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The Role of the Striatopallidal and Extended Amygdala Systems in Drug Addiction
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| Zeitschriftentitel: | Annals of the New York Academy of Sciences |
|---|---|
| Personen und Körperschaften: | |
| In: | Annals of the New York Academy of Sciences, 877, 1999, 1, S. 445-460 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
KOOB, GEORGE F. KOOB, GEORGE F. |
|---|---|
| author |
KOOB, GEORGE F. |
| spellingShingle |
KOOB, GEORGE F. Annals of the New York Academy of Sciences The Role of the Striatopallidal and Extended Amygdala Systems in Drug Addiction History and Philosophy of Science General Biochemistry, Genetics and Molecular Biology General Neuroscience |
| author_sort |
koob, george f. |
| spelling |
KOOB, GEORGE F. 0077-8923 1749-6632 Wiley History and Philosophy of Science General Biochemistry, Genetics and Molecular Biology General Neuroscience http://dx.doi.org/10.1111/j.1749-6632.1999.tb09282.x <jats:p><jats:bold>ABSTRACT: </jats:bold> Evidence Suggests that the acute reinforcing actions of drugs of abuse may be mediated by specific elements of the striatopallidal and extended amygdala systems. These include the shell of the Nucleus accumbens, the central nucleus of hte amygdala, and the sublenticular extended amygdala. Chronic administration of drugs of abuse, including cocaine, amphetamines, nicotine, alcohol, and tetrahydrocannabinol leads to an increasing dysregulation of brain reward systems that is characterized by decreases in reward function. Withdrawal from chronic administration of cocaine, amphetamine, nicotine, alcohol, and tetrahydrocannabinol raises thresholds for brain stimulation reward. Neurochemical elements in the extended amygdala may mediate these changes, including decreases in dopamine and serotonin neurotransmission in the nucleus accumbens and increases in the brain‐stress neurotransmitter, corticotropin‐releasing factor, in the central nucleus of the amygdala. The combination of decreases in function of neurotransmitters involved in the positive‐reinforcing properties of drugs of abuse with recruitment of brain‐stress systems within the extended amygdala provides a powerful mechanism for allostatic changes in hedonic set point that can lead to the compulsive drug‐seeking and drug‐taking behavior characteristic of addiction.</jats:p> The Role of the Striatopallidal and Extended Amygdala Systems in Drug Addiction Annals of the New York Academy of Sciences |
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The Role of the Striatopallidal and Extended Amygdala Systems in Drug Addiction |
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The Role of the Striatopallidal and Extended Amygdala Systems in Drug Addiction |
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The Role of the Striatopallidal and Extended Amygdala Systems in Drug Addiction |
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The Role of the Striatopallidal and Extended Amygdala Systems in Drug Addiction |
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The Role of the Striatopallidal and Extended Amygdala Systems in Drug Addiction |
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The Role of the Striatopallidal and Extended Amygdala Systems in Drug Addiction |
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the role of the striatopallidal and extended amygdala systems in drug addiction |
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History and Philosophy of Science General Biochemistry, Genetics and Molecular Biology General Neuroscience |
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1999 |
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445-460 |
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<jats:p><jats:bold>ABSTRACT: </jats:bold> Evidence Suggests that the acute reinforcing actions of drugs of abuse may be mediated by specific elements of the striatopallidal and extended amygdala systems. These include the shell of the Nucleus accumbens, the central nucleus of hte amygdala, and the sublenticular extended amygdala. Chronic administration of drugs of abuse, including cocaine, amphetamines, nicotine, alcohol, and tetrahydrocannabinol leads to an increasing dysregulation of brain reward systems that is characterized by decreases in reward function. Withdrawal from chronic administration of cocaine, amphetamine, nicotine, alcohol, and tetrahydrocannabinol raises thresholds for brain stimulation reward. Neurochemical elements in the extended amygdala may mediate these changes, including decreases in dopamine and serotonin neurotransmission in the nucleus accumbens and increases in the brain‐stress neurotransmitter, corticotropin‐releasing factor, in the central nucleus of the amygdala. The combination of decreases in function of neurotransmitters involved in the positive‐reinforcing properties of drugs of abuse with recruitment of brain‐stress systems within the extended amygdala provides a powerful mechanism for allostatic changes in hedonic set point that can lead to the compulsive drug‐seeking and drug‐taking behavior characteristic of addiction.</jats:p> |
