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Evaluation of the Microbicidal Activity and Cytokines/Chemokines Profile Released by Neutrophils from HTLV‐1‐Infected Individuals
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| Zeitschriftentitel: | Scandinavian Journal of Immunology |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Scandinavian Journal of Immunology, 74, 2011, 3, S. 310-317 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Bezerra, Caroline A. Cardoso, Thiago M. Giudice, Angela Porto, Aurélia F. Santos, Silvane B. Carvalho, Edgar M. Bacellar, Olívia Bezerra, Caroline A. Cardoso, Thiago M. Giudice, Angela Porto, Aurélia F. Santos, Silvane B. Carvalho, Edgar M. Bacellar, Olívia |
|---|---|
| author |
Bezerra, Caroline A. Cardoso, Thiago M. Giudice, Angela Porto, Aurélia F. Santos, Silvane B. Carvalho, Edgar M. Bacellar, Olívia |
| spellingShingle |
Bezerra, Caroline A. Cardoso, Thiago M. Giudice, Angela Porto, Aurélia F. Santos, Silvane B. Carvalho, Edgar M. Bacellar, Olívia Scandinavian Journal of Immunology Evaluation of the Microbicidal Activity and Cytokines/Chemokines Profile Released by Neutrophils from HTLV‐1‐Infected Individuals Immunology General Medicine |
| author_sort |
bezerra, caroline a. |
| spelling |
Bezerra, Caroline A. Cardoso, Thiago M. Giudice, Angela Porto, Aurélia F. Santos, Silvane B. Carvalho, Edgar M. Bacellar, Olívia 0300-9475 1365-3083 Wiley Immunology General Medicine http://dx.doi.org/10.1111/j.1365-3083.2011.02579.x <jats:title>Abstract</jats:title><jats:p>Human T cell lymphotropic virus type‐1 (HTLV‐1) induces activation and spontaneous proliferation of T cells with production of type‐1 pro‐inflammatory cytokines. It modifies the immune response to other antigens and increases susceptibility to infectious diseases. However, little is known about innate immunity in HTLV‐1 infection. HTLV‐1‐infected individuals have higher spontaneous neutrophil activation than HTLV‐1‐seronegative individuals, as shown by the nitroblue tetrazolium (NBT) assay. This study was conducted to evaluate neutrophil function in HTLV‐1‐infected individuals. Participants in the study included 18 HTLV‐1‐infected individuals and 14 HTLV‐1‐seronegative controls. We evaluated the ability of neutrophils (PMNs) to control a parasite infection, to produce peroxynitrite, cytokines and chemokines and to express activation markers in cultures when stimulated with LPS or infected with <jats:italic>Leishmania</jats:italic>. When compared with the control group, there was no difference in the percentage of PMNs infected with <jats:italic>Leishmania</jats:italic> or in the number of amastigotes/100 PMNs in HTLV‐1‐infected individuals. The microbicidal activity of the PMNs and the levels of CXCL8 and CCL4 released by these cells did not show a difference between HTLV‐1‐infected individuals and the control group. In both the HTLV‐1 group and the control group, infection with <jats:italic>Leishmania</jats:italic> or stimulation of PMNs led to cellular activation. These observations suggest that neutrophils from HTLV‐1‐infected individuals have preserved their ability to become activated and to produce chemokines and peroxynitrite after stimulation and that the susceptibility to infection by intracellular <jats:italic>Leishmania amazonensis</jats:italic> in HTLV‐1‐infected individuals does not depend on impairment of neutrophil function.</jats:p> Evaluation of the Microbicidal Activity and Cytokines/Chemokines Profile Released by Neutrophils from HTLV‐1‐Infected Individuals Scandinavian Journal of Immunology |
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| title |
Evaluation of the Microbicidal Activity and Cytokines/Chemokines Profile Released by Neutrophils from HTLV‐1‐Infected Individuals |
| title_unstemmed |
Evaluation of the Microbicidal Activity and Cytokines/Chemokines Profile Released by Neutrophils from HTLV‐1‐Infected Individuals |
| title_full |
Evaluation of the Microbicidal Activity and Cytokines/Chemokines Profile Released by Neutrophils from HTLV‐1‐Infected Individuals |
| title_fullStr |
Evaluation of the Microbicidal Activity and Cytokines/Chemokines Profile Released by Neutrophils from HTLV‐1‐Infected Individuals |
| title_full_unstemmed |
Evaluation of the Microbicidal Activity and Cytokines/Chemokines Profile Released by Neutrophils from HTLV‐1‐Infected Individuals |
| title_short |
