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Effects of subconjunctival bevacizumab on corneal neovascularization: results of a prospective study
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| Zeitschriftentitel: | Acta Ophthalmologica |
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| Personen und Körperschaften: | , , , , |
| In: | Acta Ophthalmologica, 90, 2012, s249, S. 0-0 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
BENAYOUN, Y ADENIS, JP CASSE, G FORTE, R ROBERT, PY BENAYOUN, Y ADENIS, JP CASSE, G FORTE, R ROBERT, PY |
|---|---|
| author |
BENAYOUN, Y ADENIS, JP CASSE, G FORTE, R ROBERT, PY |
| spellingShingle |
BENAYOUN, Y ADENIS, JP CASSE, G FORTE, R ROBERT, PY Acta Ophthalmologica Effects of subconjunctival bevacizumab on corneal neovascularization: results of a prospective study Ophthalmology General Medicine |
| author_sort |
benayoun, y |
| spelling |
BENAYOUN, Y ADENIS, JP CASSE, G FORTE, R ROBERT, PY 1755-375X 1755-3768 Wiley Ophthalmology General Medicine http://dx.doi.org/10.1111/j.1755-3768.2012.4445.x <jats:title>Abstract</jats:title><jats:p><jats:bold>Purpose</jats:bold> To evaluate the effect of subconjunctival bevacizumab injections in patients with corneal neovascularization resulting from different ocular surface disorders.</jats:p><jats:p><jats:bold>Methods</jats:bold> Prospective case series. Fourteen eyes of 13 patients with corneal neovascularization caused by different ocular surface disorders, such as healed corneal ulcers, long‐standing chronic inflammatory diseases and corneal ischaemia secondary to burn were included. All eyes received a single subconjunctival injection of 2.5 mg (0.1 ml) bevacizumab. Morphological changes in neovascularization were evaluated during 3 months using slit‐lamp biomicroscopy, corneal digital photography, and computed‐assisted semi‐automatic analysis of corneal neovascularization area.</jats:p><jats:p><jats:bold>Results</jats:bold> Recession of corneal vessels was observed in all eyes at 1 week post‐injection. The surface of the neovascular tree continued to decrease noticeably for one month and then increased again for the remainder of the follow‐up period. The corneal neovascularization area amounted to 12.14± 4.38% of the corneal surface pre‐injection, compared with 9.10± 3.16% post‐injection (p=0.02), reflecting a mean decrease in corneal neovascularization of 25 %. No local or systemic adverse events possibly related to subconjunctival bevacizumab injection were observed.</jats:p><jats:p><jats:bold>Conclusion</jats:bold> Short‐term results suggest that subconjunctival bevacizumab can be used safely and effectively for corneal neovascularization resulting from different ocular surface disorders, providing an additional strategy to improve success of corneal grafts.</jats:p> Effects of subconjunctival bevacizumab on corneal neovascularization: results of a prospective study Acta Ophthalmologica |
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Wiley, 2012 |
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Wiley, 2012 |
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1755-375X 1755-3768 |
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| title |
Effects of subconjunctival bevacizumab on corneal neovascularization: results of a prospective study |
| title_unstemmed |
Effects of subconjunctival bevacizumab on corneal neovascularization: results of a prospective study |
| title_full |
Effects of subconjunctival bevacizumab on corneal neovascularization: results of a prospective study |
| title_fullStr |
Effects of subconjunctival bevacizumab on corneal neovascularization: results of a prospective study |
| title_full_unstemmed |
Effects of subconjunctival bevacizumab on corneal neovascularization: results of a prospective study |
| title_short |
Effects of subconjunctival bevacizumab on corneal neovascularization: results of a prospective study |
| title_sort |
effects of subconjunctival bevacizumab on corneal neovascularization: results of a prospective study |
| topic |
Ophthalmology General Medicine |
| url |
http://dx.doi.org/10.1111/j.1755-3768.2012.4445.x |
| publishDate |
2012 |
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0-0 |
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<jats:title>Abstract</jats:title><jats:p><jats:bold>Purpose</jats:bold> To evaluate the effect of subconjunctival bevacizumab injections in patients with corneal neovascularization resulting from different ocular surface disorders.</jats:p><jats:p><jats:bold>Methods</jats:bold> Prospective case series. Fourteen eyes of 13 patients with corneal neovascularization caused by different ocular surface disorders, such as healed corneal ulcers, long‐standing chronic inflammatory diseases and corneal ischaemia secondary to burn were included. All eyes received a single subconjunctival injection of 2.5 mg (0.1 ml) bevacizumab. Morphological changes in neovascularization were evaluated during 3 months using slit‐lamp biomicroscopy, corneal digital photography, and computed‐assisted semi‐automatic analysis of corneal neovascularization area.</jats:p><jats:p><jats:bold>Results</jats:bold> Recession of corneal vessels was observed in all eyes at 1 week post‐injection. The surface of the neovascular tree continued to decrease noticeably for one month and then increased again for the remainder of the follow‐up period. The corneal neovascularization area amounted to 12.14± 4.38% of the corneal surface pre‐injection, compared with 9.10± 3.16% post‐injection (p=0.02), reflecting a mean decrease in corneal neovascularization of 25 %. No local or systemic adverse events possibly related to subconjunctival bevacizumab injection were observed.</jats:p><jats:p><jats:bold>Conclusion</jats:bold> Short‐term results suggest that subconjunctival bevacizumab can be used safely and effectively for corneal neovascularization resulting from different ocular surface disorders, providing an additional strategy to improve success of corneal grafts.</jats:p> |
