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The presence and localization of onychodermis (specialized nail mesenchyme) containing onychofibroblasts in the nail unit: a morphological and immunohistochemical study
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| Zeitschriftentitel: | Histopathology |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Histopathology, 61, 2012, 1, S. 123-130 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Lee, Dong‐Youn Park, Ji‐Hye Shin, Hyun‐Tae Yang, Jun‐Mo Jang, Kee‐Taek Kwon, Ghee Young Lee, Kyung‐Hoon Shim, Jong Sup Lee, Dong‐Youn Park, Ji‐Hye Shin, Hyun‐Tae Yang, Jun‐Mo Jang, Kee‐Taek Kwon, Ghee Young Lee, Kyung‐Hoon Shim, Jong Sup |
|---|---|
| author |
Lee, Dong‐Youn Park, Ji‐Hye Shin, Hyun‐Tae Yang, Jun‐Mo Jang, Kee‐Taek Kwon, Ghee Young Lee, Kyung‐Hoon Shim, Jong Sup |
| spellingShingle |
Lee, Dong‐Youn Park, Ji‐Hye Shin, Hyun‐Tae Yang, Jun‐Mo Jang, Kee‐Taek Kwon, Ghee Young Lee, Kyung‐Hoon Shim, Jong Sup Histopathology The presence and localization of onychodermis (specialized nail mesenchyme) containing onychofibroblasts in the nail unit: a morphological and immunohistochemical study General Medicine Histology Pathology and Forensic Medicine |
| author_sort |
lee, dong‐youn |
| spelling |
Lee, Dong‐Youn Park, Ji‐Hye Shin, Hyun‐Tae Yang, Jun‐Mo Jang, Kee‐Taek Kwon, Ghee Young Lee, Kyung‐Hoon Shim, Jong Sup 0309-0167 1365-2559 Wiley General Medicine Histology Pathology and Forensic Medicine http://dx.doi.org/10.1111/j.1365-2559.2012.04210.x <jats:p>Lee D‐Y, Park J‐H, Shin H‐T, Yang J‐M, Jang K‐T, Kwon G Y, Lee K‐H & Shim J S (2012) <jats:italic>Histopathology</jats:italic> <jats:bold>61,</jats:bold> 123–130</jats:p><jats:p><jats:bold>The presence and localization of onychodermis (specialized nail mesenchyme) containing onychofibroblasts in the nail unit: a morphological and immunohistochemical study</jats:bold></jats:p><jats:p><jats:bold>Aims: </jats:bold> Due to its limited availability there has been very little research on the mesenchyme of the nail unit. Recently, we discovered specialized mesenchymal cells beneath the nail matrix and proposed to call them onychofibroblasts. The purpose of this study was to further delineate more precisely by histology and immunohistochemistry the specialized nail mesenchyme.</jats:p><jats:p><jats:bold>Methods and results: </jats:bold> Thirty supernumerary digits were obtained during operations to correct polydactyly. Longitudinal and transverse sections were obtained from formalin‐fixed paraffin‐embedded blocks. In sections stained with haematoxylin and eosin, a mesenchymal area that showed much more cellularity and less eosinophilic, loose connective tissue was identified beneath the nail matrix and nail bed. Using Alcian blue staining, mucin was detected in this mesenchymal area below the nail matrix and nail bed. Immnunohistochemically, CD10 and versican were expressed strongly in the mesenchyme containing onychofibroblasts under the nail matrix and nail bed.</jats:p><jats:p><jats:bold>Conclusions: </jats:bold> These results demonstrate the presence and localization of a specialized nail mesenchyme containing onychofibroblasts in a well‐defined area beneath the nail matrix and nail bed. Thus, we propose the term onychodermis for this specialized nail mesenchyme that is histologically and immunohistochemically distinct from the dermis of other parts of the nail unit.</jats:p> The presence and localization of onychodermis (specialized nail mesenchyme) containing onychofibroblasts in the nail unit: a morphological and immunohistochemical study Histopathology |
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| title |
The presence and localization of onychodermis (specialized nail mesenchyme) containing onychofibroblasts in the nail unit: a morphological and immunohistochemical study |
| title_unstemmed |
The presence and localization of onychodermis (specialized nail mesenchyme) containing onychofibroblasts in the nail unit: a morphological and immunohistochemical study |
| title_full |
The presence and localization of onychodermis (specialized nail mesenchyme) containing onychofibroblasts in the nail unit: a morphological and immunohistochemical study |
| title_fullStr |
The presence and localization of onychodermis (specialized nail mesenchyme) containing onychofibroblasts in the nail unit: a morphological and immunohistochemical study |
| title_full_unstemmed |
The presence and localization of onychodermis (specialized nail mesenchyme) containing onychofibroblasts in the nail unit: a morphological and immunohistochemical study |
