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Measurement of ionized calcium in canine blood samples collected in prefilled and self‐filled heparinized syringes using the i‐STAT point‐of‐care analyzer
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| Zeitschriftentitel: | Veterinary Clinical Pathology |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | Veterinary Clinical Pathology, 37, 2008, 1, S. 66-72 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Tappin, Simon Rizzo, Francesca Dodkin, Steve Papasouliotis, Kostas Tasker, Séverine Murphy, Kate Tappin, Simon Rizzo, Francesca Dodkin, Steve Papasouliotis, Kostas Tasker, Séverine Murphy, Kate |
|---|---|
| author |
Tappin, Simon Rizzo, Francesca Dodkin, Steve Papasouliotis, Kostas Tasker, Séverine Murphy, Kate |
| spellingShingle |
Tappin, Simon Rizzo, Francesca Dodkin, Steve Papasouliotis, Kostas Tasker, Séverine Murphy, Kate Veterinary Clinical Pathology Measurement of ionized calcium in canine blood samples collected in prefilled and self‐filled heparinized syringes using the i‐STAT point‐of‐care analyzer General Veterinary |
| author_sort |
tappin, simon |
| spelling |
Tappin, Simon Rizzo, Francesca Dodkin, Steve Papasouliotis, Kostas Tasker, Séverine Murphy, Kate 0275-6382 1939-165X Wiley General Veterinary http://dx.doi.org/10.1111/j.1939-165x.2008.00001.x <jats:p><jats:bold>Background: </jats:bold> Heparinized syringes are commonly used with point‐of‐care analyzers (eg, i‐STAT) to measure ionized calcium (iCa<jats:sup>2+</jats:sup>); however there is little information about the validity of their use in canine patients.</jats:p><jats:p><jats:bold>Objective: </jats:bold> To examine the suitability of prefilled (40 IU heparin/mL) and self‐filled (150 IU heparin/mL) heparinized syringes for iCa<jats:sup>2+</jats:sup> measurements using the i‐STAT analyzer.</jats:p><jats:p><jats:bold>Methods: </jats:bold> Forty‐seven blood samples were collected from 41 canine patients. Two milliliters of blood were collected into a 2‐mL nonanticoagulated (NA) syringe, a commercially available preheparinized (PH) syringe (dry calcium‐balanced lithium heparin, 40 IU/mL), and a 2‐mL self‐filled heparinized (SH) syringe (liquid sodium heparin, 150 IU/mL). iCa<jats:sup>2+</jats:sup> was measured in the sample using the i‐STAT analyzer and a wet‐reagent analyzer (KoneLab 30i) used as the reference instrument. Data were analyzed using paired <jats:italic>t</jats:italic>‐tests, Pearson correlation coefficient, and Bland‐Altman difference plots.</jats:p><jats:p><jats:bold>Results: </jats:bold> There was no significant difference between the results obtained from NA and PH syringes using the i‐STAT analyzer, and the correlation was excellent (<jats:italic>r</jats:italic>=.97). The i‐STAT values from the SH syringes (mean, 1.07 mmol/L) were significantly lower (<jats:italic>P</jats:italic><.001) than those from the NA syringes (mean, 1.38 mmol/L). iCa<jats:sup>2+</jats:sup> was significantly higher with the i‐STAT analyzer than with the KoneLab analyzer for both the PH (mean i‐STAT, 1.38 mmol/L vs mean KoneLab, 1.30 mmol/L) and SH (mean i‐STAT, 1.07 mmol/L vs mean KoneLab, 1.03 mmol/L) samples.</jats:p><jats:p><jats:bold>Conclusions: </jats:bold> Blood samples collected in the PH syringes used in this study can be used interchangeably with those collected in NA syringes for measuring iCa<jats:sup>2+</jats:sup> using the i‐STAT analyzer. SH syringes with high‐concentration heparin products (5000 IU/mL) are unsuitable for measuring iCa<jats:sup>2+</jats:sup> because they cause clinically significant underestimations. Although there was good correlation between the i‐STAT and KoneLab analyzers, the results should be interpreted using analyzer‐specific reference intervals.</jats:p> Measurement of ionized calcium in canine blood samples collected in prefilled and self‐filled heparinized syringes using the i‐STAT point‐of‐care analyzer Veterinary Clinical Pathology |
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10.1111/j.1939-165x.2008.00001.x |