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| author | BENAYOUN, Y, ADENIS, JP, CASSE, G, FORTE, R, ROBERT, PY |
| author_facet | BENAYOUN, Y, ADENIS, JP, CASSE, G, FORTE, R, ROBERT, PY, BENAYOUN, Y, ADENIS, JP, CASSE, G, FORTE, R, ROBERT, PY |
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| description | <jats:title>Abstract</jats:title><jats:p><jats:bold>Purpose</jats:bold> To evaluate the effect of subconjunctival bevacizumab injections in patients with corneal neovascularization resulting from different ocular surface disorders.</jats:p><jats:p><jats:bold>Methods</jats:bold> Prospective case series. Fourteen eyes of 13 patients with corneal neovascularization caused by different ocular surface disorders, such as healed corneal ulcers, long‐standing chronic inflammatory diseases and corneal ischaemia secondary to burn were included. All eyes received a single subconjunctival injection of 2.5 mg (0.1 ml) bevacizumab. Morphological changes in neovascularization were evaluated during 3 months using slit‐lamp biomicroscopy, corneal digital photography, and computed‐assisted semi‐automatic analysis of corneal neovascularization area.</jats:p><jats:p><jats:bold>Results</jats:bold> Recession of corneal vessels was observed in all eyes at 1 week post‐injection. The surface of the neovascular tree continued to decrease noticeably for one month and then increased again for the remainder of the follow‐up period. The corneal neovascularization area amounted to 12.14± 4.38% of the corneal surface pre‐injection, compared with 9.10± 3.16% post‐injection (p=0.02), reflecting a mean decrease in corneal neovascularization of 25 %. No local or systemic adverse events possibly related to subconjunctival bevacizumab injection were observed.</jats:p><jats:p><jats:bold>Conclusion</jats:bold> Short‐term results suggest that subconjunctival bevacizumab can be used safely and effectively for corneal neovascularization resulting from different ocular surface disorders, providing an additional strategy to improve success of corneal grafts.</jats:p> |
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| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| spelling | BENAYOUN, Y ADENIS, JP CASSE, G FORTE, R ROBERT, PY 1755-375X 1755-3768 Wiley Ophthalmology General Medicine http://dx.doi.org/10.1111/j.1755-3768.2012.4445.x <jats:title>Abstract</jats:title><jats:p><jats:bold>Purpose</jats:bold> To evaluate the effect of subconjunctival bevacizumab injections in patients with corneal neovascularization resulting from different ocular surface disorders.</jats:p><jats:p><jats:bold>Methods</jats:bold> Prospective case series. Fourteen eyes of 13 patients with corneal neovascularization caused by different ocular surface disorders, such as healed corneal ulcers, long‐standing chronic inflammatory diseases and corneal ischaemia secondary to burn were included. All eyes received a single subconjunctival injection of 2.5 mg (0.1 ml) bevacizumab. Morphological changes in neovascularization were evaluated during 3 months using slit‐lamp biomicroscopy, corneal digital photography, and computed‐assisted semi‐automatic analysis of corneal neovascularization area.</jats:p><jats:p><jats:bold>Results</jats:bold> Recession of corneal vessels was observed in all eyes at 1 week post‐injection. The surface of the neovascular tree continued to decrease noticeably for one month and then increased again for the remainder of the follow‐up period. The corneal neovascularization area amounted to 12.14± 4.38% of the corneal surface pre‐injection, compared with 9.10± 3.16% post‐injection (p=0.02), reflecting a mean decrease in corneal neovascularization of 25 %. No local or systemic adverse events possibly related to subconjunctival bevacizumab injection were observed.</jats:p><jats:p><jats:bold>Conclusion</jats:bold> Short‐term results suggest that subconjunctival bevacizumab can be used safely and effectively for corneal neovascularization resulting from different ocular surface disorders, providing an additional strategy to improve success of corneal grafts.</jats:p> Effects of subconjunctival bevacizumab on corneal neovascularization: results of a prospective study Acta Ophthalmologica |
| spellingShingle | BENAYOUN, Y, ADENIS, JP, CASSE, G, FORTE, R, ROBERT, PY, Acta Ophthalmologica, Effects of subconjunctival bevacizumab on corneal neovascularization: results of a prospective study, Ophthalmology, General Medicine |
| title | Effects of subconjunctival bevacizumab on corneal neovascularization: results of a prospective study |
| title_full | Effects of subconjunctival bevacizumab on corneal neovascularization: results of a prospective study |
| title_fullStr | Effects of subconjunctival bevacizumab on corneal neovascularization: results of a prospective study |
| title_full_unstemmed | Effects of subconjunctival bevacizumab on corneal neovascularization: results of a prospective study |
| title_short | Effects of subconjunctival bevacizumab on corneal neovascularization: results of a prospective study |
| title_sort | effects of subconjunctival bevacizumab on corneal neovascularization: results of a prospective study |
| title_unstemmed | Effects of subconjunctival bevacizumab on corneal neovascularization: results of a prospective study |
| topic | Ophthalmology, General Medicine |
| url | http://dx.doi.org/10.1111/j.1755-3768.2012.4445.x |