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MAdCAM‐1 is needed for diabetes development mediated by the T cell clone, BDC‐2·5
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| Zeitschriftentitel: | Immunology |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Immunology, 116, 2005, 4, S. 525-531 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Phillips, Jenny M. Haskins, Kathryn Cooke, Anne Phillips, Jenny M. Haskins, Kathryn Cooke, Anne |
|---|---|
| author |
Phillips, Jenny M. Haskins, Kathryn Cooke, Anne |
| spellingShingle |
Phillips, Jenny M. Haskins, Kathryn Cooke, Anne Immunology MAdCAM‐1 is needed for diabetes development mediated by the T cell clone, BDC‐2·5 Immunology Immunology and Allergy |
| author_sort |
phillips, jenny m. |
| spelling |
Phillips, Jenny M. Haskins, Kathryn Cooke, Anne 0019-2805 1365-2567 Wiley Immunology Immunology and Allergy http://dx.doi.org/10.1111/j.1365-2567.2005.02254.x <jats:title>Summary</jats:title><jats:p>The NOD‐derived islet‐reactive CD4<jats:sup>+</jats:sup> T cell clone, BDC‐2·5, is able to transfer diabetes to neonatal non‐obese diabetic (NOD) mice but is unable to transfer disease to either adult NOD or NOD <jats:italic>scid</jats:italic> recipients. Transfer of diabetes to adult recipients by BDC‐2·5 is only accomplished by cotransfer of CD8<jats:sup>+</jats:sup> T cells from a diabetic donor. To understand why this CD4<jats:sup>+</jats:sup> T cell clone is able to mediate diabetes in neonatal but not the adult recipients we examined the ability of the clone to traffic in the different recipients. Our studies showed that MAdCAM‐1 has a very different expression pattern in the neonatal and adult pancreas. Blockade of this addressin prevents the clone from transferring diabetes to neonatal mice, suggesting that the differential pancreatic expression of MAdCAM‐1 in neonatal and adult pancreas provides an explanation of the differences in diabetes development.</jats:p> MAdCAM‐1 is needed for diabetes development mediated by the T cell clone, BDC‐2·5 Immunology |
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MAdCAM‐1 is needed for diabetes development mediated by the T cell clone, BDC‐2·5 |
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MAdCAM‐1 is needed for diabetes development mediated by the T cell clone, BDC‐2·5 |
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MAdCAM‐1 is needed for diabetes development mediated by the T cell clone, BDC‐2·5 |
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MAdCAM‐1 is needed for diabetes development mediated by the T cell clone, BDC‐2·5 |
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MAdCAM‐1 is needed for diabetes development mediated by the T cell clone, BDC‐2·5 |
| title_short |
MAdCAM‐1 is needed for diabetes development mediated by the T cell clone, BDC‐2·5 |
| title_sort |
madcam‐1 is needed for diabetes development mediated by the t cell clone, bdc‐2·5 |
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Immunology Immunology and Allergy |
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http://dx.doi.org/10.1111/j.1365-2567.2005.02254.x |
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2005 |
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525-531 |
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<jats:title>Summary</jats:title><jats:p>The NOD‐derived islet‐reactive CD4<jats:sup>+</jats:sup> T cell clone, BDC‐2·5, is able to transfer diabetes to neonatal non‐obese diabetic (NOD) mice but is unable to transfer disease to either adult NOD or NOD <jats:italic>scid</jats:italic> recipients. Transfer of diabetes to adult recipients by BDC‐2·5 is only accomplished by cotransfer of CD8<jats:sup>+</jats:sup> T cells from a diabetic donor. To understand why this CD4<jats:sup>+</jats:sup> T cell clone is able to mediate diabetes in neonatal but not the adult recipients we examined the ability of the clone to traffic in the different recipients. Our studies showed that MAdCAM‐1 has a very different expression pattern in the neonatal and adult pancreas. Blockade of this addressin prevents the clone from transferring diabetes to neonatal mice, suggesting that the differential pancreatic expression of MAdCAM‐1 in neonatal and adult pancreas provides an explanation of the differences in diabetes development.</jats:p> |
