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Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate‐induced and 5‐aza‐2′‐deoxycytidine‐induced PTEN upregulation...

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Zeitschriftentitel: The FEBS Journal
Personen und Körperschaften: Pan, Lina, Matloob, Ammar F., Du, Juan, Pan, Hong, Dong, Zhixiong, Zhao, Jing, Feng, Yu, Zhong, Yun, Huang, Baiqu, Lu, Jun
In: The FEBS Journal, 277, 2010, 4, S. 989-999
Format: E-Article
Sprache: Englisch
veröffentlicht:
Wiley
Schlagwörter:
Cell Biology
Molecular Biology
Biochemistry
author_facet Pan, Lina
Matloob, Ammar F.
Du, Juan
Pan, Hong
Dong, Zhixiong
Zhao, Jing
Feng, Yu
Zhong, Yun
Huang, Baiqu
Lu, Jun
Pan, Lina
Matloob, Ammar F.
Du, Juan
Pan, Hong
Dong, Zhixiong
Zhao, Jing
Feng, Yu
Zhong, Yun
Huang, Baiqu
Lu, Jun
author Pan, Lina
Matloob, Ammar F.
Du, Juan
Pan, Hong
Dong, Zhixiong
Zhao, Jing
Feng, Yu
Zhong, Yun
Huang, Baiqu
Lu, Jun
spellingShingle Pan, Lina
Matloob, Ammar F.
Du, Juan
Pan, Hong
Dong, Zhixiong
Zhao, Jing
Feng, Yu
Zhong, Yun
Huang, Baiqu
Lu, Jun
The FEBS Journal
Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate‐induced and 5‐aza‐2′‐deoxycytidine‐induced PTEN upregulation
Cell Biology
Molecular Biology
Biochemistry
author_sort pan, lina
spelling Pan, Lina Matloob, Ammar F. Du, Juan Pan, Hong Dong, Zhixiong Zhao, Jing Feng, Yu Zhong, Yun Huang, Baiqu Lu, Jun 1742-464X 1742-4658 Wiley Cell Biology Molecular Biology Biochemistry http://dx.doi.org/10.1111/j.1742-4658.2009.07542.x <jats:p>Previous studies have shown an anticancer effect of vitamin D, but the mechanisms underlying this action have not been fully explored. Here we show that 1,25‐dihydroxyvitamin D3 (VD3, the active form of vitamin D) significantly promoted apoptosis in the undifferentiated gastric cancer cell line HGC‐27, and this was accompanied by a concurrent increase in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expression on VD3 treatment. In contrast, knockdown of PTEN expression by stable transfection of PTEN small interfering RNA greatly decreased the apoptosis rate. We further demonstrated that VD3 induced PTEN expression through vitamin D receptor. In addition, our evidence showed that vitamin D receptor, Egr‐1 and p300 induced PTEN expression in a synergistic fashion. Furthermore, we found that the histone deacetylase inhibitors trichostatin A and sodium butyrate and the methylation inhibitor 5‐aza‐2′‐deoxycytidine played important roles in vitamin D‐induced apoptosis through PTEN upregulation. The data presented in this article suggest potential benefits of vitamin D in gastric cancer therapies in association with the use of trichostatin A/sodium butyrate and 5‐aza‐2′‐deoxycytidine.</jats:p><jats:p><jats:bold>Structured digital abstract</jats:bold> <jats:list list-type="explicit-label"> <jats:list-item><jats:p><jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://mint.bio.uniroma2.it/mint/search/interaction.do?interactionAc=MINT-7306489">MINT‐7306489</jats:ext-link>, <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://mint.bio.uniroma2.it/mint/search/interaction.do?interactionAc=MINT-7306501">MINT‐7306501</jats:ext-link>, <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://mint.bio.uniroma2.it/mint/search/interaction.do?interactionAc=MINT-7306512">MINT‐7306512</jats:ext-link>: <jats:italic>P300</jats:italic> (uniprotkb:<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://www.uniprot.org/uniprot/Q09472?format=text&amp;amp;ascii">Q09472</jats:ext-link>) <jats:italic>physically interacts</jats:italic> (<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://www.ebi.ac.uk/ontology-lookup/?termId=MI:0914">MI:0914</jats:ext-link>) with <jats:italic>VDR</jats:italic> (uniprotkb:<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://www.uniprot.org/uniprot/P11473?format=text&amp;amp;ascii">P11473</jats:ext-link>) and <jats:italic>EGR1</jats:italic> (uniprotkb:<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://www.uniprot.org/uniprot/P18146?format=text&amp;amp;ascii">P18146</jats:ext-link>) by <jats:italic>anti bait coimmunoprecipitation</jats:italic> (<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://www.ebi.ac.uk/ontology-lookup/?termId=MI:0006">MI:0006</jats:ext-link>)</jats:p></jats:list-item> </jats:list></jats:p> Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate‐induced and 5‐aza‐2′‐deoxycytidine‐induced PTEN upregulation The FEBS Journal
