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VIP Neurotrophism in the Central Nervous System: Multiple Effectors and Identification of a Femtomolar‐Acting Neuroprotective Peptide
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| Zeitschriftentitel: | Annals of the New York Academy of Sciences |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | Annals of the New York Academy of Sciences, 865, 1998, 1, S. 207-212 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
BRENNEMAN, DOUGLAS E. GLAZNER, GORDON HILL, JOANNA M. HAUSER, JANET DAVIDSON, ARIANE GOZES, ILLANA BRENNEMAN, DOUGLAS E. GLAZNER, GORDON HILL, JOANNA M. HAUSER, JANET DAVIDSON, ARIANE GOZES, ILLANA |
|---|---|
| author |
BRENNEMAN, DOUGLAS E. GLAZNER, GORDON HILL, JOANNA M. HAUSER, JANET DAVIDSON, ARIANE GOZES, ILLANA |
| spellingShingle |
BRENNEMAN, DOUGLAS E. GLAZNER, GORDON HILL, JOANNA M. HAUSER, JANET DAVIDSON, ARIANE GOZES, ILLANA Annals of the New York Academy of Sciences VIP Neurotrophism in the Central Nervous System: Multiple Effectors and Identification of a Femtomolar‐Acting Neuroprotective Peptide History and Philosophy of Science General Biochemistry, Genetics and Molecular Biology General Neuroscience |
| author_sort |
brenneman, douglas e. |
| spelling |
BRENNEMAN, DOUGLAS E. GLAZNER, GORDON HILL, JOANNA M. HAUSER, JANET DAVIDSON, ARIANE GOZES, ILLANA 0077-8923 1749-6632 Wiley History and Philosophy of Science General Biochemistry, Genetics and Molecular Biology General Neuroscience http://dx.doi.org/10.1111/j.1749-6632.1998.tb11180.x <jats:p><jats:bold>A<jats:sc>bstract</jats:sc>: </jats:bold> Vasoactive intestinal peptide has neurotrophic and growth‐regulating properties. As in the case of many neurotrophic molecules, VIP also has neuroprotective properties, including the prevention of cell death associated with excitotoxicity (NMDA), beta‐amyloid peptide, and gp120, the neurotoxic envelope protein from the human immunodeficiency virus. The neurotrophic and neuroprotective properties are mediated in part through the action of glial‐derived substances released by VIP. These substance include cytokines, pro tease nexin I, and ADNF, a novel neuroprotective protein with structural similarities to heat‐shock protein 60. Antiserum against ADNF produced neu ronal cell death and an increase in apoptotic neurons in cell culture. A 14 amino acid peptide (ADNF‐14) derived from ADNF has been discovered that mimics the survival‐promoting action of the parent protein. These studies support the conclusion that VIP, PACAP, and associated molecules are both important regulators of neurodevelopment and strong candidates for therapeutic development for the treatment of neurodegenerative disease.</jats:p> VIP Neurotrophism in the Central Nervous System: Multiple Effectors and Identification of a Femtomolar‐Acting Neuroprotective Peptide Annals of the New York Academy of Sciences |
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10.1111/j.1749-6632.1998.tb11180.x |
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| title |
VIP Neurotrophism in the Central Nervous System: Multiple Effectors and Identification of a Femtomolar‐Acting Neuroprotective Peptide |
| title_unstemmed |
VIP Neurotrophism in the Central Nervous System: Multiple Effectors and Identification of a Femtomolar‐Acting Neuroprotective Peptide |
| title_full |
VIP Neurotrophism in the Central Nervous System: Multiple Effectors and Identification of a Femtomolar‐Acting Neuroprotective Peptide |
| title_fullStr |
VIP Neurotrophism in the Central Nervous System: Multiple Effectors and Identification of a Femtomolar‐Acting Neuroprotective Peptide |
| title_full_unstemmed |
VIP Neurotrophism in the Central Nervous System: Multiple Effectors and Identification of a Femtomolar‐Acting Neuroprotective Peptide |
| title_short |
VIP Neurotrophism in the Central Nervous System: Multiple Effectors and Identification of a Femtomolar‐Acting Neuroprotective Peptide |
| title_sort |
vip neurotrophism in the central nervous system: multiple effectors and identification of a femtomolar‐acting neuroprotective peptide |
| topic |
History and Philosophy of Science General Biochemistry, Genetics and Molecular Biology General Neuroscience |
| url |
http://dx.doi.org/10.1111/j.1749-6632.1998.tb11180.x |
| publishDate |
1998 |
| physical |
207-212 |
| description |
<jats:p><jats:bold>A<jats:sc>bstract</jats:sc>: </jats:bold> Vasoactive intestinal peptide has neurotrophic and growth‐regulating properties. As in the case of many neurotrophic molecules, VIP also has neuroprotective properties, including the prevention of cell death associated with excitotoxicity (NMDA), beta‐amyloid peptide, and gp120, the neurotoxic envelope protein from the human immunodeficiency virus. The neurotrophic and neuroprotective properties are mediated in part through the action of glial‐derived substances released by VIP. These substance include cytokines, pro tease nexin I, and ADNF, a novel neuroprotective protein with structural similarities to heat‐shock protein 60. Antiserum against ADNF produced neu ronal cell death and an increase in apoptotic neurons in cell culture. A 14 amino acid peptide (ADNF‐14) derived from ADNF has been discovered that mimics the survival‐promoting action of the parent protein. These studies support the conclusion that VIP, PACAP, and associated molecules are both important regulators of neurodevelopment and strong candidates for therapeutic development for the treatment of neurodegenerative disease.</jats:p> |
