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Link between inflammation and aquaporin‐5 distribution in submandibular gland in sjögren’s syndrome?
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| Zeitschriftentitel: | Oral Diseases |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Oral Diseases, 18, 2012, 6, S. 568-574 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Soyfoo, MS Konno, A Bolaky, N Oak, JS Fruman, D Nicaise, C Takiguchi, M Delporte, C Soyfoo, MS Konno, A Bolaky, N Oak, JS Fruman, D Nicaise, C Takiguchi, M Delporte, C |
|---|---|
| author |
Soyfoo, MS Konno, A Bolaky, N Oak, JS Fruman, D Nicaise, C Takiguchi, M Delporte, C |
| spellingShingle |
Soyfoo, MS Konno, A Bolaky, N Oak, JS Fruman, D Nicaise, C Takiguchi, M Delporte, C Oral Diseases Link between inflammation and aquaporin‐5 distribution in submandibular gland in sjögren’s syndrome? General Dentistry Otorhinolaryngology |
| author_sort |
soyfoo, ms |
| spelling |
Soyfoo, MS Konno, A Bolaky, N Oak, JS Fruman, D Nicaise, C Takiguchi, M Delporte, C 1354-523X 1601-0825 Wiley General Dentistry Otorhinolaryngology http://dx.doi.org/10.1111/j.1601-0825.2012.01909.x <jats:p><jats:italic>Oral Diseases</jats:italic> (2012) <jats:bold>18,</jats:bold> 568–574</jats:p><jats:p><jats:bold>Objective: </jats:bold> To determine whether a link exists between inflammation and aquaporin‐5 distribution in submandibular glands from three animal models for Sjögren’s syndrome: IQI/JIC, r1ΔT/r2n and non‐obese diabetic mice.</jats:p><jats:p><jats:bold>Methods: </jats:bold> Mice of different ages were used. Inflammatory infiltrates were quantified using the focus score. Acinar aquaporin‐5 subcellular distribution was determined by immunohistochemistry and quantified using labelling indices.</jats:p><jats:p><jats:bold>Results: </jats:bold> Minor inflammatory infiltrates were present in r1f/r2n mice. Massive inflammatory infiltrates and acinar destruction were observed in 24‐week‐old non‐obese diabetic mice, 10‐and 13‐month‐old IQI/JIC mice and some r1ΔT/r2n mice. Aquaporin‐5 immunoreactivity was primarily apical in submandibular glands from 8‐ and 24‐week‐old Balb/C mice, 8‐week‐old non‐obese diabetic mice, 2‐, 4‐ and 7‐month‐old IQI/JIC mice and r1f/r2n mice. In contrast, decreased apical aquaporin‐5 labelling index with concomitant increased apical‐basolateral, apical‐cytoplasmic and/or apical‐basolateral‐cytoplasmic aquaporin‐5 labelling indices was observed in 24‐week‐old non‐obese diabetic, 10‐ and 13‐month‐old IQI/JIC and r1ΔT/r2n mice with a focus score ≥ 1.</jats:p><jats:p><jats:bold>Conclusions: </jats:bold> Altered aquaporin‐5 distribution in submandibular acinar cells from IQI/JIC, non‐obese diabetic and r1ΔT/r2n mice with a focus score ≥ 1 appears to be concomitant to the presence of inflammatory infiltrates and acinar destruction.</jats:p> Link between inflammation and aquaporin‐5 distribution in submandibular gland in sjögren’s syndrome? Oral Diseases |
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| title |
Link between inflammation and aquaporin‐5 distribution in submandibular gland in sjögren’s syndrome? |
| title_unstemmed |
Link between inflammation and aquaporin‐5 distribution in submandibular gland in sjögren’s syndrome? |
| title_full |
Link between inflammation and aquaporin‐5 distribution in submandibular gland in sjögren’s syndrome? |
| title_fullStr |
Link between inflammation and aquaporin‐5 distribution in submandibular gland in sjögren’s syndrome? |
| title_full_unstemmed |
Link between inflammation and aquaporin‐5 distribution in submandibular gland in sjögren’s syndrome? |
| title_short |
Link between inflammation and aquaporin‐5 distribution in submandibular gland in sjögren’s syndrome? |
| title_sort |