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recordtype ai
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series The FEBS Journal
source_id 49
title Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate‐induced and 5‐aza‐2′‐deoxycytidine‐induced PTEN upregulation
title_unstemmed Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate‐induced and 5‐aza‐2′‐deoxycytidine‐induced PTEN upregulation
title_full Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate‐induced and 5‐aza‐2′‐deoxycytidine‐induced PTEN upregulation
title_fullStr Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate‐induced and 5‐aza‐2′‐deoxycytidine‐induced PTEN upregulation
title_full_unstemmed Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate‐induced and 5‐aza‐2′‐deoxycytidine‐induced PTEN upregulation
title_short Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate‐induced and 5‐aza‐2′‐deoxycytidine‐induced PTEN upregulation
title_sort vitamin d stimulates apoptosis in gastric cancer cells in synergy with trichostatin a /sodium butyrate‐induced and 5‐aza‐2′‐deoxycytidine‐induced pten upregulation
topic Cell Biology
Molecular Biology
Biochemistry
url http://dx.doi.org/10.1111/j.1742-4658.2009.07542.x
publishDate 2010
physical 989-999
description <jats:p>Previous studies have shown an anticancer effect of vitamin D, but the mechanisms underlying this action have not been fully explored. Here we show that 1,25‐dihydroxyvitamin D3 (VD3, the active form of vitamin D) significantly promoted apoptosis in the undifferentiated gastric cancer cell line HGC‐27, and this was accompanied by a concurrent increase in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expression on VD3 treatment. In contrast, knockdown of PTEN expression by stable transfection of PTEN small interfering RNA greatly decreased the apoptosis rate. We further demonstrated that VD3 induced PTEN expression through vitamin D receptor. In addition, our evidence showed that vitamin D receptor, Egr‐1 and p300 induced PTEN expression in a synergistic fashion. Furthermore, we found that the histone deacetylase inhibitors trichostatin A and sodium butyrate and the methylation inhibitor 5‐aza‐2′‐deoxycytidine played important roles in vitamin D‐induced apoptosis through PTEN upregulation. The data presented in this article suggest potential benefits of vitamin D in gastric cancer therapies in association with the use of trichostatin A/sodium butyrate and 5‐aza‐2′‐deoxycytidine.</jats:p><jats:p><jats:bold>Structured digital abstract</jats:bold> <jats:list list-type="explicit-label"> <jats:list-item><jats:p><jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://mint.bio.uniroma2.it/mint/search/interaction.do?interactionAc=MINT-7306489">MINT‐7306489</jats:ext-link>, <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://mint.bio.uniroma2.it/mint/search/interaction.do?interactionAc=MINT-7306501">MINT‐7306501</jats:ext-link>, <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://mint.bio.uniroma2.it/mint/search/interaction.do?interactionAc=MINT-7306512">MINT‐7306512</jats:ext-link>: <jats:italic>P300</jats:italic> (uniprotkb:<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://www.uniprot.org/uniprot/Q09472?format=text&amp;amp;ascii">Q09472</jats:ext-link>) <jats:italic>physically interacts</jats:italic> (<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://www.ebi.ac.uk/ontology-lookup/?termId=MI:0914">MI:0914</jats:ext-link>) with <jats:italic>VDR</jats:italic> (uniprotkb:<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://www.uniprot.org/uniprot/P11473?format=text&amp;amp;ascii">P11473</jats:ext-link>) and <jats:italic>EGR1</jats:italic> (uniprotkb:<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://www.uniprot.org/uniprot/P18146?format=text&amp;amp;ascii">P18146</jats:ext-link>) by <jats:italic>anti bait coimmunoprecipitation</jats:italic> (<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://www.ebi.ac.uk/ontology-lookup/?termId=MI:0006">MI:0006</jats:ext-link>)</jats:p></jats:list-item> </jats:list></jats:p>