Evaluation of the Microbicidal Activity and Cytokines/Chemokines Profile Released by Neutrophils from HTLV‐1‐Infected Individuals |
| title_sort |
evaluation of the microbicidal activity and cytokines/chemokines profile released by neutrophils from htlv‐1‐infected individuals |
| topic |
Immunology General Medicine |
| url |
http://dx.doi.org/10.1111/j.1365-3083.2011.02579.x |
| publishDate |
2011 |
| physical |
310-317 |
| description |
<jats:title>Abstract</jats:title><jats:p>Human T cell lymphotropic virus type‐1 (HTLV‐1) induces activation and spontaneous proliferation of T cells with production of type‐1 pro‐inflammatory cytokines. It modifies the immune response to other antigens and increases susceptibility to infectious diseases. However, little is known about innate immunity in HTLV‐1 infection. HTLV‐1‐infected individuals have higher spontaneous neutrophil activation than HTLV‐1‐seronegative individuals, as shown by the nitroblue tetrazolium (NBT) assay. This study was conducted to evaluate neutrophil function in HTLV‐1‐infected individuals. Participants in the study included 18 HTLV‐1‐infected individuals and 14 HTLV‐1‐seronegative controls. We evaluated the ability of neutrophils (PMNs) to control a parasite infection, to produce peroxynitrite, cytokines and chemokines and to express activation markers in cultures when stimulated with LPS or infected with <jats:italic>Leishmania</jats:italic>. When compared with the control group, there was no difference in the percentage of PMNs infected with <jats:italic>Leishmania</jats:italic> or in the number of amastigotes/100 PMNs in HTLV‐1‐infected individuals. The microbicidal activity of the PMNs and the levels of CXCL8 and CCL4 released by these cells did not show a difference between HTLV‐1‐infected individuals and the control group. In both the HTLV‐1 group and the control group, infection with <jats:italic>Leishmania</jats:italic> or stimulation of PMNs led to cellular activation. These observations suggest that neutrophils from HTLV‐1‐infected individuals have preserved their ability to become activated and to produce chemokines and peroxynitrite after stimulation and that the susceptibility to infection by intracellular <jats:italic>Leishmania amazonensis</jats:italic> in HTLV‐1‐infected individuals does not depend on impairment of neutrophil function.</jats:p> |
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| author | Bezerra, Caroline A., Cardoso, Thiago M., Giudice, Angela, Porto, Aurélia F., Santos, Silvane B., Carvalho, Edgar M., Bacellar, Olívia |
| author_facet | Bezerra, Caroline A., Cardoso, Thiago M., Giudice, Angela, Porto, Aurélia F., Santos, Silvane B., Carvalho, Edgar M., Bacellar, Olívia, Bezerra, Caroline A., Cardoso, Thiago M., Giudice, Angela, Porto, Aurélia F., Santos, Silvane B., Carvalho, Edgar M., Bacellar, Olívia |
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| description | <jats:title>Abstract</jats:title><jats:p>Human T cell lymphotropic virus type‐1 (HTLV‐1) induces activation and spontaneous proliferation of T cells with production of type‐1 pro‐inflammatory cytokines. It modifies the immune response to other antigens and increases susceptibility to infectious diseases. However, little is known about innate immunity in HTLV‐1 infection. HTLV‐1‐infected individuals have higher spontaneous neutrophil activation than HTLV‐1‐seronegative individuals, as shown by the nitroblue tetrazolium (NBT) assay. This study was conducted to evaluate neutrophil function in HTLV‐1‐infected individuals. Participants in the study included 18 HTLV‐1‐infected individuals and 14 HTLV‐1‐seronegative controls. We evaluated the ability of neutrophils (PMNs) to control a parasite infection, to produce peroxynitrite, cytokines and chemokines and to express activation markers in cultures when stimulated with LPS or infected with <jats:italic>Leishmania</jats:italic>. When compared with the control group, there was no difference in the percentage of PMNs infected with <jats:italic>Leishmania</jats:italic> or in the number of amastigotes/100 PMNs in HTLV‐1‐infected individuals. The microbicidal activity of the PMNs and the levels of CXCL8 and CCL4 released by these cells did not show a difference between HTLV‐1‐infected individuals and the control group. In both the HTLV‐1 group and the control group, infection with <jats:italic>Leishmania</jats:italic> or stimulation of PMNs led to cellular activation. These observations suggest that neutrophils from HTLV‐1‐infected individuals have preserved their ability to become activated and to produce chemokines and peroxynitrite after stimulation and that the susceptibility to infection by intracellular <jats:italic>Leishmania amazonensis</jats:italic> in HTLV‐1‐infected individuals does not depend on impairment of neutrophil function.</jats:p> |
