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Hypothermia Reduces Brain Edema, Spontaneous Recurrent Seizure Attack, and Learning Memory Deficits in the Kainic Acid Treated Rats
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| Zeitschriftentitel: | CNS Neuroscience & Therapeutics |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | CNS Neuroscience & Therapeutics, 17, 2011, 5, S. 271-280 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Wang, Yu Liu, Ping‐Ping Li, Liang‐yong Zhang, Hui‐Min Li, Tao Wang, Yu Liu, Ping‐Ping Li, Liang‐yong Zhang, Hui‐Min Li, Tao |
|---|---|
| author |
Wang, Yu Liu, Ping‐Ping Li, Liang‐yong Zhang, Hui‐Min Li, Tao |
| spellingShingle |
Wang, Yu Liu, Ping‐Ping Li, Liang‐yong Zhang, Hui‐Min Li, Tao CNS Neuroscience & Therapeutics Hypothermia Reduces Brain Edema, Spontaneous Recurrent Seizure Attack, and Learning Memory Deficits in the Kainic Acid Treated Rats Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology |
| author_sort |
wang, yu |
| spelling |
Wang, Yu Liu, Ping‐Ping Li, Liang‐yong Zhang, Hui‐Min Li, Tao 1755-5930 1755-5949 Wiley Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology http://dx.doi.org/10.1111/j.1755-5949.2010.00168.x <jats:title>SUMMARY</jats:title><jats:p><jats:bold>Aims:</jats:bold> It is unknown whether hypothermia can disrupt the progress of epileptogenesis. The present study aimed to determine the effect of hypothermia on brain edema and epileptogenesis and to establish whether brain edema is associated with epileptogenesis after severe status epilepticus (SE). <jats:bold>Methodology:</jats:bold> Rats were injected with a single dose of Kainic acid (KA) to produce either chronic epileptic rats (rats with spontaneous recurrent seizure, SRS) or rats without spontaneous recurrent seizure (no‐SRS rats). A second KA injection was used to induce SE in SRS rats and in no‐SRS rats. The number of SRS was counted and the brain edema induced by SE was assessed by brain water content measurement. The cognitive function was assessed by the radial‐arm maze (RAM) test. <jats:bold>Results:</jats:bold> A second KA injection resulted in brain edema that was more severe in SRS rats than in no‐SRS rats. After second injection of KA, hypothermia treatment attenuated the KA induced brain edema and reduced the SRS attack in SRS rats. Additionally cognitive function was better in hypothermia‐treated SRS rats than in nomothermia treated SRS rats 1 month after the second KA injection. <jats:bold>Conclusions:</jats:bold> Hypothermia treatment immediately after SE not only exhibited protective effects against the chronic spontaneous recurrent convulsant seizures but also improved cognitive function. These antiepileptogenic properties of hypothermia may be related to its attenuating effect on brain edema induced by SE. They therefore suggest that brain edema may be involved in the progress of epileptogenesis.</jats:p> Hypothermia Reduces Brain Edema, Spontaneous Recurrent Seizure Attack, and Learning Memory Deficits in the Kainic Acid Treated Rats CNS Neuroscience & Therapeutics |
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| title |
Hypothermia Reduces Brain Edema, Spontaneous Recurrent Seizure Attack, and Learning Memory Deficits in the Kainic Acid Treated Rats |
| title_unstemmed |
Hypothermia Reduces Brain Edema, Spontaneous Recurrent Seizure Attack, and Learning Memory Deficits in the Kainic Acid Treated Rats |
| title_full |
Hypothermia Reduces Brain Edema, Spontaneous Recurrent Seizure Attack, and Learning Memory Deficits in the Kainic Acid Treated Rats |
| title_fullStr |
Hypothermia Reduces Brain Edema, Spontaneous Recurrent Seizure Attack, and Learning Memory Deficits in the Kainic Acid Treated Rats |
| title_full_unstemmed |
Hypothermia Reduces Brain Edema, Spontaneous Recurrent Seizure Attack, and Learning Memory Deficits in the Kainic Acid Treated Rats |
| title_short |
Hypothermia Reduces Brain Edema, Spontaneous Recurrent Seizure Attack, and Learning Memory Deficits in the Kainic Acid Treated Rats |
