Eintrag weiter verarbeiten
Assessment of a New Experimental Model of Isolated Right Ventricular Failure
Gespeichert in:
| Zeitschriftentitel: | Artificial Organs |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | Artificial Organs, 33, 2009, 3, S. 258-265 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Thomaz, Petronio G. Assad, Renato S. Abduch, Maria C.D. Marques, Euclides Aiello, Vera D. Stolf, Noedir A.G. Thomaz, Petronio G. Assad, Renato S. Abduch, Maria C.D. Marques, Euclides Aiello, Vera D. Stolf, Noedir A.G. |
|---|---|
| author |
Thomaz, Petronio G. Assad, Renato S. Abduch, Maria C.D. Marques, Euclides Aiello, Vera D. Stolf, Noedir A.G. |
| spellingShingle |
Thomaz, Petronio G. Assad, Renato S. Abduch, Maria C.D. Marques, Euclides Aiello, Vera D. Stolf, Noedir A.G. Artificial Organs Assessment of a New Experimental Model of Isolated Right Ventricular Failure Biomedical Engineering General Medicine Biomaterials Medicine (miscellaneous) Bioengineering |
| author_sort |
thomaz, petronio g. |
| spelling |
Thomaz, Petronio G. Assad, Renato S. Abduch, Maria C.D. Marques, Euclides Aiello, Vera D. Stolf, Noedir A.G. 0160-564X 1525-1594 Wiley Biomedical Engineering General Medicine Biomaterials Medicine (miscellaneous) Bioengineering http://dx.doi.org/10.1111/j.1525-1594.2009.00716.x <jats:title>Abstract</jats:title><jats:p>We assessed a new experimental model of isolated right ventricular (RV) failure, achieved by means of intramyocardial injection of ethanol. RV dysfunction was induced in 13 mongrel dogs via multiple injections of 96% ethanol (total dose 1 mL/kg), all over the inlet and trabecular RV free walls. Hemodynamic and metabolic parameters were evaluated at baseline, after ethanol injection, and on the 14th postoperative day (POD). Echocardiographic parameters were evaluated at baseline, on the sixth POD, and on the 13th POD. The animals were then euthanized for histopathological analysis of the hearts. There was a 15.4% mortality rate. We noticed a decrease in pulmonary blood flow right after RV failure (<jats:italic>P</jats:italic> = 0.0018), as well as during reoperation on the 14th POD (<jats:italic>P</jats:italic> = 0.002). The induced RV dysfunction caused an increase in venous lactate levels immediately after ethanol injection and on the 14th POD (<jats:italic>P</jats:italic> < 0.0003). The echocardiogram revealed a decrease in the RV ejection fraction on the sixth and 13th PODs (<jats:italic>P</jats:italic> = 0.0001). There was an increased RV end‐diastolic volume on the sixth (<jats:italic>P</jats:italic> = 0.0001) and 13th PODs (<jats:italic>P</jats:italic> = 0.0084). The right ventricle showed a 74% ± 0.06% transmural infarction area, with necrotic lesions aged 14 days. Intramyocardial ethanol injection has allowed the creation of a reproducible and inexpensive model of RV failure. The hemodynamic, metabolic, and echocardiographic parameters assessed at different protocol times are compatible with severe RV failure. This model may be useful in understanding the pathophysiology of isolated right‐sided heart failure, as well as in the assessment of ventricular assist devices.</jats:p> Assessment of a New Experimental Model of Isolated Right Ventricular Failure Artificial Organs |
| doi_str_mv |
10.1111/j.1525-1594.2009.00716.x |
| facet_avail |
Online |
| finc_class_facet |
Biologie Medizin Technik Chemie und Pharmazie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9qLjE1MjUtMTU5NC4yMDA5LjAwNzE2Lng |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9qLjE1MjUtMTU5NC4yMDA5LjAwNzE2Lng |
| institution |
DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 |
| imprint |
Wiley, 2009 |
| imprint_str_mv |
Wiley, 2009 |
| issn |
1525-1594 0160-564X |
| issn_str_mv |
1525-1594 0160-564X |
| language |
English |
| mega_collection |
Wiley (CrossRef) |
| match_str |
thomaz2009assessmentofanewexperimentalmodelofisolatedrightventricularfailure |
| publishDateSort |
2009 |
| publisher |
Wiley |
| recordtype |
ai |
| record_format |
ai |
| series |
Artificial Organs |
| source_id |
49 |
| title |
Assessment of a New Experimental Model of Isolated Right Ventricular Failure |
| title_unstemmed |
Assessment of a New Experimental Model of Isolated Right Ventricular Failure |
| title_full |
Assessment of a New Experimental Model of Isolated Right Ventricular Failure |
| title_fullStr |
Assessment of a New Experimental Model of Isolated Right Ventricular Failure |
| title_full_unstemmed |
Assessment of a New Experimental Model of Isolated Right Ventricular Failure |
| title_short |
Assessment of a New Experimental Model of Isolated Right Ventricular Failure |
| title_sort |
assessment of a new experimental model of isolated right ventricular failure |