| title_short |
The presence and localization of onychodermis (specialized nail mesenchyme) containing onychofibroblasts in the nail unit: a morphological and immunohistochemical study |
| title_sort |
the presence and localization of onychodermis (specialized nail mesenchyme) containing onychofibroblasts in the nail unit: a morphological and immunohistochemical study |
| topic |
General Medicine Histology Pathology and Forensic Medicine |
| url |
http://dx.doi.org/10.1111/j.1365-2559.2012.04210.x |
| publishDate |
2012 |
| physical |
123-130 |
| description |
<jats:p>Lee D‐Y, Park J‐H, Shin H‐T, Yang J‐M, Jang K‐T, Kwon G Y, Lee K‐H & Shim J S
(2012) <jats:italic>Histopathology</jats:italic> <jats:bold>61,</jats:bold> 123–130</jats:p><jats:p><jats:bold>The presence and localization of onychodermis (specialized nail mesenchyme) containing onychofibroblasts in the nail unit: a morphological and immunohistochemical study</jats:bold></jats:p><jats:p><jats:bold>Aims: </jats:bold> Due to its limited availability there has been very little research on the mesenchyme of the nail unit. Recently, we discovered specialized mesenchymal cells beneath the nail matrix and proposed to call them onychofibroblasts. The purpose of this study was to further delineate more precisely by histology and immunohistochemistry the specialized nail mesenchyme.</jats:p><jats:p><jats:bold>Methods and results: </jats:bold> Thirty supernumerary digits were obtained during operations to correct polydactyly. Longitudinal and transverse sections were obtained from formalin‐fixed paraffin‐embedded blocks. In sections stained with haematoxylin and eosin, a mesenchymal area that showed much more cellularity and less eosinophilic, loose connective tissue was identified beneath the nail matrix and nail bed. Using Alcian blue staining, mucin was detected in this mesenchymal area below the nail matrix and nail bed. Immnunohistochemically, CD10 and versican were expressed strongly in the mesenchyme containing onychofibroblasts under the nail matrix and nail bed.</jats:p><jats:p><jats:bold>Conclusions: </jats:bold> These results demonstrate the presence and localization of a specialized nail mesenchyme containing onychofibroblasts in a well‐defined area beneath the nail matrix and nail bed. Thus, we propose the term onychodermis for this specialized nail mesenchyme that is histologically and immunohistochemically distinct from the dermis of other parts of the nail unit.</jats:p> |
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| author | Lee, Dong‐Youn, Park, Ji‐Hye, Shin, Hyun‐Tae, Yang, Jun‐Mo, Jang, Kee‐Taek, Kwon, Ghee Young, Lee, Kyung‐Hoon, Shim, Jong Sup |
| author_facet | Lee, Dong‐Youn, Park, Ji‐Hye, Shin, Hyun‐Tae, Yang, Jun‐Mo, Jang, Kee‐Taek, Kwon, Ghee Young, Lee, Kyung‐Hoon, Shim, Jong Sup, Lee, Dong‐Youn, Park, Ji‐Hye, Shin, Hyun‐Tae, Yang, Jun‐Mo, Jang, Kee‐Taek, Kwon, Ghee Young, Lee, Kyung‐Hoon, Shim, Jong Sup |
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| description | <jats:p>Lee D‐Y, Park J‐H, Shin H‐T, Yang J‐M, Jang K‐T, Kwon G Y, Lee K‐H & Shim J S (2012) <jats:italic>Histopathology</jats:italic> <jats:bold>61,</jats:bold> 123–130</jats:p><jats:p><jats:bold>The presence and localization of onychodermis (specialized nail mesenchyme) containing onychofibroblasts in the nail unit: a morphological and immunohistochemical study</jats:bold></jats:p><jats:p><jats:bold>Aims: </jats:bold> Due to its limited availability there has been very little research on the mesenchyme of the nail unit. Recently, we discovered specialized mesenchymal cells beneath the nail matrix and proposed to call them onychofibroblasts. The purpose of this study was to further delineate more precisely by histology and immunohistochemistry the specialized nail mesenchyme.</jats:p><jats:p><jats:bold>Methods and results: </jats:bold> Thirty supernumerary digits were obtained during operations to correct polydactyly. Longitudinal and transverse sections were obtained from formalin‐fixed paraffin‐embedded blocks. In sections stained with haematoxylin and eosin, a mesenchymal area that showed much more cellularity and less eosinophilic, loose connective tissue was identified beneath the nail matrix and nail bed. Using Alcian blue staining, mucin was detected in this mesenchymal area below the nail matrix and nail bed. Immnunohistochemically, CD10 and versican were expressed strongly in the mesenchyme containing onychofibroblasts under the nail matrix and nail bed.</jats:p><jats:p><jats:bold>Conclusions: </jats:bold> These results demonstrate the presence and localization of a specialized nail mesenchyme containing onychofibroblasts in a well‐defined area beneath the nail matrix and nail bed. Thus, we propose the term onychodermis for this specialized nail mesenchyme that is histologically and immunohistochemically distinct from the dermis of other parts of the nail unit.</jats:p> |
