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Drug releasing systems in cardiovascular tissue engineering
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| Zeitschriftentitel: | Journal of Cellular and Molecular Medicine |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | Journal of Cellular and Molecular Medicine, 13, 2009, 3, S. 422-439 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Spadaccio, Cristiano Chello, Massimo Trombetta, Marcella Rainer, Alberto Toyoda, Yoshiya Genovese, Jorge A. Spadaccio, Cristiano Chello, Massimo Trombetta, Marcella Rainer, Alberto Toyoda, Yoshiya Genovese, Jorge A. |
|---|---|
| author |
Spadaccio, Cristiano Chello, Massimo Trombetta, Marcella Rainer, Alberto Toyoda, Yoshiya Genovese, Jorge A. |
| spellingShingle |
Spadaccio, Cristiano Chello, Massimo Trombetta, Marcella Rainer, Alberto Toyoda, Yoshiya Genovese, Jorge A. Journal of Cellular and Molecular Medicine Drug releasing systems in cardiovascular tissue engineering Cell Biology Molecular Medicine |
| author_sort |
spadaccio, cristiano |
| spelling |
Spadaccio, Cristiano Chello, Massimo Trombetta, Marcella Rainer, Alberto Toyoda, Yoshiya Genovese, Jorge A. 1582-1838 1582-4934 Wiley Cell Biology Molecular Medicine http://dx.doi.org/10.1111/j.1582-4934.2008.00532.x <jats:sec><jats:label /><jats:p> <jats:list list-type="explicit-label"> <jats:list-item><jats:p>Introduction</jats:p></jats:list-item> <jats:list-item><jats:p>Drug and molecules released</jats:p></jats:list-item> <jats:list-item><jats:p>Conclusion</jats:p></jats:list-item> <jats:list-item><jats:p>Acknowledgements</jats:p></jats:list-item> </jats:list> </jats:p></jats:sec><jats:sec><jats:title>Abstract</jats:title><jats:p>Heart disease and atherosclerosis are the leading causes of morbidity and mortality worldwide. The lack of suitable autologous grafts has produced a need for artificial grafts; however, current artificial grafts carry significant limitations, including thrombosis, infection, limited durability and the inability to grow. Tissue engineering of blood vessels, cardiovascular structures and whole organs is a promising approach for creating replacement tissues to repair congenital defects and/or diseased tissues. In an attempt to surmount the shortcomings of artificial grafts, tissue‐engineered cardiovascular graft (TECVG), constructs obtained using cultured autologous vascular cells seeded onto a synthetic biodegradable polymer scaffold, have been developed. Autologous TECVGs have the potential advantages of growth, durability, resistance to infection, and freedom from problems of rejection, thrombogenicity and donor scarcity. Moreover polymers engrafted with growth factors, cytokines, drugs have been developed allowing drug‐releasing systems capable of focused and localized delivery of molecules depending on the environmental requirements and the milieu in which the scaffold is placed. A broad range of applications for compound‐releasing, tissue‐engineered grafts have been suggested ranging from drug delivery to gene therapy. This review will describe advances in the development of drug‐delivery systems for cardiovascular applications focusing on the manufacturing techniques and on the compounds delivered by these systems to date.</jats:p></jats:sec> Drug releasing systems in cardiovascular tissue engineering Journal of Cellular and Molecular Medicine |
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Drug releasing systems in cardiovascular tissue engineering |
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Drug releasing systems in cardiovascular tissue engineering |
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Drug releasing systems in cardiovascular tissue engineering |
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Drug releasing systems in cardiovascular tissue engineering |
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Drug releasing systems in cardiovascular tissue engineering |
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Drug releasing systems in cardiovascular tissue engineering |
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drug releasing systems in cardiovascular tissue engineering |
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Cell Biology Molecular Medicine |
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422-439 |
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<jats:sec><jats:label /><jats:p>
<jats:list list-type="explicit-label">
<jats:list-item><jats:p>Introduction</jats:p></jats:list-item>
<jats:list-item><jats:p>Drug and molecules released</jats:p></jats:list-item>
<jats:list-item><jats:p>Conclusion</jats:p></jats:list-item>
<jats:list-item><jats:p>Acknowledgements</jats:p></jats:list-item>
</jats:list>
</jats:p></jats:sec><jats:sec><jats:title>Abstract</jats:title><jats:p>Heart disease and atherosclerosis are the leading causes of morbidity and mortality worldwide. The lack of suitable autologous grafts has produced a need for artificial grafts; however, current artificial grafts carry significant limitations, including thrombosis, infection, limited durability and the inability to grow. Tissue engineering of blood vessels, cardiovascular structures and whole organs is a promising approach for creating replacement tissues to repair congenital defects and/or diseased tissues. In an attempt to surmount the shortcomings of artificial grafts, tissue‐engineered cardiovascular graft (TECVG), constructs obtained using cultured autologous vascular cells seeded onto a synthetic biodegradable polymer scaffold, have been developed. Autologous TECVGs have the potential advantages of growth, durability, resistance to infection, and freedom from problems of rejection, thrombogenicity and donor scarcity. Moreover polymers engrafted with growth factors, cytokines, drugs have been developed allowing drug‐releasing systems capable of focused and localized delivery of molecules depending on the environmental requirements and the milieu in which the scaffold is placed. A broad range of applications for compound‐releasing, tissue‐engineered grafts have been suggested ranging from drug delivery to gene therapy. This review will describe advances in the development of drug‐delivery systems for cardiovascular applications focusing on the manufacturing techniques and on the compounds delivered by these systems to date.</jats:p></jats:sec> |
