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Mechanisms of Hepatoprotection by Nitric Oxide
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| Zeitschriftentitel: | Annals of the New York Academy of Sciences |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Annals of the New York Academy of Sciences, 962, 2002, 1, S. 415-422 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
WANG, YINNA VODOVOTZ, YORAM KIM, PETER K.M. ZAMORA, RUBEN BILLIAR, TIMOTHY R. WANG, YINNA VODOVOTZ, YORAM KIM, PETER K.M. ZAMORA, RUBEN BILLIAR, TIMOTHY R. |
|---|---|
| author |
WANG, YINNA VODOVOTZ, YORAM KIM, PETER K.M. ZAMORA, RUBEN BILLIAR, TIMOTHY R. |
| spellingShingle |
WANG, YINNA VODOVOTZ, YORAM KIM, PETER K.M. ZAMORA, RUBEN BILLIAR, TIMOTHY R. Annals of the New York Academy of Sciences Mechanisms of Hepatoprotection by Nitric Oxide History and Philosophy of Science General Biochemistry, Genetics and Molecular Biology General Neuroscience |
| author_sort |
wang, yinna |
| spelling |
WANG, YINNA VODOVOTZ, YORAM KIM, PETER K.M. ZAMORA, RUBEN BILLIAR, TIMOTHY R. 0077-8923 1749-6632 Wiley History and Philosophy of Science General Biochemistry, Genetics and Molecular Biology General Neuroscience http://dx.doi.org/10.1111/j.1749-6632.2002.tb04085.x <jats:p><jats:bold>A<jats:sc>bstract</jats:sc>: </jats:bold> Nitric oxide (NO) exerts numerous antiapoptotic effects on hepatocytes in settings of inflammation and tissue damage. These actions of NO are modulated by a variety of mechanisms under both physiologic and pathologic conditions. Nitric oxide inhibits cell death or apoptosis by modulation of heat shock proteins, <jats:italic>S</jats:italic>‐nitrosylation of caspases at their catalytic site cysteine residue, triggering of the cGMP pathway, and prevention of mitochondrial dysfunction. Our preliminary studies also suggest that NO can modulate apoptosis‐related genes in a manner consistent with an antiapoptotic effect. This review focuses on these molecular mechanisms of cytoprotection by NO.</jats:p> Mechanisms of Hepatoprotection by Nitric Oxide Annals of the New York Academy of Sciences |
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| title |
Mechanisms of Hepatoprotection by Nitric Oxide |
| title_unstemmed |
Mechanisms of Hepatoprotection by Nitric Oxide |
| title_full |
Mechanisms of Hepatoprotection by Nitric Oxide |
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Mechanisms of Hepatoprotection by Nitric Oxide |
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Mechanisms of Hepatoprotection by Nitric Oxide |
| title_short |
Mechanisms of Hepatoprotection by Nitric Oxide |
| title_sort |
mechanisms of hepatoprotection by nitric oxide |
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History and Philosophy of Science General Biochemistry, Genetics and Molecular Biology General Neuroscience |
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http://dx.doi.org/10.1111/j.1749-6632.2002.tb04085.x |
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2002 |
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415-422 |
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<jats:p><jats:bold>A<jats:sc>bstract</jats:sc>: </jats:bold> Nitric oxide (NO) exerts numerous antiapoptotic effects on hepatocytes in settings of inflammation and tissue damage. These actions of NO are modulated by a variety of mechanisms under both physiologic and pathologic conditions. Nitric oxide inhibits cell death or apoptosis by modulation of heat shock proteins, <jats:italic>S</jats:italic>‐nitrosylation of caspases at their catalytic site cysteine residue, triggering of the cGMP pathway, and prevention of mitochondrial dysfunction. Our preliminary studies also suggest that NO can modulate apoptosis‐related genes in a manner consistent with an antiapoptotic effect. This review focuses on these molecular mechanisms of cytoprotection by NO.</jats:p> |
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| description | <jats:p><jats:bold>A<jats:sc>bstract</jats:sc>: </jats:bold> Nitric oxide (NO) exerts numerous antiapoptotic effects on hepatocytes in settings of inflammation and tissue damage. These actions of NO are modulated by a variety of mechanisms under both physiologic and pathologic conditions. Nitric oxide inhibits cell death or apoptosis by modulation of heat shock proteins, <jats:italic>S</jats:italic>‐nitrosylation of caspases at their catalytic site cysteine residue, triggering of the cGMP pathway, and prevention of mitochondrial dysfunction. Our preliminary studies also suggest that NO can modulate apoptosis‐related genes in a manner consistent with an antiapoptotic effect. This review focuses on these molecular mechanisms of cytoprotection by NO.</jats:p> |
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| spelling | WANG, YINNA VODOVOTZ, YORAM KIM, PETER K.M. ZAMORA, RUBEN BILLIAR, TIMOTHY R. 0077-8923 1749-6632 Wiley History and Philosophy of Science General Biochemistry, Genetics and Molecular Biology General Neuroscience http://dx.doi.org/10.1111/j.1749-6632.2002.tb04085.x <jats:p><jats:bold>A<jats:sc>bstract</jats:sc>: </jats:bold> Nitric oxide (NO) exerts numerous antiapoptotic effects on hepatocytes in settings of inflammation and tissue damage. These actions of NO are modulated by a variety of mechanisms under both physiologic and pathologic conditions. Nitric oxide inhibits cell death or apoptosis by modulation of heat shock proteins, <jats:italic>S</jats:italic>‐nitrosylation of caspases at their catalytic site cysteine residue, triggering of the cGMP pathway, and prevention of mitochondrial dysfunction. Our preliminary studies also suggest that NO can modulate apoptosis‐related genes in a manner consistent with an antiapoptotic effect. This review focuses on these molecular mechanisms of cytoprotection by NO.</jats:p> Mechanisms of Hepatoprotection by Nitric Oxide Annals of the New York Academy of Sciences |
| spellingShingle | WANG, YINNA, VODOVOTZ, YORAM, KIM, PETER K.M., ZAMORA, RUBEN, BILLIAR, TIMOTHY R., Annals of the New York Academy of Sciences, Mechanisms of Hepatoprotection by Nitric Oxide, History and Philosophy of Science, General Biochemistry, Genetics and Molecular Biology, General Neuroscience |
| title | Mechanisms of Hepatoprotection by Nitric Oxide |
| title_full | Mechanisms of Hepatoprotection by Nitric Oxide |
| title_fullStr | Mechanisms of Hepatoprotection by Nitric Oxide |
| title_full_unstemmed | Mechanisms of Hepatoprotection by Nitric Oxide |
| title_short | Mechanisms of Hepatoprotection by Nitric Oxide |
| title_sort | mechanisms of hepatoprotection by nitric oxide |
| title_unstemmed | Mechanisms of Hepatoprotection by Nitric Oxide |
| topic | History and Philosophy of Science, General Biochemistry, Genetics and Molecular Biology, General Neuroscience |
| url | http://dx.doi.org/10.1111/j.1749-6632.2002.tb04085.x |