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Online |
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DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 |
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Wiley, 2008 |
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Wiley, 2008 |
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0275-6382 1939-165X |
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English |
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tappin2008measurementofionizedcalciumincaninebloodsamplescollectedinprefilledandselffilledheparinizedsyringesusingtheistatpointofcareanalyzer |
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2008 |
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Wiley |
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Veterinary Clinical Pathology |
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49 |
| title |
Measurement of ionized calcium in canine blood samples collected in prefilled and self‐filled heparinized syringes using the i‐STAT point‐of‐care analyzer |
| title_unstemmed |
Measurement of ionized calcium in canine blood samples collected in prefilled and self‐filled heparinized syringes using the i‐STAT point‐of‐care analyzer |
| title_full |
Measurement of ionized calcium in canine blood samples collected in prefilled and self‐filled heparinized syringes using the i‐STAT point‐of‐care analyzer |
| title_fullStr |
Measurement of ionized calcium in canine blood samples collected in prefilled and self‐filled heparinized syringes using the i‐STAT point‐of‐care analyzer |
| title_full_unstemmed |
Measurement of ionized calcium in canine blood samples collected in prefilled and self‐filled heparinized syringes using the i‐STAT point‐of‐care analyzer |
| title_short |
Measurement of ionized calcium in canine blood samples collected in prefilled and self‐filled heparinized syringes using the i‐STAT point‐of‐care analyzer |
| title_sort |
measurement of ionized calcium in canine blood samples collected in prefilled and self‐filled heparinized syringes using the i‐stat point‐of‐care analyzer |
| topic |
General Veterinary |
| url |
http://dx.doi.org/10.1111/j.1939-165x.2008.00001.x |
| publishDate |
2008 |
| physical |
66-72 |
| description |
<jats:p><jats:bold>Background: </jats:bold> Heparinized syringes are commonly used with point‐of‐care analyzers (eg, i‐STAT) to measure ionized calcium (iCa<jats:sup>2+</jats:sup>); however there is little information about the validity of their use in canine patients.</jats:p><jats:p><jats:bold>Objective: </jats:bold> To examine the suitability of prefilled (40 IU heparin/mL) and self‐filled (150 IU heparin/mL) heparinized syringes for iCa<jats:sup>2+</jats:sup> measurements using the i‐STAT analyzer.</jats:p><jats:p><jats:bold>Methods: </jats:bold> Forty‐seven blood samples were collected from 41 canine patients. Two milliliters of blood were collected into a 2‐mL nonanticoagulated (NA) syringe, a commercially available preheparinized (PH) syringe (dry calcium‐balanced lithium heparin, 40 IU/mL), and a 2‐mL self‐filled heparinized (SH) syringe (liquid sodium heparin, 150 IU/mL). iCa<jats:sup>2+</jats:sup> was measured in the sample using the i‐STAT analyzer and a wet‐reagent analyzer (KoneLab 30i) used as the reference instrument. Data were analyzed using paired <jats:italic>t</jats:italic>‐tests, Pearson correlation coefficient, and Bland‐Altman difference plots.</jats:p><jats:p><jats:bold>Results: </jats:bold> There was no significant difference between the results obtained from NA and PH syringes using the i‐STAT analyzer, and the correlation was excellent (<jats:italic>r</jats:italic>=.97). The i‐STAT values from the SH syringes (mean, 1.07 mmol/L) were significantly lower (<jats:italic>P</jats:italic><.001) than those from the NA syringes (mean, 1.38 mmol/L). iCa<jats:sup>2+</jats:sup> was significantly higher with the i‐STAT analyzer than with the KoneLab analyzer for both the PH (mean i‐STAT, 1.38 mmol/L vs mean KoneLab, 1.30 mmol/L) and SH (mean i‐STAT, 1.07 mmol/L vs mean KoneLab, 1.03 mmol/L) samples.