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| spelling | Lee, Dong‐Youn Park, Ji‐Hye Shin, Hyun‐Tae Yang, Jun‐Mo Jang, Kee‐Taek Kwon, Ghee Young Lee, Kyung‐Hoon Shim, Jong Sup 0309-0167 1365-2559 Wiley General Medicine Histology Pathology and Forensic Medicine http://dx.doi.org/10.1111/j.1365-2559.2012.04210.x <jats:p>Lee D‐Y, Park J‐H, Shin H‐T, Yang J‐M, Jang K‐T, Kwon G Y, Lee K‐H & Shim J S (2012) <jats:italic>Histopathology</jats:italic> <jats:bold>61,</jats:bold> 123–130</jats:p><jats:p><jats:bold>The presence and localization of onychodermis (specialized nail mesenchyme) containing onychofibroblasts in the nail unit: a morphological and immunohistochemical study</jats:bold></jats:p><jats:p><jats:bold>Aims: </jats:bold> Due to its limited availability there has been very little research on the mesenchyme of the nail unit. Recently, we discovered specialized mesenchymal cells beneath the nail matrix and proposed to call them onychofibroblasts. The purpose of this study was to further delineate more precisely by histology and immunohistochemistry the specialized nail mesenchyme.</jats:p><jats:p><jats:bold>Methods and results: </jats:bold> Thirty supernumerary digits were obtained during operations to correct polydactyly. Longitudinal and transverse sections were obtained from formalin‐fixed paraffin‐embedded blocks. In sections stained with haematoxylin and eosin, a mesenchymal area that showed much more cellularity and less eosinophilic, loose connective tissue was identified beneath the nail matrix and nail bed. Using Alcian blue staining, mucin was detected in this mesenchymal area below the nail matrix and nail bed. Immnunohistochemically, CD10 and versican were expressed strongly in the mesenchyme containing onychofibroblasts under the nail matrix and nail bed.</jats:p><jats:p><jats:bold>Conclusions: </jats:bold> These results demonstrate the presence and localization of a specialized nail mesenchyme containing onychofibroblasts in a well‐defined area beneath the nail matrix and nail bed. Thus, we propose the term onychodermis for this specialized nail mesenchyme that is histologically and immunohistochemically distinct from the dermis of other parts of the nail unit.</jats:p> The presence and localization of onychodermis (specialized nail mesenchyme) containing onychofibroblasts in the nail unit: a morphological and immunohistochemical study Histopathology |
| spellingShingle | Lee, Dong‐Youn, Park, Ji‐Hye, Shin, Hyun‐Tae, Yang, Jun‐Mo, Jang, Kee‐Taek, Kwon, Ghee Young, Lee, Kyung‐Hoon, Shim, Jong Sup, Histopathology, The presence and localization of onychodermis (specialized nail mesenchyme) containing onychofibroblasts in the nail unit: a morphological and immunohistochemical study, General Medicine, Histology, Pathology and Forensic Medicine |
| title | The presence and localization of onychodermis (specialized nail mesenchyme) containing onychofibroblasts in the nail unit: a morphological and immunohistochemical study |
| title_full | The presence and localization of onychodermis (specialized nail mesenchyme) containing onychofibroblasts in the nail unit: a morphological and immunohistochemical study |
| title_fullStr | The presence and localization of onychodermis (specialized nail mesenchyme) containing onychofibroblasts in the nail unit: a morphological and immunohistochemical study |
| title_full_unstemmed | The presence and localization of onychodermis (specialized nail mesenchyme) containing onychofibroblasts in the nail unit: a morphological and immunohistochemical study |
| title_short | The presence and localization of onychodermis (specialized nail mesenchyme) containing onychofibroblasts in the nail unit: a morphological and immunohistochemical study |
| title_sort | the presence and localization of onychodermis (specialized nail mesenchyme) containing onychofibroblasts in the nail unit: a morphological and immunohistochemical study |
| title_unstemmed | The presence and localization of onychodermis (specialized nail mesenchyme) containing onychofibroblasts in the nail unit: a morphological and immunohistochemical study |
| topic | General Medicine, Histology, Pathology and Forensic Medicine |
| url | http://dx.doi.org/10.1111/j.1365-2559.2012.04210.x |