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| author | BRENNEMAN, DOUGLAS E., GLAZNER, GORDON, HILL, JOANNA M., HAUSER, JANET, DAVIDSON, ARIANE, GOZES, ILLANA |
| author_facet | BRENNEMAN, DOUGLAS E., GLAZNER, GORDON, HILL, JOANNA M., HAUSER, JANET, DAVIDSON, ARIANE, GOZES, ILLANA, BRENNEMAN, DOUGLAS E., GLAZNER, GORDON, HILL, JOANNA M., HAUSER, JANET, DAVIDSON, ARIANE, GOZES, ILLANA |
| author_sort | brenneman, douglas e. |
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| container_start_page | 207 |
| container_title | Annals of the New York Academy of Sciences |
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| description | <jats:p><jats:bold>A<jats:sc>bstract</jats:sc>: </jats:bold> Vasoactive intestinal peptide has neurotrophic and growth‐regulating properties. As in the case of many neurotrophic molecules, VIP also has neuroprotective properties, including the prevention of cell death associated with excitotoxicity (NMDA), beta‐amyloid peptide, and gp120, the neurotoxic envelope protein from the human immunodeficiency virus. The neurotrophic and neuroprotective properties are mediated in part through the action of glial‐derived substances released by VIP. These substance include cytokines, pro tease nexin I, and ADNF, a novel neuroprotective protein with structural similarities to heat‐shock protein 60. Antiserum against ADNF produced neu ronal cell death and an increase in apoptotic neurons in cell culture. A 14 amino acid peptide (ADNF‐14) derived from ADNF has been discovered that mimics the survival‐promoting action of the parent protein. These studies support the conclusion that VIP, PACAP, and associated molecules are both important regulators of neurodevelopment and strong candidates for therapeutic development for the treatment of neurodegenerative disease.</jats:p> |
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| imprint_str_mv | Wiley, 1998 |
| institution | DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4 |
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| spelling | BRENNEMAN, DOUGLAS E. GLAZNER, GORDON HILL, JOANNA M. HAUSER, JANET DAVIDSON, ARIANE GOZES, ILLANA 0077-8923 1749-6632 Wiley History and Philosophy of Science General Biochemistry, Genetics and Molecular Biology General Neuroscience http://dx.doi.org/10.1111/j.1749-6632.1998.tb11180.x <jats:p><jats:bold>A<jats:sc>bstract</jats:sc>: </jats:bold> Vasoactive intestinal peptide has neurotrophic and growth‐regulating properties. As in the case of many neurotrophic molecules, VIP also has neuroprotective properties, including the prevention of cell death associated with excitotoxicity (NMDA), beta‐amyloid peptide, and gp120, the neurotoxic envelope protein from the human immunodeficiency virus. The neurotrophic and neuroprotective properties are mediated in part through the action of glial‐derived substances released by VIP. These substance include cytokines, pro tease nexin I, and ADNF, a novel neuroprotective protein with structural similarities to heat‐shock protein 60. Antiserum against ADNF produced neu ronal cell death and an increase in apoptotic neurons in cell culture. A 14 amino acid peptide (ADNF‐14) derived from ADNF has been discovered that mimics the survival‐promoting action of the parent protein. These studies support the conclusion that VIP, PACAP, and associated molecules are both important regulators of neurodevelopment and strong candidates for therapeutic development for the treatment of neurodegenerative disease.</jats:p> VIP Neurotrophism in the Central Nervous System: Multiple Effectors and Identification of a Femtomolar‐Acting Neuroprotective Peptide Annals of the New York Academy of Sciences |
| spellingShingle | BRENNEMAN, DOUGLAS E., GLAZNER, GORDON, HILL, JOANNA M., HAUSER, JANET, DAVIDSON, ARIANE, GOZES, ILLANA, Annals of the New York Academy of Sciences, VIP Neurotrophism in the Central Nervous System: Multiple Effectors and Identification of a Femtomolar‐Acting Neuroprotective Peptide, History and Philosophy of Science, General Biochemistry, Genetics and Molecular Biology, General Neuroscience |
| title | VIP Neurotrophism in the Central Nervous System: Multiple Effectors and Identification of a Femtomolar‐Acting Neuroprotective Peptide |
| title_full | VIP Neurotrophism in the Central Nervous System: Multiple Effectors and Identification of a Femtomolar‐Acting Neuroprotective Peptide |
| title_fullStr | VIP Neurotrophism in the Central Nervous System: Multiple Effectors and Identification of a Femtomolar‐Acting Neuroprotective Peptide |
| title_full_unstemmed | VIP Neurotrophism in the Central Nervous System: Multiple Effectors and Identification of a Femtomolar‐Acting Neuroprotective Peptide |
| title_short | VIP Neurotrophism in the Central Nervous System: Multiple Effectors and Identification of a Femtomolar‐Acting Neuroprotective Peptide |
| title_sort | vip neurotrophism in the central nervous system: multiple effectors and identification of a femtomolar‐acting neuroprotective peptide |
| title_unstemmed | VIP Neurotrophism in the Central Nervous System: Multiple Effectors and Identification of a Femtomolar‐Acting Neuroprotective Peptide |
| topic | History and Philosophy of Science, General Biochemistry, Genetics and Molecular Biology, General Neuroscience |
| url | http://dx.doi.org/10.1111/j.1749-6632.1998.tb11180.x |