis signalling |
| title_fullStr | Novel peptide dermaseptin‐PS1 exhibits anticancer activity via induction of intrinsic apoptosis signalling |
| title_full_unstemmed | Novel peptide dermaseptin‐PS1 exhibits anticancer activity via induction of intrinsic apoptosis signalling |
| title_short | Novel peptide dermaseptin‐PS1 exhibits anticancer activity via induction of intrinsic apoptosis signalling |
| title_sort | novel peptide dermaseptin‐<scp>ps</scp>1 exhibits anticancer activity via induction of intrinsic apoptosis signalling |
| title_unstemmed | Novel peptide dermaseptin‐PS1 exhibits anticancer activity via induction of intrinsic apoptosis signalling |
| topic | Cell Biology, Molecular Medicine |
| url | http://dx.doi.org/10.1111/jcmm.14032 |