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Effects of H2‐receptor antagonists on ethanol metabolism in Japanese volunteers.
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| Zeitschriftentitel: | British Journal of Clinical Pharmacology |
|---|---|
| Personen und Körperschaften: | , |
| In: | British Journal of Clinical Pharmacology, 26, 1988, 1, S. 96-99 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Tanaka, E Nakamura, K Tanaka, E Nakamura, K |
|---|---|
| author |
Tanaka, E Nakamura, K |
| spellingShingle |
Tanaka, E Nakamura, K British Journal of Clinical Pharmacology Effects of H2‐receptor antagonists on ethanol metabolism in Japanese volunteers. Pharmacology (medical) Pharmacology |
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tanaka, e |
| spelling |
Tanaka, E Nakamura, K 0306-5251 1365-2125 Wiley Pharmacology (medical) Pharmacology http://dx.doi.org/10.1111/j.1365-2125.1988.tb03370.x <jats:p>The effects of H2‐receptor antagonists (cimetidine, ranitidine, and famotidine) on ethanol metabolism were investigated. Neither in aldehyde dehydrogenase (ALDH)‐1 deficient subjects nor in those with normal ALDH‐1, did the three H2‐receptor antagonists and placebo differ in their effects on the pharmacokinetic parameters of ethanol (i.e. peak time (tmax), metabolic rate (k0), peak serum concentration (Cmax), volume of distribution (V) and area under the concentration‐time curve (AUC). The AUC of acetaldehyde was slightly but significantly (P less than 0.05) larger only after treatment with cimetidine. Cmax and tmax of acetaldehyde were unchanged.</jats:p> Effects of H2‐receptor antagonists on ethanol metabolism in Japanese volunteers. British Journal of Clinical Pharmacology |
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Wiley, 1988 |
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1988 |
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British Journal of Clinical Pharmacology |
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| title |
Effects of H2‐receptor antagonists on ethanol metabolism in Japanese volunteers. |
| title_unstemmed |
Effects of H2‐receptor antagonists on ethanol metabolism in Japanese volunteers. |
| title_full |
Effects of H2‐receptor antagonists on ethanol metabolism in Japanese volunteers. |
| title_fullStr |
Effects of H2‐receptor antagonists on ethanol metabolism in Japanese volunteers. |
| title_full_unstemmed |
Effects of H2‐receptor antagonists on ethanol metabolism in Japanese volunteers. |
| title_short |
Effects of H2‐receptor antagonists on ethanol metabolism in Japanese volunteers. |
| title_sort |
effects of h2‐receptor antagonists on ethanol metabolism in japanese volunteers. |
| topic |
Pharmacology (medical) Pharmacology |
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http://dx.doi.org/10.1111/j.1365-2125.1988.tb03370.x |
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1988 |
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96-99 |
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<jats:p>The effects of H2‐receptor antagonists (cimetidine, ranitidine, and famotidine) on ethanol metabolism were investigated. Neither in aldehyde dehydrogenase (ALDH)‐1 deficient subjects nor in those with normal ALDH‐1, did the three H2‐receptor antagonists and placebo differ in their effects on the pharmacokinetic parameters of ethanol (i.e. peak time (tmax), metabolic rate (k0), peak serum concentration (Cmax), volume of distribution (V) and area under the concentration‐time curve (AUC). The AUC of acetaldehyde was slightly but significantly (P less than 0.05) larger only after treatment with cimetidine. Cmax and tmax of acetaldehyde were unchanged.</jats:p> |
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| description | <jats:p>The effects of H2‐receptor antagonists (cimetidine, ranitidine, and famotidine) on ethanol metabolism were investigated. Neither in aldehyde dehydrogenase (ALDH)‐1 deficient subjects nor in those with normal ALDH‐1, did the three H2‐receptor antagonists and placebo differ in their effects on the pharmacokinetic parameters of ethanol (i.e. peak time (tmax), metabolic rate (k0), peak serum concentration (Cmax), volume of distribution (V) and area under the concentration‐time curve (AUC). The AUC of acetaldehyde was slightly but significantly (P less than 0.05) larger only after treatment with cimetidine. Cmax and tmax of acetaldehyde were unchanged.</jats:p> |
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| imprint_str_mv | Wiley, 1988 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| series | British Journal of Clinical Pharmacology |
| source_id | 49 |
| spelling | Tanaka, E Nakamura, K 0306-5251 1365-2125 Wiley Pharmacology (medical) Pharmacology http://dx.doi.org/10.1111/j.1365-2125.1988.tb03370.x <jats:p>The effects of H2‐receptor antagonists (cimetidine, ranitidine, and famotidine) on ethanol metabolism were investigated. Neither in aldehyde dehydrogenase (ALDH)‐1 deficient subjects nor in those with normal ALDH‐1, did the three H2‐receptor antagonists and placebo differ in their effects on the pharmacokinetic parameters of ethanol (i.e. peak time (tmax), metabolic rate (k0), peak serum concentration (Cmax), volume of distribution (V) and area under the concentration‐time curve (AUC). The AUC of acetaldehyde was slightly but significantly (P less than 0.05) larger only after treatment with cimetidine. Cmax and tmax of acetaldehyde were unchanged.</jats:p> Effects of H2‐receptor antagonists on ethanol metabolism in Japanese volunteers. British Journal of Clinical Pharmacology |
| spellingShingle | Tanaka, E, Nakamura, K, British Journal of Clinical Pharmacology, Effects of H2‐receptor antagonists on ethanol metabolism in Japanese volunteers., Pharmacology (medical), Pharmacology |
| title | Effects of H2‐receptor antagonists on ethanol metabolism in Japanese volunteers. |
| title_full | Effects of H2‐receptor antagonists on ethanol metabolism in Japanese volunteers. |
| title_fullStr | Effects of H2‐receptor antagonists on ethanol metabolism in Japanese volunteers. |
| title_full_unstemmed | Effects of H2‐receptor antagonists on ethanol metabolism in Japanese volunteers. |
| title_short | Effects of H2‐receptor antagonists on ethanol metabolism in Japanese volunteers. |
| title_sort | effects of h2‐receptor antagonists on ethanol metabolism in japanese volunteers. |
| title_unstemmed | Effects of H2‐receptor antagonists on ethanol metabolism in Japanese volunteers. |
| topic | Pharmacology (medical), Pharmacology |
| url | http://dx.doi.org/10.1111/j.1365-2125.1988.tb03370.x |