</jats:p><jats:p><jats:bold>Conclusions: </jats:bold> Blood samples collected in the PH syringes used in this study can be used interchangeably with those collected in NA syringes for measuring iCa<jats:sup>2+</jats:sup> using the i‐STAT analyzer. SH syringes with high‐concentration heparin products (5000 IU/mL) are unsuitable for measuring iCa<jats:sup>2+</jats:sup> because they cause clinically significant underestimations. Although there was good correlation between the i‐STAT and KoneLab analyzers, the results should be interpreted using analyzer‐specific reference intervals.</jats:p> |
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| author | Tappin, Simon, Rizzo, Francesca, Dodkin, Steve, Papasouliotis, Kostas, Tasker, Séverine, Murphy, Kate |
| author_facet | Tappin, Simon, Rizzo, Francesca, Dodkin, Steve, Papasouliotis, Kostas, Tasker, Séverine, Murphy, Kate, Tappin, Simon, Rizzo, Francesca, Dodkin, Steve, Papasouliotis, Kostas, Tasker, Séverine, Murphy, Kate |
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| description | <jats:p><jats:bold>Background: </jats:bold> Heparinized syringes are commonly used with point‐of‐care analyzers (eg, i‐STAT) to measure ionized calcium (iCa<jats:sup>2+</jats:sup>); however there is little information about the validity of their use in canine patients.</jats:p><jats:p><jats:bold>Objective: </jats:bold> To examine the suitability of prefilled (40 IU heparin/mL) and self‐filled (150 IU heparin/mL) heparinized syringes for iCa<jats:sup>2+</jats:sup> measurements using the i‐STAT analyzer.</jats:p><jats:p><jats:bold>Methods: </jats:bold> Forty‐seven blood samples were collected from 41 canine patients. Two milliliters of blood were collected into a 2‐mL nonanticoagulated (NA) syringe, a commercially available preheparinized (PH) syringe (dry calcium‐balanced lithium heparin, 40 IU/mL), and a 2‐mL self‐filled heparinized (SH) syringe (liquid sodium heparin, 150 IU/mL). iCa<jats:sup>2+</jats:sup> was measured in the sample using the i‐STAT analyzer and a wet‐reagent analyzer (KoneLab 30i) used as the reference instrument. Data were analyzed using paired <jats:italic>t</jats:italic>‐tests, Pearson correlation coefficient, and Bland‐Altman difference plots.</jats:p><jats:p><jats:bold>Results: </jats:bold> There was no significant difference between the results obtained from NA and PH syringes using the i‐STAT analyzer, and the correlation was excellent (<jats:italic>r</jats:italic>=.97). The i‐STAT values from the SH syringes (mean, 1.07 mmol/L) were significantly lower (<jats:italic>P</jats:italic><.001) than those from the NA syringes (mean, 1.38 mmol/L). iCa<jats:sup>2+</jats:sup> was significantly higher with the i‐STAT analyzer than with the KoneLab analyzer for both the PH (mean i‐STAT, 1.38 mmol/L vs mean KoneLab, 1.30 mmol/L) and SH (mean i‐STAT, 1.07 mmol/L vs mean KoneLab, 1.03 mmol/L) samples.</jats:p><jats:p><jats:bold>Conclusions: </jats:bold> Blood samples collected in the PH syringes used in this study can be used interchangeably with those collected in NA syringes for measuring iCa<jats:sup>2+</jats:sup> using the i‐STAT analyzer. SH syringes with high‐concentration heparin products (5000 IU/mL) are unsuitable for measuring iCa<jats:sup>2+</jats:sup> because they cause clinically significant underestimations. Although there was good correlation between the i‐STAT and KoneLab analyzers, the results should be interpreted using analyzer‐specific reference intervals.</jats:p> |
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| imprint | Wiley, 2008 |
| imprint_str_mv | Wiley, 2008 |