| topic |
Biomedical Engineering General Medicine Biomaterials Medicine (miscellaneous) Bioengineering |
| url |
http://dx.doi.org/10.1111/j.1525-1594.2009.00716.x |
| publishDate |
2009 |
| physical |
258-265 |
| description |
<jats:title>Abstract</jats:title><jats:p>We assessed a new experimental model of isolated right ventricular (RV) failure, achieved by means of intramyocardial injection of ethanol. RV dysfunction was induced in 13 mongrel dogs via multiple injections of 96% ethanol (total dose 1 mL/kg), all over the inlet and trabecular RV free walls. Hemodynamic and metabolic parameters were evaluated at baseline, after ethanol injection, and on the 14th postoperative day (POD). Echocardiographic parameters were evaluated at baseline, on the sixth POD, and on the 13th POD. The animals were then euthanized for histopathological analysis of the hearts. There was a 15.4% mortality rate. We noticed a decrease in pulmonary blood flow right after RV failure (<jats:italic>P</jats:italic> = 0.0018), as well as during reoperation on the 14th POD (<jats:italic>P</jats:italic> = 0.002). The induced RV dysfunction caused an increase in venous lactate levels immediately after ethanol injection and on the 14th POD (<jats:italic>P</jats:italic> < 0.0003). The echocardiogram revealed a decrease in the RV ejection fraction on the sixth and 13th PODs (<jats:italic>P</jats:italic> = 0.0001). There was an increased RV end‐diastolic volume on the sixth (<jats:italic>P</jats:italic> = 0.0001) and 13th PODs (<jats:italic>P</jats:italic> = 0.0084). The right ventricle showed a 74% ± 0.06% transmural infarction area, with necrotic lesions aged 14 days. Intramyocardial ethanol injection has allowed the creation of a reproducible and inexpensive model of RV failure. The hemodynamic, metabolic, and echocardiographic parameters assessed at different protocol times are compatible with severe RV failure. This model may be useful in understanding the pathophysiology of isolated right‐sided heart failure, as well as in the assessment of ventricular assist devices.</jats:p> |
| container_issue |
3 |
| container_start_page |
258 |
| container_title |
Artificial Organs |
| container_volume |
33 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792336236735627272 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T14:57:15.02Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Assessment+of+a+New+Experimental+Model+of+Isolated+Right+Ventricular+Failure&rft.date=2009-03-01&genre=article&issn=1525-1594&volume=33&issue=3&spage=258&epage=265&pages=258-265&jtitle=Artificial+Organs&atitle=Assessment+of+a+New+Experimental+Model+of+Isolated+Right+Ventricular+Failure&aulast=Stolf&aufirst=Noedir+A.G.&rft_id=info%3Adoi%2F10.1111%2Fj.1525-1594.2009.00716.x&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792336236735627272 |
| author | Thomaz, Petronio G., Assad, Renato S., Abduch, Maria C.D., Marques, Euclides, Aiello, Vera D., Stolf, Noedir A.G. |
| author_facet | Thomaz, Petronio G., Assad, Renato S., Abduch, Maria C.D., Marques, Euclides, Aiello, Vera D., Stolf, Noedir A.G., Thomaz, Petronio G., Assad, Renato S., Abduch, Maria C.D., Marques, Euclides, Aiello, Vera D., Stolf, Noedir A.G. |
| author_sort | thomaz, petronio g. |
| container_issue | 3 |
| container_start_page | 258 |
| container_title | Artificial Organs |
| container_volume | 33 |
| description | <jats:title>Abstract</jats:title><jats:p>We assessed a new experimental model of isolated right ventricular (RV) failure, achieved by means of intramyocardial injection of ethanol. RV dysfunction was induced in 13 mongrel dogs via multiple injections of 96% ethanol (total dose 1 mL/kg), all over the inlet and trabecular RV free walls. Hemodynamic and metabolic parameters were evaluated at baseline, after ethanol injection, and on the 14th postoperative day (POD). Echocardiographic parameters were evaluated at baseline, on the sixth POD, and on the 13th POD. The animals were then euthanized for histopathological analysis of the hearts. There was a 15.4% mortality rate. We noticed a decrease in pulmonary blood flow right after RV failure (<jats:italic>P</jats:italic> = 0.0018), as well as during reoperation on the 14th POD (<jats:italic>P</jats:italic> = 0.002). The induced RV dysfunction caused an increase in venous lactate levels immediately after ethanol injection and on the 14th POD (<jats:italic>P</jats:italic> < 0.0003). The echocardiogram revealed a decrease in the RV ejection fraction on the sixth and 13th PODs (<jats:italic>P</jats:italic> = 0.0001). There was an increased RV end‐diastolic volume on the sixth (<jats:italic>P</jats:italic> = 0.0001) and 13th PODs (<jats:italic>P</jats:italic> = 0.0084). The right ventricle showed a 74% ± 0.06% transmural infarction area, with necrotic lesions aged 14 days. Intramyocardial ethanol injection has allowed the creation of a reproducible and inexpensive model of RV failure. The hemodynamic, metabolic, and echocardiographic parameters assessed at different protocol times are compatible with severe RV failure. This model may be useful in understanding the pathophysiology of isolated right‐sided heart failure, as well as in the assessment of ventricular assist devices.</jats:p> |