link between inflammation and aquaporin‐5 distribution in submandibular gland in sjögren’s syndrome? |
| topic |
General Dentistry Otorhinolaryngology |
| url |
http://dx.doi.org/10.1111/j.1601-0825.2012.01909.x |
| publishDate |
2012 |
| physical |
568-574 |
| description |
<jats:p><jats:italic>Oral Diseases</jats:italic> (2012) <jats:bold>18,</jats:bold> 568–574</jats:p><jats:p><jats:bold>Objective: </jats:bold> To determine whether a link exists between inflammation and aquaporin‐5 distribution in submandibular glands from three animal models for Sjögren’s syndrome: IQI/JIC, r1ΔT/r2n and non‐obese diabetic mice.</jats:p><jats:p><jats:bold>Methods: </jats:bold> Mice of different ages were used. Inflammatory infiltrates were quantified using the focus score. Acinar aquaporin‐5 subcellular distribution was determined by immunohistochemistry and quantified using labelling indices.</jats:p><jats:p><jats:bold>Results: </jats:bold> Minor inflammatory infiltrates were present in r1f/r2n mice. Massive inflammatory infiltrates and acinar destruction were observed in 24‐week‐old non‐obese diabetic mice, 10‐and 13‐month‐old IQI/JIC mice and some r1ΔT/r2n mice. Aquaporin‐5 immunoreactivity was primarily apical in submandibular glands from 8‐ and 24‐week‐old Balb/C mice, 8‐week‐old non‐obese diabetic mice, 2‐, 4‐ and 7‐month‐old IQI/JIC mice and r1f/r2n mice. In contrast, decreased apical aquaporin‐5 labelling index with concomitant increased apical‐basolateral, apical‐cytoplasmic and/or apical‐basolateral‐cytoplasmic aquaporin‐5 labelling indices was observed in 24‐week‐old non‐obese diabetic, 10‐ and 13‐month‐old IQI/JIC and r1ΔT/r2n mice with a focus score ≥ 1.</jats:p><jats:p><jats:bold>Conclusions: </jats:bold> Altered aquaporin‐5 distribution in submandibular acinar cells from IQI/JIC, non‐obese diabetic and r1ΔT/r2n mice with a focus score ≥ 1 appears to be concomitant to the presence of inflammatory infiltrates and acinar destruction.</jats:p> |
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| author | Soyfoo, MS, Konno, A, Bolaky, N, Oak, JS, Fruman, D, Nicaise, C, Takiguchi, M, Delporte, C |
| author_facet | Soyfoo, MS, Konno, A, Bolaky, N, Oak, JS, Fruman, D, Nicaise, C, Takiguchi, M, Delporte, C, Soyfoo, MS, Konno, A, Bolaky, N, Oak, JS, Fruman, D, Nicaise, C, Takiguchi, M, Delporte, C |
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| description | <jats:p><jats:italic>Oral Diseases</jats:italic> (2012) <jats:bold>18,</jats:bold> 568–574</jats:p><jats:p><jats:bold>Objective: </jats:bold> To determine whether a link exists between inflammation and aquaporin‐5 distribution in submandibular glands from three animal models for Sjögren’s syndrome: IQI/JIC, r1ΔT/r2n and non‐obese diabetic mice.</jats:p><jats:p><jats:bold>Methods: </jats:bold> Mice of different ages were used. Inflammatory infiltrates were quantified using the focus score. Acinar aquaporin‐5 subcellular distribution was determined by immunohistochemistry and quantified using labelling indices.</jats:p><jats:p><jats:bold>Results: </jats:bold> Minor inflammatory infiltrates were present in r1f/r2n mice. Massive inflammatory infiltrates and acinar destruction were observed in 24‐week‐old non‐obese diabetic mice, 10‐and 13‐month‐old IQI/JIC mice and some r1ΔT/r2n mice. Aquaporin‐5 immunoreactivity was primarily apical in submandibular glands from 8‐ and 24‐week‐old Balb/C mice, 8‐week‐old non‐obese diabetic mice, 2‐, 4‐ and 7‐month‐old IQI/JIC mice and r1f/r2n mice. In contrast, decreased apical aquaporin‐5 labelling index with concomitant increased apical‐basolateral, apical‐cytoplasmic and/or apical‐basolateral‐cytoplasmic aquaporin‐5 labelling indices was observed in 24‐week‐old non‐obese diabetic, 10‐ and 13‐month‐old IQI/JIC and r1ΔT/r2n mice with a focus score ≥ 1.</jats:p><jats:p><jats:bold>Conclusions: </jats:bold> Altered aquaporin‐5 distribution in submandibular acinar cells from IQI/JIC, non‐obese diabetic and r1ΔT/r2n mice with a focus score ≥ 1 appears to be concomitant to the presence of inflammatory infiltrates and acinar destruction.</jats:p> |
