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Essential Roles of Heparin‐Binding Epidermal Growth Factor‐Like Growth Factor in the Brain
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| Zeitschriftentitel: | CNS Neuroscience & Therapeutics |
|---|---|
| Personen und Körperschaften: | , |
| In: | CNS Neuroscience & Therapeutics, 18, 2012, 10, S. 803-810 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Oyagi, Atsushi Hara, Hideaki Oyagi, Atsushi Hara, Hideaki |
|---|---|
| author |
Oyagi, Atsushi Hara, Hideaki |
| spellingShingle |
Oyagi, Atsushi Hara, Hideaki CNS Neuroscience & Therapeutics Essential Roles of Heparin‐Binding Epidermal Growth Factor‐Like Growth Factor in the Brain Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology |
| author_sort |
oyagi, atsushi |
| spelling |
Oyagi, Atsushi Hara, Hideaki 1755-5930 1755-5949 Wiley Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology http://dx.doi.org/10.1111/j.1755-5949.2012.00371.x <jats:title>Summary</jats:title><jats:sec><jats:label /><jats:p>Heparin‐binding epidermal growth factor‐like growth factor (<jats:styled-content style="fixed-case">HB</jats:styled-content>‐<jats:styled-content style="fixed-case">EGF</jats:styled-content>) is a member of the <jats:styled-content style="fixed-case">EGF</jats:styled-content> family of growth factors, which interacts with the <jats:styled-content style="fixed-case">EGF</jats:styled-content> receptor to exert mitogenic activity for various types of cells. Through its interactions with various molecules, it is involved in diverse biological processes, including wound healing, blast implantation, and tumor formation. At the same time, <jats:styled-content style="fixed-case">HB</jats:styled-content>‐<jats:styled-content style="fixed-case">EGF</jats:styled-content> is widely expressed in the central nervous system, including the hippocampus and cerebral cortex, and is considered to play pivotal roles in the developing and adult nervous system. Because <jats:styled-content style="fixed-case">HB</jats:styled-content>‐<jats:styled-content style="fixed-case">EGF</jats:styled-content> protein levels in the brain are much higher than those of <jats:styled-content style="fixed-case">TGF</jats:styled-content>‐α and <jats:styled-content style="fixed-case">EGF</jats:styled-content>, it is possible that <jats:styled-content style="fixed-case">HB</jats:styled-content>‐<jats:styled-content style="fixed-case">EGF</jats:styled-content> serves as a major physiologic ligand for the <jats:styled-content style="fixed-case">EGF</jats:styled-content> receptor (<jats:styled-content style="fixed-case">E</jats:styled-content>rb<jats:styled-content style="fixed-case">B</jats:styled-content>1) within the central nervous system. Recent studies indicate that <jats:styled-content style="fixed-case">HB</jats:styled-content>‐<jats:styled-content style="fixed-case">EGF</jats:styled-content> contributes to the neuronal survival and proliferation of glial/stem cells. <jats:styled-content style="fixed-case">HB</jats:styled-content>‐<jats:styled-content style="fixed-case">EGF</jats:styled-content> also promotes the survival of dopaminergic neurons, an action mediated by mitogen‐activated protein kinase (<jats:styled-content style="fixed-case">MAPK</jats:styled-content>) as well as by the <jats:styled-content style="fixed-case">A</jats:styled-content>kt signaling pathway. In this review, we discuss recent findings on the implications of <jats:styled-content style="fixed-case">HB</jats:styled-content>‐<jats:styled-content style="fixed-case">EGF</jats:styled-content> in higher brain functions of the central nervous system.</jats:p></jats:sec> Essential Roles of Heparin‐Binding Epidermal Growth Factor‐Like Growth Factor in the Brain CNS Neuroscience & Therapeutics |
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10.1111/j.1755-5949.2012.00371.x |
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Medizin Psychologie Chemie und Pharmazie Biologie |
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Wiley, 2012 |
| imprint_str_mv |
Wiley, 2012 |
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1755-5930 1755-5949 |
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1755-5930 1755-5949 |
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2012 |
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Wiley |
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CNS Neuroscience & Therapeutics |
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49 |
| title |
Essential Roles of Heparin‐Binding Epidermal Growth Factor‐Like Growth Factor in the Brain |
| title_unstemmed |
Essential Roles of Heparin‐Binding Epidermal Growth Factor‐Like Growth Factor in the Brain |
| title_full |
Essential Roles of Heparin‐Binding Epidermal Growth Factor‐Like Growth Factor in the Brain |
| title_fullStr |
Essential Roles of Heparin‐Binding Epidermal Growth Factor‐Like Growth Factor in the Brain |
| title_full_unstemmed |
Essential Roles of Heparin‐Binding Epidermal Growth Factor‐Like Growth Factor in the Brain |
| title_short |