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author Pan, Lina, Matloob, Ammar F., Du, Juan, Pan, Hong, Dong, Zhixiong, Zhao, Jing, Feng, Yu, Zhong, Yun, Huang, Baiqu, Lu, Jun
author_facet Pan, Lina, Matloob, Ammar F., Du, Juan, Pan, Hong, Dong, Zhixiong, Zhao, Jing, Feng, Yu, Zhong, Yun, Huang, Baiqu, Lu, Jun, Pan, Lina, Matloob, Ammar F., Du, Juan, Pan, Hong, Dong, Zhixiong, Zhao, Jing, Feng, Yu, Zhong, Yun, Huang, Baiqu, Lu, Jun
author_sort pan, lina
container_issue 4
container_start_page 989
container_title The FEBS Journal
container_volume 277
description <jats:p>Previous studies have shown an anticancer effect of vitamin D, but the mechanisms underlying this action have not been fully explored. Here we show that 1,25‐dihydroxyvitamin D3 (VD3, the active form of vitamin D) significantly promoted apoptosis in the undifferentiated gastric cancer cell line HGC‐27, and this was accompanied by a concurrent increase in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expression on VD3 treatment. In contrast, knockdown of PTEN expression by stable transfection of PTEN small interfering RNA greatly decreased the apoptosis rate. We further demonstrated that VD3 induced PTEN expression through vitamin D receptor. In addition, our evidence showed that vitamin D receptor, Egr‐1 and p300 induced PTEN expression in a synergistic fashion. Furthermore, we found that the histone deacetylase inhibitors trichostatin A and sodium butyrate and the methylation inhibitor 5‐aza‐2′‐deoxycytidine played important roles in vitamin D‐induced apoptosis through PTEN upregulation. The data presented in this article suggest potential benefits of vitamin D in gastric cancer therapies in association with the use of trichostatin A/sodium butyrate and 5‐aza‐2′‐deoxycytidine.</jats:p><jats:p><jats:bold>Structured digital abstract</jats:bold> <jats:list list-type="explicit-label"> <jats:list-item><jats:p><jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://mint.bio.uniroma2.it/mint/search/interaction.do?interactionAc=MINT-7306489">MINT‐7306489</jats:ext-link>, <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://mint.bio.uniroma2.it/mint/search/interaction.do?interactionAc=MINT-7306501">MINT‐7306501</jats:ext-link>, <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://mint.bio.uniroma2.it/mint/search/interaction.do?interactionAc=MINT-7306512">MINT‐7306512</jats:ext-link>: <jats:italic>P300</jats:italic> (uniprotkb:<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://www.uniprot.org/uniprot/Q09472?format=text&amp;amp;ascii">Q09472</jats:ext-link>) <jats:italic>physically interacts</jats:italic> (<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://www.ebi.ac.uk/ontology-lookup/?termId=MI:0914">MI:0914</jats:ext-link>) with <jats:italic>VDR</jats:italic> (uniprotkb:<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://www.uniprot.org/uniprot/P11473?format=text&amp;amp;ascii">P11473</jats:ext-link>) and <jats:italic>EGR1</jats:italic> (uniprotkb:<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://www.uniprot.org/uniprot/P18146?format=text&amp;amp;ascii">P18146</jats:ext-link>) by <jats:italic>anti bait coimmunoprecipitation</jats:italic> (<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://www.ebi.ac.uk/ontology-lookup/?termId=MI:0006">MI:0006</jats:ext-link>)</jats:p></jats:list-item> </jats:list></jats:p>