| doi_str_mv | 10.1111/j.1525-1594.2009.00716.x |
| facet_avail | Online |
| finc_class_facet | Biologie, Medizin, Technik, Chemie und Pharmazie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9qLjE1MjUtMTU5NC4yMDA5LjAwNzE2Lng |
| imprint | Wiley, 2009 |
| imprint_str_mv | Wiley, 2009 |
| institution | DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1 |
| issn | 1525-1594, 0160-564X |
| issn_str_mv | 1525-1594, 0160-564X |
| language | English |
| last_indexed | 2024-03-01T14:57:15.02Z |
| match_str | thomaz2009assessmentofanewexperimentalmodelofisolatedrightventricularfailure |
| mega_collection | Wiley (CrossRef) |
| physical | 258-265 |
| publishDate | 2009 |
| publishDateSort | 2009 |
| publisher | Wiley |
| record_format | ai |
| recordtype | ai |
| series | Artificial Organs |
| source_id | 49 |
| spelling | Thomaz, Petronio G. Assad, Renato S. Abduch, Maria C.D. Marques, Euclides Aiello, Vera D. Stolf, Noedir A.G. 0160-564X 1525-1594 Wiley Biomedical Engineering General Medicine Biomaterials Medicine (miscellaneous) Bioengineering http://dx.doi.org/10.1111/j.1525-1594.2009.00716.x <jats:title>Abstract</jats:title><jats:p>We assessed a new experimental model of isolated right ventricular (RV) failure, achieved by means of intramyocardial injection of ethanol. RV dysfunction was induced in 13 mongrel dogs via multiple injections of 96% ethanol (total dose 1 mL/kg), all over the inlet and trabecular RV free walls. Hemodynamic and metabolic parameters were evaluated at baseline, after ethanol injection, and on the 14th postoperative day (POD). Echocardiographic parameters were evaluated at baseline, on the sixth POD, and on the 13th POD. The animals were then euthanized for histopathological analysis of the hearts. There was a 15.4% mortality rate. We noticed a decrease in pulmonary blood flow right after RV failure (<jats:italic>P</jats:italic> = 0.0018), as well as during reoperation on the 14th POD (<jats:italic>P</jats:italic> = 0.002). The induced RV dysfunction caused an increase in venous lactate levels immediately after ethanol injection and on the 14th POD (<jats:italic>P</jats:italic> < 0.0003). The echocardiogram revealed a decrease in the RV ejection fraction on the sixth and 13th PODs (<jats:italic>P</jats:italic> = 0.0001). There was an increased RV end‐diastolic volume on the sixth (<jats:italic>P</jats:italic> = 0.0001) and 13th PODs (<jats:italic>P</jats:italic> = 0.0084). The right ventricle showed a 74% ± 0.06% transmural infarction area, with necrotic lesions aged 14 days. Intramyocardial ethanol injection has allowed the creation of a reproducible and inexpensive model of RV failure. The hemodynamic, metabolic, and echocardiographic parameters assessed at different protocol times are compatible with severe RV failure. This model may be useful in understanding the pathophysiology of isolated right‐sided heart failure, as well as in the assessment of ventricular assist devices.</jats:p> Assessment of a New Experimental Model of Isolated Right Ventricular Failure Artificial Organs |
| spellingShingle | Thomaz, Petronio G., Assad, Renato S., Abduch, Maria C.D., Marques, Euclides, Aiello, Vera D., Stolf, Noedir A.G., Artificial Organs, Assessment of a New Experimental Model of Isolated Right Ventricular Failure, Biomedical Engineering, General Medicine, Biomaterials, Medicine (miscellaneous), Bioengineering |
| title | Assessment of a New Experimental Model of Isolated Right Ventricular Failure |
| title_full | Assessment of a New Experimental Model of Isolated Right Ventricular Failure |
| title_fullStr | Assessment of a New Experimental Model of Isolated Right Ventricular Failure |
| title_full_unstemmed | Assessment of a New Experimental Model of Isolated Right Ventricular Failure |
| title_short | Assessment of a New Experimental Model of Isolated Right Ventricular Failure |
| title_sort | assessment of a new experimental model of isolated right ventricular failure |
| title_unstemmed | Assessment of a New Experimental Model of Isolated Right Ventricular Failure |
| topic | Biomedical Engineering, General Medicine, Biomaterials, Medicine (miscellaneous), Bioengineering |
| url | http://dx.doi.org/10.1111/j.1525-1594.2009.00716.x |