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| institution | DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4 |
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| spelling | Bezerra, Caroline A. Cardoso, Thiago M. Giudice, Angela Porto, Aurélia F. Santos, Silvane B. Carvalho, Edgar M. Bacellar, Olívia 0300-9475 1365-3083 Wiley Immunology General Medicine http://dx.doi.org/10.1111/j.1365-3083.2011.02579.x <jats:title>Abstract</jats:title><jats:p>Human T cell lymphotropic virus type‐1 (HTLV‐1) induces activation and spontaneous proliferation of T cells with production of type‐1 pro‐inflammatory cytokines. It modifies the immune response to other antigens and increases susceptibility to infectious diseases. However, little is known about innate immunity in HTLV‐1 infection. HTLV‐1‐infected individuals have higher spontaneous neutrophil activation than HTLV‐1‐seronegative individuals, as shown by the nitroblue tetrazolium (NBT) assay. This study was conducted to evaluate neutrophil function in HTLV‐1‐infected individuals. Participants in the study included 18 HTLV‐1‐infected individuals and 14 HTLV‐1‐seronegative controls. We evaluated the ability of neutrophils (PMNs) to control a parasite infection, to produce peroxynitrite, cytokines and chemokines and to express activation markers in cultures when stimulated with LPS or infected with <jats:italic>Leishmania</jats:italic>. When compared with the control group, there was no difference in the percentage of PMNs infected with <jats:italic>Leishmania</jats:italic> or in the number of amastigotes/100 PMNs in HTLV‐1‐infected individuals. The microbicidal activity of the PMNs and the levels of CXCL8 and CCL4 released by these cells did not show a difference between HTLV‐1‐infected individuals and the control group. In both the HTLV‐1 group and the control group, infection with <jats:italic>Leishmania</jats:italic> or stimulation of PMNs led to cellular activation. These observations suggest that neutrophils from HTLV‐1‐infected individuals have preserved their ability to become activated and to produce chemokines and peroxynitrite after stimulation and that the susceptibility to infection by intracellular <jats:italic>Leishmania amazonensis</jats:italic> in HTLV‐1‐infected individuals does not depend on impairment of neutrophil function.</jats:p> Evaluation of the Microbicidal Activity and Cytokines/Chemokines Profile Released by Neutrophils from HTLV‐1‐Infected Individuals Scandinavian Journal of Immunology |
| spellingShingle | Bezerra, Caroline A., Cardoso, Thiago M., Giudice, Angela, Porto, Aurélia F., Santos, Silvane B., Carvalho, Edgar M., Bacellar, Olívia, Scandinavian Journal of Immunology, Evaluation of the Microbicidal Activity and Cytokines/Chemokines Profile Released by Neutrophils from HTLV‐1‐Infected Individuals, Immunology, General Medicine |
| title | Evaluation of the Microbicidal Activity and Cytokines/Chemokines Profile Released by Neutrophils from HTLV‐1‐Infected Individuals |
| title_full | Evaluation of the Microbicidal Activity and Cytokines/Chemokines Profile Released by Neutrophils from HTLV‐1‐Infected Individuals |
| title_fullStr | Evaluation of the Microbicidal Activity and Cytokines/Chemokines Profile Released by Neutrophils from HTLV‐1‐Infected Individuals |
| title_full_unstemmed | Evaluation of the Microbicidal Activity and Cytokines/Chemokines Profile Released by Neutrophils from HTLV‐1‐Infected Individuals |
| title_short | Evaluation of the Microbicidal Activity and Cytokines/Chemokines Profile Released by Neutrophils from HTLV‐1‐Infected Individuals |
| title_sort | evaluation of the microbicidal activity and cytokines/chemokines profile released by neutrophils from htlv‐1‐infected individuals |
| title_unstemmed | Evaluation of the Microbicidal Activity and Cytokines/Chemokines Profile Released by Neutrophils from HTLV‐1‐Infected Individuals |
| topic | Immunology, General Medicine |
| url | http://dx.doi.org/10.1111/j.1365-3083.2011.02579.x |