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| author | Phillips, Jenny M., Haskins, Kathryn, Cooke, Anne |
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| description | <jats:title>Summary</jats:title><jats:p>The NOD‐derived islet‐reactive CD4<jats:sup>+</jats:sup> T cell clone, BDC‐2·5, is able to transfer diabetes to neonatal non‐obese diabetic (NOD) mice but is unable to transfer disease to either adult NOD or NOD <jats:italic>scid</jats:italic> recipients. Transfer of diabetes to adult recipients by BDC‐2·5 is only accomplished by cotransfer of CD8<jats:sup>+</jats:sup> T cells from a diabetic donor. To understand why this CD4<jats:sup>+</jats:sup> T cell clone is able to mediate diabetes in neonatal but not the adult recipients we examined the ability of the clone to traffic in the different recipients. Our studies showed that MAdCAM‐1 has a very different expression pattern in the neonatal and adult pancreas. Blockade of this addressin prevents the clone from transferring diabetes to neonatal mice, suggesting that the differential pancreatic expression of MAdCAM‐1 in neonatal and adult pancreas provides an explanation of the differences in diabetes development.</jats:p> |
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| institution | DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1 |
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| spelling | Phillips, Jenny M. Haskins, Kathryn Cooke, Anne 0019-2805 1365-2567 Wiley Immunology Immunology and Allergy http://dx.doi.org/10.1111/j.1365-2567.2005.02254.x <jats:title>Summary</jats:title><jats:p>The NOD‐derived islet‐reactive CD4<jats:sup>+</jats:sup> T cell clone, BDC‐2·5, is able to transfer diabetes to neonatal non‐obese diabetic (NOD) mice but is unable to transfer disease to either adult NOD or NOD <jats:italic>scid</jats:italic> recipients. Transfer of diabetes to adult recipients by BDC‐2·5 is only accomplished by cotransfer of CD8<jats:sup>+</jats:sup> T cells from a diabetic donor. To understand why this CD4<jats:sup>+</jats:sup> T cell clone is able to mediate diabetes in neonatal but not the adult recipients we examined the ability of the clone to traffic in the different recipients. Our studies showed that MAdCAM‐1 has a very different expression pattern in the neonatal and adult pancreas. Blockade of this addressin prevents the clone from transferring diabetes to neonatal mice, suggesting that the differential pancreatic expression of MAdCAM‐1 in neonatal and adult pancreas provides an explanation of the differences in diabetes development.</jats:p> MAdCAM‐1 is needed for diabetes development mediated by the T cell clone, BDC‐2·5 Immunology |
| spellingShingle | Phillips, Jenny M., Haskins, Kathryn, Cooke, Anne, Immunology, MAdCAM‐1 is needed for diabetes development mediated by the T cell clone, BDC‐2·5, Immunology, Immunology and Allergy |
| title | MAdCAM‐1 is needed for diabetes development mediated by the T cell clone, BDC‐2·5 |
| title_full | MAdCAM‐1 is needed for diabetes development mediated by the T cell clone, BDC‐2·5 |
| title_fullStr | MAdCAM‐1 is needed for diabetes development mediated by the T cell clone, BDC‐2·5 |
| title_full_unstemmed | MAdCAM‐1 is needed for diabetes development mediated by the T cell clone, BDC‐2·5 |
| title_short | MAdCAM‐1 is needed for diabetes development mediated by the T cell clone, BDC‐2·5 |
| title_sort | madcam‐1 is needed for diabetes development mediated by the t cell clone, bdc‐2·5 |
| title_unstemmed | MAdCAM‐1 is needed for diabetes development mediated by the T cell clone, BDC‐2·5 |
| topic | Immunology, Immunology and Allergy |
| url | http://dx.doi.org/10.1111/j.1365-2567.2005.02254.x |