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The variation of the novel allele HLA‐B*0739 suggests low alloreactivity when mismatched with HLA‐B*0702
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| Zeitschriftentitel: | Tissue Antigens |
|---|---|
| Personen und Körperschaften: | , |
| In: | Tissue Antigens, 66, 2005, 1, S. 56-57 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Horn, P.A. Blasczyk, R. Horn, P.A. Blasczyk, R. |
|---|---|
| author |
Horn, P.A. Blasczyk, R. |
| spellingShingle |
Horn, P.A. Blasczyk, R. Tissue Antigens The variation of the novel allele HLA‐B*0739 suggests low alloreactivity when mismatched with HLA‐B*0702 Genetics Biochemistry Immunology General Medicine Immunology and Allergy |
| author_sort |
horn, p.a. |
| spelling |
Horn, P.A. Blasczyk, R. 0001-2815 1399-0039 Wiley Genetics Biochemistry Immunology General Medicine Immunology and Allergy http://dx.doi.org/10.1111/j.1399-0039.2005.00422.x <jats:p><jats:bold>Abstract: </jats:bold> We here report the identification of a new HLA‐B*07 allele in a male Caucasian. The new allele was initially typed as B*0713 by sequence‐specific primed PCR. Because of the infrequence of that allele, a sequencing‐based typing was performed to confirm that result. This yielded the detection of the novel allele. It is closest to B*070201, while it differs from B*0713 in 12 positions in exon 2. Compared to B*070201, the new variant is characterized by a non‐synonymous nucleotide exchange (C→T) at nucleotide position 118 of exon 2. Previously, this was considered a constant position, suggesting that it is likely to be caused by a single‐point mutation. It results in the amino acid exchange Ala→Val at position 40 of the mature polypeptide. As this position is located in an outer loop of the HLA molecule, it is highly unlikely to affect peptide binding or T‐cell receptor interaction. Thus, the newly found allele should have a low alloreactive potential in case of a mismatch to the most common HLA‐B allele B*0702.</jats:p> The variation of the novel allele HLA‐B*0739 suggests low alloreactivity when mismatched with HLA‐B*0702 Tissue Antigens |
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| title |
The variation of the novel allele HLA‐B*0739 suggests low alloreactivity when mismatched with HLA‐B*0702 |
| title_unstemmed |
The variation of the novel allele HLA‐B*0739 suggests low alloreactivity when mismatched with HLA‐B*0702 |
| title_full |
The variation of the novel allele HLA‐B*0739 suggests low alloreactivity when mismatched with HLA‐B*0702 |
| title_fullStr |
The variation of the novel allele HLA‐B*0739 suggests low alloreactivity when mismatched with HLA‐B*0702 |
| title_full_unstemmed |
The variation of the novel allele HLA‐B*0739 suggests low alloreactivity when mismatched with HLA‐B*0702 |
| title_short |
The variation of the novel allele HLA‐B*0739 suggests low alloreactivity when mismatched with HLA‐B*0702 |
| title_sort |
the variation of the novel allele hla‐b*0739 suggests low alloreactivity when mismatched with hla‐b*0702 |
| topic |
Genetics Biochemistry Immunology General Medicine Immunology and Allergy |
| url |
http://dx.doi.org/10.1111/j.1399-0039.2005.00422.x |
| publishDate |
2005 |
| physical |
56-57 |
| description |
<jats:p><jats:bold>Abstract: </jats:bold> We here report the identification of a new HLA‐B*07 allele in a male Caucasian. The new allele was initially typed as B*0713 by sequence‐specific primed PCR. Because of the infrequence of that allele, a sequencing‐based typing was performed to confirm that result. This yielded the detection of the novel allele. It is closest to B*070201, while it differs from B*0713 in 12 positions in exon 2. Compared to B*070201, the new variant is characterized by a non‐synonymous nucleotide exchange (C→T) at nucleotide position 118 of exon 2. Previously, this was considered a constant position, suggesting that it is likely to be caused by a single‐point mutation. It results in the amino acid exchange Ala→Val at position 40 of the mature polypeptide. As this position is located in an outer loop of the HLA molecule, it is highly unlikely to affect peptide binding or T‐cell receptor interaction. Thus, the newly found allele should have a low alloreactive potential in case of a mismatch to the most common HLA‐B allele B*0702.</jats:p> |