Essential Roles of Heparin‐Binding Epidermal Growth Factor‐Like Growth Factor in the Brain |
| title_sort |
essential roles of heparin‐binding epidermal growth factor‐like growth factor in the brain |
| topic |
Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology |
| url |
http://dx.doi.org/10.1111/j.1755-5949.2012.00371.x |
| publishDate |
2012 |
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803-810 |
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<jats:title>Summary</jats:title><jats:sec><jats:label /><jats:p>Heparin‐binding epidermal growth factor‐like growth factor (<jats:styled-content style="fixed-case">HB</jats:styled-content>‐<jats:styled-content style="fixed-case">EGF</jats:styled-content>) is a member of the <jats:styled-content style="fixed-case">EGF</jats:styled-content> family of growth factors, which interacts with the <jats:styled-content style="fixed-case">EGF</jats:styled-content> receptor to exert mitogenic activity for various types of cells. Through its interactions with various molecules, it is involved in diverse biological processes, including wound healing, blast implantation, and tumor formation. At the same time, <jats:styled-content style="fixed-case">HB</jats:styled-content>‐<jats:styled-content style="fixed-case">EGF</jats:styled-content> is widely expressed in the central nervous system, including the hippocampus and cerebral cortex, and is considered to play pivotal roles in the developing and adult nervous system. Because <jats:styled-content style="fixed-case">HB</jats:styled-content>‐<jats:styled-content style="fixed-case">EGF</jats:styled-content> protein levels in the brain are much higher than those of <jats:styled-content style="fixed-case">TGF</jats:styled-content>‐α and <jats:styled-content style="fixed-case">EGF</jats:styled-content>, it is possible that <jats:styled-content style="fixed-case">HB</jats:styled-content>‐<jats:styled-content style="fixed-case">EGF</jats:styled-content> serves as a major physiologic ligand for the <jats:styled-content style="fixed-case">EGF</jats:styled-content> receptor (<jats:styled-content style="fixed-case">E</jats:styled-content>rb<jats:styled-content style="fixed-case">B</jats:styled-content>1) within the central nervous system. Recent studies indicate that <jats:styled-content style="fixed-case">HB</jats:styled-content>‐<jats:styled-content style="fixed-case">EGF</jats:styled-content> contributes to the neuronal survival and proliferation of glial/stem cells. <jats:styled-content style="fixed-case">HB</jats:styled-content>‐<jats:styled-content style="fixed-case">EGF</jats:styled-content> also promotes the survival of dopaminergic neurons, an action mediated by mitogen‐activated protein kinase (<jats:styled-content style="fixed-case">MAPK</jats:styled-content>) as well as by the <jats:styled-content style="fixed-case">A</jats:styled-content>kt signaling pathway. In this review, we discuss recent findings on the implications of <jats:styled-content style="fixed-case">HB</jats:styled-content>‐<jats:styled-content style="fixed-case">EGF</jats:styled-content> in higher brain functions of the central nervous system.</jats:p></jats:sec> |
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| description | <jats:title>Summary</jats:title><jats:sec><jats:label /><jats:p>Heparin‐binding epidermal growth factor‐like growth factor (<jats:styled-content style="fixed-case">HB</jats:styled-content>‐<jats:styled-content style="fixed-case">EGF</jats:styled-content>) is a member of the <jats:styled-content style="fixed-case">EGF</jats:styled-content> family of growth factors, which interacts with the <jats:styled-content style="fixed-case">EGF</jats:styled-content> receptor to exert mitogenic activity for various types of cells. Through its interactions with various molecules, it is involved in diverse biological processes, including wound healing, blast implantation, and tumor formation. At the same time, <jats:styled-content style="fixed-case">HB</jats:styled-content>‐<jats:styled-content style="fixed-case">EGF</jats:styled-content> is widely expressed in the central nervous system, including the hippocampus and cerebral cortex, and is considered to play pivotal roles in the developing and adult nervous system. Because <jats:styled-content style="fixed-case">HB</jats:styled-content>‐<jats:styled-content style="fixed-case">EGF</jats:styled-content> protein levels in the brain are much higher than those of <jats:styled-content style="fixed-case">TGF</jats:styled-content>‐α and <jats:styled-content style="fixed-case">EGF</jats:styled-content>, it is possible that <jats:styled-content style="fixed-case">HB</jats:styled-content>‐<jats:styled-content style="fixed-case">EGF</jats:styled-content> serves as a major physiologic ligand for the <jats:styled-content style="fixed-case">EGF</jats:styled-content> receptor (<jats:styled-content style="fixed-case">E</jats:styled-content>rb<jats:styled-content style="fixed-case">B</jats:styled-content>1) within the central nervous system. Recent studies indicate that <jats:styled-content