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| spelling | Tappin, Simon Rizzo, Francesca Dodkin, Steve Papasouliotis, Kostas Tasker, Séverine Murphy, Kate 0275-6382 1939-165X Wiley General Veterinary http://dx.doi.org/10.1111/j.1939-165x.2008.00001.x <jats:p><jats:bold>Background: </jats:bold> Heparinized syringes are commonly used with point‐of‐care analyzers (eg, i‐STAT) to measure ionized calcium (iCa<jats:sup>2+</jats:sup>); however there is little information about the validity of their use in canine patients.</jats:p><jats:p><jats:bold>Objective: </jats:bold> To examine the suitability of prefilled (40 IU heparin/mL) and self‐filled (150 IU heparin/mL) heparinized syringes for iCa<jats:sup>2+</jats:sup> measurements using the i‐STAT analyzer.</jats:p><jats:p><jats:bold>Methods: </jats:bold> Forty‐seven blood samples were collected from 41 canine patients. Two milliliters of blood were collected into a 2‐mL nonanticoagulated (NA) syringe, a commercially available preheparinized (PH) syringe (dry calcium‐balanced lithium heparin, 40 IU/mL), and a 2‐mL self‐filled heparinized (SH) syringe (liquid sodium heparin, 150 IU/mL). iCa<jats:sup>2+</jats:sup> was measured in the sample using the i‐STAT analyzer and a wet‐reagent analyzer (KoneLab 30i) used as the reference instrument. Data were analyzed using paired <jats:italic>t</jats:italic>‐tests, Pearson correlation coefficient, and Bland‐Altman difference plots.</jats:p><jats:p><jats:bold>Results: </jats:bold> There was no significant difference between the results obtained from NA and PH syringes using the i‐STAT analyzer, and the correlation was excellent (<jats:italic>r</jats:italic>=.97). The i‐STAT values from the SH syringes (mean, 1.07 mmol/L) were significantly lower (<jats:italic>P</jats:italic><.001) than those from the NA syringes (mean, 1.38 mmol/L). iCa<jats:sup>2+</jats:sup> was significantly higher with the i‐STAT analyzer than with the KoneLab analyzer for both the PH (mean i‐STAT, 1.38 mmol/L vs mean KoneLab, 1.30 mmol/L) and SH (mean i‐STAT, 1.07 mmol/L vs mean KoneLab, 1.03 mmol/L) samples.</jats:p><jats:p><jats:bold>Conclusions: </jats:bold> Blood samples collected in the PH syringes used in this study can be used interchangeably with those collected in NA syringes for measuring iCa<jats:sup>2+</jats:sup> using the i‐STAT analyzer. SH syringes with high‐concentration heparin products (5000 IU/mL) are unsuitable for measuring iCa<jats:sup>2+</jats:sup> because they cause clinically significant underestimations. Although there was good correlation between the i‐STAT and KoneLab analyzers, the results should be interpreted using analyzer‐specific reference intervals.</jats:p> Measurement of ionized calcium in canine blood samples collected in prefilled and self‐filled heparinized syringes using the i‐STAT point‐of‐care analyzer Veterinary Clinical Pathology |
| spellingShingle | Tappin, Simon, Rizzo, Francesca, Dodkin, Steve, Papasouliotis, Kostas, Tasker, Séverine, Murphy, Kate, Veterinary Clinical Pathology, Measurement of ionized calcium in canine blood samples collected in prefilled and self‐filled heparinized syringes using the i‐STAT point‐of‐care analyzer, General Veterinary |
| title | Measurement of ionized calcium in canine blood samples collected in prefilled and self‐filled heparinized syringes using the i‐STAT point‐of‐care analyzer |
| title_full | Measurement of ionized calcium in canine blood samples collected in prefilled and self‐filled heparinized syringes using the i‐STAT point‐of‐care analyzer |
| title_fullStr | Measurement of ionized calcium in canine blood samples collected in prefilled and self‐filled heparinized syringes using the i‐STAT point‐of‐care analyzer |
| title_full_unstemmed | Measurement of ionized calcium in canine blood samples collected in prefilled and self‐filled heparinized syringes using the i‐STAT point‐of‐care analyzer |
| title_short | Measurement of ionized calcium in canine blood samples collected in prefilled and self‐filled heparinized syringes using the i‐STAT point‐of‐care analyzer |
| title_sort | measurement of ionized calcium in canine blood samples collected in prefilled and self‐filled heparinized syringes using the i‐stat point‐of‐care analyzer |
| title_unstemmed | Measurement of ionized calcium in canine blood samples collected in prefilled and self‐filled heparinized syringes using the i‐STAT point‐of‐care analyzer |
| topic | General Veterinary |
| url | http://dx.doi.org/10.1111/j.1939-165x.2008.00001.x |