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| description | <jats:p><jats:bold>Abstract: </jats:bold> We here report the identification of a new HLA‐B*07 allele in a male Caucasian. The new allele was initially typed as B*0713 by sequence‐specific primed PCR. Because of the infrequence of that allele, a sequencing‐based typing was performed to confirm that result. This yielded the detection of the novel allele. It is closest to B*070201, while it differs from B*0713 in 12 positions in exon 2. Compared to B*070201, the new variant is characterized by a non‐synonymous nucleotide exchange (C→T) at nucleotide position 118 of exon 2. Previously, this was considered a constant position, suggesting that it is likely to be caused by a single‐point mutation. It results in the amino acid exchange Ala→Val at position 40 of the mature polypeptide. As this position is located in an outer loop of the HLA molecule, it is highly unlikely to affect peptide binding or T‐cell receptor interaction. Thus, the newly found allele should have a low alloreactive potential in case of a mismatch to the most common HLA‐B allele B*0702.</jats:p> |
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| spelling | Horn, P.A. Blasczyk, R. 0001-2815 1399-0039 Wiley Genetics Biochemistry Immunology General Medicine Immunology and Allergy http://dx.doi.org/10.1111/j.1399-0039.2005.00422.x <jats:p><jats:bold>Abstract: </jats:bold> We here report the identification of a new HLA‐B*07 allele in a male Caucasian. The new allele was initially typed as B*0713 by sequence‐specific primed PCR. Because of the infrequence of that allele, a sequencing‐based typing was performed to confirm that result. This yielded the detection of the novel allele. It is closest to B*070201, while it differs from B*0713 in 12 positions in exon 2. Compared to B*070201, the new variant is characterized by a non‐synonymous nucleotide exchange (C→T) at nucleotide position 118 of exon 2. Previously, this was considered a constant position, suggesting that it is likely to be caused by a single‐point mutation. It results in the amino acid exchange Ala→Val at position 40 of the mature polypeptide. As this position is located in an outer loop of the HLA molecule, it is highly unlikely to affect peptide binding or T‐cell receptor interaction. Thus, the newly found allele should have a low alloreactive potential in case of a mismatch to the most common HLA‐B allele B*0702.</jats:p> The variation of the novel allele HLA‐B*0739 suggests low alloreactivity when mismatched with HLA‐B*0702 Tissue Antigens |
| spellingShingle | Horn, P.A., Blasczyk, R., Tissue Antigens, The variation of the novel allele HLA‐B*0739 suggests low alloreactivity when mismatched with HLA‐B*0702, Genetics, Biochemistry, Immunology, General Medicine, Immunology and Allergy |
| title | The variation of the novel allele HLA‐B*0739 suggests low alloreactivity when mismatched with HLA‐B*0702 |
| title_full | The variation of the novel allele HLA‐B*0739 suggests low alloreactivity when mismatched with HLA‐B*0702 |
| title_fullStr | The variation of the novel allele HLA‐B*0739 suggests low alloreactivity when mismatched with HLA‐B*0702 |
| title_full_unstemmed | The variation of the novel allele HLA‐B*0739 suggests low alloreactivity when mismatched with HLA‐B*0702 |
| title_short | The variation of the novel allele HLA‐B*0739 suggests low alloreactivity when mismatched with HLA‐B*0702 |
| title_sort | the variation of the novel allele hla‐b*0739 suggests low alloreactivity when mismatched with hla‐b*0702 |
| title_unstemmed | The variation of the novel allele HLA‐B*0739 suggests low alloreactivity when mismatched with HLA‐B*0702 |
| topic | Genetics, Biochemistry, Immunology, General Medicine, Immunology and Allergy |
| url | http://dx.doi.org/10.1111/j.1399-0039.2005.00422.x |