| title_sort |
hypothermia reduces brain edema, spontaneous recurrent seizure attack, and learning memory deficits in the kainic acid treated rats |
| topic |
Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology |
| url |
http://dx.doi.org/10.1111/j.1755-5949.2010.00168.x |
| publishDate |
2011 |
| physical |
271-280 |
| description |
<jats:title>SUMMARY</jats:title><jats:p><jats:bold>Aims:</jats:bold> It is unknown whether hypothermia can disrupt the progress of epileptogenesis. The present study aimed to determine the effect of hypothermia on brain edema and epileptogenesis and to establish whether brain edema is associated with epileptogenesis after severe status epilepticus (SE). <jats:bold>Methodology:</jats:bold> Rats were injected with a single dose of Kainic acid (KA) to produce either chronic epileptic rats (rats with spontaneous recurrent seizure, SRS) or rats without spontaneous recurrent seizure (no‐SRS rats). A second KA injection was used to induce SE in SRS rats and in no‐SRS rats. The number of SRS was counted and the brain edema induced by SE was assessed by brain water content measurement. The cognitive function was assessed by the radial‐arm maze (RAM) test. <jats:bold>Results:</jats:bold> A second KA injection resulted in brain edema that was more severe in SRS rats than in no‐SRS rats. After second injection of KA, hypothermia treatment attenuated the KA induced brain edema and reduced the SRS attack in SRS rats. Additionally cognitive function was better in hypothermia‐treated SRS rats than in nomothermia treated SRS rats 1 month after the second KA injection. <jats:bold>Conclusions:</jats:bold> Hypothermia treatment immediately after SE not only exhibited protective effects against the chronic spontaneous recurrent convulsant seizures but also improved cognitive function. These antiepileptogenic properties of hypothermia may be related to its attenuating effect on brain edema induced by SE. They therefore suggest that brain edema may be involved in the progress of epileptogenesis.</jats:p> |
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| author | Wang, Yu, Liu, Ping‐Ping, Li, Liang‐yong, Zhang, Hui‐Min, Li, Tao |
| author_facet | Wang, Yu, Liu, Ping‐Ping, Li, Liang‐yong, Zhang, Hui‐Min, Li, Tao, Wang, Yu, Liu, Ping‐Ping, Li, Liang‐yong, Zhang, Hui‐Min, Li, Tao |
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| description | <jats:title>SUMMARY</jats:title><jats:p><jats:bold>Aims:</jats:bold> It is unknown whether hypothermia can disrupt the progress of epileptogenesis. The present study aimed to determine the effect of hypothermia on brain edema and epileptogenesis and to establish whether brain edema is associated with epileptogenesis after severe status epilepticus (SE). <jats:bold>Methodology:</jats:bold> Rats were injected with a single dose of Kainic acid (KA) to produce either chronic epileptic rats (rats with spontaneous recurrent seizure, SRS) or rats without spontaneous recurrent seizure (no‐SRS rats). A second KA injection was used to induce SE in SRS rats and in no‐SRS rats. The number of SRS was counted and the brain edema induced by SE was assessed by brain water content measurement. The cognitive function was assessed by the radial‐arm maze (RAM) test. <jats:bold>Results:</jats:bold> A second KA injection resulted in brain edema that was more severe in SRS rats than in no‐SRS rats. After second injection of KA, hypothermia treatment attenuated the KA induced brain edema and reduced the SRS attack in SRS rats. Additionally cognitive function was better in hypothermia‐treated SRS rats than in nomothermia treated SRS rats 1 month after the second KA injection. <jats:bold>Conclusions:</jats:bold> Hypothermia treatment immediately after SE not only exhibited protective effects against the chronic spontaneous recurrent convulsant seizures but also improved cognitive function. These antiepileptogenic properties of hypothermia may be related to its attenuating effect on brain edema induced by SE. They therefore suggest that brain edema may be involved in the progress of epileptogenesis.</jats:p> |