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| author_facet | Spadaccio, Cristiano, Chello, Massimo, Trombetta, Marcella, Rainer, Alberto, Toyoda, Yoshiya, Genovese, Jorge A., Spadaccio, Cristiano, Chello, Massimo, Trombetta, Marcella, Rainer, Alberto, Toyoda, Yoshiya, Genovese, Jorge A. |
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| description | <jats:sec><jats:label /><jats:p> <jats:list list-type="explicit-label"> <jats:list-item><jats:p>Introduction</jats:p></jats:list-item> <jats:list-item><jats:p>Drug and molecules released</jats:p></jats:list-item> <jats:list-item><jats:p>Conclusion</jats:p></jats:list-item> <jats:list-item><jats:p>Acknowledgements</jats:p></jats:list-item> </jats:list> </jats:p></jats:sec><jats:sec><jats:title>Abstract</jats:title><jats:p>Heart disease and atherosclerosis are the leading causes of morbidity and mortality worldwide. The lack of suitable autologous grafts has produced a need for artificial grafts; however, current artificial grafts carry significant limitations, including thrombosis, infection, limited durability and the inability to grow. Tissue engineering of blood vessels, cardiovascular structures and whole organs is a promising approach for creating replacement tissues to repair congenital defects and/or diseased tissues. In an attempt to surmount the shortcomings of artificial grafts, tissue‐engineered cardiovascular graft (TECVG), constructs obtained using cultured autologous vascular cells seeded onto a synthetic biodegradable polymer scaffold, have been developed. Autologous TECVGs have the potential advantages of growth, durability, resistance to infection, and freedom from problems of rejection, thrombogenicity and donor scarcity. Moreover polymers engrafted with growth factors, cytokines, drugs have been developed allowing drug‐releasing systems capable of focused and localized delivery of molecules depending on the environmental requirements and the milieu in which the scaffold is placed. A broad range of applications for compound‐releasing, tissue‐engineered grafts have been suggested ranging from drug delivery to gene therapy. This review will describe advances in the development of drug‐delivery systems for cardiovascular applications focusing on the manufacturing techniques and on the compounds delivered by these systems to date.</jats:p></jats:sec> |
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| spelling | Spadaccio, Cristiano Chello, Massimo Trombetta, Marcella Rainer, Alberto Toyoda, Yoshiya Genovese, Jorge A. 1582-1838 1582-4934 Wiley Cell Biology Molecular Medicine http://dx.doi.org/10.1111/j.1582-4934.2008.00532.x <jats:sec><jats:label /><jats:p> <jats:list list-type="explicit-label"> <jats:list-item><jats:p>Introduction</jats:p></jats:list-item> <jats:list-item><jats:p>Drug and molecules released</jats:p></jats:list-item> <jats:list-item><jats:p>Conclusion</jats:p></jats:list-item> <jats:list-item><jats:p>Acknowledgements</jats:p></jats:list-item> </jats:list> </jats:p></jats:sec><jats:sec><jats:title>Abstract</jats:title><jats:p>Heart disease and atherosclerosis are the leading causes of morbidity and mortality worldwide. The lack of suitable autologous grafts has produced a need for artificial grafts; however, current artificial grafts carry significant limitations, including thrombosis, infection, limited durability and the inability to grow. Tissue engineering of blood vessels, cardiovascular structures and whole organs is a promising approach for creating replacement tissues to repair congenital defects and/or diseased tissues. In an attempt to surmount the shortcomings of artificial grafts, tissue‐engineered cardiovascular graft (TECVG), constructs obtained using cultured autologous vascular cells seeded onto a synthetic biodegradable polymer scaffold, have been developed. Autologous TECVGs have the potential advantages of growth, durability, resistance to infection, and freedom from problems of rejection, thrombogenicity and donor scarcity. Moreover polymers engrafted with growth factors, cytokines, drugs have been developed allowing drug‐releasing systems capable of focused and localized delivery of molecules depending on the environmental requirements and the milieu in which the scaffold is placed. A broad range of applications for compound‐releasing, tissue‐engineered grafts have been suggested ranging from drug delivery to gene therapy. This review will describe advances in the development of drug‐delivery systems for cardiovascular applications focusing on the manufacturing techniques and on the compounds delivered by these systems to date.</jats:p></jats:sec> Drug releasing systems in cardiovascular tissue engineering Journal of Cellular and Molecular Medicine |
| spellingShingle | Spadaccio, Cristiano, Chello, Massimo, Trombetta, Marcella, Rainer, Alberto, Toyoda, Yoshiya, Genovese, Jorge A., Journal of Cellular and Molecular Medicine, Drug releasing systems in cardiovascular tissue engineering, Cell Biology, Molecular Medicine |
| title | Drug releasing systems in cardiovascular tissue engineering |
| title_full | Drug releasing systems in cardiovascular tissue engineering |
| title_fullStr | Drug releasing systems in cardiovascular tissue engineering |
| title_full_unstemmed | Drug releasing systems in cardiovascular tissue engineering |
| title_short | Drug releasing systems in cardiovascular tissue engineering |
| title_sort | drug releasing systems in cardiovascular tissue engineering |
| title_unstemmed | Drug releasing systems in cardiovascular tissue engineering |
| topic | Cell Biology, Molecular Medicine |
| url | http://dx.doi.org/10.1111/j.1582-4934.2008.00532.x |