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| description | <jats:p><jats:bold>ABSTRACT: </jats:bold> Evidence Suggests that the acute reinforcing actions of drugs of abuse may be mediated by specific elements of the striatopallidal and extended amygdala systems. These include the shell of the Nucleus accumbens, the central nucleus of hte amygdala, and the sublenticular extended amygdala. Chronic administration of drugs of abuse, including cocaine, amphetamines, nicotine, alcohol, and tetrahydrocannabinol leads to an increasing dysregulation of brain reward systems that is characterized by decreases in reward function. Withdrawal from chronic administration of cocaine, amphetamine, nicotine, alcohol, and tetrahydrocannabinol raises thresholds for brain stimulation reward. Neurochemical elements in the extended amygdala may mediate these changes, including decreases in dopamine and serotonin neurotransmission in the nucleus accumbens and increases in the brain‐stress neurotransmitter, corticotropin‐releasing factor, in the central nucleus of the amygdala. The combination of decreases in function of neurotransmitters involved in the positive‐reinforcing properties of drugs of abuse with recruitment of brain‐stress systems within the extended amygdala provides a powerful mechanism for allostatic changes in hedonic set point that can lead to the compulsive drug‐seeking and drug‐taking behavior characteristic of addiction.</jats:p> |
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| spelling | KOOB, GEORGE F. 0077-8923 1749-6632 Wiley History and Philosophy of Science General Biochemistry, Genetics and Molecular Biology General Neuroscience http://dx.doi.org/10.1111/j.1749-6632.1999.tb09282.x <jats:p><jats:bold>ABSTRACT: </jats:bold> Evidence Suggests that the acute reinforcing actions of drugs of abuse may be mediated by specific elements of the striatopallidal and extended amygdala systems. These include the shell of the Nucleus accumbens, the central nucleus of hte amygdala, and the sublenticular extended amygdala. Chronic administration of drugs of abuse, including cocaine, amphetamines, nicotine, alcohol, and tetrahydrocannabinol leads to an increasing dysregulation of brain reward systems that is characterized by decreases in reward function. Withdrawal from chronic administration of cocaine, amphetamine, nicotine, alcohol, and tetrahydrocannabinol raises thresholds for brain stimulation reward. Neurochemical elements in the extended amygdala may mediate these changes, including decreases in dopamine and serotonin neurotransmission in the nucleus accumbens and increases in the brain‐stress neurotransmitter, corticotropin‐releasing factor, in the central nucleus of the amygdala. The combination of decreases in function of neurotransmitters involved in the positive‐reinforcing properties of drugs of abuse with recruitment of brain‐stress systems within the extended amygdala provides a powerful mechanism for allostatic changes in hedonic set point that can lead to the compulsive drug‐seeking and drug‐taking behavior characteristic of addiction.</jats:p> The Role of the Striatopallidal and Extended Amygdala Systems in Drug Addiction Annals of the New York Academy of Sciences |
| spellingShingle | KOOB, GEORGE F., Annals of the New York Academy of Sciences, The Role of the Striatopallidal and Extended Amygdala Systems in Drug Addiction, History and Philosophy of Science, General Biochemistry, Genetics and Molecular Biology, General Neuroscience |
| title | The Role of the Striatopallidal and Extended Amygdala Systems in Drug Addiction |
| title_full | The Role of the Striatopallidal and Extended Amygdala Systems in Drug Addiction |
| title_fullStr | The Role of the Striatopallidal and Extended Amygdala Systems in Drug Addiction |
| title_full_unstemmed | The Role of the Striatopallidal and Extended Amygdala Systems in Drug Addiction |
| title_short | The Role of the Striatopallidal and Extended Amygdala Systems in Drug Addiction |
| title_sort | the role of the striatopallidal and extended amygdala systems in drug addiction |
| title_unstemmed | The Role of the Striatopallidal and Extended Amygdala Systems in Drug Addiction |
| topic | History and Philosophy of Science, General Biochemistry, Genetics and Molecular Biology, General Neuroscience |
| url | http://dx.doi.org/10.1111/j.1749-6632.1999.tb09282.x |