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| imprint | Wiley, 2012 |
| imprint_str_mv | Wiley, 2012 |
| institution | DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1 |
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| spelling | Soyfoo, MS Konno, A Bolaky, N Oak, JS Fruman, D Nicaise, C Takiguchi, M Delporte, C 1354-523X 1601-0825 Wiley General Dentistry Otorhinolaryngology http://dx.doi.org/10.1111/j.1601-0825.2012.01909.x <jats:p><jats:italic>Oral Diseases</jats:italic> (2012) <jats:bold>18,</jats:bold> 568–574</jats:p><jats:p><jats:bold>Objective: </jats:bold> To determine whether a link exists between inflammation and aquaporin‐5 distribution in submandibular glands from three animal models for Sjögren’s syndrome: IQI/JIC, r1ΔT/r2n and non‐obese diabetic mice.</jats:p><jats:p><jats:bold>Methods: </jats:bold> Mice of different ages were used. Inflammatory infiltrates were quantified using the focus score. Acinar aquaporin‐5 subcellular distribution was determined by immunohistochemistry and quantified using labelling indices.</jats:p><jats:p><jats:bold>Results: </jats:bold> Minor inflammatory infiltrates were present in r1f/r2n mice. Massive inflammatory infiltrates and acinar destruction were observed in 24‐week‐old non‐obese diabetic mice, 10‐and 13‐month‐old IQI/JIC mice and some r1ΔT/r2n mice. Aquaporin‐5 immunoreactivity was primarily apical in submandibular glands from 8‐ and 24‐week‐old Balb/C mice, 8‐week‐old non‐obese diabetic mice, 2‐, 4‐ and 7‐month‐old IQI/JIC mice and r1f/r2n mice. In contrast, decreased apical aquaporin‐5 labelling index with concomitant increased apical‐basolateral, apical‐cytoplasmic and/or apical‐basolateral‐cytoplasmic aquaporin‐5 labelling indices was observed in 24‐week‐old non‐obese diabetic, 10‐ and 13‐month‐old IQI/JIC and r1ΔT/r2n mice with a focus score ≥ 1.</jats:p><jats:p><jats:bold>Conclusions: </jats:bold> Altered aquaporin‐5 distribution in submandibular acinar cells from IQI/JIC, non‐obese diabetic and r1ΔT/r2n mice with a focus score ≥ 1 appears to be concomitant to the presence of inflammatory infiltrates and acinar destruction.</jats:p> Link between inflammation and aquaporin‐5 distribution in submandibular gland in sjögren’s syndrome? Oral Diseases |
| spellingShingle | Soyfoo, MS, Konno, A, Bolaky, N, Oak, JS, Fruman, D, Nicaise, C, Takiguchi, M, Delporte, C, Oral Diseases, Link between inflammation and aquaporin‐5 distribution in submandibular gland in sjögren’s syndrome?, General Dentistry, Otorhinolaryngology |
| title | Link between inflammation and aquaporin‐5 distribution in submandibular gland in sjögren’s syndrome? |
| title_full | Link between inflammation and aquaporin‐5 distribution in submandibular gland in sjögren’s syndrome? |
| title_fullStr | Link between inflammation and aquaporin‐5 distribution in submandibular gland in sjögren’s syndrome? |
| title_full_unstemmed | Link between inflammation and aquaporin‐5 distribution in submandibular gland in sjögren’s syndrome? |
| title_short | Link between inflammation and aquaporin‐5 distribution in submandibular gland in sjögren’s syndrome? |
| title_sort | link between inflammation and aquaporin‐5 distribution in submandibular gland in sjögren’s syndrome? |
| title_unstemmed | Link between inflammation and aquaporin‐5 distribution in submandibular gland in sjögren’s syndrome? |
| topic | General Dentistry, Otorhinolaryngology |
| url | http://dx.doi.org/10.1111/j.1601-0825.2012.01909.x |