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| imprint | Wiley, 2011 |
| imprint_str_mv | Wiley, 2011 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| spelling | Wang, Yu Liu, Ping‐Ping Li, Liang‐yong Zhang, Hui‐Min Li, Tao 1755-5930 1755-5949 Wiley Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology http://dx.doi.org/10.1111/j.1755-5949.2010.00168.x <jats:title>SUMMARY</jats:title><jats:p><jats:bold>Aims:</jats:bold> It is unknown whether hypothermia can disrupt the progress of epileptogenesis. The present study aimed to determine the effect of hypothermia on brain edema and epileptogenesis and to establish whether brain edema is associated with epileptogenesis after severe status epilepticus (SE). <jats:bold>Methodology:</jats:bold> Rats were injected with a single dose of Kainic acid (KA) to produce either chronic epileptic rats (rats with spontaneous recurrent seizure, SRS) or rats without spontaneous recurrent seizure (no‐SRS rats). A second KA injection was used to induce SE in SRS rats and in no‐SRS rats. The number of SRS was counted and the brain edema induced by SE was assessed by brain water content measurement. The cognitive function was assessed by the radial‐arm maze (RAM) test. <jats:bold>Results:</jats:bold> A second KA injection resulted in brain edema that was more severe in SRS rats than in no‐SRS rats. After second injection of KA, hypothermia treatment attenuated the KA induced brain edema and reduced the SRS attack in SRS rats. Additionally cognitive function was better in hypothermia‐treated SRS rats than in nomothermia treated SRS rats 1 month after the second KA injection. <jats:bold>Conclusions:</jats:bold> Hypothermia treatment immediately after SE not only exhibited protective effects against the chronic spontaneous recurrent convulsant seizures but also improved cognitive function. These antiepileptogenic properties of hypothermia may be related to its attenuating effect on brain edema induced by SE. They therefore suggest that brain edema may be involved in the progress of epileptogenesis.</jats:p> Hypothermia Reduces Brain Edema, Spontaneous Recurrent Seizure Attack, and Learning Memory Deficits in the Kainic Acid Treated Rats CNS Neuroscience & Therapeutics |
| spellingShingle | Wang, Yu, Liu, Ping‐Ping, Li, Liang‐yong, Zhang, Hui‐Min, Li, Tao, CNS Neuroscience & Therapeutics, Hypothermia Reduces Brain Edema, Spontaneous Recurrent Seizure Attack, and Learning Memory Deficits in the Kainic Acid Treated Rats, Pharmacology (medical), Physiology (medical), Psychiatry and Mental health, Pharmacology |
| title | Hypothermia Reduces Brain Edema, Spontaneous Recurrent Seizure Attack, and Learning Memory Deficits in the Kainic Acid Treated Rats |
| title_full | Hypothermia Reduces Brain Edema, Spontaneous Recurrent Seizure Attack, and Learning Memory Deficits in the Kainic Acid Treated Rats |
| title_fullStr | Hypothermia Reduces Brain Edema, Spontaneous Recurrent Seizure Attack, and Learning Memory Deficits in the Kainic Acid Treated Rats |
| title_full_unstemmed | Hypothermia Reduces Brain Edema, Spontaneous Recurrent Seizure Attack, and Learning Memory Deficits in the Kainic Acid Treated Rats |
| title_short | Hypothermia Reduces Brain Edema, Spontaneous Recurrent Seizure Attack, and Learning Memory Deficits in the Kainic Acid Treated Rats |
| title_sort | hypothermia reduces brain edema, spontaneous recurrent seizure attack, and learning memory deficits in the kainic acid treated rats |
| title_unstemmed | Hypothermia Reduces Brain Edema, Spontaneous Recurrent Seizure Attack, and Learning Memory Deficits in the Kainic Acid Treated Rats |
| topic | Pharmacology (medical), Physiology (medical), Psychiatry and Mental health, Pharmacology |
| url | http://dx.doi.org/10.1111/j.1755-5949.2010.00168.x |