style="fixed-case">HB</jats:styled-content>‐<jats:styled-content style="fixed-case">EGF</jats:styled-content> contributes to the neuronal survival and proliferation of glial/stem cells. <jats:styled-content style="fixed-case">HB</jats:styled-content>‐<jats:styled-content style="fixed-case">EGF</jats:styled-content> also promotes the survival of dopaminergic neurons, an action mediated by mitogen‐activated protein kinase (<jats:styled-content style="fixed-case">MAPK</jats:styled-content>) as well as by the <jats:styled-content style="fixed-case">A</jats:styled-content>kt signaling pathway. In this review, we discuss recent findings on the implications of <jats:styled-content style="fixed-case">HB</jats:styled-content>‐<jats:styled-content style="fixed-case">EGF</jats:styled-content> in higher brain functions of the central nervous system.</jats:p></jats:sec> |
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| spelling | Oyagi, Atsushi Hara, Hideaki 1755-5930 1755-5949 Wiley Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology http://dx.doi.org/10.1111/j.1755-5949.2012.00371.x <jats:title>Summary</jats:title><jats:sec><jats:label /><jats:p>Heparin‐binding epidermal growth factor‐like growth factor (<jats:styled-content style="fixed-case">HB</jats:styled-content>‐<jats:styled-content style="fixed-case">EGF</jats:styled-content>) is a member of the <jats:styled-content style="fixed-case">EGF</jats:styled-content> family of growth factors, which interacts with the <jats:styled-content style="fixed-case">EGF</jats:styled-content> receptor to exert mitogenic activity for various types of cells. Through its interactions with various molecules, it is involved in diverse biological processes, including wound healing, blast implantation, and tumor formation. At the same time, <jats:styled-content style="fixed-case">HB</jats:styled-content>‐<jats:styled-content style="fixed-case">EGF</jats:styled-content> is widely expressed in the central nervous system, including the hippocampus and cerebral cortex, and is considered to play pivotal roles in the developing and adult nervous system. Because <jats:styled-content style="fixed-case">HB</jats:styled-content>‐<jats:styled-content style="fixed-case">EGF</jats:styled-content> protein levels in the brain are much higher than those of <jats:styled-content style="fixed-case">TGF</jats:styled-content>‐α and <jats:styled-content style="fixed-case">EGF</jats:styled-content>, it is possible that <jats:styled-content style="fixed-case">HB</jats:styled-content>‐<jats:styled-content style="fixed-case">EGF</jats:styled-content> serves as a major physiologic ligand for the <jats:styled-content style="fixed-case">EGF</jats:styled-content> receptor (<jats:styled-content style="fixed-case">E</jats:styled-content>rb<jats:styled-content style="fixed-case">B</jats:styled-content>1) within the central nervous system. Recent studies indicate that <jats:styled-content style="fixed-case">HB</jats:styled-content>‐<jats:styled-content style="fixed-case">EGF</jats:styled-content> contributes to the neuronal survival and proliferation of glial/stem cells. <jats:styled-content style="fixed-case">HB</jats:styled-content>‐<jats:styled-content style="fixed-case">EGF</jats:styled-content> also promotes the survival of dopaminergic neurons, an action mediated by mitogen‐activated protein kinase (<jats:styled-content style="fixed-case">MAPK</jats:styled-content>) as well as by the <jats:styled-content style="fixed-case">A</jats:styled-content>kt signaling pathway. In this review, we discuss recent findings on the implications of <jats:styled-content style="fixed-case">HB</jats:styled-content>‐<jats:styled-content style="fixed-case">EGF</jats:styled-content> in higher brain functions of the central nervous system.</jats:p></jats:sec> Essential Roles of Heparin‐Binding Epidermal Growth Factor‐Like Growth Factor in the Brain CNS Neuroscience & Therapeutics |
| spellingShingle | Oyagi, Atsushi, Hara, Hideaki, CNS Neuroscience & Therapeutics, Essential Roles of Heparin‐Binding Epidermal Growth Factor‐Like Growth Factor in the Brain, Pharmacology (medical), Physiology (medical), Psychiatry and Mental health, Pharmacology |
| title | Essential Roles of Heparin‐Binding Epidermal Growth Factor‐Like Growth Factor in the Brain |
| title_full | Essential Roles of Heparin‐Binding Epidermal Growth Factor‐Like Growth Factor in the Brain |
| title_fullStr | Essential Roles of Heparin‐Binding Epidermal Growth Factor‐Like Growth Factor in the Brain |
| title_full_unstemmed | Essential Roles of Heparin‐Binding Epidermal Growth Factor‐Like Growth Factor in the Brain |
| title_short | Essential Roles of Heparin‐Binding Epidermal Growth Factor‐Like Growth Factor in the Brain |
| title_sort | essential roles of heparin‐binding epidermal growth factor‐like growth factor in the brain |
| title_unstemmed | Essential Roles of Heparin‐Binding Epidermal Growth Factor‐Like Growth Factor in the Brain |
| topic | Pharmacology (medical), Physiology (medical), Psychiatry and Mental health, Pharmacology |
| url | http://dx.doi.org/10.1111/j.1755-5949.2012.00371.x |