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spelling Pan, Lina Matloob, Ammar F. Du, Juan Pan, Hong Dong, Zhixiong Zhao, Jing Feng, Yu Zhong, Yun Huang, Baiqu Lu, Jun 1742-464X 1742-4658 Wiley Cell Biology Molecular Biology Biochemistry http://dx.doi.org/10.1111/j.1742-4658.2009.07542.x <jats:p>Previous studies have shown an anticancer effect of vitamin D, but the mechanisms underlying this action have not been fully explored. Here we show that 1,25‐dihydroxyvitamin D3 (VD3, the active form of vitamin D) significantly promoted apoptosis in the undifferentiated gastric cancer cell line HGC‐27, and this was accompanied by a concurrent increase in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expression on VD3 treatment. In contrast, knockdown of PTEN expression by stable transfection of PTEN small interfering RNA greatly decreased the apoptosis rate. We further demonstrated that VD3 induced PTEN expression through vitamin D receptor. In addition, our evidence showed that vitamin D receptor, Egr‐1 and p300 induced PTEN expression in a synergistic fashion. Furthermore, we found that the histone deacetylase inhibitors trichostatin A and sodium butyrate and the methylation inhibitor 5‐aza‐2′‐deoxycytidine played important roles in vitamin D‐induced apoptosis through PTEN upregulation. The data presented in this article suggest potential benefits of vitamin D in gastric cancer therapies in association with the use of trichostatin A/sodium butyrate and 5‐aza‐2′‐deoxycytidine.</jats:p><jats:p><jats:bold>Structured digital abstract</jats:bold> <jats:list list-type="explicit-label"> <jats:list-item><jats:p><jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://mint.bio.uniroma2.it/mint/search/interaction.do?interactionAc=MINT-7306489">MINT‐7306489</jats:ext-link>, <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://mint.bio.uniroma2.it/mint/search/interaction.do?interactionAc=MINT-7306501">MINT‐7306501</jats:ext-link>, <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://mint.bio.uniroma2.it/mint/search/interaction.do?interactionAc=MINT-7306512">MINT‐7306512</jats:ext-link>: <jats:italic>P300</jats:italic> (uniprotkb:<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://www.uniprot.org/uniprot/Q09472?format=text&amp;amp;ascii">Q09472</jats:ext-link>) <jats:italic>physically interacts</jats:italic> (<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://www.ebi.ac.uk/ontology-lookup/?termId=MI:0914">MI:0914</jats:ext-link>) with <jats:italic>VDR</jats:italic> (uniprotkb:<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://www.uniprot.org/uniprot/P11473?format=text&amp;amp;ascii">P11473</jats:ext-link>) and <jats:italic>EGR1</jats:italic> (uniprotkb:<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://www.uniprot.org/uniprot/P18146?format=text&amp;amp;ascii">P18146</jats:ext-link>) by <jats:italic>anti bait coimmunoprecipitation</jats:italic> (<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://www.ebi.ac.uk/ontology-lookup/?termId=MI:0006">MI:0006</jats:ext-link>)</jats:p></jats:list-item> </jats:list></jats:p> Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate‐induced and 5‐aza‐2′‐deoxycytidine‐induced PTEN upregulation The FEBS Journal
spellingShingle Pan, Lina, Matloob, Ammar F., Du, Juan, Pan, Hong, Dong, Zhixiong, Zhao, Jing, Feng, Yu, Zhong, Yun, Huang, Baiqu, Lu, Jun, The FEBS Journal, Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate‐induced and 5‐aza‐2′‐deoxycytidine‐induced PTEN upregulation, Cell Biology, Molecular Biology, Biochemistry
title Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate‐induced and 5‐aza‐2′‐deoxycytidine‐induced PTEN upregulation
title_full Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate‐induced and 5‐aza‐2′‐deoxycytidine‐induced PTEN upregulation
title_fullStr Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate‐induced and 5‐aza‐2′‐deoxycytidine‐induced PTEN upregulation
title_full_unstemmed Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate‐induced and 5‐aza‐2′‐deoxycytidine‐induced PTEN upregulation
title_short Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate‐induced and 5‐aza‐2′‐deoxycytidine‐induced PTEN upregulation
title_sort vitamin d stimulates apoptosis in gastric cancer cells in synergy with trichostatin a /sodium butyrate‐induced and 5‐aza‐2′‐deoxycytidine‐induced pten upregulation
title_unstemmed Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate‐induced and 5‐aza‐2′‐deoxycytidine‐induced PTEN upregulation
topic Cell Biology, Molecular Biology, Biochemistry
url http://dx.doi.org/10.1111/j.1742-4658.2009.07542.x